CN103239618B - Traditional Chinese medicine composition for treating chronic hepatitis and cirrhosis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating chronic hepatitis and cirrhosis and preparation method thereof Download PDFInfo
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- CN103239618B CN103239618B CN201210031025.9A CN201210031025A CN103239618B CN 103239618 B CN103239618 B CN 103239618B CN 201210031025 A CN201210031025 A CN 201210031025A CN 103239618 B CN103239618 B CN 103239618B
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Abstract
The invention provides a traditional Chinese medicine composition for treating chronic hepatitis and cirrhosis. The traditional Chinese medicine composition comprises twelve raw medicines including radix salviae miltiorrhizae, radix glehniae, radix ophiopogonis, rehmannia root and radix paeoniae rubra. The preparation method comprises the following steps of extracting through a conventional method; filtering extracting solution; concentrating; and then adding normal auxiliary materials, and preparing clinically acceptable forms through the conventional technology.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, be specifically related to a kind of Chinese medicine composition and preparation method thereof for the treatment of chronic hepatitis, liver cirrhosis.
Background technology
Hepatitis is mankind's commonly encountered diseases, frequently-occurring disease, and hepatitis B is known as one of three large difficult disease by World Health Organization (WHO).From existing Drug therapy situation, great majority are based on nourishing the liver tonifying liver, and the course for the treatment of is long, and costly, the medicine had in addition is often taken and can be developed immunity to drugs, and make hepatitis be difficult to radical cure.At present, the active drug of radical cure hepatitis is not yet had.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of chronic hepatitis;
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of liver cirrhosis;
Another object of the present invention is the preparation method providing this Chinese medicine composition.
The object of the invention is to be achieved through the following technical solutions:
The crude drug of Chinese medicine composition of the present invention consists of:
Traditional Chinese medicinal composition raw materials composition of the present invention is preferably:
Traditional Chinese medicinal composition raw materials of the present invention forms more preferably:
Traditional Chinese medicinal composition raw materials of the present invention forms more preferably:
The preparation method of Chinese medicine composition of the present invention is: adopt conventional method to extract, extracting solution filters, concentrated, add customary adjuvant conveniently technique make the clinical acceptable dosage forms such as capsule, tablet, powder, oral liquid, soft capsule, pill, tincture, syrup, suppository, gel, spray.
Described general extraction methods comprises soak by water, and decocting number of times is 1-3 time, each 0.5-2 hour; Be preferably soak by water twice, each 1 hour.
Described general extraction methods can also be alcohol reflux or supersound extraction, and its concentration of alcohol is 30%-95%, is preferably 60%-90%, more preferably 70%;
Described alcohol reflux, extraction time is 1-3 time, each 0.5-1.5 hour; Be preferably reflux, extract, twice, 1.5 hours first times, second time 1 hour;
Described ethanol ultrasonic extraction, extraction time 2-4 time, each 0.5-1 hour; Be preferably supersound extraction 3 times, 1 hour first time, second time 0.5 hour, 0.5 hour third time.
The preparation method of Chinese medicine composition of the present invention can also comprise extracting solution concentrated after through purification by macroporous resin;
Described macroporous resin is low pole, first washes holder with water, then uses the alcoholic solution eluting of 30-70%, collects 30-70% ethanol elution, recycling design, dry.
Described eluting solvent elects 50% alcoholic solution as.
For enabling above-mentioned dosage form realize, the acceptable adjuvant of pharmacy need be added when preparing these dosage forms, such as: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc.
Experimental example 1
1, experiment material:
Laboratory animal: SD male rat, SPF, body weight 170 ± 10g;
Experimental group medicine: prepare by the embodiment of the present invention 1;
Positive control medicine: liver-protecting tablet (making by 2010 editions " Chinese Pharmacopoeias " first " liver-protecting tablet " preparation method)
2, experimental technique:
Grouping and modeling: 55 rats are divided into normal group (8) and modeling group (24) at random.Modeling group rat subcutaneous injection 100%CCl first
43ml/kg, thereafter 50%CCl
4olive oil solution 2ml/kg, 2 times weekly, totally 9 weeks.Normal rats injection is with the olive oil of dosage.Modeling 6 weeks rear 24 rats are divided into model group, liver-protecting tablet group, of the present invention group at random, often organize 8.Each group of dosage 5g/kg, after treating 3 weeks, each group residue rat is with after 2% barbital sodium intraperitoneal injection of anesthesia, and postcava is taken a blood sample, and gets hepatic tissue specimen.Observation index and the strong proline of method hepatic tissue (Hyp) content (JamallShi method); Serum ALT, AST, GGT activity, serum alb, Tbil content.
