CN103263561B - Traditional Chinese medicine preparation for treating asthma with kidney-yang deficiency - Google Patents

Traditional Chinese medicine preparation for treating asthma with kidney-yang deficiency Download PDF

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CN103263561B
CN103263561B CN201310151922.8A CN201310151922A CN103263561B CN 103263561 B CN103263561 B CN 103263561B CN 201310151922 A CN201310151922 A CN 201310151922A CN 103263561 B CN103263561 B CN 103263561B
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kidney
yang
asthma
chinese medicine
medicine preparation
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CN103263561A (en
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张倩
陈显久
燕炯
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Shanxi Medical University
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Shanxi Medical University
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Abstract

The invention relates to the field of traditional Chinese medicines for asthma and provides a traditional Chinese medicine preparation for treating asthma with kidney-yang deficiency so as to overcome problems in treatment of asthma with kidney-yang deficiency. The traditional Chinese medicine preparation is prepared from raw materials consisting of raw rehmannia root, prepared rehmannia root, Chinese yam, malaytea scurfpea fruit, English walnut seed, Chinese magnoliavine fruit, achyranthes root, medicinal evodia fruit and barbary wolfberry fruit in a certain weight ratio and can be processed to form a pill, a tablet or a capsule. The traditional Chinese medicine preparation provided by the invention can reinforce the kidney to strengthen yang, nourish yin to support yang, tonify kidney-Qi, converge consumed Qi, warm the interior, promote diuresis and treat stranguria; through combined usage of the raw materials, the effects of yang-tonifying and asthma-relieving are obtained; the traditional Chinese medicine preparation mainly treats the symptom of asthma with kidney-yang deficiency by benefiting kidney-yang and tonifying and strengthening Qi, is simple to take and has wide clinical application prospects.

