CN103271353A - Liver protecting and health care composition and preparation method thereof - Google Patents
Liver protecting and health care composition and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a liver protecting and health care composition and a preparation method thereof. The composition is characterized by mainly comprising the following main components in mass fraction: 0.01 to 1 part of nano red selenium, 0.3 to 2 parts of organic germanium, 5 to 10 parts of potassium magnesium aspartate, 3 to 8 parts of acidum asparticum calcium, 0.5 to 2 parts of zinc acetate, 3 to 10 parts of collagen, 5 to 20 parts of amino acid, 2 to 10 parts of vitamin C or salt, 1 to 5 parts of sweet regulator, 0.5 to 3 parts of acid regulator, 0.5 to 3 parts of preservative, and 100 to 300 parts of water; the average grain diameter of the nano red selenium is not greater than 100nm; the vitamin C salt is vitamin C sylvite or vitamin C sodium salt; the sweet regulator is selected from at least one of the trehalose, glycine, xylitol or xylooligosaccharide; the acid regulator is citric acid; and the preservative is sodium diacetate or sodium dehydroacetate. The preparation method comprises the following steps of: hydrolyzing respectively, and then uniformly mixing and standing.
Description
Technical field
The present invention relates to field of health care products, specifically is a kind of liver health composition and preparation method thereof that protects.Said composition contains humatite matter such as nanometer selenium.
Background technology
Present common liver liver-protecting product and the technology of protecting, be based on Chinese medicine and extract thereof mostly, be aided with amino acid, vitamin etc., mostly pay attention to sobering up, sober-up function, the injury of liver is embodied protect liver and protect the liver from alleviating alcohol, ignored recovery and the raising of human body integral function, function ratio is more single.For example, Chinese patent CN101889679B discloses " a kind of composition and application in food, health food thereof with effects of relieving alcoholism and protecting liver ", and said composition contains the raw material of following mass percent: curcumin 0.15-5%, zinc lactate 0.04-1.0%, glutamine 10-50%, alanine 10-50%, xylo-oligosaccharide 10-50%.Prove through animal experiment and human feeding trial, said composition has the content that increases the interior alcohol dehydrogenase of body and acetaldehyde dehydrogenase, decompose ethanol fast, thereby have and promote alcohol metabolism in the liver, the effect of concentration of alcohol and activity keto concentration in the attenuating blood, increase simultaneously human body to the tolerance of alcohol, reduce headache due to the alcohol, feel sick, discomfort such as vomiting, and reduce alcohol to the infringement of liver.Its active principle that mainly relieves the effect of alcohol is curcumin, glutamine and alanine.Though contain zinc lactate in this prescription, its content is lower, and mineral types is single, and effect is single simple; Because curcumin is water insoluble, said composition then is difficult to make liquid form product.Chinese patent application numbers 201010516560.4 discloses " a kind of have capsule-shaped food of protecting liver, nourishing the liver, anticancer, preventing cancer function and preparation method thereof ", its composition of raw materials is: pollen 90.8-363.2mg, the plain 90.8-363.2mg of grape pip, soya bean protein 90.8-363.2mg, crataegin 90.8-363.2mg, organic selenium 10-50 μ g, glutinous rice capsule 100-120mg.Though contain organic selenium 10-50ug in this prescription, content is less, and mineral types is single; Pollen wherein, grape pip element, soya bean protein, crataegin etc. need concentration extraction in 80～100 ℃ container respectively, organic selenium of 80% concentration that organic selenium then obtains from the first extract plant of rich selenium.Though this application does not further specify concrete acquisition methods, the difficulty of obtaining of its organic selenium well imagines that the concentration extraction of components such as its pollen also will consume a large amount of energy.Chinese patent application numbers 201210116568.0 discloses a kind of " health products of Antialcoholic liver-protecting ", and it comprises: pure water 300-800g, L-arabinose 5-15g, theanine 5-15g, ion thing 10-50ppm, mushroom extract 0.1-1g, green-tea extract 0.1-0.5g, curcumin 0.1-0.5g.Ion thing wherein refers to one or more the composition in ionization copper, ionization iron, ionization zinc, ionized calcium, ionization potassium, ionization selenium, the ionization manganese; Wherein said green-tea extract is that polyphenol content is the green-tea extract more than 75%, and transition metal such as Tea Polyphenols chance manganese, iron, copper, zinc are perishable.Chinese patent ZL00129443.1 discloses a kind of " multielement calcium-rich liver-protecting sobering up beverage ", its main active principle is calcium ion, auxiliary components has zinc, strontium and vitamin, wherein contains elements such as micro-magnesium, iron, zinc, strontium, germanium, selenium, cobalt in employed " polybasic ion calcium " raw material.This beverage contains 3～8% white granulated sugar, and need be with boiling water towards molten, and need be insulation more than 90 ℃ 5 minutes; Not only need consumes energy in the preparation, and in the prescription because the introducing of a large amount of white granulated sugars and essence, pigment, do not meet the healthy consumption theory of modern people's uphold nature, more be not suitable for diabetes patients.The described ionization selenium of these two patents (application) and nanometer selenium do not belong to the identical concept category, and ionization thing and humatite matter do not belong to the identical concept category yet.In the scope of applicant retrieval, do not see as yet and contain nanometer selenium and protect the liver health product based on the humatite prime element.