Statistical method: data all adopt SPSS12.0 software kit to carry out statistical analysis.Calculating chart represents with X ± S, carries out variance analysis.
3, experimental result: model group liver Hyp content, Serum ALT, AST, GGT activity, and Tbil work content all significantly raises, Alb content significantly declines.The liver Hyp content of of the present invention group, Serum ALT, AST, GGT activity, and Tbil work content is significantly lower than model group, and Alb content is significantly higher than model group, and significant difference is had compared with liver-protecting tablet group, the results are shown in Table 1-4.Result confirms: the present invention has significant therapeutic effect to the Liver Damage in Rats caused by CCL4, hepatic fibrosis tool.
Table 1 the present invention is on the impact of the rat Hyp of hepatic injury
Note: * is * P < 0.05, * * P < 0.01 compared with model group; △ is P < 0.05 compared with liver-protecting tablet group
Table 2 the present invention is on the impact of rat ALT, AST of hepatic injury
Note: * is * P < 0.05, * * P < 0.01 compared with model group; △ is P < 0.05 compared with liver-protecting tablet group
Table 3 the present invention is on the impact of the rat blood serum GGT of hepatic injury
Note: * is * P < 0.05, * * P < 0.01 compared with model group; △ is P < 0.05 compared with liver-protecting tablet group
Table 4 the present invention is on the impact of rat blood serum Tbil, Alb of hepatic injury
Note: * is * P < 0.05, * * P < 0.01 compared with model group; △ is P < 0.05 compared with liver-protecting tablet group.
Following embodiment all can realize the effect described in above-mentioned experimental example
Detailed description of the invention:
Embodiment 1
Above 12 taste medicines, decoct with water secondary, each 1 hour, collecting decoction, and filter, filtrate reduced in volume to relative density is 1.05 ~ 1.08 (50 DEG C of surveys), and the adjustment total amount that adds water, to 1000ml, stirs evenly, subpackage, sterilizing, to obtain final product.
Embodiment 2
Above 12 tastes, decoct with water secondary, each 1 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05-1.08 (50 DEG C of survey), adds ethylparaben 0.5 weight portion, the adjustment total amount to 1000 that adds water parts by volume, stir evenly, filter, subpackage, sterilizing, makes mixture.
Embodiment 3
Above 12 tastes, 70% alcohol reflux secondary, 1.5 hours first times, second time 1 hour, collecting decoction, filters, concentrating under reduced pressure, D101 purification by macroporous resin on concentrated solution, first uses 2BV water elution, use 5BV 50% alcoholic solution eluting again, collect 50% ethanol elution, being concentrated into relative density is 1.05-1.08 (50 DEG C of surveys), passes through common process, add customary adjuvant, make tablet.
Embodiment 4
Above 12 tastes, 90% ethanol ultrasonic extraction 3 times, 1 hour first time, second time 0.5 hour, 0.5 hour third time, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05-1.08 (50 DEG C of survey), by common process, add customary adjuvant, make capsule.
Embodiment 5
Above 12 tastes decoct with water 3 times, 1.5 hours first times, second time 1 hour, 1 hour third time, and collecting decoction, filters, filtrate reduced in volume; D101 purification by macroporous resin on concentrated solution, first uses 2BV water elution, then uses 5BV 60% alcoholic solution eluting, collect 60% ethanol elution, being concentrated into relative density is 1.05-1.08 (50 DEG C of surveys), passes through common process, add customary adjuvant, make pill.
