CN103271850B

CN103271850B - Method for preparing bacteriostatic bath foam from pepper extract

Info

Publication number: CN103271850B
Application number: CN201310178652.XA
Authority: CN
Inventors: 吴娟
Original assignee: Suzhou Guli Biotechnology Co Ltd
Current assignee: Suzhou Guli Biotechnology Co Ltd
Priority date: 2013-05-15
Filing date: 2013-05-15
Publication date: 2015-06-03
Anticipated expiration: 2033-05-15
Also published as: CN103271850A

Abstract

The invention relates to a method for preparing bacteriostatic bath foam from a pepper extract. The method comprises the following steps of: dissolving 0.1 % of EDTA-2Na and 1 to 7 % of potassium hydroxide into deionized water and heating to 85 DEG C to obtain a spare water phase; mixing 3 to 10 % of dodecanoic acid, 4 to 15 % of tetradecanoic acid and 1 to 2 % of ethylene glycol distearate and heating to 85 DEG C to obtain a spare oil phase; and adding the oil phase into the water phase, mixing and stirring until the mixture is transparent, adding 10 to 40 % of the pepper extract, 0 to 3 % of alkanolamide and 10 to 35 % of 35 % cocanidoproryl betaine alkali solution, stirring and cooling to below 50 DEG C, adding essence and a preservative, adjusting the pH value to be 6-7, continuously stirring and cooling to 40 DEG C, and outputting to obtain the product. The bacteriostatic bath foam containing the pepper extract has a certain bacteriostatic effect on escherichia coli, staphylococcus aureus and the like, has an effect of preventing eczema, pruritus, mange and the like, and has a certain effect of nourishing skin. The bath foam is simple in formula and can meet the natural, environmentally-friendly and efficiently antibacterial basic requirements of the modern markets.

Description

A kind of Fructus Zanthoxyli extract is the preparation method of the antibacterial bath foam of raw material

Technical field

The present invention relates to a kind of antibacterial type bath foam of natural extract, particularly relate to a kind of Folium Zanthoxyli Bungeani extract antibacterial type bath foam.

Background technology

Bath foam is the necessary of people's daily life, as fluid product, be characterized in allocating various functional raw material into, by the Transdermal absorption of effective ingredient, improve the microcirculation situation of skin, strengthen the disease-resistant and repair ability of skin, reach the multipurpose of cleaning skin, nursing skin, promotion skin health.

Constantly perfect along with article of everyday use, bath foam product the liking deeply by consumers in general of plant extract type.The body wash liquid formula of various antibacterial type is applied patent and delivers document.

Application number: Cornu Cervi Pantotrichum, Radix Ginseng Flos Caryophylli, Radix Angelicae Sinensis are extracted extracting solution by the production method main processes of 200910175652.8 sophora alopecuroide bacteriostatic bath foams; Medicinal liquid mixing will be extracted, add Radix Sophorae Flavescentis total alkaloids extractum and become Chinese medicine admixing medical solutions, add deionized water, add hydroxyethyl-cellulose, stir, heat and add sodium lauryl sulphate, cocoanut fatty acid diethanolamide, polyoxyethylenated alcohol sodium sulfate, Pearl Concentrate stirring and dissolving, rise to uniform temperature, stir to be dissolved, after cooling, add acetylbutyrylcellulose, glycerol stirs, be up to the standards and be finished product.

Application number: 201110452222.3 kinds of Chinese medicine antibacterial nourishing bath foams and preparation method thereof, being be raw material by 25 ~ 35 weight portion Radix Sophorae Flavescentiss, 15 ~ 25 weight portion Cortex Phellodendris, 25 ~ 35 weight portion Radix Gentianaes, 15 ~ 25 weight portion Fructus Cnidiis, 15 ~ 25 weight portion Rhizoma Smilacis Glabraes, take water as the Chinese medicine extraction liquid that extracting solution extracts the d=1.5 ~ 1.8g/ml obtained.Chinese medicine antibacterial nourishing bath foam of the present invention has certain fungistatic effect to escherichia coli, staphylococcus aureus, Candida albicans.

By Wu Jianguo, Tan Qun etc. study the development of the Folium Zanthoxyli Bungeani bath foam delivered, be published in Speciality Petrochemicals progress the 13rd volume the 8th phase literature periodical, mainly have studied the Pericarpium Zanthoxyli bath foam obtained for raw material with Folium Zanthoxyli Bungeani extract, preparation process is for will add people's AESA successively under deionized water heated and stirred, lauryl alcohol ammonium sulfate, Oleum Cocois diethanol phthalein amine, lauryl phosphoric acid vinegar potassium salt, alkyl glucose former times, cocos nucifera oil phthalein amine CAB and E D TA disodium, cooling after dissolving completely, add people's Folium Zanthoxyli Bungeani extract, regulate p H to 6-7, stirring is cooled to less than 45 DEG C, add people's antiseptic and essence, continue to stir cooling, obtained product.