Summary of the invention
At the deficiencies in the prior art, the technical problem that quasi-solution of the present invention is determined is that a kind of liver health composition and preparation method thereof that protects is provided.Said composition contains humatite matter such as nanometer selenium, has good sobering up and liver protecting functions and strengthens general immunity power effect, and is of many uses; This preparation method adopts normal temperature and pressure production, and technology is simple, and is easy to operate, is fit to suitability for industrialized production.
The technical scheme that the present invention solves described composition technical problem is, designs a kind of liver health composition that protects, and the mass fraction that it is characterized in that said composition is formed and is mainly: 0.01～1 part on red nano selenium; 0.3～2 part of organic germanium; 5～10 parts of Potassium Magnesium Aspartatas; Asparagus amino-acid calcium 3-8 part; 0.5～2 part of zinc acetate; 3～10 parts of collagens; 5～20 parts in amino acid; 2～10 parts of vitamin C or its salt; 100～300 parts in sweet taste conditioning agent 1-5 part, 0.5～3 part of tart flavour conditioning agent, 0.5～3 part of anticorrisive agent and water; Average grain diameter≤the 100nm of described red nano selenium; Vitamin C salt is vitamin C sylvite or vitamin C sodium salt; The sweet taste conditioning agent is at least a in trehalose, glycine, xylitol or the xylo-oligosaccharide; The tart flavour conditioning agent is citric acid, and anticorrisive agent is sodium Diacetate or dehydro sodium acetate.
The technical scheme that the present invention solves described preparation method's technical problem is, design a kind of preparation method who protects the liver health composition, this preparation method adopts the mass fraction that protects the liver health composition of the present invention to form and following technology: at normal temperatures and pressures, (1). earlier red nano selenium, collagen, amino acid and anticorrisive agent are dissolved in water together, all after the dissolving, leave standstill more than 24 hours, make A solution; (2). organic germanium, Potassium Magnesium Aspartata, asparagus amino-acid calcium, zinc acetate and sweet taste conditioning agent are dissolved in water together, make B solution; (3). with vitamin C or its salt and tart flavour conditioning agent be dissolved in water together, make C solution; (4). B solution and C solution are added in the A solution after leaving standstill, and constantly be stirred to and mix, leave standstill more than 48 hours, get its supernatant and namely make the described liver health composition that protects.
Compared with prior art, preparation method's normal temperature and pressure of the present invention is produced, and technology is simple, and is easy to operate, pollution-free, and low energy consumption is easy to promote, and is fit to suitability for industrialized production.The present invention protects that liver health composition liver protection effect is obvious, and health-care efficacy is comprehensive, and existing good sobering up and liver protecting functions can strengthen general immunity power again; Before both can wine, edible after drinking, also be fit to person in middle and old age and immunocompromised person edible health at ordinary times; Both can make oral liquid, tablet or capsule etc., also can be used as functional additive adds in relevant food, beverage or feed, the fertilizer, of many uses.
The specific embodiment
Further narrate the present invention below in conjunction with embodiment.
The present invention design protect liver health composition (abbreviation composition), the mass fraction that it is characterized in that said composition is formed and is mainly: 0.01～1 part on red nano selenium; 0.3～2 part of organic germanium; 5～10 parts of Potassium Magnesium Aspartatas; Asparagus amino-acid calcium 3-8 part; 0.5～2 part of zinc acetate; 3～10 parts of collagens; 5～20 parts in amino acid; 2～10 parts of vitamin C or its salt; 100～300 parts in sweet taste conditioning agent 1-5 part, 0.5～3 part of tart flavour conditioning agent, 0.5～3 part of anticorrisive agent and water; Average grain diameter≤the 100nm of described red nano selenium; Vitamin C salt is vitamin C sylvite or vitamin C sodium salt; The sweet taste conditioning agent is at least a in trehalose, glycine, xylitol or the xylo-oligosaccharide; The tart flavour conditioning agent is citric acid, and anticorrisive agent is sodium Diacetate or dehydro sodium acetate.
Sweet taste flavor enhancement and tart flavour conditioning agent that the present composition is selected are flavor enhancement, also are the nutritional labelings to the human body beneficial.