Embodiment 6
Above 12 tastes, 50% alcohol reflux three times, 1.5 hours first times, second time 1 hour, 1 hour third time, collecting decoction, filters, filtrate reduced in volume; D101 purification by macroporous resin on concentrated solution, first uses 2BV water elution, then uses 5BV 40% alcoholic solution eluting, collect 40% ethanol elution, being concentrated into relative density is 1.05-1.08 (50 DEG C of surveys), passes through common process, add customary adjuvant, make powder.
Claims (6)
1. treat a Chinese medicine composition for chronic hepatitis, liver cirrhosis, it is characterized in that the crude drug of this Chinese medicine composition consists of:
2. Chinese medicine composition as claimed in claim 1, is characterized in that the crude drug of this Chinese medicine composition consists of:
3. Chinese medicine composition as claimed in claim 1, is characterized in that the crude drug of this Chinese medicine composition consists of:
4. Chinese medicine composition as claimed in claim 1, is characterized in that the crude drug of this Chinese medicine composition consists of:
5. the preparation method of the Chinese medicine composition as described in as arbitrary in claim 1-4, it is characterized in that the method is: extracted according to a conventional method by crude drug, extracting solution filters, concentrated, add customary adjuvant conveniently technique make capsule, tablet, powder, oral liquid, pill, tincture, syrup.
6. preparation method as claimed in claim 5, is characterized in that described conventional method is soak by water, and decocting number of times is 1-3 time, each 0.5-2 hour.
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| CN201210031025.9A CN103239618B (en) | 2012-02-13 | 2012-02-13 | Traditional Chinese medicine composition for treating chronic hepatitis and cirrhosis and preparation method thereof |
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| CN103239618B true CN103239618B (en) | 2015-02-11 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933430B (en) * | 2014-03-18 | 2016-11-23 | 吴侠 | Chronic hepatitis B medicine and preparation method thereof |
| CN108042732A (en) * | 2018-01-17 | 2018-05-18 | 张岚 | A kind of medicine pill and preparation method for primary biliary cirrhosis |
| CN113491741A (en) * | 2021-08-27 | 2021-10-12 | 首都医科大学附属北京佑安医院 | Traditional Chinese medicine composition for treating chronic hepatitis and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1291504A (en) * | 1999-08-27 | 2001-04-18 | 王天会 | Medicine for treating cirrhosis ascites |
| CN101444613A (en) * | 2008-12-19 | 2009-06-03 | 宗翠红 | Traditional Chinese medicine formula for treating chronic hepatitis |
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2012
- 2012-02-13 CN CN201210031025.9A patent/CN103239618B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1291504A (en) * | 1999-08-27 | 2001-04-18 | 王天会 | Medicine for treating cirrhosis ascites |
| CN101444613A (en) * | 2008-12-19 | 2009-06-03 | 宗翠红 | Traditional Chinese medicine formula for treating chronic hepatitis |
Non-Patent Citations (4)
| Title |
|---|
| 146例慢性重型肝炎综合治疗与中西医结合治疗疗效比较;汪晓军等;《中西医结合肝病杂志》;20110630;第21卷(第03期);131-134 * |
| 中医治疗乙型肝炎的的近况;马德安等;《甘肃中医》;19970430;第10卷(第02期);46-48 * |
| 中医药治疗病毒性乙型肝炎研究进展;钟有添等;《赣南医学院学报》;20040430;第24卷(第02期);224-227 * |
| 中西医结合治疗肝硬变56例疗效观察;田艳萍等;《山西中医》;19971231;第13卷(第06期);22-23 * |
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Inventor after: Li Xiuhui Inventor after: Gou Chunyan Inventor after: Liu Wei Inventor after: Li Li Inventor after: Hu Jianhua Inventor after: Zhang Lili Inventor after: Fu Lijia Inventor before: Fu Lijia Inventor before: Fu Jianjia Inventor before: Ma Yun Inventor before: Zhao Minzi |
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Effective date of registration: 20230919 Address after: No. 8, West End, Youanmenwai, Fengtai District, Beijing, 100069 Patentee after: Beijing Youan Hospital, Capital Medical University Address before: 102200, 8, Zhenxing Road, Changping District science and Technology Park, Beijing Patentee before: BEIJING ASIA-EAST BIO-PHARMACEUTICAL Co.,Ltd. |
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