Folium Zanthoxyli Bungeani is the by-product in Pericarpium Zanthoxyli plantation, development Folium Zanthoxyli Bungeani bath foam can develop a large amount of discarded Pericarpium Zanthoxyli branch and leaf, the considerable economic benefit for agricultural economy band.The chemical composition of Folium Zanthoxyli Bungeani is similar to peel, extract mainly contains volatile oil, alkaloid, flavone etc., experiment proves that Folium Zanthoxyli Bungeani extract is to staphylococcus aureus, bacillus subtilis and escherichia coli all have fungistatic effect, especially to staphylococcus aureus and bacillus subtilis successful, and the application of exploitation Folium Zanthoxyli Bungeani in bath article, both the trend of cosmetics to natural chemotherapy effectization future development had been complied with, consumer can be met again to skin care, clean, the needs of nursing.

Summary of the invention

The invention provides the antibacterial bath foam preparation method of a kind of Fructus Zanthoxyli extract, not only production cost is low, fungistatic effect is obvious, and develop a large amount of discarded Pericarpium Zanthoxyli branch and leaf and can promote agro based economic development.

The antibacterial bath foam preparation method of a kind of Fructus Zanthoxyli extract, being dissolved in deionized water by EDTA-2Na 0.1%, potassium hydroxide 1% ~ 7%, being heated to 85 DEG C, is aqueous phase; Dodecoic acid 3% ~ 10%, tetradecylic acid 4% ~ 15%, ethylene glycol distearate 1% ~ 2% are mixed, being heated to 85 DEG C, is oil phase; Oil phase is added in aqueous phase, mix and blend, until transparent, add Fructus Zanthoxyli extract 10 ~ 40%, alkanolamide 0 ~ 3%, 35% cocamido propyl betaine solution 10% ~ 35%, stir and be cooled to less than 50 DEG C, add appropriate amount of essence and antiseptic, regulate p H to 6-7, continue stirring again and be cooled to 40 DEG C, discharging, be product.

In dodecoic acid, tetradecylic acid and potassium hydroxide and generate potassium dodecanoate, tetradecylic acid potassium surfactant, it is the foaming agent of bath foam.Increase the frothing capacity that fatty acid salt content can significantly improve bath foam, the frothing capacity of potassium dodecanoate is slightly better than tetradecylic acid potassium, but zest is slightly larger than tetradecylic acid potassium, and the cost ratio dodecoic acid height of tetradecylic acid is more, so the consumption of the two should be determined by product price.Potassium hydroxide is as nertralizer, and its consumption is advisable to control product about pH=7.Potassium dodecanoate, tetradecylic acid potassium detergency ability are better, and are very easy to rinse, and overcome the shortcoming that bath foam has soapy feeling.

35% cocamido propyl betaine solution is betaine type amphoteric surfac-tant, there is washing and conditioning effect, zest is low, add the zest that can reduce anion surfactant in formula, certain thickening effect is had to anion surfactant, and there is good stable foam effect, its consumption should be determined according to bath foam type and effect.Alkanolamide mainly plays thickening and steady bubble effect in formula, and its consumption is advisable with about 3%.

The best in quality formula proportion that the present invention selects is: dodecoic acid 8.5%; Tetradecylic acid 4.5%; Potassium hydroxide 3.8%; 35% cocamido propyl betaine solution 30%; Alkanolamide 3%; Ethylene glycol distearate 1.5%; EDTA-2Na 0. 1%; Fructus Zanthoxyli extract 40%; Antiseptic, essence each 0.1%; Deionized water is appropriate.

The preparation of Folium Zanthoxyli Bungeani extract: pericarpium zanthoxyli bungeani leaf is pulverized, the methanol of concentration 50% is added as extractant by solid-liquid ratio 1g: 25ml, at room temperature shake, separation of supernatant, and obtaining extractum by after supernatant concentration drying, be scattered in by extractum in purified water, solid-liquid ratio is 1g: 40ml, then add normal hexane concussion extraction, collect aqueous phase extract; Again aqueous phase raffinate is added chloroform, concussion extraction, collects aqueous phase raffinate; Then aqueous phase raffinate is added ethyl acetate in right amount, concussion extraction, concentrate drying obtains extract.

