CN103271946A - External use compound scorpion traditional Chinese medicine composition for treating senile plaque expelling, chloasma skin pigmentation and skin sunlight allergy (solar dermatitis) - Google Patents
External use compound scorpion traditional Chinese medicine composition for treating senile plaque expelling, chloasma skin pigmentation and skin sunlight allergy (solar dermatitis) Download PDFInfo
- Publication number
- CN103271946A CN103271946A CN2013100252633A CN201310025263A CN103271946A CN 103271946 A CN103271946 A CN 103271946A CN 2013100252633 A CN2013100252633 A CN 2013100252633A CN 201310025263 A CN201310025263 A CN 201310025263A CN 103271946 A CN103271946 A CN 103271946A
- Authority
- CN
- China
- Prior art keywords
- scorpio
- skin
- scolopendra
- scorpion
- senile plaque
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to an external use compound scorpion traditional Chinese medicine composition for treating senile plaque expelling, chloasma skin pigmentation and skin sunlight allergy (solar dermatitis), and the composition is composed of mixed high temperature processed medicinal materials of scorpion and centipede, and borneol and vaseline. The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) high temperature treatment of scorpion and centipede: the scorpion and centipede medicinal material is added into melted vaseline for uniformly mixed, and is heated with gradual process, and the highest temperature is 200 DEG C., wherein, the 190 DEG C. constant temperature time is kept for not less than 30 minutes, and the 200-210 DEG C. time is kept for not less than 40 minutes, and the high temperature processed object (2) of scorpion and centipede medicinal material is obtained, and the alcohol extract product of scorpion and centipede high temperature processed medicinal material is prepared. (3) the mixed extract product, the borneol and the vaseline are proportioned by weight, and the compound scorpion composition is obtained. The compound scorpion composition is used for preparing various external use preparations, and can effectively treat senile plaque expelling, chloasma skin pigmentation and sunlight skin allergy (solar dermatitis).
Description
Technical field
The present invention relates to a kind of compositions, be particularly related to a kind of externally used compound Scorpio Chinese medicine composition for the treatment of senile plaque, chloasma cutaneous pigmentation and skin sunlight allergy (solar dermatitis) effect, said composition is made up of mixed extract, Borneolum Syntheticum and the vaseline of Scorpio, Scolopendra high-temperature process medical material, and it can be used in dispels senile plaque, chloasma cutaneous pigmentation and treatment skin sunlight allergy.
Background technology
Senile plaque is called " senile pigmented spots " again, refers to a kind of lipofuscin pigment speckle that occurs on old people's skin.Its origin cause of formation mainly is to enter after old age when human body, every hypofunction, the body intracellular metabolic slows down, the blood circulation trend slowly, the cellular metabolism function also goes down, interior free yl is excessively piled up, can not in time remove, and the cell of skin surface is subjected to external environment easily at this moment, as light, heat, damage waits influence that oxidation takes place, degeneration, because the decline of function of human body can not in time be removed, produce brown lipofuscin age pigment, be deposited in the basal layer cell of skin more, old and feeble histiocyte loses due decomposition and rejection function, the capillary of skin microcirculation is not smooth, thereby forms senile plaque at human body surface.Doctor trained in Western medicine gives antioxidant more in the treatment of senile plaque at present, and as vitamin E, but effect is also undesirable.Theory of Chinese medical science thinks that the formation of senile plaque is not smooth because of QI-blood circulation, and passages through which vital energy circulates is obstructed, causes blood stasis to be stagnated, and the stagnation of QI is not smooth, and painstaking effort can not reach skin face, nutrition skin and form mottle.The traditional Chinese medical science is emphasized to transfer to other localities, interior supporting, and has one's own knack in the treatment of senile plaque, but high because of the senile plaque incidence rate, it is unsuitable to take medicine for a long time, lacks simple prophylactico-therapeutic measures.And other cutaneous pigmentation specklees such as chloasma are also many because influenced by various internal and external environments, and QI-blood circulation is not smooth, skin speckle due to metabolism is slow.
Skin sunlight allergy has another name called solar dermatitis, is a kind of caused by light, anaphylaxis dermatoses of betiding exposure portion, belongs to immune disease.As seen local skin erythema, redness, burning pain, pruritus, vesicle, the visible fever of the body of severe patient, feel sick, vomiting, cardiopalmus General Symptoms.Clinical many be the Therapeutic Principle with antiinflammatory, pain relieving.The general outer Calamine Lotion, acetate solution, 17-hydroxy-11-dehydrocorticosterone, antihistaminic put on the skin alleviated, but more desquamation is often arranged or leave in various degree pigmentation, this disease is outbreak repeatedly easily, there is not simple method, doctor trained in Western medicine think immune desensitization treatment be unique can essence the method for the treatment of, but easily cause the immunologic function disorder of skin defence tissue.