Description

A kind of Chinese medicine preparation for the treatment of insufficiency of kidney-YANG asthma
Technical field
The present invention relates to the asthma field of Chinese medicines, be specially a kind of Chinese medicine preparation for the treatment of insufficiency of kidney-YANG asthma.
Background technology
Breathe heavily and pant, pant.The syndrome of dyspnea is that flaring of alaenasi, can not equal the disease crouching as Clinical symptoms with dyspnea, opening mouth and lifting shoulder due to dyspnea even.Though the syndrome of dyspnea is an independently disease, but be found in multiple acute and chronic diseases process, related wide range, not only be more common in lung pattern disease, and can affect due to the lung because of other internal organs pathological changes, in western medicine as the generations such as pneumonia, asthmatic bronchitis, emphysema, pulmonary heart disease, cardiac asthma, pulmonary tuberculosis, pneumosilicosis and hysteria be take dyspnea as main manifestations person.
The traditional Chinese medical science thinks, the pathogeny of the syndrome of dyspnea is mainly at lung and kidney, " the lung being the dominator of QI, the kidney being the root of QI ", kidney and lung are with the cashier of department's gas, therefore kidney unit is solid, takes the photograph and receive not normal gas and do not return formerly, negative and positive are not wanted to continue, and QI rising in reverse order in lung for breathing heavily.As deficiency of YANG QI, YANG QI deficiency, cloudy damage of essence consumption, and it is not normal to cause lung kidney cashier.The true strength trauma of kidney, not solid, to take the photograph and receive not normally, gas is become homeless and is received, and superinverse is breathed heavily in lung.Clinical main manifestations is dyspnea and shortness of breath, exhales inhale less more, and gas must not continue, spiritlessness and weakness, and spontaneous perspiration and cold extremities, oliguria, light red tongue is fat, deep-thready pulse.
The method treatments such as the current multiplex antibiotic of western medical treatment, hormone, aminophylline, took effect at that time, but relapse rate are high.Chinese traditional treatment bronchial asthma is determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, is divided into heat symptom-complex, sympotoms caused by cold factors, yin deficiency, YANG asthenia disease, and existing Chinese patent medicine mostly is a kind of medicine, entirely treats, and specific aim is poor.
Summary of the invention
The present invention is in order to solve the treatment problem of insufficiency of kidney-YANG asthma, and a kind of Chinese medicine preparation for the treatment of insufficiency of kidney-YANG asthma is provided.
The present invention is realized by following technology incidence of criminal offenses, treat a Chinese medicine preparation for insufficiency of kidney-YANG asthma, by the raw material of following weight portion, made: Radix Rehmanniae 3-9 part, Radix Rehmanniae Preparata 3-9 part, Rhizoma Dioscoreae 12-18 part, Fructus Psoraleae 3-9 part, semen juglandis 6-12 part, Fructus Schisandrae Chinensis 1-6 part, Radix Achyranthis Bidentatae 1-6 part, Fructus Evodiae 3-9 part, Fructus Lycii 3-9 part.
The optimum ratio scheme of each component of Chinese medicine preparation of the present invention is: 6 parts of Radix Rehmanniae, 6 parts of Radix Rehmanniae Preparata, 15 parts of Rhizoma Dioscoreaes, 6 parts of Fructus Psoraleaes, 9 parts of semen juglandiss, 3 parts of Fructus Schisandrae Chinensis, 3 parts of Radix Achyranthis Bidentataes, 6 parts of Fructus Evodiaes, 6 parts of Fructus Lycii.
The preparation method of Chinese medicine preparation of the present invention is: by formula proportion, take described raw material, wash respectively, under 120 ℃, 0.3Mpa condition, sterilizing is 30 minutes, pulverizes; Cross 80-100 mesh sieve, fine powder mixes.Chinese medicine preparation of the present invention also can be made into tablet, pill or capsule.
In Chinese medicine preparation of the present invention, Radix Rehmanniae, property is sweet, bitter, cold.GUIXIN, liver, kidney channel, clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis, sends out speckle dermexanthesis.Radix Rehmanniae Preparata, property is sweet, tepor, returns liver, kidney channel, the yin nourishing of enriching blood, life essence-filling, marrow-benefitting; For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.Rhizoma Dioscoreae, property is sweet, flat, returns spleen, lung, kidney channel, supplementing QI and nourishing YIN, spleen reinforcing lung kidney, treating spontaneous emission and leukorrhagia; For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, and leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.Fructus Psoraleae, bitter, pungent, warm, return kidney, spleen channel, kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha, helping inspiration to relieve asthma; For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea.Semen juglandis, property is sweet, warm, returns kidney, lung, large intestine channel, tonifying the kidney to consolidate the essence, warming the lung Dingchuan, loosening bowel to relieve constipation; Controlling suffers from a deficiency of the kidney breathes heavily and coughs, lumbago flaccidity of the lower limbs, sexual impotence, seminal emission, frequent micturition, stranguria caused by urinary stone, constipation due to dry stool.Fructus Schisandrae Chinensis, sour in the mouth, sweet, warm, returns lung, the heart, kidney channel, restrains astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming; For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.Radix Achyranthis