For being applicable to that better the diabetes patient uses, the further feature of the present composition is: said composition also comprises 0.01～0.5 part of the chromium picolinate that mass fraction forms.Described sweet taste conditioning agent is at least a in trehalose, glycine, xylitol or the xylo-oligosaccharide, also is fit to diabetes patient.
Micro-humatite element and nutriment for the additional needed by human body that more is conducive to general equilibrium; The further feature of the present composition is: said composition also comprises at least a in the following interpolation material that mass fraction forms: 0.01～0.5 part of manganese acetate; 0.3～1 part of 0.2～2 part of ferrous lactate or boric acid.
The composition quality mark preferred group of an embodiment of the present invention becomes: 0.01～1 part on the red nano selenium of average grain diameter≤50nm; 0.3～2 part of organic germanium (Ge-132); 5～10 parts of Potassium Magnesium Aspartatas; Asparagus amino-acid calcium 3-8 part; 0.5～2 part of zinc acetate; 0.01～0.5 part of chromium picolinate; 0.01～0.5 part of manganese acetate; 0.2～2 part of ferrous lactate; 5～20 parts in amino acid; 2～10 parts of vitamin C sodium salts; 3～10 parts of the daltonian Isin glue collagens in molecular weight≤3000; 2～5 parts of trehaloses; Xylitol 1-5 part; 0.5～3 part of citric acid; 0.3～1 part of boric acid; 100～300 parts of 0.5～3 part of dehydro sodium acetate and distilled water.
The present composition is red transparency liquid, and color is pale red from low to high with the content of red nano selenium and gradually changes to dark red; The pH value is 5～6, is faintly acid, sweet mouthfeel; Be rich in multiple micro-humatite element and nutriment to the human body beneficial, absorption of human body utilization rate height, edible safety, effect is comprehensive, can liver protecting, effectively remove interior free yl, improve body immunity.
Any component raw material of the designed use of the present composition all satisfies the requirement of state food safe and sanitary, and has positive liver protecting health-care effect.Wherein:
The average grain diameter of red nano selenium is answered≤100nm, the product of the preferred average grain diameter of the embodiment of the invention≤50nm red nano selenium.
Collagen can be the corresponding collagen that extracts from pig, ox, chicken etc., also can be the Isin glue collagen that extracts from fish-skin, fish scale.The daltonian Isin glue collagen in embodiment of the invention preferred molecular weight≤3000.
Amino acid can be compound amino acid, can be single amino acid also, or the two is in conjunction with product.The embodiment of the invention adopts be compound amino acid and single amino acid design proportion in conjunction with product, compound amino acid is to provide full nutrition, single amino acid is that the detoxifcation of strengthening the present composition protects special efficacies such as liver.Single amino acid refers to a kind of of methionine, lysine, valine, threonine, glycine, glutamic acid, cystine or alanine, perhaps the composition of two or more arbitrary proportions.
Vitamin C salt can be its sylvite or sodium salt.The sodium salt of preferred vitamin C of the present invention.It not only has ascorbic physiological function, can play the identical effect of replenishing vitamins C, and replenish sodium element, and its performance is more stable, no longer includes ascorbic highly acid, also more is conducive to other humatite matter compatible
Anticorrisive agent can be sodium Diacetate, also can be dehydro sodium acetate; The preferred dehydro sodium acetate of the present invention.
Water should meet drinking water quality standard, can be distilled water, deionized water, mineral water or drinking public water supply.The preferred distilled water of the embodiment of the invention.
Minerals and vitamins is the same, is the indispensable element of human body.Mineral element is combined with enzyme, helps body metabolism.Enzyme is indispensable protein in the metabolic processes, and what make enzyme activation is mineral matter.If mineral deficiency, enzyme just can't operate as normal, metabolic activity just stops thereupon.Mineral matter is that human body can't produce, can't synthesize, and required mineral matter all needs external replenishing.Early-stage Study shows that bio-absorbable utilization rate and the security in vivo of humatite matter all is higher than inorganic mineral.Present composition design mix all has the experimental basis of science.Now simply be described below:
Selenium is a kind of trace element of needed by human, participates in the metabolism body endoperoxide and iodine, regulates the level of iodine in the organism and the level of free radical, can strengthen body diseases prevention, resistance against diseases.Can effectively prevent and treat multiple disease though mend selenium, scope is narrow between the nutrition dosage of selenium and the toxicity dose, to such an extent as to people are studying low toxicity selenium product efficiently for many years always.Up-to-date studies show that, red nanometer selenium more is better than organic selenium in many aspects, demonstrates the efficient feature of low toxicity.The biological effectiveness of nanometer selenium is approved that it is health food (No. the 134th, hygienic food and health number 1998) that health ministry has been ratified the nanometer selenium capsule.