The present invention takes the lead in having studies have shown that by experiment and derives from arthropodan Scorpio and Scolopendra, the steroid hormone constituents that contains, the fatty acid composition is the treatment senile plaque, the effective ingredient of chloasma cutaneous pigmentation and solar dermatitis, especially the steroid hormone composition that forms of pyrolytic conversion, after removing other impurity components by high temperature, can bring into play immunoregulation effect, be used for the sunlight skin allergy, arthropodan steroid hormone is remarkable to the metabolism of regulating skin, such as the ecdyson class, can promote lipofuscin to decompose, come off, have the treatment senile plaque, the effect of chloasma cutaneous pigmentation.With steroidal class, micromolecule fatty acid be effective ingredient be different from the past to Scorpio and Scolopendra be understanding and the use of effective ingredient with scorpion venom, albumen, aminoacid, enzyme etc., and destroyed substantially by such thermo-labile component after the high-temperature process.The present invention studies have shown that by clinical practice mixing the medicinal substances extract compatibility with the Scorpio after the high-temperature process, Scolopendra promotes the Borneolum Syntheticum of Transdermal absorption and keep vaseline moisture of skin, horny layer softening again, and senile plaque, chloasma cutaneous pigmentation and solar dermatitis can be effectively treated in the external agent that other external agent matrix components commonly used are made.
Summary of the invention
The invention provides a kind of externally used compound Scorpio compositions of dispeling senile plaque, chloasma cutaneous pigmentation and treatment skin sunlight allergy (solar dermatitis) effect that has, it is characterized in that this compound recipe Scorpio compositions of dispeling senile plaque, chloasma cutaneous pigmentation and the irritated effect for the treatment of sunlight is that mixed extract and Borneolum Syntheticum, vaseline by Scorpio, Scolopendra combines.
Scorpio nature and flavor suffering, flat, hot with powder detoxifcation, pungent in taste acting on the lung, lung governing skin and hair; The Scolopendra nature and flavor are salty, warm, and are salty with softening the hard mass, and the two all has detoxicating and resolving stagnation of pathogens, and the merit of removing obstruction in the collateral to relieve pain is usually used in internal injury diseases such as acute and chronic infantile convulsion, apoplexy facial paralysis, tetanic spasm, intractable polarization headache, rheumatic arthralgia.Though be all the medicine commonly used of department of dermatologry, do not see but this compound is used for the purposes of senile plaque, chloasma cutaneous pigmentation and skin sunlight allergy.The present composition has promoting blood circulation to restore menstrual flow, and the stasis of blood is opened in detoxifcation, and dispelling wind is antipruritic, the effect of removing the necrotic tissue and promoting granulation.From the steroid hormone of the steroid hormone of arthropod Scorpio, Scolopendra and pyrolytic conversion can promote slough decomposition, come off, and the performance immunoregulation effect, this steroid hormone that also is we study the animal origin of recognizing first by experiment can effectively be treated senile plaque, chloasma cutaneous pigmentation and and and Ia daylight skin allergy.Fatty acid has horny layer softening, keeps moisture, forms protecting film in the compositions, prevents ultraviolet injury, regulates lipid inflammatory mediator balance, is beneficial to the effect of skin inflammatory treatment; Combination is anticorrosion with the Borneolum Syntheticum heat clearing away, and antalgesic-antipruritic is strengthened assimilation effect; Vaseline can keep skin wet, as the carrier of fat-soluble steroidal constituents, makes the skin histology of wound site keep optimum state, has accelerated the repair ability of skin self, and can stop antibacterial and contact skin, reduces possibility of infection.
Of the present invention have an externally used compound Scorpio compositions of dispeling senile plaque, chloasma cutaneous pigmentation and the irritated effect for the treatment of skin sunlight, it is characterized in that: in the compositions, wherein the weight proportion of the crude drug of Scorpio, Scolopendra mixed extract is 12～8: 1～5, crude drug is used for producing mixed extract after the high-temperature process for the Scorpio of this weight proportion, Scolopendra, and the weight proportion of Scorpio, Scolopendra crude drug and Borneolum Syntheticum, vaseline compositions is: 12～8: 1～5: 3～6: 8～120.