Bidentatae, bitter, sweet, sour, flat, return liver, kidney channel, promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, relieving stranguria by diuresis, ignite descending; For soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG, stranguria edema, dysuria.Fructus Evodiae, acrid in the mouth, hardship, heat, slightly poisonous, return liver, spleen, stomach, kidney channel; Dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal; For headache due to JUE YIN disorder, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, deficiency and coldness, have loose bowels.Fructus Lycii, property is sweet, flat, returns liver, kidney channel, nourishing the liver and kidney, replenishing vital essence to improve eyesight; For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat quench one's thirst, blood deficiency and yellow complexion, blurred vision be not clear.Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae enriching yin boost qi; Fructus Psoraleae, semen juglandis, Fructus Evodiae reinforcing the kidney and supporting YANG, helping inspiration to relieve asthma; The gas of Fructus Schisandrae Chinensis convergence dissipation; Radix Achyranthis Bidentatae relieving stranguria by diuresis.All enter kidney channel, not only reinforcing the kidney and supporting YANG, and energy YIN nourishing is with supporing yang; Both can the kidney invigorating gas, the gas that can restrain again dissipation; Double energy warming the interior, relieving stranguria by diuresis; Close and with it, reach the effect of YANG invigorating Zhichuan.The present invention cures mainly the symptom of insufficiency of kidney-YANG asthma by tonification kidney yang, QI invigorating solid and gas.
Chinese medicine of the present invention is as follows for clinical situation: patient's 100 examples during year August in August, 2011 to 2012, and male 55 examples wherein, female's 45 examples, the course of disease is half a year at least.Patient's every day, oral embodiment 2 finished products, once a day, at every turn a, take seven days as a course for the treatment of, be used in conjunction 4 the course for the treatment of observe the curative effect.
Diagnosis basis: according to < < People's Republic of China (PRC) Chinese medicine industry standard---the regulation of traditional Chinese medical science disease Standardization of diagnosis and curative effect (ZY/T001.1-94) > >, with reference to " bronchial wheezing, breathe heavily the diagnosis basis of disease ", insufficiency of kidney-YANG patient, dyspnea and shortness of breath, exhale inhale less, gas must not continue, spiritlessness and weakness more, spontaneous perspiration and cold extremities, oliguria.Dyspnea with rapid and short breath with the passing of time, severe palpitation, moving breath with cough, shortness of breath, uncomfortable in chest as stop up, can not put down sleeping, abundant expectoration and gluing, or dysphoria and insomnia, cyanosis of the lips and nails.Body of the tongue purple or red tongue tongue are few, faint pulse disease or knot, generation.Shortness of breath usually, moving for very.Waist soreness, vertigo and tinnitus, does not endure hardships tired, and lower limb are owed temperature, clear urine in large amounts.Light red tongue, deep-thready pulse.
Efficacy evaluation: according to < < People's Republic of China (PRC) Chinese medicine industry standard---the regulation of traditional Chinese medical science disease Standardization of diagnosis and curative effect (ZY/T001.1-94) > >, with reference to " bronchial wheezing, breathe heavily the efficacy evaluation of disease ", cure: asthma is calmed down, auscultation two lung wheezing sounds disappear, other transference cures; Take a turn for the better: asthma alleviates, auscultation is even to be heard and wheezing sound, and other symptoms alleviate; Do not heal: asthma attack symptom is without improving or increasing the weight of.
Therapeutic Method: get Radix Rehmanniae 6g, Radix Rehmanniae Preparata 6g, Rhizoma Dioscoreae 15 g, Fructus Psoraleae 6g, semen juglandis 9g, Fructus Schisandrae Chinensis 3g, Radix Achyranthis Bidentatae 3g, Fructus Evodiae 6g, Fructus Lycii 6g.Above medicine washes respectively, and under 120 ℃, 0.3Mpa condition, sterilizing is 30 minutes, pulverizes; Cross 80-100 mesh sieve, fine powder is divided into seven parts after mixing, and every part fills a bag.The mode of taking is oral, once a day, at every turn a, take seven days as a curative effect, be used in conjunction 4 the course for the treatment of observe the curative effect.
Therapeutic outcome: healing person's 75 examples account for 75%, improvement person's 20 examples account for 20%, and more person's 5 examples do not account for 5%.Total effective rate reaches 95%.Use other embodiments of the invention and use the therapeutic effect of the present embodiment 2 without significant difference.
Model case:
1, Liu, man, 34 years old, suffer from recurrent cough and pant 4 years, after activity, rapid breathing is obvious on ordinary days, and exercise tolerance declines, and each medical rear symptom is alleviated to some extent, but tachypnea has not yet to see improvement, and asthma symptom aggravation recently, is diagnosed as insufficiency of kidney-YANG asthma.Take medicine of the present invention after one month, all transference cures, follow up a case by regular visits to so far not recurrence.