Studies show that, organic germanium, be sesquialter oxidation carboxyethyl germanium (Ge-132), almost non-toxic property, have and bring out self interferon, increase the nk cytoactive, the activation phagocyte, promote body to produce antitumor, anti-ageing biological action, its material that uses as new resource for food of China Ministry of Public Health approved.Many studies confirm that, organic germanium at lipoid peroxidization resistant, alleviate aspects such as ethanol hepatic injury and have remarkable result.
Zinc is composition or the coenzyme of human body six big enzymes, 200 kinds of metalloenzyme, and general metabolism is played extensive effect.These enzymes play an important role in the metabolism of tissue respiration and protein, fat, sugar and nucleic acid etc.
The more important thing is that selenium and germanium have synergy, selenium element and zinc element also have synergy.The present composition organically combines red nano selenium, organic germanium and organic zinc, makes it in microelement-supplementing, has further strengthened three's collaborative effectiveness.
Manganese also is one of trace element of needed by human, is that several enzyme systems comprise that a composition of the specific glycosyl transferase of manganese and phosphoenolpy ruvate carboxy kinase is also essential by the normal bone structure.
Chromium (trivalent) is the important composition composition of glucose tolerance factor (GTF), and it can increase the activity of insulin, participates in the synthetic and nucleic acid of protein, the metabolism of fat, reduces body fat content.Chromium can also make immune system strengthen, and improves body to undesirable condition and resistance that stress situation.Use the effect of Organic Chromium better than inorganic chromium.Common Organic Chromium has chromium picolinate, nicotinic acid chromium, Cr-enriched yeast etc.
Boron is to keep one of the health of bone and calcium, phosphorus, the needed trace element of magnesium eubolism.To preventing that calcium loss, prevention of osteoporosis disease have effect, the shortage of boron can increase the weight of the shortage of vitamin D; On the other hand, boron also helps to improve male testical sterone secretory volume, tones up the muscles, and is the indispensable nutrient of sportsman.Boron improves brain function in addition, improves the effect of respond.
Amino acid is necessary base substance in the human life motion, its physiological action be promote that protein is synthetic, collagen, growth hormone secretion, the protection liver function prevents hepatic disorder after drinking, improves the functions such as immunocompetence of body.
Vitamin C (VC) has stronger antioxidation as the necessary vitamin of human body, can protect other antioxidants, plays important regulatory role in the redox metabolic response of human body.As long as the VC abundance, then VC, glutathione and-SH can form strong anti-oxidant set boxing, removes free radical, stops the toxic action of lipid peroxidation and some chemical substance, the eubolism of liver-protective detoxification ability and cell.Also the non-oxidizability of VC just can make the selenium element reduction in the sodium selenite become simple substance selenium, and then can prepare red nano selenium.
Collagen is a kind of biological polymer substance, is the nutriment that human body delays senility and must supply.
The main effect of Potassium Magnesium Aspartata (PMA) is the aerobic metabolism process of accelerating in the tricarboxylic acid cycle, eliminates the ammonia that produces in the motion. reduce ammonia concentration.
Trehalose is a kind of natural materials, it is to the protective effect of bio-tissue and large biological molecule, trehalose has the effect of stabilate film (cell membrane) and protein structure and resist drying, can stop the lymphocytic destruction of the T of HIV, have hypoglycemic, effect such as protect the liver; Trehalose is the natural green carbohydrate, compares with other carbohydrate, and the absorption of trehalose in human body is slow, and blood glucose response is mild, is diabetes patient's health food.
Xylitol metabolism does not in vivo need insulin to participate in, and blood glucose value is raise, and can eliminate diabetes patient more than three (many drinks, diuresis, many foods) symptom, is sweetener, nutritious supplementary pharmaceutical and the auxiliary therapeutical agent of diabetes patient's safety therefore.
Xylo-oligosaccharide claims wood oligose again, can optionally promote the proliferation activity of intestinal bifidobacteria, and its bifidobacterium factor functional is 10-20 times of other polymerization carbohydrate; Xylo-oligosaccharide has the effect of reducing blood lipid, norcholesterol; Prevent functions such as diarrhoea, constipation, opposing tumour and decomposition carcinogenic substance in addition.
The present invention has designed described preparation of compositions method simultaneously, this preparation method adopts the mass fraction that protects the liver health composition of the present invention to form and following technology: at normal temperatures and pressures, (1). earlier red nano selenium, collagen, amino acid and anticorrisive agent are dissolved in water together, all after the dissolving, leave standstill more than 24 hours, make A solution; (2). organic germanium, Potassium Magnesium Aspartata, asparagus amino-acid calcium, zinc acetate and sweet taste conditioning agent are dissolved in water together, make B solution; (3). with vitamin C or its salt and tart flavour conditioning agent be dissolved in water together, make C solution; (4). B solution and C solution are added in the A solution after leaving standstill, and constantly be stirred to and mix, leave standstill more than 48 hours, get its supernatant and namely make the described liver health composition that protects.