Have an externally used compound Scorpio preparation of compositions method of dispeling senile plaque, chloasma cutaneous pigmentation and the irritated effect for the treatment of skin sunlight according to claim 1-2 is described, it is characterized in that comprising the steps:
(1) high-temperature process of Scorpio, Scolopendra: the vaseline of getting 1/10～5 times of composite formula quality, 60～70 ℃ of heating and meltings, with Scorpio, Scolopendra medical material, the vaseline mix that adds fusion is even, places in the heating clamber, and gradually order heats up, maximum temperature is 220 ℃, wherein 190 ℃ keep constant temperature time to be no less than 30 minutes, and 200～210 ℃ of retention times are no less than 40 minutes, namely get the high-temperature process thing of Scorpio, Scolopendra medical material; Also crude drug vaseline be can not be added and a small amount of edible oil and fat or medical material direct heating acquisition high-temperature process thing smeared.
(2) the high-temperature process thing of Scorpio, Scolopendra is measured 95% alcohol heating reflux with 8～12 times, extract 3 times, each 2～3 hours, merging filtrate reclaimed ethanol, obtains ethanol extraction, concentrates, and namely gets Scorpio, Scolopendra mixed extract.
(3) with Scorpio, Scolopendra mixed extract and Borneolum Syntheticum, vaseline by weight ratio, low-temperature mixed evenly namely gets compound recipe Scorpio compositions.
At present mostly Scorpio, the Scolopendra report that is used for department of dermatologry is to be used as medicine to give birth to the product medical material, does not see to use after the high-temperature process, and this is the difference of the present invention and other usages.About the chemical research of Scorpio, existing report shows that all it mainly contains: compositions such as scorpion venom, trimethylamine, betanin, sulfacid, Palmic acid, and wherein scorpion venom is considered to the material base of Scorpio performance endogenous wind stopping relieving convulsion drug action; The chemical research of Scolopendra shows, it mainly contains: albumen, aminoacid, enzyme, cholesterol, fatty acid composition, in the method for making of the present invention, pass through high-temperature process, heat-labile scorpion venom, trimethylamine, protide, aminoacid, enzyme have been removed, clear and definite is effective substance with sterol (steroid hormone) class, the fatty acid that dissociates, and is different from other reports.
Following experimental example will be in order to illustrate Scorpio, Scolopendra through after the high-temperature process, and the chemical constituent that can detect is different from the existing literature report.
Experimental example one: the chemical research of Scorpio Scolopendra high-temperature process thing
Be 10: 3 high-temperature process thing 1.72kg with Scorpio, Scolopendra weight proportion, use 95% ethanol, with 8 times of amount volumes, heating and refluxing extraction 3 times, each 2 hours, filter, reclaim under reduced pressure obtains ethanol extraction 216g.Get ethanol extraction 216g and carry out rough segmentation with silica gel column chromatography, petroleum ether-ethyl acetate solvent system eluting, eluent is after the TLC thin layer detects, close person merges with composition, it is separated with method through modern separation technology such as silica gel column chromatography, Toyopearl gel column chromatography repeatedly again, be divided into from obtaining 6 monomeric compounds.Through the integration analysis of physico-chemical analysis and various spectral datas, determined the chemical constitution of 6 monomeric compounds, and carried out attribution data that separation process sees the following form.
Chemical compound 1 is colourless acicular crystal, is soluble in methanol.The Molish reaction negative, the Libermann-Burchard reacting positive prompts for phytosterin compound.Molecular weight is 386.In conjunction with
1H-NMR,
13Its molecular formula of supposition such as C-NMR and DEPT spectrum are C
27H
46O, calculating degree of unsaturation is 5, in conjunction with
1H-NMR,
13Wave spectrum such as C-NMR, DEPT has carried out accurate ownership to the whole hydrocarbon signal of chemical compound 1, determines that chemical compound 1 is cholesterol (cholesterol).
Chemical compound 2 is colourless acicular crystal, is soluble in methanol.The Molish reaction negative, the Libermann-Burchard reacting positive prompts for phytosterin compound.Molecular weight is 318.In conjunction with
1H-NMR,
13Its molecular formula of supposition such as C-NMR and DEPT spectrum are C
21H
34O
2, calculating degree of unsaturation is 5, in conjunction with DEPT,
1H
1Wave spectrums such as H COSY, HSQC and HMBC spectrum determine that this chemical compound 2 is pregnant steroid-5-alkene-3, and the 20-glycol (pregn-5-ene-3,20-diol).
