CN103251812A

CN103251812A - Chinese medicinal preparation for treating shingles

Info

Publication number: CN103251812A
Application number: CN 201310207101
Authority: CN
Inventors: 魏兴艳
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-05-21
Filing date: 2013-05-21
Publication date: 2013-08-21

Abstract

The invention discloses a Chinese medicinal preparation for treating shingles. According to the Chinese medicine, the shingles are mainly caused by exogenous pathogenic poison, endoretention of damp heat of the spleen or stagnated fire of the liver and gall. The Chinese medicinal preparation is prepared by decocting clossogyne tenuifolia, rhizoma pleionis, brucea javanica, puberulous glochidion branchlet and leaf, phellodendron amurense, rubus alceaefolius poir, ficus sarmentosa, Chinese wampee seed, dutchmanspipe root, spongetree root, Japanese mazus herb, greater bunet root and licorice into a decoction with water. Clinical experiments show that the total effective rate of the Chinese medicinal preparation reaches 100%, so that the Chinese medicinal preparation is worthy of clinical popularization and application.

Description

A kind of Chinese medicine preparation for the treatment of herpes zoster

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of herpes zoster.

Background technology

Herpes zoster is virogenetic acute inflammation dermatosis, and sick rising has pain suddenly or earlier, sometimes pain and vesicle and see, foreknowledge skin lesion and pain sometimes, erythra is done one-sided distribution along nervus peripheralis, being common in waist, flank, secondly is facial, chest, and idol has symmetry to take place.Local lesion appears on the skin of flushing, pimple becomes the shinny blister of gregariousness sorghum rice size very soon, assemble a place or number place as beading, being arranged in band shape. skin is normal between the bleb group, and bleb liquid is transparent just, transfers muddiness to after 5-6 days, between have hemorrhage or suppurate, with regional glandular enlargement, the course of disease is about 2 weeks, and pain can continue 1-2 month sometimes.With neuralgia, pain unbearably, minority can be left over post herpetic neuralgia, its morbidity has year by year the trend that increases, sends out, severe patient influences patient's sleep and operate as normal.Doctor trained in Western medicine does not still have desirable medicine at present, and general treatment is based on pain relieving, antiviral, prevention secondary infection, but most of patients treats easily to leave over after herpes disappears the neuralgia of varying degree.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of herpes zoster.The traditional Chinese medical science think herpes zoster many because of accumulate in the evil poison of diseases caused by exogenous pathogenic factor, the dampness-heat in the spleen or the liver and gall stagnated fire due to, evil poison is damp and hot fights mutually, accumulate in skin, the retardance meridians, coagulation of QI-blood forms, scorchingly hot in strongly fragrant QI and blood scorching hot, pain then; The pyretic toxicity fire-transformation is delaied blood system, sends out to be erythema; Damp and hot being stranded in the liver spleen must not catharsis be vesicle.

The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment herpes zoster is made by following parts by weight of Chinese traditional medicine: Herba bidentis parviflorae 7-15 part, Pseudobulbus cremastrae seu pleiones 8-20 part, Fructus Bruceae 3-7 part, Folium glochidionis puberi 9-30 part, Cortex Phellodendri 10-15 part, Radix seu Folium Rubi alceaefolii 6-20 part, Radix Thalictri Trichopi 10-15 part, Semen clausenae lansii 5-18 part, Radix Aristolochiae 1-3 part, Radix acaciae farnesianae 3-7 part, Herba mazi japonici 10-23 part, Radix Sanguisorbae 8-14 part, Radix Glycyrrhizae 3-5 part.

Preferably, 11 parts of Herba bidentis parvifloraes, 14 parts of Pseudobulbus cremastrae seu pleiones, 5 parts of Fructus Bruceaes, 19 parts of Folium glochidionis puberi, 12 parts of Cortex Phellodendris, 13 parts of Radix seu Folium Rubi alceaefoliis, 13 parts of Radix Thalictri Trichopi, 11 parts of Semen clausenae lansiis, 1.5 parts of Radix Aristolochiaes, 5 parts of Radix acaciae farnesianaes, 16 parts of Herba mazi japonicis, 11 parts of Radix Sanguisorbaes, 4 parts in Radix Glycyrrhizae.

Preparation method is by traditional preparation method, and decocting is made decoction.