2, Wang, female, 54 years old, the syndrome of dyspnea was gone through for many years, and every winter outbreak adds very.This year outbreak is more lasting, and dyspnea is moving breathe heavily very, and gas must not continue, spiritlessness and weakness, spontaneous perspiration and cold extremities, oliguria, pale tongue, deep-thready pulse.Dialectical: lung insufficiency of kidney-YANG asthma, gas must not be consolidated, and needs kidney-replenishing, the gas of convergence dissipation.Take after medicine first quarter moon of the present invention, patient main suit's symptom alleviates, and continues to take medicine after one month, and all transference cures, follow up a case by regular visits to so far not recurrence.
3, week certain, man, 2 years old, its female Dai Shu: infant cough stifling, must not put down sleeping, neurolysis, extremity cold of the limbs, the thin walking retardation in children of bone, is in a cold sweat.Be diagnosed as deficiency of spleen-YANG and kidneyYANG, because of improper feeding, take good care of oneself inappropriate, yang-energy is biochemical not enough, and then damage spleen kidney.Take after medicine first quarter moon of the present invention, all remissions, then take after several days, all transference cures, follow up a case by regular visits to so far not recurrence.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1: a kind of Chinese medicine preparation for the treatment of insufficiency of kidney-YANG asthma, by the raw material of following weight portion, made: Radix Rehmanniae 3g, Radix Rehmanniae Preparata 3g, Rhizoma Dioscoreae 12 g, Fructus Psoraleae 3g, semen juglandis 6g, Fructus Schisandrae Chinensis 1g, Radix Achyranthis Bidentatae 1g, Fructus Evodiae 3g, Fructus Lycii 3g.Above medicine washes respectively, and under 120 ℃, 0.3Mpa condition, sterilizing is 30 minutes, pulverizes; Cross 80-100 mesh sieve, fine powder mixes, and is then divided into five parts, and every part fills a bag.Chinese medicine preparation of the present invention also can be made into tablet, pill or capsule.The present embodiment institute pharmacy, above-mentioned diagnosis basis, criterion of therapeutical effect and the Therapeutic Method of same employing carries out clinical trial, 85 patients (wherein male 48 female 37) are treated to therapeutic outcome: healing person's 41 examples account for 48.24%, improvement person's 38 examples account for 44.71%, healing person's 6 examples do not account for 7.05%.Total effective rate reaches 92.95%.
Embodiment 2: a kind of Chinese medicine preparation for the treatment of insufficiency of kidney-YANG asthma, by the raw material of following weight portion, made: Radix Rehmanniae 6g, Radix Rehmanniae Preparata 6g, Rhizoma Dioscoreae 15 g, Fructus Psoraleae 6g, semen juglandis 9g, Fructus Schisandrae Chinensis 3g, Radix Achyranthis Bidentatae 3g, Fructus Evodiae 6g, Fructus Lycii 6g.Above process for preparing medicine is with embodiment 1, and fine powder is divided into seven parts after mixing, and every part fills a bag.Also can be processed as pill, tablet or capsule.
Embodiment 3: a kind of Chinese medicine preparation for the treatment of insufficiency of kidney-YANG asthma, by the raw material of following weight portion, made: Radix Rehmanniae 9g, Radix Rehmanniae Preparata 9g, Rhizoma Dioscoreae 18 g, Fructus Psoraleae 9g, semen juglandis 12g, Fructus Schisandrae Chinensis 6g, Radix Achyranthis Bidentatae 6g, Fructus Evodiae 9g, Fructus Lycii 9g.Above process for preparing medicine is with embodiment 1, and fine powder is divided into ten parts after mixing, and every part fills a bag.Also can be processed as pill, tablet or capsule.Embodiment institute pharmacy, above-mentioned diagnosis basis, criterion of therapeutical effect and the Therapeutic Method of same employing carries out clinical trial, 93 patients (wherein male 48 female 45) are treated, therapeutic outcome: healing person's 50 examples account for 53.76%, improvement person's 38 examples account for 40.86%, more person's 5 examples do not account for 5.38%, and total effective rate reaches 94.62%.
Embodiment 4: a kind of Chinese medicine preparation for the treatment of insufficiency of kidney-YANG asthma, by the raw material of following weight portion, made: Radix Rehmanniae 5g, Radix Rehmanniae Preparata 5g, Rhizoma Dioscoreae 14g, Fructus Psoraleae 5g, semen juglandis 8g, Fructus Schisandrae Chinensis 3g, Radix Achyranthis Bidentatae 3g, Fructus Evodiae 5g, Fructus Lycii 5g.Above process for preparing medicine is with embodiment 1, and fine powder is divided into 6 parts after mixing, and every part fills a bag.Also can be processed as pill, tablet or capsule.Embodiment institute pharmacy, above-mentioned diagnosis basis, criterion of therapeutical effect and the Therapeutic Method of same employing carries out clinical trial, 75 routine patients (wherein male 35 female 40) are treated, therapeutic outcome: healing person's 32 examples account for 42.67%, improvement person's 37 examples account for 49.33%, do not heal, 6 examples account for 8%, and total effective rate reaches 92%.
Embodiment 5: a kind of Chinese medicine preparation for the treatment of insufficiency of kidney-YANG asthma, by the raw material of following weight portion, made: Radix Rehmanniae 6g, Radix Rehmanniae Preparata 6g, Rhizoma Dioscoreae 16 g, Fructus Psoraleae 6g, semen juglandis 9g, Fructus Schisandrae Chinensis 4g, Radix Achyranthis Bidentatae 4g, Fructus Evodiae 6g, Fructus Lycii 6g.Above process for preparing medicine is with embodiment 1, and fine powder is divided into 9 parts after mixing, and every part fills a bag.Also can be processed as pill, tablet or capsule.Embodiment institute pharmacy, adopts above-mentioned diagnosis basis, criterion of therapeutical effect and Therapeutic Method to carry out clinical trial equally, and 50 patients (wherein male 26 female 24) are treated, therapeutic outcome: healing person's 25 examples account for 50%, improvement person's 21 examples account for 42%, and more person's 4 examples do not account for 8%, and total effective rate reaches 92%.