Chemical compound 3 is white powder, is soluble in chloroform.Molecular weight is 358.In conjunction with
1H-NMR and
13Its molecular formula of supposition such as C-NMR spectrum are C
21H
42O
4, calculating degree of unsaturation is 1.Chemical compound 3 is aliphatic category chemical compounds.In conjunction with
1H-NMR,
13C-NMR determines that chemical compound 3 is glyceryl monostearate (monostearkn).
Chemical compound 4 is white powder, is soluble in chloroform.Bromophenol blue reaction displaing yellow, demonstration may be a fatty acid compound.Molecular weight is 256.In conjunction with
1H-NMR and
13Its molecular formula of supposition such as C-NMR spectrum are C
16H
32O
2, degree of unsaturation is 1.Determine that this chemical compound 4 is Palmic acid (palmitic acid).
Chemical compound 5 is white powder, is soluble in chloroform.Bromophenol blue reaction displaing yellow, demonstration may be a fatty acid compound.Molecular weight is 256.In conjunction with
1H-NMR and
13Its molecular formula of supposition such as C-NMR spectrum are C
18H
36O
2, degree of unsaturation is 1.Do not have unsaturated hydrogen signal in low place, prompt for long-chain fatty acid.In conjunction with
1H-NMR and
13The C-NMR spectrum determines that chemical compound 5 is stearic acid (stearic acid).
Chemical compound 6 is white powder, is soluble in chloroform.Bromophenol blue reaction displaing yellow, demonstration may be a fatty acid compound.Molecular weight is 340.Be C22H44O2 in conjunction with its molecular formula of supposition such as 1H-NMR and 13C-NMR spectrums, calculating degree of unsaturation is 1.Whole hydrocarbon signal to this chemical compound has carried out accurate ownership, determines that this chemical compound 6 is mountain Yu acid (docosanoic acid).
Experimental result as can be seen, after Scorpio, the Scolopendra high-temperature process, it is bigger that the kind of contained chemical constituent and the product of giving birth to are compared variation, mainly contain steroidal class, organic acid, pregnant steroid-5-alkene-3 wherein, the 20-glycol is for to find in the Scorpio after heat treated first, and is different from compositions such as the scorpion venom that contains in the product of giving birth to, protide, aminoacid, enzyme.
Experimental example two: the GC-MS chemical composition analysis after Scorpio, Scolopendra and the mixing medical material high-temperature process thereof
Scorpio, Scolopendra and the two weight proportion are 10: 5 mixing medical material, carry out high-temperature process as follows: getting with the quality of medicinal material ratio is 1: 1 vaseline, 60～70 ℃ of heating and meltings, with Scorpio, Scolopendra and mixing medical material, the vaseline mix that adds fusion respectively is even, place in the heating clamber, gradually order heats up, maximum temperature is 220 ℃, wherein 190 ℃ keep constant temperature time to be no less than 30 minutes, 200～210 ℃ of retention times are no less than 40 minutes, namely get the high-temperature process thing of Scorpio, Scolopendra and mixing medical material.
Precision takes by weighing above high-temperature process thing 5g, adds 95% ethanol 100mL, and reflux, extract, 3h will extract liquid cooling then and put, and vaseline is separated out, and filters, and concentrated extracting solution is to extractum.Get concentrating sample and put and add 3mL normal hexane-ether (2: 1) mixed liquor in the 10mL volumetric flask, 0.8moL/L potassium hydroxide-methanol solution 3mL shakes up, and leaves standstill 20min, and adding distil water is got supernatant to scale, filters through 0.22 μ m microporous filter membrane, carries out GC-MS and analyzes.
GC-MS condition: Agilent DB-1701, quartz capillary chromatographic column (60m * 250 μ m * 0.25 μ m); 250 ℃ of injector temperatures, 280 ℃ of detector temperatures; Temperature programming: 35 ℃ of initial temperatures, speed with 25 ℃/min is warming up to 200 ℃, speed with 3 ℃/min is warming up to 210 ℃ of maintenance 3min then, and then be warming up to 230 ℃ with the speed of 2 ℃/min and keep 2min, and then be warming up to 243 ℃ with the speed of 2 ℃/min, be warming up to 280 ℃ with the speed of 10 ℃/min at last and keep 40min; Split ratio (5: 1); Sample size 1 μ L; Carrier gas is helium; Flow velocity 1.2mL/min.Mass spectrum condition: 230 ℃ of ion source temperatures, ionization mode EI, electron energy 70eV; Mass scanning scope m/z50～550.