The present composition increases or adjusts when new component is arranged, and its preparation method is done corresponding adjustment.
When present composition increase had mass fraction to consist of 0.01～0.5 part chromium picolinate, the preparation method consisted of described mass fraction 0.01～0.5 part chromium picolinate and is dissolved in water with the tart flavour conditioning agent in preparation C solution process.
Present composition design also comprises at least a in the following interpolation material that mass fraction forms: 0.01～0.5 part of manganese acetate; When 0.3～1 part of 0.2～2 part of ferrous lactate or boric acid, the preparation method is 0.01～0.5 part of manganese acetate that described mass fraction is formed or/and ferrous lactate is dissolved in water with the sweet taste conditioning agent in preparation B solution process for 0.2～2 part; Perhaps the boric acid that described mass fraction is formed is dissolved in water with the tart flavour conditioning agent in preparation C solution process for 0.3～1 part.
The present composition is when designing 0.3～1 part of 0.2～2 part of 0.01～0.5 part of chromium picolinate, manganese acetate, ferrous lactate containing described mass fraction and consist of 0.01～0.5 part and boric acid simultaneously, the preparation method is dissolved in water with the sweet taste conditioning agent and is dissolved in water with the tart flavour conditioning agent in C solution process at preparation B solution respectively as previously mentioned.
Compared with prior art, preparation method of the present invention is normal temperature and pressure production, and technology is simple, and is easy to operate, pollution-free, and low energy consumption is easy to promote, and is fit to suitability for industrialized production.
The present composition is red transparency liquid.This is a kind of basic product.Utilize this basic product can prepare different secondary products: for example:
1. according to mineral element content requirement and the national Related product quality safety standard of product design, basic product is diluted, is distributed into oral liquid or the drinks of various dose, directly drink;
2. according to mineral element content requirement and the national Related product quality safety standard of product design, basic product is made the dry powdery thing through dry technologies such as conventional low temperature drying or freeze dryings, this dry powdery thing adds the excipients of pharmacy permission, can make chewable tablets, buccal tablets, oral, capsule or dripping pill etc.;
3. according to mineral element content requirement and the national Related product quality safety standard of product design, basic product composition or its dry powdery thing are added in the functional food as the food function hardening agent, make health functional food, for example biscuit cake class, noodles wheaten food class, fruit drink class etc.;
4. according to mineral element content requirement and the national Related product quality safety standard of product design, basic product composition or its dry powdery thing as the beauty and skin care raw material, are added in beauty and skin care aqua or the paste, make function beauty treatment skin-protection product;
5. according to mineral element content requirement and the national Related product quality safety standard of product design, basic product composition or its dry powdery thing are added in the animal feed as function intensified dose, make the function animal feed;
6. according to mineral element content requirement and the national Related product quality safety standard of product design, basic product composition or its dry powdery thing as extraordinary fertilizer, are used for the plantation of extraordinary agricultural such as crops, fruit, vegetables, edible mushroom.
The present invention does not address part and is applicable to prior art.
Provide specific embodiments of the invention below.These embodiment only are used for further concrete narration the present invention, do not limit the protection domain of the application's claim.
Embodiment 1
Design a kind of liver health composition that protects, its material by following mass fraction is formed: 0.01 part on red nano selenium; 0.3 part of organic germanium (Ge-132); 5 parts of Potassium Magnesium Aspartatas; 3 parts of asparagus amino-acid calciums; 0.5 part of zinc acetate; 3 parts of collagens; 5 parts of compound amino acids; 0.5 part of glycine, 0.5 part of lysine, 0.5 part of threonine, 0.5 part of valine, 0.5 part of methionine, 0.5 part in glutamic acid, Catergen part; 0.5 part of trehalose; 1 part of xylo-oligosaccharide; 0.5 part of citric acid; 100 parts of dehydro sodium acetate and distilled water.
Its preparation method is:
1. under the normal temperature and pressure, with red nano selenium, collagen, compound amino acid, glycine, lysine, methionine, threonine, valine, glutamic acid and 50 parts of stirring and dissolving of dehydro sodium acetate adding distil water, to all leaving standstill 24 hours after the dissolving, make A solution;
2. under the normal temperature and pressure, organic germanium, Potassium Magnesium Aspartata, asparagus amino-acid calcium, zinc acetate, trehalose and 30 parts of stirring and dissolving of xylo-oligosaccharide adding distil water to clarification, are made B solution;
3. under the normal temperature and pressure, with citric acid and the extremely clarification of 20 parts of stirring and dissolving of vitamin C adding distil water, make C solution;
4. under the normal temperature and pressure, B solution and C solution are slowly joined A solution respectively, and constantly are stirred to evenly, leave standstill 48 hours after, its supernatant is the humatite matter that the present invention contains nanometer selenium and protects the liver health composition.