In the side: Herba bidentis parviflorae, Pseudobulbus cremastrae seu pleiones heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, eliminating carbuncle eliminating stagnation; Fructus Bruceae, Folium glochidionis puberi, Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication, detumescence; Radix seu Folium Rubi alceaefolii, Radix Thalictri Trichopi blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain; Semen clausenae lansii, Radix Aristolochiae promoting the circulation of QI to relieve pain, removing toxic substances and promoting subsidence of swelling; Radix acaciae farnesianae, Herba mazi japonici antiinflammatory evacuation of pus, detoxifcation; The Radix Sanguisorbae cooling blood for hemostasis, skin ulcer is held back in detoxifcation; The invigorating middle warmer of Radix Glycyrrhizae QI invigorating, heat-clearing and toxic substances removing is alleviated pain relieving.

Clinical data

1, physical data selected 150 routine cases are the court's department of dermatologry in hospital and the out-patient, be divided into treatment group and matched group at random, 75 examples are organized in treatment, male 47 examples, woman's 28 examples, at 50～70 years old age, average 63 years old, send out in women's head-ornaments portion 8 examples, send out in extremity trunk 67 examples, the course of disease is the shortest 3～5 days, and was the longest, above 14 days; Matched group 75 examples, male 45 examples, women 30 examples, 55～75 years old age, average 67 years old, send out in women's head-ornaments portion 9 examples, send out the shortest 5～7 days, the longest in the extremity trunk 66 routine courses of disease, surpass 15 days, two groups of sexes, age, courses of disease, send out in the position relatively, the difference not statistically significant has comparability.

2, the diagnostic criteria clinical diagnosis meets the diagnostic criteria of herpes zoster in the national traditional chinese medical science administration issue " Chinese medicine disease diagnosis criterion of therapeutical effect ".1. skin lesion mostly is the blister of Semen phaseoli radiati or Semen Glycines size, assembles a place or many places in threes and fours, is arranged in band shape, the substrate flushing, occur when serious learning point, blood blister even or downright bad; 2. from the beginning of skin rubefaction, and companion's skin irritation or bright hotness, can be with slight heating, symptoms such as tired discomfort, inappetence.Conscious pain is obvious, has unbearably severe pain and the rash back that disappears to lose pain symptom.

3, oral Chinese medicine preparation of the present invention is organized in the Therapeutic Method treatment, namely get Herba bidentis parviflorae 11g, Pseudobulbus cremastrae seu pleiones 14g, Fructus Bruceae 5g, Folium glochidionis puberi 19g, Cortex Phellodendri 12g, Radix seu Folium Rubi alceaefolii 13g, Radix Thalictri Trichopi 13g, Semen clausenae lansii 11g, Radix Aristolochiae 1.5g, Radix acaciae farnesianae 5g, Herba mazi japonici 16g, Radix Sanguisorbae 11g, Radix Glycyrrhizae 4g, decocting becomes decoction, potion divided and took for 3 times every day; Matched group adds 0.9% normal saline solution angular vein and instils 1 time/d with acyclovir injection 0.75g; Two groups equal 7 days be a course for the treatment of.

4, criterion of therapeutical effect (1) criterion of therapeutical effect is drafted with reference to Ministry of Public Health " new Chinese medicine clinical research guideline ".Clinical recovery: overall health of patients is improved, and diet, sleep are normal, blister atrophy, dry, incrustation, decrustation; Produce effects: overall health of patients is obviously improved, the whole atrophys of blister, and the part incrustation is arranged; Effectively: most of blister atrophy drying, still be mixed with the ulceration face; Invalid: as not reach effective standard.(2) pain criterion of therapeutical effect: disappear: pain complete obiteration, no simultaneous phenomenon; Produce effects: pain is obviously alleviated, and diet, sleep are not had influence; Effectively: pain relief, to diet, the sleep slightly influential; Invalid: pain does not have alleviation, has a strong impact on diet, sleep.

5, (1) two group for the treatment of back of therapeutic outcome curative effect relatively sees Table 1.

Table 1 liang group treatment back curative effect relatively

Compare P＜0.05 with matched group

Two groups relatively, and treatment group cure rate, total effective rate obviously are better than matched group and have the significance meaning.P＜0.05。

The curative effect of (2) two groups of herpes zoster pain relatively sees Table 2.

The curative effect of table 2 liang group herpes zoster pain is (%) relatively

Two groups are compared P＜0.01.To the treatment of pain of herpes zoster, also shown the good effect of Chinese medicine preparation, the analgesic effect for the treatment of group is better than matched group (P＜0.01).

The time of (3) two groups of erythra blister pain disappearances (my god) see Table 3.

The table 3 liang time that group erythra blister pain disappears (my god)

As shown in table 3, from the time that the erythra of herpes zoster, blister, incrustation disappear, the treatment group is also showing good advantage.

