CN103262974B - A kind of medlar polysaccharide chewable tablet and preparation method thereof - Google Patents
A kind of medlar polysaccharide chewable tablet and preparation method thereof Download PDFInfo
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- CN103262974B CN103262974B CN201310216021.2A CN201310216021A CN103262974B CN 103262974 B CN103262974 B CN 103262974B CN 201310216021 A CN201310216021 A CN 201310216021A CN 103262974 B CN103262974 B CN 103262974B
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- medlar polysaccharide
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Abstract
The invention discloses a kind of medlar polysaccharide chewable tablet and preparation method thereof, it is made up of wolfberry fruit extract, dextrin, menthol and dolomol.This chewable tablets has following advantages: taste is sour-sweet, good mouthfeel, easily chew, easy absorption, does not have GI irritation, can reach immunoregulatory effect in the crowd of taking, and can play anti-ageing, antitumor, antifatigue, anti anoxia, hypoglycemic, hypotensive, improve the functions such as immunity of organisms, be applicable to each age cohort and any sensitive group, not containing small molecular sugar, be suitable for patients with diabetes mellitus.
Description
Technical field
The present invention relates to a kind of LBP-X preparation, more specifically, relate to a kind of medlar polysaccharide chewable tablet and preparation method thereof.
Background technology
Matrimony vine (Lycium chinense Mill.) is conventional Chinese medicine, is again health food, doctor's food homology.The another name of matrimony vine is a lot, is again tribute fruit, blood matrimony vine, matrimony vine beans, the place of production is called " red fruit ", " improving eyesight is sub " etc.The ripening fruits of its defoliation bush plant of Shi Xia section matrimony vine, machaka, because cultivation forms the upright shrub with tree crown through artificial pruning, the thick diameter 10-20cm of single trunk stem, plant height about 1.5m, about crown diameter 1.6m, leaf alternate or cluster, lanceolar or long ellipticity lanceolar, corolla funnel-form, violet, fruit is berry, redness, likeness in form spindle, more like carnelian pendant.Be royal tribute in history, have " red treasured " laudatory title, be rich in plant polyose, protein, vitamins and other nutritious components.The primary efficacy of matrimony vine is nourishing liver and kidney, benefiting shrewd head; , soreness of waist and knee joint smart thanks to for consumptive disease; Dizzy tinnitus, Nei Rexiao is thirsty, the deficiency of blood is sallow, and blurred vision is failed to understand.Successive dynasties expert in health preserving, physician value tonic effect of matrimony vine very much.Just point out in Shennong's Herbal: take hard muscles and bones for a long time; " Mingyi Bielu " is called matrimony vine and is good at " nourishing the essence and strengthening QI "; " dietetic materia medica " also records matrimony vine " the beneficial people of energy, removes consumptive disease ".Matrimony vine effect in nourishing liver and kidney, benefiting shrewd head is not only ancient Chinese medicine doctor and dietotherapy scholar praised highly.Modern pharmacological research proves, (the Lycium chinense polysaccharide of Main Ingredients and Appearance LBP-X contained by matrimony vine, be called for short LBP) be most important functional component in matrimony vine, it is a kind of water-soluble polysaccharide, clearly this polysaccharide system proteoglycan, molecular weight is 22 ~ 25kD, and the protein main chain that the polysaccharide side chain be made up of six kinds of second carbon monose ARA, CLC, GAL, MAN, XYL and RHA and 18 seed amino acids form is formed.LBP-X is fruit of Chinese wolfberry immunity moderation, the main active delayed senility, the immunologic function of people can be improved, promote that body produces NK-killer cell, and improve its activity, indirectly antivirus action can be played by improving body's immunity, to the neural endocrine one immunological network important role of equilibrium, hypothalamus one hypophysis of human body can be directly acted on, promote metabolic function, the adjustment of endocrine function and reproductive function, it is to malignant tumour, the prevention of AIDS also can play positive role with treatment, it can improve the elderly's fatiguability in addition, the symptoms such as poor appetite and eye-blurred, and there is reducing blood lipid, AFL, antitumor, the anti-ageing effect of waiting for a long time.