The present embodiment gained protect the liver health composition, what can direct packaging become the 10ml/ bottle protects the liver health care oral liquid, with every day 10-30ml dosage for the people daily liver healht-care that protects, also can be drinking before oral 10-20ml or/and the oral 10-20ml in back that drinks for relieving alcoholism and protecting liver; After 100 times of said composition water or the Other Drinks dilutions, can make the functional health beverage.
Embodiment 2
Design a kind of liver health composition that protects, its material by following mass fraction is formed: 0.1 part on red nano selenium; 1 part of organic germanium; 8 parts of Potassium Magnesium Aspartatas; 5 parts of asparagus amino-acid calciums; 1 part of zinc acetate; 5 parts of collagens; 10 parts of compound amino acids; 1 part of glycine; 0.5 part of lysine, 0.5 part of threonine, 0.5 part of valine, 0.5 part of methionine, 0.5 part in glutamic acid, 5 parts of vitamin C sodium salts; 2 parts of trehaloses; 1 part of xylitol; 1 part of citric acid; 300 parts of 1.5 parts of sodium Diacetates and distilled water.
Its preparation method is:
1. under the normal temperature and pressure, with red nano selenium, collagen, compound amino acid, glycine, lysine, methionine, threonine, valine, glutamic acid and 150 parts of stirring and dissolving of sodium Diacetate adding distil water, to all leaving standstill 24 hours after the dissolving, make A solution;
2. under the normal temperature and pressure, organic germanium, Potassium Magnesium Aspartata, asparagus amino-acid calcium, zinc acetate, trehalose and 80 parts of stirring and dissolving of xylitol adding distil water to clarification, are made B solution;
3. under the normal temperature and pressure, with citric acid and the extremely clarification of 70 parts of stirring and dissolving of vitamin C sodium salt adding distil water, make C solution;
4. under the normal temperature and pressure, B solution and C solution are slowly joined A solution respectively, and constantly are stirred to evenly, leave standstill 48 hours after, its supernatant is the present invention and protects the liver health composition.
The present embodiment gained protect the liver health composition, can direct packaging become the spray of small bottle packing, every day, the mouth spray was 3-5 time, each 0.5-1ml is used for dailyly protecting the liver health care or/and mouthful spray before and after drinking; Also can dilute with water after 10 times, what be distributed into the 10ml/ bottle protects the liver health care oral liquid, with every day 10-30ml dosage for the daily liver healht-care that protects of people, also can be drinking before oral 10-20ml or/and the oral 10-20ml in back that drinks for relieving alcoholism and protecting liver; After 500 times of water or the Other Drinks dilutions, can make the functional health beverage.
Embodiment 3
Design a kind of liver health composition that protects, its material by following mass fraction is formed: 1 part on red nano selenium; 2 parts of organic germaniums; 10 parts of Potassium Magnesium Aspartatas; 8 parts of asparagus amino-acid calciums; 2 parts of zinc acetates; 10 parts of collagens; 20 parts of compound amino acids; 10 parts of vitamin C sodium salts; 2 parts of trehaloses; 3 parts of xylo-oligosaccharides; 3 parts of citric acids; 200 parts of 3 parts of dehydro sodium acetates and distilled water.
Its preparation method is:
1. under the normal temperature and pressure, with red nano selenium, collagen, compound amino acid and 100 parts of stirring and dissolving of dehydro sodium acetate adding distil water, to all leaving standstill 24 hours after the dissolving, make A solution;
2. under the normal temperature and pressure, organic germanium, Potassium Magnesium Aspartata, asparagus amino-acid calcium, zinc acetate, trehalose and 60 parts of stirring and dissolving of xylo-oligosaccharide adding distil water to clarification, are made B solution;
3. under the normal temperature and pressure, with citric acid and the extremely clarification of 40 parts of stirring and dissolving of vitamin C sodium salt adding distil water, make C solution;
4. under the normal temperature and pressure, B solution and C solution are slowly joined A solution respectively, and constantly are stirred to evenly, leave standstill 48 hours after, its supernatant is the liver health composition that protects of the present invention.
The liver health composition that protects of present embodiment gained is high concentration composition, can adopt conventional low temperature drying or freeze drying mode to make pulvis and use; Can dilute the spray that is distributed into small bottle packing after 50 times, every day, the mouth spray was 3-5 time, and each 0.5-1ml protects the liver health care for daily, or/and mouthful spray before and after drinking, with relieving alcoholism and protecting liver; What also can dilute with water be distributed into the 10ml/ bottle after 200 times protects the liver health care oral liquid, with every day 10-30ml dosage for the daily liver healht-care that protects of people, also can be drinking before oral 10-20ml or/and the oral 10-20ml in back that drinks for relieving alcoholism and protecting liver; After 1000 times of said composition water or the Other Drinks dilutions, can make the functional health beverage.