6, model case Liu, the man, 58 years old, the peasant was in first visit on March 5 in 2009.The main suit: before 2 days shirtfronts and back pain, then sore spot skin rubefaction and the big phlysis pain of Semen phaseoli radiati that intensive as group occur unbearably, difficult peace is suffered untold misery round the clock, is diagnosed as herpes zoster through my institute's department of dermatologry.Disease is seen face dolorosa, and yellowish complexion is tired, front, anterior midline right side, back, posterior midline right side the 3rd rib to the nine intercostals have the cluster vesicle that differs in size, and are zonal distribution, and are big as Semen Glycines, little of Semen phaseoli radiati, blush all around, the ulceration that has, through taking the bright described Chinese medicine preparation treatment of this law, comfortable sleepy with regard to ending bitterly at that time, after the top is treated 5 days, be clearly better, at ordinary times not bitterly, can fall asleep night, herpes gradually forms a scab, and the absorption that comes off is obeyed 7 doses and heal altogether; So far do not send out.

The specific embodiment

Embodiment one: take by weighing Herba bidentis parviflorae 11g, Pseudobulbus cremastrae seu pleiones 14g, Fructus Bruceae 5g, Folium glochidionis puberi 19g, Cortex Phellodendri 12g, Radix seu Folium Rubi alceaefolii 13g, Radix Thalictri Trichopi 13g, Semen clausenae lansii 11g, Radix Aristolochiae 1.5g, Radix acaciae farnesianae 5g, Herba mazi japonici 16g, Radix Sanguisorbae 11g, Radix Glycyrrhizae 4g.By traditional preparation method, decocting is made decoction.

Embodiment two: take by weighing Herba bidentis parviflorae 15g, Pseudobulbus cremastrae seu pleiones 20g, Fructus Bruceae 3g, Folium glochidionis puberi 30g, Cortex Phellodendri 10g, Radix seu Folium Rubi alceaefolii 20g, Radix Thalictri Trichopi 10g, Semen clausenae lansii 5g, Radix Aristolochiae 3g, Radix acaciae farnesianae 7g, Herba mazi japonici 23g, Radix Sanguisorbae 8g, Radix Glycyrrhizae 3g by traditional preparation method, decocting is made decoction.

Embodiment three: take by weighing Herba bidentis parviflorae 7g, Pseudobulbus cremastrae seu pleiones 8g, Fructus Bruceae 7g, Folium glochidionis puberi 9g, Cortex Phellodendri 15g, Radix seu Folium Rubi alceaefolii 6g, Radix Thalictri Trichopi 15g, Semen clausenae lansii 18g, Radix Aristolochiae 1g, Radix acaciae farnesianae 3g, Herba mazi japonici 10g, Radix Sanguisorbae 14g, Radix Glycyrrhizae 5g by traditional preparation method, decocting is made decoction.

Claims

1. Chinese medicine preparation for the treatment of herpes zoster is characterized in that this Chinese medicine preparation made by following parts by weight of Chinese traditional medicine: Herba bidentis parviflorae 7-15 part, Pseudobulbus cremastrae seu pleiones 8-20 part, Fructus Bruceae 3-7 part, Folium glochidionis puberi 9-30 part, Cortex Phellodendri 10-15 part, Radix seu Folium Rubi alceaefolii 6-20 part, Radix Thalictri Trichopi 10-15 part, Semen clausenae lansii 5-18 part, Radix Aristolochiae 1-3 part, Radix acaciae farnesianae 3-7 part, Herba mazi japonici 10-23 part, Radix Sanguisorbae 8-14 part, Radix Glycyrrhizae 3-5 part.

2. a kind of Chinese medicine preparation for the treatment of herpes zoster according to claim 1 is characterized in that this Chinese medicine preparation made by following parts by weight of Chinese traditional medicine: 11 parts of Herba bidentis parvifloraes, 14 parts of Pseudobulbus cremastrae seu pleiones, 5 parts of Fructus Bruceaes, 19 parts of Folium glochidionis puberi, 12 parts of Cortex Phellodendris, 13 parts of Radix seu Folium Rubi alceaefoliis, 13 parts of Radix Thalictri Trichopi, 11 parts of Semen clausenae lansiis, 1.5 parts of Radix Aristolochiaes, 5 parts of Radix acaciae farnesianaes, 16 parts of Herba mazi japonicis, 11 parts of Radix Sanguisorbaes, 4 parts in Radix Glycyrrhizae.