CN103263465B - Silkworm virus disease prevention and treatment silkworm drug and preparation method thereof - Google Patents
Silkworm virus disease prevention and treatment silkworm drug and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a silkworm virus disease prevention and treatment silkworm drug and a preparation method thereof. The silkworm drug mainly comprises the following raw materials: milkvetch root, dandelion, garden radish seed, largehead atractylodes rhizome, licorice root, honeysuckle, Chinese gall, Chinese honeylocust spine and the like. The preparation method mainly comprises the following steps: crushing raw herbs, carrying out reflux extraction, carrying out concentration, and drying. The silkworm drug has the following characteristics that: a treatment effect is significant, disease course progression can be effectively controlled, a significant prevention and treatment effect is provided for silkworm virus diseases, and characteristics of safety and no toxic-side effect are provided for humans and animals. In addition, the preparation method has characteristics of simple preparation process and strong feasibility, and is suitable for industrial production.
Description
Technical field
The present invention relates to Veterinary Medicine field, be specifically related to a kind of silkworm medicine preventing and treating silkworm virosis and preparation method thereof.
Background technology
Silkworm under pod rearing conditions very easily by the impact of pathogenic microorganism, parasite or other extraneous factors, thus affect the growth of silkworm normal growth, cause flacherie, and flacherie jeopardizes cocoon yield and quality, once diffusion spreads, the failure in operation of whole silkworm industry also can be caused.In the middle of the 19th century, European silkworm industry suffers crushing blow because of pebrine.France L. Pasteur, in founding female moth method of inspection year, controls spreading of this disease.After this, the scientific research also in succession carrying out flacherie such as Japanese, Chinese.
Silkworm viral disease is the most common on producing, and endangers also more serious flacherie.Because of the kind of virus and the difference of parasitic site, mainly be divided into nuclear polyhedrosis (also known as nuclear polyhedrosis, nucleus polyhedron disease, be called for short NPV), mind-intesting cytoplasmic polyhedrosis (Cytoplasm polyhedron disease, be called for short CPV), viral flacherie (be commonly called as transparent head disease, be called for short FV) and pus core disease (abbreviation DNV) four kinds.These four kinds of virosiss, have generation in vast silkworm district of China, and owing to raising the difference in season, generation and the harm of four kinds of virosiss also there are differences, but their extent of injury accounts for the overwhelming majority in whole silkworm district.The harm in sericulture is produced of silkworm virosis is serious, and therefore medical treatment is in silkworm virus disease control very important status.At present, have and silkworm virus medicine is studied, correlational study becomes fruit part can be applied in the middle of reality, as: virus disease control new drug virus is controlled, room and rural area pilot production prove to have stronger killing effect to silkworm virosis cause of disease by experiment, efficacy stability, its prevention effect is obvious, working concentration is easily grasped, nontoxic, free from extraneous odour, non-corrosiveness, to silkworm physiology have no adverse effects [Wang Gengxian etc. virus controls the prevention effect research [J] to silkworm virosis. Sericulture of China, 2004]; Flacherie kills No. 1, star, new drug A, erythromycin and flacherie spirit built agent etc. all has obvious inhibitory action to nuclear polyhedrosis virus, and flacherie kill No. 1, star have significant effect [stone is U.S. peaceful etc. several drugs is to the inhibition test [J] of silkworm grasserie. Guangxi silkworm industry, 2002]; Silkworm is after adding the medicaments such as the micro-spirit of food pus, the spirit of bright silkworm, compound phenol, also serve in control silkworm virosis obvious effect [Xi Changying etc. silkworm adds the micro-spirit of food pus, the spirit of bright silkworm, compound phenol Preliminary Report on Experiment [J]. the communication of silkworm and mulberry Folium Camelliae sinensis, 2000], but as the selection of silkworm antiviral chemicals composition, because receive the route of synthesis of its complexity and the very big restriction of high price, seem that development space receives extruding.But, deficiency is highlighted to the research of silkworm virosis Chinese herbal medicine, less achievement in research can be applied in the middle of reality, if number of patent application is the silkworm medicine disclosing a kind of antiviral silkworm diseases in " the silkworm medicine of antiviral silkworm diseases " of 200610054277.8, comprise Chinese Drug Rhizomes of Coptis, Cortex Phellodendri, the Radix Astragali, Bulbus Allii, Radix Isatidis, Radix Angelicae Sinensis, Herba Taxilli, Herba Epimedii, Radix Ophiopogonis, Pheretima, Radix Glycyrrhizae totally 11 taste Chinese medicines.Consider that Chinese herbal medicine is the product of the distinctive Chinese medical theory of China and practice, many Chinese herbal medicine and Multiple components thereof have good antivirus action, there is the advantages such as effect is unique, antiviral spectrum is wide, toxic and side effects is little, evident in efficacy, and cheap, and medicine source is extensive.Therefore, what utilize Chinese herbal medicine development silkworm control virus medicine provides new medicinal selection, has great importance to sericulture development.