The result examines altogether and knows 37 kinds of chemical constituents, selects the bigger chemical compound of relative amount value to see the following form:
GC-MS analysis result after Scorpio, Scolopendra and the mixing medical material high-temperature process
According to bibliographical information in the past: bright Scorpio contain scorpion venom, trimethylamine, betanin, sulfacid, Palmic acid, soft or hard fat acid, cholesterol and ammonium salt, lecithin, also contain picric acid complete (for and scorpion venom with the column picrate that is stored in the poison gland), in addition, still contain the scorpion acid sodium-salt.Containing fatty acids such as Palmic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, mountain Yu acid in the Scorpio oil, is the acid ingredient based on satisfied fatty acid.Mainly do not contain fatty acid, protein, aminoacid, enzyme and cholesterol constituents in Jia Re the Scolopendra.Contain 21 kinds of free amino acids and 12 kinds of trace element, 10 kinds of enzymes such as phosphatase A, proteolytic enzyme, acetylcholinesterase, arginine esterase, batroxobin, cellulase, a-amylase, hyaluronidase, alkali phosphatase and acid phosphatase are arranged in the thick poison of Scolopendra, also have hydroxyl peptidase, ATP enzyme, nuotide pyrophosphatase, aminoacid naphthylamines enzyme, arginine esterase etc.
And the Scorpio after the heat treated, Scolopendra, bigger variation takes place in chemical constituent, above chemical research and GC-MS composition source analysis result show, mainly contain two constituents in the Scorpio after the high-temperature process, the Scolopendra: steroidal class and fatty acid, and compositions such as enzyme, aminoacid are destroyed; The kind of unsaturated fatty acid-olefin(e) acid increases in the high-temperature process medical material; Pregnant steroid-5-the alkene-3 that highlights in the Scorpio after the high-temperature process, 20-glycol, 5-cholestene-3-ketone are its representative composition.
The application of the described compound recipe Scorpio of claim 1-3 compositions in preparation treatment senile plaque, chloasma cutaneous pigmentation and the irritated external used medicine of skin sunlight, it is characterized in that in compositions, adding acceptable accessories and make the external agent, comprise Emulsion, tincture water preparation, ointment, rubber unguentum agent, be used for the treatment of senile plaque, chloasma cutaneous pigmentation and daylight skin allergy.
Embodiment one: externally-applied soft ointment is made in mixed extract and Borneolum Syntheticum, the vaseline combination of Scorpio, Scolopendra high-temperature process
(1) makes the oil-in-water type exterior-applied emulsion
Get weight proportion and be 5: 1: 2 Scorpio, Scolopendra, Borneolum Syntheticum crude drug, be prepared as follows:
(1) high-temperature process of Scorpio, Scolopendra: get Scorpio, Scolopendra crude drug, add the vaseline of 3 times of the two composite formula quality, 70 ℃ of heating and meltings, with Scorpio, Scolopendra medical material, the vaseline mix that adds fusion is even, places in the baking oven, and gradually order heats up, maximum temperature is 220 ℃, wherein 190 ℃ keep constant temperature time to be no less than 30 minutes, and 200～210 ℃ of retention times are no less than 40 minutes, take out, cool, namely get the high-temperature process thing of Scorpio, Scolopendra medical material.
(2) the high-temperature process thing of Scorpio, Scolopendra is measured 95% alcohol heating reflux with 12 times, extract 3 times, each 2～3 hours, merging filtrate reclaimed ethanol, obtains ethanol extraction, concentrates, and namely gets the mixed extract of Scorpio, Scolopendra high-temperature process medical material.
(3) Scorpio, Scolopendra mixed extract are added the Borneolum Syntheticum fine powder, add propylene glycol and be uniformly dispersed.
(4) make the potash soap emulsifying agent with stearic acid and sodium bicarbonate with saponification method again, add triethanolamine, vaseline, paraffin oil, ethyl hydroxybenzoate solution and 65 ℃ of insulations of distilled water emulsifying 10min and make oil-in-water type substrate.
(5) propylene glycol solution with Scorpio, Scolopendra mixed extract and Borneolum Syntheticum fine powder joins in the oil-in-water type substrate, and 50 ℃ of emulsifyings are even, namely make externally-applied soft ointment.