Folium Zanthoxyli Bungeani extract and surfactant compatibility good, maximum addition can reach 40%, does not substantially affect physical and chemical index and the performance of bath foam product.Folium Zanthoxyli Bungeani is got thing and is had obvious antipruritic effect for bath foam, and to treatment erythra, also certain effect Folium Zanthoxyli Bungeani extract is had to be all-natural product, have no side effect, use safety, Folium Zanthoxyli Bungeani extract is used for bath foam, complies with the trend of the market that cosmetics develop to naturalization and curative effectization.Also make full use of discarded Folium Zanthoxyli Bungeani is that agricultural opens a new developing direction simultaneously.

Involved in the present invention to the unit of component percentages be mass percent (wt%)

The kind of the antiseptic of described essence and consumption can carry out selecting and adding according to pharmaceutical field common practise.

EDTA-2Na 0. 1%, potassium hydroxide 3.8% are dissolved in deionized water by embodiment 1, are heated to 85 DEG C, are aqueous phase; Dodecoic acid 8.5%, tetradecylic acid 4.5%, ethylene glycol distearate 1.5% being mixed, be heated to 85 DEG C, is oil phase; Oil phase is added in aqueous phase, mix and blend, until transparent, add Fructus Zanthoxyli extract 40%, alkanolamide 3%, 35% cocamido propyl betaine solution 30%, stir and be cooled to less than 50 DEG C, add appropriate amount of essence and antiseptic, regulate p H to 6-7, continue stirring again and be cooled to 40 DEG C, discharging, be product.Bacteriostasis rate reaches 99%

EDTA-2Na 0. 1%, potassium hydroxide 3.8% are dissolved in deionized water by embodiment 2, are heated to 85 DEG C, are aqueous phase; Dodecoic acid 8.5%, tetradecylic acid 4.5%, ethylene glycol distearate 1.5% being mixed, be heated to 85 DEG C, is oil phase; Oil phase is added in aqueous phase, mix and blend, until transparent, add Fructus Zanthoxyli extract 10%, alkanolamide 3%, 35% cocamido propyl betaine solution 30%, stir and be cooled to less than 50 DEG C, add appropriate amount of essence and antiseptic, regulate p H to 6-7, continue stirring again and be cooled to 40 DEG C, discharging, be product.Bacteriostasis rate reaches 89%.

Embodiment 1 proof test

1. malicious combability measurements

Select the healthy mice of body weight 20-25g, male and female half and half, are divided into and give the Pericarpium Zanthoxyli bath foam liquid that accumulated dose is 20g/kg for 2 times ~ 3 times in 24 h, adopt administration by gavage, be inserted into white mouse gastric inject with syringe.Continuous Observation seven days, none is dead for white mice, and has no abnormal symptom.Result of the test shows, the LD50 of stock solution to male and female white mice is all greater than 20g/kg, the nontoxic level in true border.

2. recruitment evaluation

Choose 40 volunteers to try out Folium Zanthoxyli Bungeani bath foam, trial period 30 d, use Folium Zanthoxyli Bungeani bath foam 2-3 time weekly, collect the evaluation that experimenter suppresses de-sludging performance, skin pruritus, bathes rear pleasant sense, dispels the projects such as erythra,

Result on trial shows, Folium Zanthoxyli Bungeani bath foam detergency is strong, foaming abundancy, and antipruritic effect is obvious, and after bathing, dermal sensation is pleasant, and also has certain effect to treatment erythra.

Pericarpium Zanthoxyli bath foam result on trial

Test event	Tested number	Efficiently individual quantity	Effective percentage
				De-sludging performance	40	40	100.0%
Skin pruritus suppresses	40	28	93.3%
				Pleasant sense after bath	40	39	97.5%
Dispel erythra	40	36	90.0%

Claims

1. Folium Zanthoxyli Bungeani extract is a preparation method for the antibacterial bath foam of raw material, it is characterized in that step is as follows:

1) EDTA-2Na 0. 1wt%, potassium hydroxide 3.8wt% are dissolved in deionized water, are heated to 85 DEG C, obtain aqueous phase for subsequent use;

2) dodecoic acid 8.5wt%, tetradecylic acid 4.5wt%, ethylene glycol distearate 1.5wt% are mixed, be heated to 85 DEG C, obtain oil phase for subsequent use;

3) oil phase is added in aqueous phase, mix and blend, until transparent, add Folium Zanthoxyli Bungeani extract 40wt%, alkanolamide 3wt%, 35% cocamido propyl betaine solution 30wt%, stir and be cooled to less than 50 DEG C, add essence and antiseptic, regulate pH to 6-7, continue stirring again and be cooled to 40 DEG C, discharging, be product.