Chewable tablets refers to the tablet swallowed after chewing or suck clothes in oral cavity makes sheet dissolve, and usually adds sucrose, peppermint wet goods sweetener and flavorant adjustment taste chewable tablets taking convenience, can swallow, chew containing sucking or taking with after aqueous dispersion.Through chewing, rear surface is long-pending to increase tablet, medicine dissolving in vivo and absorption can be promoted, even if also can ensure to take medicine on time under exsiccosis, especially the patient of old man, child, paralytic, difficulty of swallowing and gastrointestinal function difference is applicable to, medicine can be reduced to GI burden, but owing to typically employed by sucrose, some problems can be brought to patients with diabetes mellitus.
Matrimony vine tradition eating method is drunk for making tea, because immersion process matrimony vine pericarp does not destroy, causes LBP-X to be difficult to be sufficiently solubilized and absorb.Matrimony vine is lightly seasoned, slightly tart flavour, and therefore few people chew food, also there are no relevant chewable tablets product.
In sum, there is preparation mouthfeel in this area good, be more suitable for the needs of the medlar polysaccharide chewable tablet of patients with diabetes mellitus.
Summary of the invention
First object of the present invention is to provide a kind of medlar polysaccharide chewable tablet.
Second object of the present invention is the preparation method providing a kind of medlar polysaccharide chewable tablet.
For reaching these objects, the present invention by the following technical solutions:
In a first aspect of the present invention, provide a kind of medlar polysaccharide chewable tablet, it is characterized in that, described medlar polysaccharide chewable tablet comprises following component: wolfberry fruit extract, dextrin, menthol and dolomol.
Medlar polysaccharide chewable tablet of the present invention can comprise each component of following percentage by weight:
Wolfberry fruit extract 70-90%;
Dextrin 8.5-29.5%;
Menthol 0.05-0.15%;
Dolomol 0.45-1.45%.
The percentage by weight of wherein said wolfberry fruit extract can be 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 78%, 89% or 90%.
The percentage by weight of described dextrin can be 8.5%, 9.5%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29% or 29.5%.
The percentage by weight of described menthol can be 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.10%, 0.11%, 0.12%, 0.13%, 0.14% or 0.15%.
The percentage by weight of described dolomol can be 0.45%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4% or 1.45%.
In a second aspect of the present invention, provide the preparation method of the medlar polysaccharide chewable tablet described in first aspect, described method comprises and each component of the medlar polysaccharide chewable tablet described in first aspect being mixed, the method described in medlar polysaccharide chewable tablet that obtains comprises is undertaken mixing rear compressing tablet by each component of the medlar polysaccharide chewable tablet described in first aspect, obtains medlar polysaccharide chewable tablet.
The preparation method of medlar polysaccharide chewable tablet of the present invention can comprise the following steps:
A, by described Fructus lycii P.E and described dextrin mixing, obtain mixed powder;
B, edible ethanol is added softwood processed in described mixed powder, cross screen cloth wet granular, and wet granular is dry, acquisition dried particles;
C, described dried particles is crossed the whole grain of screen cloth;
D, the particle after menthol, dolomol and whole grain is mixed to get in mixer total mixed particle.
E, described total mixed particle is carried out compressing tablet, obtain described medlar polysaccharide chewable tablet.
In the preparation method of medlar polysaccharide chewable tablet of the present invention, described screen cloth can be 15-25 mesh sieve, is preferably 20 mesh sieves.
In the preparation method of medlar polysaccharide chewable tablet of the present invention, the baking temperature in described step b can be 45-55 degree, is preferably 50 degree.
In this article, " wolfberry fruit extract " refers to that the matrimony vine that wherein Thick many candies is greater than 15% with glucose meter extracts product, and main component is LBP-X, and it can from business by way of buying.Wolfberry fruit extract part such as, in the present invention used from Xuancheng City hundred careless plant Trade Co., Ltd., the Xi'an Bioisystech Co., Ltd etc. that moistens buy.
Advantage of the present invention:
1, this product ingredient comprises wolfberry fruit extract (80%), dextrin (18.9%), menthol (0.1%), dolomol (1%), taste is sour-sweet, good mouthfeel, there is no GI irritation, product of the present invention is applicable to each age cohort and any sensitive group, not containing small molecular sugar, be suitable for patients with diabetes mellitus.