(2) make ointment type external agent
(1) getting weight proportion is 5: 1: 2 Scorpio, Scolopendra, Borneolum Syntheticum crude drug, prepares the mixed extract of Scorpio, Scolopendra high-temperature process medical material by as above step.
(2) get the Scorpio medical material: the Scolopendra medical material: the vaseline weight proportion is 5: 1: 20 vaseline, heat 70～80 ℃, to the vaseline fusion, the mixed extract that adds Scorpio, Scolopendra high-temperature process medical material, make it to be uniformly dispersed, be cooled to 60 ℃, add the Borneolum Syntheticum fine powder, be evenly distributed and namely get ointment type compound recipe Scorpio external preparation.
Embodiment two: senile plaque, chloasma are observed-treated to the clinical effectiveness of compound recipe Scorpio external preparation
Medicine is formed: the oil-in-water type exterior-applied emulsion of going up the method preparation
The medicine-feeding method: local outer rubbing method, wipe affected part outward, 1～4 time on the 1st, and suitably press and smear 3～5 minutes, promote the local skin circulation, and increase drug absorption, medication 10～15 days.
Clinical observation result: the senile plaque patient is totally 58 people, is outpatient service prescription on individual diagnosis patient, 50～75 years old age, and effective percentage 94.83%, patient with chloasma 39 people get rid of the endogenous reason, as the yellowish-brown speckle of skin due to the internal disease, effective percentage 87.18%.Therapeutic outcome sees the following form:
Criterion of therapeutical effect:
Cure: speckle desalination and disappearance, identical with the normal skin color.
Produce effects: the speckle desalination also alleviates, and the speckle edge fogs, and the speckle projection diminishes, and color trends towards transforming to normal skin.
Invalid: all disease no changes.
Scorpio powder detoxifcation collateral dredging in the compositions, Scolopendra softening the hard mass, detoxicating and resolving stagnation of pathogens, the two compatibility is played the merit of resolving mass and removing the obstruction of the collateral, promoting blood circulation to restore menstrual flow altogether, and the stasis of blood is opened in the performance detoxifcation, and dispelling wind is antipruritic, and the effect of removing the necrotic tissue and promoting granulation is used for the treatment of senile plaque, chloasma.Combination is with Borneolum Syntheticum fragrance walk to scurry to have one's ideas straightened out collateral dredging, saturating meat, and it is anticorrosion to have heat clearing away concurrently, and the merit of antalgesic-antipruritic can help the medicine gas of principal agent to go into the saturating flesh of skin, strengthens Transdermal absorption.Vaseline can keep skin wet, makes skin histology keep optimum state, has accelerated the repair ability of skin self, and can stop antibacterial and contact skin, reduces possibility of infection.
Said composition treatment senile plaque be better than the old senile plaque for New Development senile plaque effect, but obvious effective rate is all obvious, and along with the increase at age, cure and reduce, but still more obvious to the improvement of senile plaque; The effect of hair style chloasma is better than late hair style to morning at age, but need be in conjunction with the treatment by oral administration of medicines therapy.The said composition preparation, easy to use, directly affected part administration has no side effect, and is splendid selection for the treatment of senile plaque occurred frequently, chloasma.
Embodiment three: daylight skin allergy (solar dermatitis) is observed-treated to the clinical effectiveness of compound recipe Scorpio external preparation
Medicine is formed: the ointment type compound recipe Scorpio external preparation of going up the method preparation
The patient selects: 32 routine out-patients all meet the solar dermatitis diagnostic criteria, male 14 examples wherein, women 18 examples; Age
18～47 years old, average 27.6 years old; The course of disease 1～7 day, average 6.7 days; Site of pathological change: face, cervical region, two upper limb.
Get rid of: 1. serious concurrent internal medicine disease patient; 2. drug allergy body constitution patient; 3. gestation, women breast-feeding their children.
The medicine-feeding method: local outer rubbing method, wipe affected part outward, every day 1～4 time, smear evenly one week of continuous use.
Criterion of therapeutical effect: 1. cure: erythra all disappears, and red and swollen, pain disappears; 2. produce effects: deflorescence is greater than 70%; 3. effective: the deflorescence degree is between 30% to 70%; 4. invalid: deflorescence is less than 30% or increase the weight of.
The clinical treatment result: totally 32 people are outpatient service prescription on individual diagnosis patient, total effective rate 93.75%.