Claims (3)

1. a Chinese medicine preparation for the treatment of insufficiency of kidney-YANG asthma, is characterized in that: the raw material by following weight portion is made: Radix Rehmanniae 3-9 part, Radix Rehmanniae Preparata 3-9 part, Rhizoma Dioscoreae 12-18 part, Fructus Psoraleae 3-9 part, semen juglandis 6-12 part, Fructus Schisandrae Chinensis 1-6 part, Radix Achyranthis Bidentatae 1-6 part, Fructus Evodiae 3-9 part, Fructus Lycii 3-9 part.
2. a kind of Chinese medicine preparation for the treatment of insufficiency of kidney-YANG asthma according to claim 1, is characterized in that: the raw material by following weight portion is made: 6 parts of Radix Rehmanniae, 6 parts of Radix Rehmanniae Preparata, 15 parts of Rhizoma Dioscoreaes, 6 parts of Fructus Psoraleaes, 9 parts of semen juglandiss, 3 parts of Fructus Schisandrae Chinensis, 3 parts of Radix Achyranthis Bidentataes, 6 parts of Fructus Evodiaes, 6 parts of Fructus Lycii.
3. a preparation method for the Chinese medicine preparation for the treatment of insufficiency of kidney-YANG asthma as claimed in claim 1 or 2, is characterized in that: concrete steps are: by formula proportion, take described raw material, wash respectively, under 120 ℃, 0.3Mpa condition, sterilizing is 30 minutes, pulverizes; Cross 80-100 mesh sieve, fine powder mixes.
CN201310151922.8A 2013-04-27 2013-04-27 Traditional Chinese medicine preparation for treating asthma with kidney-yang deficiency Expired - Fee Related CN103263561B (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1060214A (en) * 1991-07-27 1992-04-15 四川涪陵制药厂 The preparation method of kidney and relieve asthma Chinese medicine patent medicine
CN1367012A (en) * 2002-01-24 2002-09-04 于江 Peach and apricot health-care food for curing cough and asthma
CN101444593A (en) * 2008-11-24 2009-06-03 律北平 Chinese traditional medical formula taken orally for curing asthma
CN102671086A (en) * 2012-05-29 2012-09-19 哈尔滨济博生物技术开发有限公司 Drug for curing yin deficiency bronchial asthma
CN102772616A (en) * 2011-05-12 2012-11-14 冯月花 Tablet for preventing and treating asthma

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1060214A (en) * 1991-07-27 1992-04-15 四川涪陵制药厂 The preparation method of kidney and relieve asthma Chinese medicine patent medicine
CN1367012A (en) * 2002-01-24 2002-09-04 于江 Peach and apricot health-care food for curing cough and asthma
CN101444593A (en) * 2008-11-24 2009-06-03 律北平 Chinese traditional medical formula taken orally for curing asthma
CN102772616A (en) * 2011-05-12 2012-11-14 冯月花 Tablet for preventing and treating asthma
CN102671086A (en) * 2012-05-29 2012-09-19 哈尔滨济博生物技术开发有限公司 Drug for curing yin deficiency bronchial asthma

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