Summary of the invention
In order to overcome the shortcoming of above-mentioned prior art, the object of the invention is to provide a kind of silkworm medicine preventing and treating silkworm virosis and preparation method thereof.
To achieve these goals, the technical solution used in the present invention is:
Prevent and treat a silkworm medicine for silkworm virosis, the raw material comprising following parts by weight is prepared from: Radix Astragali 10-40 part, Herba Taraxaci 10-30 part, Semen Raphani 5-25 part, Rhizoma Atractylodis Macrocephalae 5-35 part, Flos Lonicerae 8-35 part, Radix Glycyrrhizae 15-35 times, Galla Chinensis 8-25 part.
The silkworm medicine of the control silkworm virosis that the present invention relates to, its preferred version is prepared from by the raw material comprising following weight portion: Radix Astragali 20-30 part, Herba Taraxaci 15-25 part, Semen Raphani 8-20 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Flos Lonicerae 12-25 part, Radix Glycyrrhizae 20-30 times, Galla Chinensis 10-20 part.
The silkworm medicine of the control silkworm virosis that the present invention relates to, its further preferred version is prepared from by the raw material comprising following weight portion: the Radix Astragali 25 parts, Herba Taraxaci 25 parts, Semen Raphani 15 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Flos Lonicerae 15 parts, 20 parts, Radix Glycyrrhizae, Galla Chinensis 18 parts.In addition, Fructus Gleditsia acupuncture 12 parts can also being added in the feed, increasing Antiviral Effect ability, for preventing and treating virosis better effects if.
The silkworm medicine of control silkworm virosis of the present invention, its active component is prepared by following methods:
Get whole raw medicinal material, be crushed to 5 ~ 20 orders, alcohol extracting method is adopted to extract twice, it be the volume fraction of 1:8 ~ 15 is 45 ~ 65% alcoholic solution that first time adds feed liquid weight ratio, reflux, extract, 150min, it be the volume fraction of 1:8 ~ 10 is 45 ~ 65% alcoholic solution that second time adds feed liquid weight ratio, reflux, extract, 120min; Merge extractive liquid, by gained extracting solution vacuum evaporation to 0.5 times with the laggard row spraying dry of lower volume, obtains described active component.
The silkworm medicine of control silkworm virosis of the present invention, its active component is prepared by following preferred version:
Get whole raw medicinal material, be crushed to 10 orders, alcohol extracting method is adopted to extract twice, it be the volume fraction of 1:10 is 55% alcoholic solution that first time adds feed liquid weight ratio, reflux, extract, 150min, it be the volume fraction of 1:8 is 55% alcoholic solution that second time adds feed liquid weight ratio, reflux, extract, 120min; Merge extractive liquid, by gained extracting solution vacuum evaporation to 0.5 times with the laggard row spraying dry of lower volume, obtains described active component.
In the present invention, the details of main Chinese medicinal materials is as follows:
The Radix Astragali
The Radix Astragali (Milkvetch Root), also known as Radix Astragali or northern Millefolium, also makes Radix Astragali or Radix astragali, latin name Leguminosae, one of conventional Chinese medicine, be the root of leguminous plant Radix Astagali or Radix Astragali, main product is in the Inner Mongol of China, Shanxi, Heilungkiang and other places.It has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting, and have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Herba Taraxaci
This product is Dandelion Compositae herbaceos perennial, latin name Herba Taraxaci, mainly be distributed in China northeast, North China, East China, Central China, northwest, southwestern various places, there is abundant carotene and C and mineral, to the effect that dyspepsia, constipation are all improved, leaf is also improved eczema in addition, clean blood effect of dermatitis of releiving, joint discomfort, and root then has antiinflammation, can treat cholelithiasis, rheumatism.In addition, Herba Taraxaci also has the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting, is widely used in clinical.
Semen Raphani
This product is the dry mature seed of crucifer Radix Raphani Raphanus sativus L., its water extract has significant inhibitory action to staphylococcus and escherichia coli etc., and water logging agent also has inhibitory action in various degree to Trichophyton concentricunm, oidium schoenleinii, Du Ang Shi sporidiole bacteria difficult to understand, rust little spore tinea bacterium, ulotrichy little spore tinea bacterium and star nocardia.
The Rhizoma Atractylodis Macrocephalae
This product is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz., main product is in Xinchang, Zhejiang Province, balcony, Dongyang etc., there is invigorating the spleen and benefiting QI, dampness diuretic, the multinomial medicinal function such as hidroschesis, be usually used in insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Flos Lonicerae
The dry flower that this product is caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb. or the flower that band is just opened, its kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, sends out speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain etc., equal Be very effective.
Radix Glycyrrhizae
This product is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L., mainly be distributed in the Inner Mongol, Shanxi, Gansu etc., cure mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.
Galla Chinensis
This product is the insect gall on Anacardiaceae plant Fructus rhois chinensis Rhus chinensis Mill., potanin sumac Rhus potaninii Maxim. or Radix Rhois Sinicae Rhus punjabensis Stew.var.sinica (Diels) Rehd.et Wils. leaf, have and astringe the lung, hidroschesis, astringing intestine to stop diarrhea, controlling nocturnal emission with astringent drugs, hemostasis, the effects such as removing toxic substances.
Fructus Gleditsia acupuncture
This product is the Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam., originate in the ground such as Gansu, Shaanxi, Hebei, Shandong, Shanxi, Anhui, Jiangsu, Hubei, Guangdong, Guangxi, Sichuan, Guizhou, there is sterilization evacuation of pus, relieve internal heat anticancer, control with treating the effect such as tinea.
The silkworm medicine for the treatment of silkworm virosis provided by the present invention can prevention and therapy silkworm virosis, evident in efficacy, effectively can control course advancement, and to silkworm and the nontoxic pair of person poultry safety; Its preparation technology is simple, efficiency is high, feasibility is strong, is applicable to suitability for industrialized production.
Detailed description of the invention
The technological means realized to make the present invention is easy to understand, and is further elaborated the present invention below in conjunction with specific embodiment.
Embodiment 1
Radix Astragali 1250g Herba Taraxaci 1250g Semen Raphani 750g Rhizoma Atractylodis Macrocephalae 1000g
Flos Lonicerae 750g Radix Glycyrrhizae 1000g Galla Chinensis 900g
Get whole 7 taste raw medicinal materials, be crushed to 10 orders, after component feeding, it is 55% alcoholic solution that first time adds 70L volume fraction, reflux, extract, 150min, and it is 55% alcoholic solution that second time adds 55L volume fraction, reflux, extract, 120min; Merge extractive liquid, carries out spraying dry by gained extracting solution vacuum evaporation 50L, obtains described active component.
Embodiment 2
Radix Astragali 1000g Herba Taraxaci 750g Semen Raphani 400g Rhizoma Atractylodis Macrocephalae 750g
Flos Lonicerae 600g Radix Glycyrrhizae 1000g Galla Chinensis 500g
Get whole 7 taste raw medicinal materials, be crushed to 10 orders, after component feeding, it is 55% alcoholic solution that first time adds 50L volume fraction, reflux, extract, 150min, and it is 55% alcoholic solution that second time adds 40L volume fraction, reflux, extract, 120min; Merge extractive liquid, carries out spraying dry by gained extracting solution vacuum evaporation 35L, obtains described active component.
Embodiment 3
Radix Astragali 1500g Herba Taraxaci 1250g Semen Raphani 1000g Rhizoma Atractylodis Macrocephalae 1250g
Flos Lonicerae 1250g Radix Glycyrrhizae 1500g Galla Chinensis 1000g
Get whole 7 taste raw medicinal materials, be crushed to 10 orders, after component feeding, it is 55% alcoholic solution that first time adds 85L volume fraction, reflux, extract, 150min, and it is 55% alcoholic solution that second time adds 70L volume fraction, reflux, extract, 120min; Merge extractive liquid, carries out spraying dry by gained extracting solution vacuum evaporation 60L, obtains described active component.
Embodiment 4
Radix Astragali 1250g Herba Taraxaci 1250g Semen Raphani 750g Rhizoma Atractylodis Macrocephalae 1000g
Flos Lonicerae 750g Radix Glycyrrhizae 1000g Galla Chinensis 900g Fructus Gleditsia acupuncture 600g
Get whole 8 taste raw medicinal materials, be crushed to 10 orders, after component feeding, it is 55% alcoholic solution that first time adds 75L volume fraction, reflux, extract, 150min, and it is 55% alcoholic solution that second time adds 60L volume fraction, reflux, extract, 120min; Merge extractive liquid, carries out spraying dry by gained extracting solution vacuum evaporation 50L, obtains described active component.
Embodiment 5
Various embodiments of the present invention medicine is adopted to carry out clinical trial
Prophylactic tria district routine raise 2 age silkworm, within whole 2 length of times every day add respectively food each embodiment medicine prevent for 1 time, carry out after playing silkworm 3 ages hypodermic needle thorn inoculation each concentration virus (counteracting toxic substances).Therapeutic test district routine raise 2 age silkworm, the virus (counteracting toxic substances) of each concentration of hypodermic needle thorn inoculation is carried out after playing silkworm 3 ages, then add food each embodiment medicine every day respectively to treat for 1 time, check plot replaces with clear water when the medication of medication district, 30, every community, often processes 3 replicated plots.Play sickness rate %, average attack rate X% and prevention effect P% that silkworm investigates each concentration virus 4 ages, the results are shown in Table 1.
The each embodiment medicine of table 1 is to the prevention effect of silkworm virosis
Result of the test shows, each embodiment medicine all has significant prevention effect to silkworm virosis.The therapeutic effect of embodiment 1 medicine to silkworm blood type grasserie, mind-intesting cytoplasmic polyhedrosis, viral flacherie reaches more than 70%, preventive effect more than 66%.Embodiment 4 medication effect can reach more than 75%, and preventive effect reaches more than 70%.In addition, the effect in therapeutic test district is better than the effect in prophylactic tria district.
Claims (6)
1. prevent and treat a silkworm medicine for silkworm virosis, it is characterized in that, it is prepared from by the raw material comprising following parts by weight:
Radix Astragali 10-40 part Herba Taraxaci 10-30 part Semen Raphani 5-25 part Rhizoma Atractylodis Macrocephalae 5-35 part
Flos Lonicerae 8-35 part Radix Glycyrrhizae 15-35 times of Galla Chinensis 8-25 part.
2. the silkworm medicine of control silkworm virosis according to claim 1, it is characterized in that, it is prepared from by the raw material comprising following parts by weight:
Radix Astragali 20-30 part Herba Taraxaci 15-25 part Semen Raphani 8-20 part Rhizoma Atractylodis Macrocephalae 15-25 part
Flos Lonicerae 12-25 part Radix Glycyrrhizae 20-30 times of Galla Chinensis 10-20 part.
3. the silkworm medicine of control silkworm virosis according to claim 2, it is characterized in that, it is prepared from by the raw material comprising following parts by weight:
The Radix Astragali 25 parts of Herba Taraxacis 25 parts of Semen Raphanis 15 parts of Rhizoma Atractylodis Macrocephalaes 20 parts
Flos Lonicerae 15 portions of Radix Glycyrrhizaes 20 parts of Galla Chinensiss 18 parts.
4. the silkworm medicine of control silkworm virosis according to claim 3, is characterized in that: also comprise Fructus Gleditsia acupuncture 12 parts.
5. the silkworm medicine of the control silkworm virosis according to any one of Claims 1 to 4, is characterized in that its active fraction preparation method comprises the steps:
Get whole raw medicinal material, be crushed to 5 ~ 20 orders, alcohol extracting method is adopted to extract twice, it be the volume fraction of 1:8 ~ 15 is 45 ~ 65% alcoholic solution that first time adds feed liquid weight ratio, reflux, extract, 150min, it be the volume fraction of 1:8 ~ 12 is 45 ~ 65% alcoholic solution that second time adds feed liquid weight ratio, reflux, extract, 120min; Merge extractive liquid, by gained extracting solution vacuum evaporation to 0.5 times with the laggard row spraying dry of lower volume, obtains described active component.
6. the preparation method of control silkworm virosis silkworm medicine according to claim 5, is characterized in that its active fraction preparation method comprises the steps:
Get whole raw medicinal material, be crushed to 10 orders, alcohol extracting method is adopted to extract twice, it be the volume fraction of 1:10 is 55% alcoholic solution that first time adds feed liquid weight ratio, reflux, extract, 150min, it be the volume fraction of 1:8 is 45% alcoholic solution that second time adds feed liquid weight ratio, reflux, extract, 120min; Merge extractive liquid, by gained extracting solution vacuum evaporation to 0.5 times with the laggard row spraying dry of lower volume, obtains described active component.
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