Embodiment 4
Design a kind of liver health composition that protects, its material by following mass fraction is formed: on the basis of embodiment 1 described mass fraction component, increase by 0.01 part of pyrrole carboxylic acid chromium; 0.01 part of manganese acetate; 0.3 part of 0.2 part of ferrous lactate and boric acid.
Its preparation method is: manganese acetate and ferrous lactate are joined in the B solution in the lump dissolve, pyrrole carboxylic acid chromium and boric acid are joined in the C solution in the lump dissolve, other method is identical with embodiment 1.
The using method of protecting the liver health composition of present embodiment gained is identical with embodiment 1.
Embodiment 5
Design a kind of liver health composition that protects, its material by following mass fraction is formed: on the basis that embodiment 2 described mass fraction materials are formed, increase by 0.1 part of pyrrole carboxylic acid chromium; 0.2 part of manganese acetate; 0.5 part of 1 part of ferrous lactate and boric acid.
Its preparation method is: manganese acetate and ferrous lactate are joined in the B solution in the lump dissolve, pyrrole carboxylic acid chromium and boric acid are joined in the C solution in the lump dissolve, other method is identical with embodiment 2.
The using method of protecting the liver health composition of present embodiment gained is identical with embodiment 2.
Embodiment 6
Design a kind of liver health composition that protects, its material by following mass fraction is formed: on the basis that embodiment 3 materials are formed, increase by 0.5 part of pyrrole carboxylic acid chromium; 0.5 part of manganese acetate; 2 parts of ferrous lactates; 1 part of boric acid; 2 parts of 3 parts of trehaloses and xylo-oligosaccharides.
Its preparation method is: manganese acetate and ferrous lactate are joined in the B solution in the lump dissolve, pyrrole carboxylic acid chromium and boric acid are joined in the C solution in the lump dissolve, other method is identical with embodiment 3;
The using method of protecting the liver health composition of present embodiment gained is identical with embodiment 3.
Embodiment 7
Design a kind of liver health composition that protects, the consisting of of its mass fraction: 0.1 part on the red nano selenium of average grain diameter≤50nm; 1 part of organic germanium (Ge-132); 8 parts of Potassium Magnesium Aspartatas; 6 parts of asparagus amino-acid calciums; 1.5 parts of zinc acetates; 0.03 part of chromium picolinate; 0.02 part of manganese acetate; 1 part of ferrous lactate; 0 part of amino acid/11; 6 parts of vitamin C sodium salts; 8 parts of the daltonian Isin glue collagens in molecular weight≤3000; 2 parts of trehaloses; 5 parts of xylitols; 1.5 parts of citric acids; 0.6 part of boric acid; 300 parts of 1.5 parts of dehydro sodium acetates and distilled water.
Its preparation method is identical with embodiment 1 or 5.The using method of protecting the liver health composition of present embodiment gained is identical with embodiment 1 or 2.
Claims (8)
1. one kind is protected the liver health composition, it is characterized in that the mass fraction composition of said composition is mainly: 0.01 ~ 1 part on red nano selenium; 0.3 ~ 2 part of organic germanium; 5 ~ 10 parts of Potassium Magnesium Aspartatas; Asparagus amino-acid calcium 3-8 part; 0.5 ~ 2 part of zinc acetate; 3 ~ 10 parts of collagens; 5 ~ 20 parts in amino acid; 2 ~ 10 parts of vitamin C or its salt; 100 ~ 300 parts in 0. 5 ~ 3 parts of sweet taste conditioning agent 1-5 parts, 0.5 ~ 3 part of tart flavour conditioning agent, anticorrisive agent and water; Average grain diameter≤the 100nm of described red nano selenium; Vitamin C salt is vitamin C sylvite or vitamin C sodium salt; The sweet taste conditioning agent is at least a in trehalose, glycine, xylitol or the xylo-oligosaccharide; The tart flavour conditioning agent is citric acid, and anticorrisive agent is sodium Diacetate or dehydro sodium acetate.
2. the liver health composition that protects according to claim 1 is characterized in that chromium picolinate 0.01 ~ 0. 5 that said composition comprises that also mass fraction forms part.
3. the liver health composition that protects according to claim 1 is characterized in that at least a in the following interpolation material that said composition comprises that also mass fraction forms: manganese acetate 0.01 ~ 0. 5 part; 0.3 ~ 1 part of 0.2 ~ 2 part of ferrous lactate or boric acid.