After treatment, 62.5%, 7 day effective percentage 31.25% of 3 days effective percentage for the treatment of group, inefficiency 6.25% is not seen other obvious adverse reaction during the medication, therapeutic outcome sees the following form:
After solar dermatitis mainly showed as sunlight exposure, exposure portion red swelling of the skin or edematous erythema, vesicle are arranged was burnt and twinge.Its histopathology characteristics are: behind the ultraviolet radiation, epidermis produces sunburn cell, i.e. the dyskeratosis cell of similar apoptotic cell, this cell cytosol is homogeneity, mostly be acidophilia dyeing, karyopycnosis, edge blurry or be difficult for seeing clearly, bunchiness is arranged in the subcuticle tissue; The corium variation is mainly shallow-layer vasodilation, endotheliocytic swelling, and neutrophil cell is that main cell mixing soaks into around the blood vessel, causes the generation pain sensation.
This drug combination preparation can form suitable physiological environment, and the teleneuron that protection is exposed alleviates calcination pain; Regulate the skin environment, promote skin metabolism and skin regeneration, alleviate blister, erythema; Form overcoat, avoid the infection of skin ambustion, the protection wound surface.
Claims (4)
1. the externally used compound Scorpio compositions of a treatment senile plaque, chloasma cutaneous pigmentation and skin sunlight allergy (solar dermatitis) is characterized in that the compound recipe Scorpio compositions of the irritated effect of this treatment senile plaque, chloasma cutaneous pigmentation and skin sunlight is to be combined by the extract after the mixing high-temperature process of Scorpio, Scolopendra and Borneolum Syntheticum, vaseline.
2. the externally used compound Scorpio compositions with treatment senile plaque, chloasma cutaneous pigmentation and the irritated effect of skin sunlight according to claim 1, it is characterized in that: in the compositions, wherein the weight proportion of the crude drug of Scorpio, Scolopendra mixed extract is 12～8: 1～5, be used for producing mixed extract after the high-temperature process, the Scorpio of this weight proportion, Scolopendra medical material, the weight proportion that makes up with Borneolum Syntheticum, vaseline is 12～8: 1～5: 3～6: 8～120.
3. according to the described externally used compound Scorpio preparation of compositions method with treatment senile plaque, chloasma cutaneous pigmentation and skin sunlight allergy (solar dermatitis) effect of claim 1-2, it is characterized in that comprising the steps:
(1) high-temperature process of Scorpio, Scolopendra: the vaseline of getting 1/10～5 times of composite formula quality, 60～70 ℃ of heating and meltings, with Scorpio, Scolopendra medical material, the vaseline mix that adds fusion is even, places in the heating clamber, and gradually order heats up, maximum temperature is 220 ℃, wherein 190 ℃ keep constant temperature time to be no less than 30 minutes, and 200～210 ℃ of retention times are no less than 40 minutes, namely get the high-temperature process thing of Scorpio, Scolopendra medical material; Also crude drug vaseline be can not be added and a small amount of edible oil and fat or medical material direct heating acquisition high-temperature process thing smeared.
(2) the high-temperature process thing of Scorpio, Scolopendra is measured 95% alcohol heating reflux with 8～12 times, extract 3 times, each 2～3 hours, merging filtrate reclaimed ethanol, obtains ethanol extraction, concentrates, and namely gets Scorpio, Scolopendra mixed extract.
(3) with Scorpio, Scolopendra mixed extract and Borneolum Syntheticum, vaseline by weight ratio, low-temperature mixed evenly namely gets compound recipe Scorpio compositions.