2, matrimony vine tradition eating method is drunk for making tea, because immersion process matrimony vine pericarp does not destroy, causes Qi polysaccharide to be difficult to be sufficiently solubilized and absorb.Matrimony vine is lightly seasoned, slightly tart flavour, and also few people chew food.In order to give full play to, Qi polysaccharide is antitumor, the health-care efficacy of immunity moderation power, evade matrimony vine taste not good, not easily by the reality that majority accepts, this product development be the chewable tablets that is main component with Qi polysaccharide.Be different from other like products, formula for a product design of the present invention is very easily taken, very convenient.
3, product of the present invention contains very abundant wolfberry fruit extract, easily chew, easy absorption, can reach immunoregulatory effect in the crowd of taking, and can play anti-ageing, antitumor, antifatigue, anti anoxia, hypoglycemic, hypotensive, improve the functions such as immunity of organisms.
Detailed description of the invention
Technical scheme of the present invention is further illustrated below by detailed description of the invention.
Embodiment 1: the preparation (1000) of medlar polysaccharide chewable tablet
Prescription 1:
Wolfberry fruit extract 700 grams
295 grams, dextrin
Menthol 0.5 gram
Dolomol 4.5 grams
1, Fructus lycii P.E, dextrin are crossed 80 mesh sieves respectively, weigh for subsequent use, menthol, dolomol weigh for subsequent use;
2, inventory Fructus lycii P.E and dextrin are mixed 30 minutes, obtain mixed powder;
3, appropriate edible ethanol is added softwood processed in above-mentioned mixed powder, with 20 mesh sieve wet granulars, wet granular is dry, and baking temperature is 50 DEG C, is dried to moisture qualified;
4, dried particles is for subsequent use after crossing the whole grain of 20 mesh sieve;
5, the particle after qualified menthol, dolomol and whole grain is placed in mixer and within always mixed 5 minutes, obtains always mixed particle.
6, above-mentioned total mixed particle is carried out compressing tablet.
Embodiment 2: the preparation (1000) of medlar polysaccharide chewable tablet
Prescription 2:
Wolfberry fruit extract 900 grams
85 grams, dextrin
Menthol 1.5 grams
Dolomol 14.5 grams
1, Fructus lycii P.E, dextrin are crossed 80 mesh sieves respectively, weigh for subsequent use, menthol, dolomol weigh for subsequent use;
2, inventory Fructus lycii P.E and dextrin are mixed 30 minutes, obtain mixed powder;
3, appropriate edible ethanol is added softwood processed in above-mentioned mixed powder, with 20 mesh sieve wet granulars, wet granular is dry, and baking temperature is 45 DEG C, is dried to moisture qualified;
4, dried particles is for subsequent use after crossing the whole grain of 20 mesh sieve;
5, the particle after qualified menthol, dolomol and whole grain is placed in mixer and within always mixed 5 minutes, obtains always mixed particle.
6, above-mentioned total mixed particle is carried out compressing tablet.
Embodiment 3: the preparation (1000) of medlar polysaccharide chewable tablet
Prescription 3:
Wolfberry fruit extract 800 grams
189 grams, dextrin
Menthol 1 gram
Dolomol 10 grams
1, Fructus lycii P.E, dextrin are crossed 80 mesh sieves respectively, weigh for subsequent use, menthol, dolomol weigh for subsequent use;
2, inventory Fructus lycii P.E and dextrin are mixed 30 minutes, obtain mixed powder;
3, appropriate edible ethanol is added softwood processed in above-mentioned mixed powder, with 20 mesh sieve wet granulars, wet granular is dry, and baking temperature is 55 DEG C, is dried to moisture qualified;
4, dried particles is for subsequent use after crossing the whole grain of 20 mesh sieve;
5, the particle after qualified menthol, dolomol and whole grain is placed in mixer and within always mixed 5 minutes, obtains always mixed particle.
6, above-mentioned total mixed particle is carried out compressing tablet.
Embodiment 4
Carry out sensory test to the medlar polysaccharide chewable tablet obtained in embodiment 1-3, number of subjects is 100, and result is as follows, wherein table in provide for thinking that chewable tablets meets the percentage of the experimenter of oneself requirement:
| Sugariness | Hardness | Satisfaction | |
| Embodiment 1 | 96% | 95% | 98% |
| Embodiment 2 | 97% | 94% | 98% |
| Embodiment 3 | 96% | 94% | 96% |
Applicant states, the present invention illustrates detailed construction feature of the present invention and method by above-described embodiment, but the present invention is not limited to above-mentioned detailed construction feature and method, namely do not mean that the present invention must rely on above-mentioned detailed construction feature and method could be implemented.Person of ordinary skill in the field should understand, any improvement in the present invention, to equivalence replacement and the increase of accessory, the concrete way choice etc. of parts selected by the present invention, all drops within protection scope of the present invention and open scope.
Claims (3)
1. be applicable to a diabetes patient's medlar polysaccharide chewable tablet, it is characterized in that, described medlar polysaccharide chewable tablet is made up of each component of following percentage by weight:
Wolfberry fruit extract 80%;
Dextrin 18.9%;
Menthol 0.1%;
Dolomol 1%;
Described wolfberry fruit extract is that the matrimony vine that wherein Thick many candies is greater than 15% with glucose meter extracts product, and main component is LBP-X;
The preparation method of described chewable tablets, comprises the following steps:
A, by described wolfberry fruit extract and described dextrin mixing, obtain mixed powder;
B, edible ethanol is added softwood processed in described mixed powder, cross 15-25 eye mesh screen wet granular, and by wet granular 45-55 DEG C of drying, acquisition dried particles;
C, described dried particles is crossed the whole grain of 15-25 eye mesh screen;
D, the particle after menthol, dolomol and whole grain is mixed to get in mixer total mixed particle;
E, described total mixed particle is carried out compressing tablet, obtain described medlar polysaccharide chewable tablet.
2. medlar polysaccharide chewable tablet according to claim 1, is characterized in that, screen cloth described in step b and step c is 20 mesh sieves.
3. medlar polysaccharide chewable tablet according to claim 1, is characterized in that, the baking temperature of described step b is 50 DEG C.
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103932081B (en) * | 2014-03-25 | 2016-05-18 | 金诃藏药股份有限公司 | Red-black matrimony vine double-layer tablet and preparation method thereof |
| CN106474083B (en) * | 2016-12-09 | 2019-05-17 | 宁夏回族自治区药品检验所 | Sweet Qi sugar is rather without sugar chawing tablet and its preparation process and application |
| CN106667937B (en) * | 2017-01-03 | 2020-01-17 | 河北省农林科学院经济作物研究所 | Lycium ruthenicum polysaccharide chewable tablet |
| CN107927652A (en) * | 2017-12-18 | 2018-04-20 | 中科国思生物科技研究（广州）有限公司 | A kind of wolfberry chewable tablet and preparation method thereof |
| CN109805147A (en) * | 2019-02-25 | 2019-05-28 | 青海淼塔源农牧科技有限公司 | A kind of red medlar polysaccharide chewable tablet and its preparation process |
| CN109673983A (en) * | 2019-02-25 | 2019-04-26 | 青海淼塔源农牧科技有限公司 | A kind of lycium ruthenicum anthocyanidin chewable tablets and its preparation process |
| CN114404373A (en) * | 2021-12-22 | 2022-04-29 | 中国科学院西北高原生物研究所 | Cynomorium songaricum chewable tablet and preparation method thereof |
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| JP4519444B2 (en) * | 2003-10-31 | 2010-08-04 | ライオン株式会社 | Orally disintegrating tablets |
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| CN1839827A (en) * | 2006-01-16 | 2006-10-04 | 重庆医药工业研究院有限责任公司 | Strontium ranelate chewing tablet and its preparation process |
| CN102283858A (en) * | 2011-09-05 | 2011-12-21 | 中国人民解放军第三军医大学第三附属医院 | Application of lycium barbarum polysaccharides for preparing drugs for preventing and treating chronic stress and posttraumatic stress disorder |
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Inventor after: Wu Zhongfu Inventor after: Xu Yibing Inventor after: Chen Lin Inventor after: Wang Yetao Inventor after: Yu Yinghao Inventor before: Wu Zhongfu Inventor before: Wei Dan Inventor before: Zhu Xueyi Inventor before: Wang Dakui Inventor before: Li Cheng |
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