4. the liver health composition that protects according to claim 1 is characterized in that the mass fraction composition of said composition is mainly: 0.01 ~ 1 part on the red nano selenium of average grain diameter≤50nm; 0.3 ~ 2 part of organic germanium; 5 ~ 10 parts of Potassium Magnesium Aspartatas; Asparagus amino-acid calcium 3-8 part; 0.5 ~ 2 part of zinc acetate; Chromium picolinate 0.01 ~ 0. 5 part; Manganese acetate 0.01 ~ 0. 5 part; 0.2 ~ 2 part of ferrous lactate; 5 ~ 20 parts in amino acid; 2 ~ 10 parts of vitamin C sodium salts; 3 ~ 10 parts of the daltonian Isin glue collagens in molecular weight≤3000; 2 ~ 5 parts of trehaloses; Xylitol 1-5 part; 0.5 ~ 3 part of citric acid; 0.3 ~ 1 part of boric acid; 100 ~ 300 parts of 0. 5 ~ 3 parts of dehydro sodium acetates and distilled water.
5. preparation method who protects the liver health composition, this preparation method adopts the described mass fraction that protects the liver health composition of claim 1 to form and following technology: at normal temperatures and pressures, (1) earlier red nano selenium, collagen, amino acid and anticorrisive agent are dissolved in water together, all after the dissolving, leave standstill more than 24 hours, make A solution; (2) organic germanium, Potassium Magnesium Aspartata, asparagus amino-acid calcium, zinc acetate and sweet taste conditioning agent are dissolved in water together, make B solution; (3) with vitamin C or its salt and tart flavour conditioning agent be dissolved in water together, make C solution; (4) B solution and C solution are added in the A solution after leaving standstill, and constantly be stirred to and mix, leave standstill more than 48 hours, get its supernatant and namely make the described liver health composition that protects.
6. the preparation method who protects the liver health composition according to claim 5, it is characterized in that this preparation method adopts the described mass fraction that protects the liver health composition of claim 2 to form and following technology: the chromium picolinate that described mass fraction is consisted of 0.01 ~ 0. 5 part is dissolved in water with the tart flavour conditioning agent in preparing C solution process.
7. the preparation method who protects the liver health composition according to claim 5 is characterized in that this preparation method adopts the described mass fraction that protects the liver health composition of claim 3 to form and following technology: manganese acetate 0.01 ~ 0. 5 that described mass fraction is formed part or/and ferrous lactate in preparing B solution process, be dissolved in water with the sweet taste conditioning agent for 0.2 ~ 2 part; Perhaps the boric acid that described mass fraction is formed is dissolved in water with the tart flavour conditioning agent in preparation C solution process for 0.3 ~ 1 part.
8. the preparation method who protects the liver health composition according to claim 5 is characterized in that this preparation method adopts the described mass fraction that protects the liver health composition of claim 4 to form and following technology: manganese acetate 0.01 ~ 0. 5 that described mass fraction is formed part and ferrous lactate are dissolved in water with the sweet taste conditioning agent in preparing B solution process for 0.2 ~ 2 part; The boric acid that described mass fraction is consisted of 0.01 ~ 0. 5 part chromium picolinate and 0.3 ~ 1 part is dissolved in water with the tart flavour conditioning agent in preparation C solution process.
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| CN103876158A (en) * | 2013-11-18 | 2014-06-25 | 国家海洋局第三海洋研究所 | Elemental selenium and sugar compound and preparation method thereof |
| CN106261362A (en) * | 2016-08-08 | 2017-01-04 | 南昌大学 | A kind of honeysuckle composition beverage with the liver protecting effect and preparation method |
| CN110200287A (en) * | 2019-06-29 | 2019-09-06 | 华南理工大学 | A kind of oyster polypeptide-nano granules of selenium compound and the preparation method and application thereof with relieving alcoholism and protecting liver effect |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103876158A (en) * | 2013-11-18 | 2014-06-25 | 国家海洋局第三海洋研究所 | Elemental selenium and sugar compound and preparation method thereof |
| CN103876158B (en) * | 2013-11-18 | 2016-09-28 | 国家海洋局第三海洋研究所 | A kind of elemental selenium and sugared complex and preparation method thereof |
| CN106261362A (en) * | 2016-08-08 | 2017-01-04 | 南昌大学 | A kind of honeysuckle composition beverage with the liver protecting effect and preparation method |
| CN110200287A (en) * | 2019-06-29 | 2019-09-06 | 华南理工大学 | A kind of oyster polypeptide-nano granules of selenium compound and the preparation method and application thereof with relieving alcoholism and protecting liver effect |
| CN110200287B (en) * | 2019-06-29 | 2023-06-09 | 华南理工大学 | Oyster polypeptide-nano selenium particle compound with effects of dispelling effects of alcohol and protecting liver as well as preparation method and application thereof |
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| CN103271353B (en) | 2014-09-03 |
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