4. the application of the described compound recipe Scorpio of claim 1-3 compositions in preparation treatment senile plaque, chloasma cutaneous pigmentation and sunlight skin allergy (solar dermatitis) external used medicine, it is characterized in that in compositions, adding acceptable accessories and make the external agent, comprise Emulsion, tincture, ointment, rubber unguentum agent, be used for the treatment of senile plaque, chloasma cutaneous pigmentation and sunlight skin allergy (solar dermatitis).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310025263.3A CN103271946B (en) | 2013-01-23 | 2013-01-23 | The externally used compound scorpio composition and its preparation method and purposes for treating senile plaque, chloasma cutaneous pigmentation and solar dermatitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310025263.3A CN103271946B (en) | 2013-01-23 | 2013-01-23 | The externally used compound scorpio composition and its preparation method and purposes for treating senile plaque, chloasma cutaneous pigmentation and solar dermatitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103271946A true CN103271946A (en) | 2013-09-04 |
| CN103271946B CN103271946B (en) | 2019-08-16 |
Family
ID=49054194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310025263.3A Active CN103271946B (en) | 2013-01-23 | 2013-01-23 | The externally used compound scorpio composition and its preparation method and purposes for treating senile plaque, chloasma cutaneous pigmentation and solar dermatitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103271946B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1419915A (en) * | 2002-12-12 | 2003-05-28 | 彭俊卿 | External applied liquid medicine for treating psoriasis |
| US20030157570A1 (en) * | 2001-10-17 | 2003-08-21 | Burmer Glenna C. | Diagnostic and therapeutic compositions and methods related to G protein-coupled receptor (GPCR) anaphylatoxin C3a receptor |
-
2013
- 2013-01-23 CN CN201310025263.3A patent/CN103271946B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030157570A1 (en) * | 2001-10-17 | 2003-08-21 | Burmer Glenna C. | Diagnostic and therapeutic compositions and methods related to G protein-coupled receptor (GPCR) anaphylatoxin C3a receptor |
| CN1419915A (en) * | 2002-12-12 | 2003-05-28 | 彭俊卿 | External applied liquid medicine for treating psoriasis |
Non-Patent Citations (2)
| Title |
|---|
| 刘端勇，等: "全蝎蜈蚣对胶原免疫性关节炎大鼠的关节损伤改善作用", 《中药药理与临床》 * |
| 赵建波等主编: "《皮肤病妙法良方大全》", 31 May 2011 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103271946B (en) | 2019-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107998020B (en) | Skin cream with anti-allergic effect | |
| CN109125474A (en) | A kind of silver yellow ginseng essential oil for treating solar dermatitis | |
| CN109331095A (en) | A kind of clearing damp rash composition and preparation method thereof | |
| CN108704021B (en) | Composition for skin allergy and skin barrier damage and preparation method thereof | |
| CN111481475A (en) | Edible lipstick capable of improving female hormone and preparation method thereof | |
| AU638932B2 (en) | Pharmaceutical product having epidermial regenerative activity based on the active ingredient of mimosa tenuiflora and process for its obtention | |
| Aliasl et al. | Comparing the healing effects of Arnebia euchroma ointment with petrolatum on the ulcers caused by fractional CO2 laser: a single-blinded clinical trial | |
| CN108143646A (en) | A kind of antipruritic cream composition of glycyrrhetinic acid and preparation method thereof | |
| CN101721347A (en) | Beauty skin care product containing artificially-cultured giant salamander tissue substance or extract | |
| US8545904B1 (en) | Topical composition containing Carapa (andiroba) oil for psoriasis and other related dermatological disorders | |
| RU2366412C2 (en) | Compositions and treatment methods for hyperproliferative skin conditions | |
| CN105560331A (en) | Eczematous dermatitis prevention medicine, and preparation method and application thereof | |
| CN105362410A (en) | Traditional Chinese medicine preparation for treating burn and scalds and preparation method | |
| CN102872158B (en) | External drug combination for curing eczema and preparation method thereof | |
| CN103800401B (en) | Granulation promoting healing ointment | |
| CN104906014A (en) | Bee venom olive massage oil and application method thereof | |
| CN103271946A (en) | External use compound scorpion traditional Chinese medicine composition for treating senile plaque expelling, chloasma skin pigmentation and skin sunlight allergy (solar dermatitis) | |
| CN113855751A (en) | A Chinese and western medicinal preparation for rapidly treating dermatoses, and its preparation method | |
| CN109010187A (en) | A kind of face cream and preparation method thereof for treating acne | |
| CN108938543A (en) | A kind of lip treatments and preparation method thereof preventing and treating cheilitis | |
| CN114053329B (en) | Application of broussonetia papyrifera polysaccharide in preparation of medicines or sunscreen cosmetics for preventing and treating ultraviolet injury | |
| KR20040081118A (en) | Skin perparation for external use containing purpuricenus temminckii frass as the active ingredient | |
| CN112603958B (en) | Traditional Chinese medicine composition for treating myofascitis and preparation method and application thereof | |
| CN115671239B (en) | Anti-inflammatory, detumescence, antibacterial, antipruritic, anticracking and repairing jelly-curing cream and preparation method thereof | |
| CN106729200A (en) | A kind of compound Yinqiao detoxification emulsifiable paste for preventing and treating acne |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |