CN108042732A - A kind of medicine pill and preparation method for primary biliary cirrhosis - Google Patents
A kind of medicine pill and preparation method for primary biliary cirrhosis Download PDFInfo
- Publication number
- CN108042732A CN108042732A CN201810041794.4A CN201810041794A CN108042732A CN 108042732 A CN108042732 A CN 108042732A CN 201810041794 A CN201810041794 A CN 201810041794A CN 108042732 A CN108042732 A CN 108042732A
- Authority
- CN
- China
- Prior art keywords
- parts
- root
- primary biliary
- biliary cirrhosis
- liver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 45
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 title claims abstract description 24
- 208000033222 Biliary cirrhosis primary Diseases 0.000 title claims abstract description 24
- 208000012654 Primary biliary cholangitis Diseases 0.000 title claims abstract description 24
- 239000006187 pill Substances 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 210000000582 semen Anatomy 0.000 claims abstract description 30
- 244000202566 Hydrocotyle vulgaris Species 0.000 claims abstract description 17
- 235000015916 Hydrocotyle vulgaris Nutrition 0.000 claims abstract description 17
- 241001313086 Betula platyphylla Species 0.000 claims abstract description 16
- 235000001553 Betula platyphylla Nutrition 0.000 claims abstract description 16
- 235000003332 Ilex aquifolium Nutrition 0.000 claims abstract description 16
- 235000002296 Ilex sandwicensis Nutrition 0.000 claims abstract description 16
- 235000002294 Ilex volkensiana Nutrition 0.000 claims abstract description 16
- 241001571732 Lysimachia fortunei Species 0.000 claims abstract description 16
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 16
- 240000008027 Akebia quinata Species 0.000 claims abstract description 15
- 235000007756 Akebia quinata Nutrition 0.000 claims abstract description 15
- 241000723221 Crepis Species 0.000 claims abstract description 15
- 241001183967 Isodon Species 0.000 claims abstract description 15
- 241000756042 Polygonatum Species 0.000 claims abstract description 15
- 235000008737 Polygonatum biflorum Nutrition 0.000 claims abstract description 15
- 241001530209 Swertia Species 0.000 claims abstract description 15
- 240000008042 Zea mays Species 0.000 claims abstract description 15
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims abstract description 15
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims abstract description 15
- 235000005822 corn Nutrition 0.000 claims abstract description 15
- 239000009636 Huang Qi Substances 0.000 claims abstract description 13
- 241000132064 Ainsliaea Species 0.000 claims abstract description 12
- 241000233855 Orchidaceae Species 0.000 claims abstract description 11
- 239000004615 ingredient Substances 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 241000694589 Gesneria viridiflora Species 0.000 claims abstract description 5
- 240000006766 Cornus mas Species 0.000 claims abstract 5
- 240000007695 Nandina domestica Species 0.000 claims abstract 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 238000007654 immersion Methods 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 15
- 241000234653 Cyperus Species 0.000 claims description 14
- 238000010410 dusting Methods 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 12
- 244000025254 Cannabis sativa Species 0.000 claims description 10
- 238000009835 boiling Methods 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 9
- 235000012907 honey Nutrition 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 235000019991 rice wine Nutrition 0.000 claims description 6
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 claims description 3
- 241000045403 Astragalus propinquus Species 0.000 claims description 3
- 240000004670 Glycyrrhiza echinata Species 0.000 claims description 3
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 3
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 3
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 3
- 240000007711 Peperomia pellucida Species 0.000 claims description 3
- 235000006533 astragalus Nutrition 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 239000000571 coke Substances 0.000 claims description 3
- 235000019441 ethanol Nutrition 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 229940010454 licorice Drugs 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 244000132619 red sage Species 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 238000009738 saturating Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 abstract description 45
- 230000001737 promoting effect Effects 0.000 abstract description 26
- 239000008280 blood Substances 0.000 abstract description 25
- 210000004369 blood Anatomy 0.000 abstract description 25
- 230000000694 effects Effects 0.000 abstract description 25
- 210000003734 kidney Anatomy 0.000 abstract description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 21
- 208000004880 Polyuria Diseases 0.000 abstract description 20
- 230000035619 diuresis Effects 0.000 abstract description 20
- 201000010099 disease Diseases 0.000 abstract description 16
- 210000000952 spleen Anatomy 0.000 abstract description 15
- 230000017531 blood circulation Effects 0.000 abstract description 14
- 230000002279 cholagogic effect Effects 0.000 abstract description 11
- 231100000419 toxicity Toxicity 0.000 abstract description 8
- 230000001988 toxicity Effects 0.000 abstract description 8
- 230000002411 adverse Effects 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 4
- 230000002588 toxic effect Effects 0.000 abstract description 4
- 238000012795 verification Methods 0.000 abstract description 4
- 241000721047 Danaus plexippus Species 0.000 abstract description 2
- 229940126678 chinese medicines Drugs 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 244000075634 Cyperus rotundus Species 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 description 17
- 238000011282 treatment Methods 0.000 description 17
- 206010023126 Jaundice Diseases 0.000 description 14
- 206010011224 Cough Diseases 0.000 description 13
- 206010030113 Oedema Diseases 0.000 description 13
- 208000002193 Pain Diseases 0.000 description 13
- 208000024891 symptom Diseases 0.000 description 13
- 229940079593 drug Drugs 0.000 description 12
- 241000411851 herbal medicine Species 0.000 description 12
- 241000209020 Cornus Species 0.000 description 11
- 241000133556 Nandina Species 0.000 description 10
- 208000025865 Ulcer Diseases 0.000 description 10
- 239000000796 flavoring agent Substances 0.000 description 10
- 235000019634 flavors Nutrition 0.000 description 10
- 231100000397 ulcer Toxicity 0.000 description 10
- 235000009508 confectionery Nutrition 0.000 description 9
- 206010007247 Carbuncle Diseases 0.000 description 8
- 210000001015 abdomen Anatomy 0.000 description 8
- 208000002173 dizziness Diseases 0.000 description 7
- 208000014674 injury Diseases 0.000 description 7
- 231100000614 poison Toxicity 0.000 description 7
- 206010062717 Increased upper airway secretion Diseases 0.000 description 6
- 206010037660 Pyrexia Diseases 0.000 description 6
- 230000003110 anti-inflammatory effect Effects 0.000 description 6
- 206010003549 asthenia Diseases 0.000 description 6
- 201000001352 cholecystitis Diseases 0.000 description 6
- 208000026435 phlegm Diseases 0.000 description 6
- 230000008736 traumatic injury Effects 0.000 description 6
- 208000006820 Arthralgia Diseases 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 208000001848 dysentery Diseases 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000001939 inductive effect Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 238000005728 strengthening Methods 0.000 description 5
- 238000007920 subcutaneous administration Methods 0.000 description 5
- 230000008961 swelling Effects 0.000 description 5
- 208000003251 Pruritus Diseases 0.000 description 4
- 208000004078 Snake Bites Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 201000007227 lymph node tuberculosis Diseases 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 210000003800 pharynx Anatomy 0.000 description 4
- 239000002574 poison Substances 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 4
- 229960001661 ursodiol Drugs 0.000 description 4
- 206010001928 Amenorrhoea Diseases 0.000 description 3
- 241000193830 Bacillus <bacterium> Species 0.000 description 3
- 208000034656 Contusions Diseases 0.000 description 3
- 206010011878 Deafness Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 208000007443 Neurasthenia Diseases 0.000 description 3
- 241000270295 Serpentes Species 0.000 description 3
- 206010046788 Uterine haemorrhage Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 206010000269 abscess Diseases 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 208000034526 bruise Diseases 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 210000004351 coronary vessel Anatomy 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 210000000232 gallbladder Anatomy 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 208000006454 hepatitis Diseases 0.000 description 3
- 231100000283 hepatitis Toxicity 0.000 description 3
- 230000002218 hypoglycaemic effect Effects 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 230000003908 liver function Effects 0.000 description 3
- 208000004396 mastitis Diseases 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 201000008827 tuberculosis Diseases 0.000 description 3
- 206010000060 Abdominal distension Diseases 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 2
- 206010003399 Arthropod bite Diseases 0.000 description 2
- 241001415830 Bubo Species 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- 206010013954 Dysphoria Diseases 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 206010018612 Gonorrhoea Diseases 0.000 description 2
- 208000000616 Hemoptysis Diseases 0.000 description 2
- 206010019909 Hernia Diseases 0.000 description 2
- 208000031361 Hiccup Diseases 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010067482 No adverse event Diseases 0.000 description 2
- 208000033809 Suppuration Diseases 0.000 description 2
- FINHMKGKINIASC-UHFFFAOYSA-N Tetramethylpyrazine Chemical compound CC1=NC(C)=C(C)N=C1C FINHMKGKINIASC-UHFFFAOYSA-N 0.000 description 2
- 206010053615 Thermal burn Diseases 0.000 description 2
- 206010044302 Tracheitis Diseases 0.000 description 2
- 208000037386 Typhoid Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 206010001093 acute tonsillitis Diseases 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 210000000013 bile duct Anatomy 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- 208000016335 bubo Diseases 0.000 description 2
- 239000000496 cardiotonic agent Substances 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 206010016766 flatulence Diseases 0.000 description 2
- 208000001786 gonorrhea Diseases 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 208000023513 hiccough Diseases 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 208000001581 lymphogranuloma venereum Diseases 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000001114 myogenic effect Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000007096 poisonous effect Effects 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010044008 tonsillitis Diseases 0.000 description 2
- 201000008297 typhoid fever Diseases 0.000 description 2
- 208000019206 urinary tract infection Diseases 0.000 description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- 206010049865 Achromotrichia acquired Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 241001480043 Arthrodermataceae Species 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000003910 Baronia <angiosperm> Species 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 208000003014 Bites and Stings Diseases 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 241001115458 Carphophis Species 0.000 description 1
- 206010008635 Cholestasis Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- YDDUMTOHNYZQPO-RVXRWRFUSA-N Cynarine Chemical compound O([C@@H]1C[C@@](C[C@H]([C@@H]1O)O)(OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C(O)=O)C(=O)\C=C\C1=CC=C(O)C(O)=C1 YDDUMTOHNYZQPO-RVXRWRFUSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 201000006353 Filariasis Diseases 0.000 description 1
- 208000036119 Frailty Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 206010067715 Gastrointestinal sounds abnormal Diseases 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 101710173228 Glutathione hydrolase proenzyme Proteins 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 241000530047 Herpetospermum pedunculosum Species 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 208000019395 Lactation disease Diseases 0.000 description 1
- 201000008197 Laryngitis Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010029164 Nephrotic syndrome Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 241000593989 Scardinius erythrophthalmus Species 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 241000607762 Shigella flexneri Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 206010042170 Strangury Diseases 0.000 description 1
- 206010042576 Suppressed lactation Diseases 0.000 description 1
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 208000009257 Visceral Prolapse Diseases 0.000 description 1
- 206010063840 Visceroptosis Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000702 anti-platelet effect Effects 0.000 description 1
- 230000001663 anti-spastic effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 208000003796 chancre Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 229950009125 cynarine Drugs 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940124567 diuretic antihypertensive agent Drugs 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 description 1
- 229960001123 epoprostenol Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 208000003512 furunculosis Diseases 0.000 description 1
- 208000001130 gallstones Diseases 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- WGXUDTHMEITUBO-YFKPBYRVSA-N glutaurine Chemical compound OC(=O)[C@@H](N)CCC(=O)NCCS(O)(=O)=O WGXUDTHMEITUBO-YFKPBYRVSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 206010019847 hepatosplenomegaly Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 208000001024 intrahepatic cholestasis Diseases 0.000 description 1
- 230000007872 intrahepatic cholestasis Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 201000005630 leukorrhea Diseases 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 201000002266 mite infestation Diseases 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 208000009928 nephrosis Diseases 0.000 description 1
- 231100001027 nephrosis Toxicity 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 230000003119 painkilling effect Effects 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 210000003240 portal vein Anatomy 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 201000010727 rectal prolapse Diseases 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Botany (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of medicine pills and preparation method for primary biliary cirrhosis, belong to the field of Chinese medicines.The raw material of effective ingredient of the present invention forms：Radix Astragali, rigescent hawksbeard root, corn stigma, rabdosia lophanthide, dogwood fruit, shoulder plate return, nutgrass flatsedge, holly leaf, fiveleaf akebia root, lysimachia fortunei maxim, Radix Glycyrrhizae, Semen sesami nigrum, japanese white birch bark, frangrant ainsliaea herb, Radix Salviae Miltiorrhizae, pennywort, scarlet swertia herb, variegated leaf orchid, Rhizoma Chuanxiong, Herba Hyperici Patuli, common nandina branchlet, whorledleaf solomonseal rhizome, yellow grass flower, Semen Herpetospermi.The present invention selects medicinal material to meet a monarch and his subjects left side and is allowed to manage, it suits the remedy to the case for the cause of disease, tonify the liver and kidney, invigorating the spleen helps fortune, clearing liver cholagogic, the promoting flow of qi and blood circulation, disperse blood stasis and dredge collateral, promote breath and open depression, clearing heat and promoting diuresis, the efficacy of removing toxicity for detumescence effect, good absorption effect, it is evident in efficacy, it has no toxic side effect and clinical adverse, it is higher to primary biliary cirrhosis cure rate according to clinical verification.
Description
Technical field
The present invention relates to the field of Chinese medicines more particularly to a kind of medicine pills and preparation for primary biliary cirrhosis
Method.
Background technology
Primary biliary cirrhosis (primary biliary cirrhosis, PBC) is a kind of unknown slow of reason
Property progressive cholestatic liver diseases, are the chronic nonsuppurative inflammation in liver based on small bile duct, show as with bile duct
Destruction, portal vein area inflammation and liver parenchyma clastic, finally progress to hepatic sclerosis.Primary biliary cirrhosis is a kind of chronic disease
Disease, patient are mostly women, and age of onset is generally 35~65 years old, may be related with autoimmunity, and clinic is with pruitus, Huang
With the characteristics of subcutaneous ulcer, hepatosplenomegaly.At present, ursodesoxycholic acid (UDCA) is that unique contrast clinical trial confirms to treat this disease effectively
Western medicine drug, but studies have shown that UDCA cannot reduce case fatality rate, liver transfer operation rate, and because needing prolonged application, some patientss poison is secondary to be made
With apparent, clinical costly, patient compliance is poor.
Primary biliary cirrhosis is a kind of chronic bile stasis of blood product property liver diseases, and complicated clinical manifestation is returned in the traditional Chinese medical science
Belong to the scopes such as traditional Chinese medical science ＂ jaundice, tympanites ＂.The cause of disease has affection of exogenous damp, improper diet, disorder of emotion, overstrain internal injury and natural endowment not
Sufficient several respects, TCM Syndrome Features are mainly asthenia in origin and asthenia in superficiality, are originally deficiency of vial QI, and based on the deficiency of liver-yin and kidney-yin, mark is real with the wet stasis of blood of heat
Based on malicious pent-up, but disease is run through always with the stasis of blood.The present invention suits the remedy to the case according to the cause of disease, have tonify the liver and kidney, invigorating the spleen helps fortune,
Clearing liver cholagogic, the promoting flow of qi and blood circulation, disperse blood stasis and dredge collateral, promote breath and open depression, clearing heat and promoting diuresis, the efficacy of removing toxicity for detumescence effect, good absorption effect, curative effect are shown
It writes, has no toxic side effect and clinical adverse, it is higher to primary biliary cirrhosis cure rate according to clinical verification.
The content of the invention
The present invention provides a kind of medicine pills and preparation method for primary biliary cirrhosis, have help liver
Kidney, invigorating the spleen help fortune, clearing liver cholagogic, the promoting flow of qi and blood circulation, disperse blood stasis and dredge collateral, promote breath and open depression, clearing heat and promoting diuresis, the efficacy of removing toxicity for detumescence effect, cure the disease
Source is asked to treat both principal and secondary aspect of disease, the effect of fine is respectively provided with to primary biliary cirrhosis caused by a variety of causes.
To achieve the above object, technical scheme is implemented as follows：
The raw material composition and weight of the effective ingredient is made in a kind of medicine pill for primary biliary cirrhosis
Number is：
20~40 parts of Radix Astragali, 20~40 parts of rigescent hawksbeard root, 20~35 parts of corn stigma, 20~35 parts of rabdosia lophanthide,
15~30 parts of dogwood fruit, shoulder plate return 15~30 parts, 15~30 parts of nutgrass flatsedge, 15~30 parts of holly leaf,
15~25 parts of fiveleaf akebia root, 15~25 parts of lysimachia fortunei maxim, 10~20 parts of Radix Glycyrrhizae, 10~20 parts of Semen sesami nigrum,
10~20 parts of japanese white birch bark, 10~20 parts of frangrant ainsliaea herb, 9~15 parts of Radix Salviae Miltiorrhizae, 9~15 parts of pennywort,
9~15 parts of scarlet swertia herb, 6~12 parts of variegated leaf orchid, 6~12 parts of Rhizoma Chuanxiong, 4~10 parts of Herba Hyperici Patuli,
4~10 parts of common nandina branchlet, 3~9 parts of whorledleaf solomonseal rhizome, yellow grass spend 3~9 parts, 1~5 part of Semen Herpetospermi.
Be made the effective ingredient raw material composition and parts by weight be：
25~35 parts of Radix Astragali, 25~35 parts of rigescent hawksbeard root, 24~30 parts of corn stigma, 24~30 parts of rabdosia lophanthide,
18~25 parts of dogwood fruit, shoulder plate return 18~25 parts, 18~25 parts of nutgrass flatsedge, 18~25 parts of holly leaf,
18~22 parts of fiveleaf akebia root, 18~22 parts of lysimachia fortunei maxim, 12~18 parts of Radix Glycyrrhizae, 12~18 parts of Semen sesami nigrum,
12~18 parts of japanese white birch bark, 12~16 parts of frangrant ainsliaea herb, 10~13 parts of Radix Salviae Miltiorrhizae, 9~12 parts of pennywort,
9~12 parts of scarlet swertia herb, 7~10 parts of variegated leaf orchid, 7~10 parts of Rhizoma Chuanxiong, 5~8 parts of Herba Hyperici Patuli,
5~8 parts of common nandina branchlet, 4~7 parts of whorledleaf solomonseal rhizome, yellow grass spend 4~7 parts, 2~4 parts of Semen Herpetospermi.
Be made the effective ingredient raw material composition and parts by weight be：
32 parts of Radix Astragali, 30 parts of rigescent hawksbeard root, 28 parts of corn stigma, 26 parts of rabdosia lophanthide,
22 parts of dogwood fruit, shoulder plate return 22 parts, 22 parts of nutgrass flatsedge, 22 parts of holly leaf,
20 parts of fiveleaf akebia root, 20 parts of lysimachia fortunei maxim, 16 parts of Radix Glycyrrhizae, 16 parts of Semen sesami nigrum,
15 parts of japanese white birch bark, 15 parts of frangrant ainsliaea herb, 12 parts of Radix Salviae Miltiorrhizae, 10 parts of pennywort,
10 parts of scarlet swertia herb, variegated leaf are 8 parts blue, 8 parts of Rhizoma Chuanxiong, 7 parts of Herba Hyperici Patuli,
7 parts of common nandina branchlet, 6 parts of whorledleaf solomonseal rhizome, yellow grass spend 6 parts, 3 parts of Semen Herpetospermi.
A kind of preparation method of medicine pill for primary biliary cirrhosis, comprises the following steps that：
（1）By rigescent hawksbeard root, corn stigma, rabdosia lophanthide, dogwood fruit, shoulder plate return, nutgrass flatsedge, lysimachia fortunei maxim, Semen sesami nigrum, japanese white birch bark, Phnom Penh
Rabbit ear, pennywort, scarlet swertia herb, Herba Hyperici Patuli, common nandina branchlet, yellow grass flower, Semen Herpetospermi are put into after cleaning in container, add in 8-10
Times amount distilled water immersion 4-5 it is small when, heating boil 3-4 it is small when, extract immersion liquid；The 6-8 times of distilled water measured, heating are added in again
Boil 2-3 it is small when, extract immersion liquid；Finally add the 4-6 times of distilled water measured, heating boil 1-2 it is small when, extract immersion liquid；Merge
Immersion liquid three times, filtering, it is spare to obtain filtrate；
（2）Holly leaf, fiveleaf akebia root, variegated leaf orchid, whorledleaf solomonseal rhizome are cleaned and be put into container, the ethyl alcohol for adding in the concentration 80% of 4 times of amounts is molten
Liquid, when immersion 1-2 is small, when heating and refluxing extraction 3-4 is small, it is spare to obtain filtrate for filtering；
（3）By astragalus mongholicus tablet plus cooked honey and a little boiling water, mix thoroughly it is slightly bored, put fried in pot to yellow and it is tack-free when, take out
It dries in the air cool, crushing is ground, and is crossed 140 mesh dusting covers, is obtained fine powder, spare；
（4）Net licorice tablet is taken, adds in cooked honey and a little boiling water, it is slightly bored after mixing thoroughly, it puts in frying container, is fried with slow fire depth
Yellow is taken out when tack-free, cools, and crushing is ground, and crosses 140 mesh dusting covers, obtains fine powder, spare；
（5）Danshen Tablets are taken, yellow rice wine is added to mix thoroughly, bored profit is put in pot, fried with slow boiling to saturating, and taking-up cools, and crushing is ground, and crosses 140 mesh
Dusting cover obtains fine powder, spare；
（6）Take the sprinkling of Rhizoma Chuanxiong piece yellow rice wine uniform, slightly bored, it is degree to put stir-fry to micro- coke in pot, and taking-up cools, and crushing is ground, and crosses 140
Mesh dusting cover obtains fine powder, spare；
（7）By step（1）, step（2）The filtrate of gained, with step（3）, step（4）, step（5）, step（6）Middle gained
Fine powder mixes, and after addition refined honey stirs evenly, is prepared as the pill of every 3g.
The pharmacological property of Chinese medicine used in the present invention is as follows：
Radix Astragali：It is sweet in flavor；It is warm-natured.Enter the heart；Lung；Spleen；Kidney channel.Invigorating qi for strengthening superficies；Diuresis；Pus draining and toxin expelling；Myogenic sore.Cure mainly the shortness of breath heart
Throb with fear；Burnout；It is weak；Spontaneous perspiration；Night sweat；Chronic diarrhea；Rectal prolapse；Physically weak edema；The prolapse of uterus；Chronic nephritis；Ulcer is difficult to burst；Or it bursts long not
It holds back.《Xinhua's book on Chinese herbal medicine outline》It carries：" there are invigorating qi for strengthening superficies, pus draining and toxin expelling, the function of myogenic." modern medicine study confirmation, Radix Astragali tool
There are diuretic antihypertensive, anti-inflammatory analgesic, cardiac stimulant, antioxidant radical generation and improve the multiple pharmacological effects such as body's immunity, it can be from
Various aspects act on body, improve the hemodynamic that the relevant blood vessels venereal diseases such as angiocarpy, the cerebrovascular, diabetes, nephrosis become patient
The functions such as and vascular endothelial cell.
Rigescent hawksbeard root：Bitter；It is sweet；It is warm-natured.It tonifies the liver and kidney；Invigorating spleen to remove dampness.It has a dizzy spell；Soreness and weakness of waist and knees；Oedema；Band chancre
Product；Hypogalactia.《Kunming common herbal medicine among the people》：Qi-restoratives, strong liver kidney.Control dizzy physically weak, weakness of limbs, milk is few, eye-blurred, muscles and bones
Pain.
Corn stigma：It is sweet in flavor；It is light；It is mild-natured.Return kidney；Stomach；Liver；Gallbladder channel.Inducing diuresis to remove edema；Clearing liver cholagogic.It cures mainly：Oedema；Urine
Leaching drip；Jaundice；Cholecystitis；Gall stone；Hypertension；Diabetes；Alactation.《Modern Practical Chinese medicinal》：For diuretics, to kidney
Disease, edema illness, diabetes etc. are effective.It is again effective medicine of cholecystitis, cholelith, hepatic inflammatory jaundice etc..
Rabdosia lophanthide：Bitter；It is cold in nature.Return liver；Courage；Large intestine channel.It is clearing heat and detoxicating；Removing dampness through diuresis and removing jaundice；Eliminating stasis to subdue swelling.Cure mainly damp and hot Huang
Subcutaneous ulcer；Cholecystitis；Diarrhea；Sore swells；Injuries from falls as well.《Common Chinese herbal medicine color atlas》：Clearing liver cholagogic, removing jaundice clearing damp, cool blood dissipate phlegm.
Oxyhepatitis is controlled, is beaten the stasis of blood swell.
Dogwood fruit：It is sour；Slightly warm in nature, Return liver；Kidney channel.It tonifies the liver and kidney；Astringing and avoiding visceroptosis cures mainly：It has a dizzy spell；Deaf ear
Ring；Soreness and weakness of waist and knees；Xian essence involuntary emission；Frequent urination；Incessant sweating due to debility；Woman uterine bleeding.《Elementary Medicine》：This astringent of Fructus Corni, what
It is evil hair can be led to.It is all the lower part cold of insufficiency type to cover all diseases, with benefit nourishing liver and kidney, with Yi Qiyuan, then the five internal organs Amway, the person of closing are led to and profit person
Only, the meaning of the light dredging of Fei Ruota medicines.Modern medicine study shows：Dogwood fruit has antibacterial, adjusts immune, hypoglycemic, drop
The functions such as blood fat, anti-oxidant, anticancer, cardiac stimulant.
Plate is shouldered to return：It is sour；It is bitter；It is mild-natured.Return lung；Small intestinl channel.It is clearing heat and detoxicating；It is inducing diuresis and reducing edema；Dissipate stasis of blood hemostasis.Cure mainly furunculosis carbuncle
It is swollen；Erysipelas；The paralysed cheek；Mastitis；Ting ear；Tonsillitis；Cold, fever；Cough with lung heat；Pertussis；Scrofula；Haemorrhoids；Lymphogranuloma inguinale bubo；It rushes down
Dysentery；Jaundice；Tympanites；Oedema；Stranguria with turbid discharge；Under band；Malaria；Wind-fire red eye；Treating swelling and pain by traumatic injury；It spits blood；It has blood in stool；Snakebite and bugbite.《Detailed outline picks up
It loses》：Control expansion, oedema, mass in the abdomen, yellowish-white subcutaneous ulcer, malaria is not cured long, lymphogranuloma inguinale bubo, bruise, all poisonous snakes wound.
Nutgrass flatsedge：Bitter；It is pungent；It is cool in nature.Return liver；Lung channel.Promote breath and open depression；Dispelling wind and arresting itching；Wide born of the same parents' profit phlegm.It cures mainly and uncomfortable in chest does not relax；
Rubella itch；Carbuncle is with pyogenic infections.《Lv Cliff rocks book on Chinese herbal medicine》：Pruitus is controlled, wind is given birth to all over body.
Holly leaf：Bitter；It is cool in nature.Enter liver；Kidney channel.Clearind deficient heat；Liver and kidney benefiting；Wind-damp dispelling.Cure mainly hectic fever due to yin deficiency；Cough is coughed up
Blood；It has a dizzy spell；Soreness and weakness of waist and knees；Arthralgia pain due to rheumatism；Leucoderma.《Bencao Jingshu》It carries：" this medicine directly enters meridian of Foot-SHAO YIN, takes a tonic or nourishing food to build up one's health the moon gas,
Then from disappearing, the meaning such as taken away the firewood under the cauldron goes out convulsive seizure due to phlegm-fire.It and can relieve heat poison malignant sore." modern medicine study confirms that holly leaf can increase coronary artery
Flow, enhances myocardial contractive power, and contained dicaffeoylquinic acid has prostacyclin more significant promotion release action.
Fiveleaf akebia root：Bitter；It is mild-natured；Return liver；Kidney channel.Dispelling wind and removing obstruction in the meridians；Inducing diuresis for removing edema；The promoting flow of qi and blood circulation；Filling liver kidney；Strengthening the bones and muscles.
Cure mainly arthralgia pain due to rheumatism；Traumatic injury；Amenorrhea；Hernia；Testiclar gall；It is bored that gastral cavity abdomen is swollen；Difficult urination；Under band；Worm snake bite.《Zhejiang
River common herbal medicine among the people》：Wind-expelling pain-stopping, the promoting flow of qi and blood circulation, diuresis removing toxic substances.
Lysimachia fortunei maxim：Bitter；It is pungent；It is cool in nature.Clearing heat and promoting diuresis；Cooling and activating blood；Removing toxicity for detumescence.Cure mainly jaundice；Rush down dysentery；Hot eyes；
It spits blood；Blood strangury；Leukorrhea；Uterine bleeding；Dysmenorrhoea；Amenorrhoea；Abscess of throat；Carbuncle sore tumefacting virus；Filariasis；Scrofula；Bruise；Snakebite and bugbite.《Fujian
Traditional herbal medicine》：" blood circulation promoting competent silt, diuresis are relieved oedema or abdominal distension through diuresis or purgation." modern medicine study proves：Lysimachia fortunei maxim raises liver total bilirubin, has
Effect is substantially reduced, and is played an important role of anti-inflammatory.
Radix Glycyrrhizae：It is sweet in flavor；It is mild-natured.The thoughts of returning home；Lung；Spleen；Stomach.It invigorates the spleen and benefits qi；It is clearing heat and detoxicating；Expelling phlegm and arresting coughing；Relieving spasm to stop pain；It adjusts
With all medicines.It cures mainly weakness of the spleen and the stomach；Lassitude hypodynamia；Palpitation；Coughing with a lot of sputum；Gastral cavity abdomen four limbs contraction；Carbuncle sore tumefacting virus；Alleviate
Drug toxicity.《Compendium of Materia Medica》It carries：" Radix Glycyrrhizae is monarch in all medicines.72 kinds of mammary calculus poison are controlled, draft is malicious by every means for solution 1,002, adjusts
With it is active from medicine." modern medicine study confirms that Radix Glycyrrhizae has stronger detoxication, also have antiulcer, anti-inflammatory, antispastic antibechic,
Lowering blood pressure and blood fat, antitumaous effect are widely used in treatment sphagitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis
Etc. diseases, additionally with anti-gastric-ulcer, gastritis effect.
Semen sesami nigrum：It is sweet in flavor；It is mild-natured.Return liver；Spleen；Kidney channel.It tonifies the liver and kidney；Blood-nourishing strengthening the essence；It relaxes bowel.For dizzy eye
Flower, Hiccough and deaf, poliosis, post disease alopecia, dry constipation of intestines.Modern medicine study proves：Semen sesami nigrum have hypoglycemic effect,
Promote adrenal gland effect, anti-inflammatory effect and have certain effect to angiocarpy.
Japanese white birch bark：Bitter；It is mild-natured.Return lung；Stomach；Large intestine channel.Clearing heat and promoting diuresis, expelling phlegm and arresting coughing, subdhing swelling and detoxicating.Control pneumonia, dysentery
Disease, diarrhea, jaundice, ephritis, urinary tract infections, chronic bronchitis, acute tonsillitis, periodontitis, acute mastitis, furuncle are itched
Rash, scald.《Bencao Jingshu》：" japanese white birch bark, five subcutaneous ulcers all it is damp and hot accumulate Yu Yangming caused by, hardship is flat can be except damp and hot, therefore leads all subcutaneous ulcers.It hides
Row heat toxin sore , Zong Seok controls lung wind toxin with it when device cures the wound cold with it, all takes the adopted ear of its bitter cool energy relieve heat heat symptoms caused by an exopathgen poison." modern times doctor
Learning research has shown that：Japanese white birch bark plays an important role of cough-relieving, eliminating the phlegm, relievings asthma and antibacterial.
Frangrant ainsliaea herb：It is sweet in flavor；Slight bitter；It is cool in nature.Return lung；Liver Channel.Heat-clearing qi-restoratives；Cooling blood and hemostasis；Eliminating damp, detoxifying.Cure mainly consumptive disease
Hectic fever due to yin；Tuberculosis hemoptysis；Woman uterine bleeding；Jaundice with damp-heat pathogen；Oedema；Swollen ulcer drug；Scrofula tuberculosis；Bruise fishing person hinders.《Quanzhou book on Chinese herbal medicine》：
Clearing heat and purging lung fire, cooling blood and hemostasis.Control lung carbuncle, acute appendicitis, deficiency syndrome of the lung steaming bone and consumptive fever, swollen ulcer drug.
Radix Salviae Miltiorrhizae：Bitter；Cold nature；It is nontoxic.Enter the heart；Liver Channel.Promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire, cool blood to disappear carbuncle.
For chest impediment and cardialgia, gastral cavity abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea Amenorrhea, sore swell and ache curative.
《This warp》It carries：" main trusted subordinate's perverse trend, borborygmus is faint such as to leak water, fever and chills accumulation；Broken disease stops dysphoria, QI invigorating except lump in the abdomen." modern medicine grinds
Study carefully confirmation, Radix Salviae Miltiorrhizae has anti-inflammatory analgetic, coronary artery dilator, improves myocardial ischemia situation, blood pressure lowering, hypoglycemic, reducing blood lipid, guarantor
Liver, the reparation of antibacterial and promotion tissue and regenerated effect, Radix Salviae Miltiorrhizae also have anti-platelet aggregation, reduce blood viscosity and adjusting
The function of inside and outside blood coagulation system.
Pennywort：Acrid flavour；Slight bitter；It is cool in nature.Clearing heat and promoting diuresis；Removing toxicity for detumescence.Cure mainly jaundice；Dysentery；Oedema；Stranguria；Mesh screen；
Larynx swells；Carbuncle sore tumefacting virus；Herpes zoster；Traumatic injury.《Book on Chinese herbal medicine pushes away old》：Acute tonsillitis and sphagitis, mange are controlled, snake stings
Wound, ulcer, dermatitis rhus, rheumatalgia, dampen etc..Modern pharmacological research proves：Pennywort：Pennywort water decoction in vitro test is to golden yellow
Color staphylococcus has to be acted on compared with high inhibition, and to proteus, the inhibition that shigella flexneri, typhoid bacillus also have not degree is made
With.
Scarlet swertia herb：Bitter；It is cold in nature.Clearing liver cholagogic；It is clearing heat and detoxicating；Dampness removing.Cure mainly acute icteric hepatitis；Cholecystitis；
Anemopyretic cold；Acute toothache；Abscess of throat；Indigestion；Acute bacillary dysentery；Urinary infection；Hiccough and deaf；Burn and scald.《Yunnan
Chinese herbal medicine selects》：Clearing liver cholagogic except damp and clearing heat, controls acute icteric hepatitis, cholecystitis.
Variegated leaf is blue：It is sweet in flavor；It is pungent；It is mild-natured.It moistens the lung and relieve the cough；It tonifies Qi of the kidney；The promoting flow of qi and blood circulation；Subdhing swelling and detoxicating.Cure mainly pulmonary tuberculosis cough；
Tracheitis；It is dizzy weak；Neurasthenia；Impotence；Traumatic injury；Arthralgia；Abscess of throat；Acute mastitis；Boil；Scrofula；Poisonous snake
It bites.《Zhejiang common herbal medicine among the people》：" clearing heat and detoxicating, anti-inflammatory detumescence.Control venomous snake bite, carbuncle swells boil, tuberculosis cough, tracheae
It is scorching."
Rhizoma Chuanxiong：Acrid flavour；It is warm-natured.Return liver；Courage；Pericardium channel.Promoting blood circulation；Promote breath and open depression；Wind-expelling pain-stopping.Zhu Zhi wei lump in the abdomen lumps；Chest
Coerce pain；Dizziness of having a headache；Wind-cold-dampness arthralgia；Traumatic injury；Ulcer sores.《Book on Chinese herbal medicine is just》It carries：" dispersing wind and cold controls pain, and broken stasis of blood stores, and leads to
Blood vessels, unhitch gas, by pain, apocenosis detumescence, by blood promoting menstruation." modern medical science the study found that Rhizoma Chuanxiong extracting solution to inhibit it is white
Blood disease cell has certain effect, and preparation has certain antibacterial action, especially to typhoid bacillus, paratyphosum Bacterium, comma bacillus,
Pseudomonas aeruginosa and pathogenic dermatophyte etc. have inhibitory action, and the ligustrazine, forulic acid contained by Rhizoma Chuanxiong are received with promoting blood circulation and removing blood stasis
Effect, expansible coronary artery promotes coronary flow, allevating angina pectoris, and has anti-thrombosis function, in contained Rhizoma Chuanxiong
The effects that ester has smooth muscle spasmolysis and inhibits myenteron, uterine contractile.
Herba Hyperici Patuli：Bitter；It is cold in nature.Return liver；Kidney；Bladder warp.Clearing heat and promoting diuresis is detoxified；Dispersing the stagnated liver-QI and dredging collateral；Stasis-dispelling and pain-killing.It cures mainly wet
Heat gonorrhea disease；Hepatitis；Flu；Tonsillitis；The hernia swelling and hanging down of either of the testes；Arthralgia and myalgia；Traumatic injury.
Common nandina branchlet：Acrid flavour, it is bitter；It is cold in nature.It is distributed in lung channel.Clearing away damp-heat；Lowering the adverse flow of qi.Jaundice with damp-heat pathogen；Rush down dysentery；Heat gonorrhea；Hot eyes swells
Bitterly；Cough；Diaphragm is eaten.《Guizhou prescription collection among the people》：Antibechic Zhichuan, it is excited strong.
Whorledleaf solomonseal rhizome：It is sweet in flavor；Slight bitter；It is cool in nature.It is nourishing liver and kidney, nourishing Yin and promoting production of body fluid.For neurasthenia, high blood pressure is had a headache, pharynx
Laryngalgia, quenches one's thirst, mouth parched and tongue scorched.《The sweet peaceful blue or green Chinese herbal medicine choosing in Shan》：" tonifying spleen moistening lung, promotes the production of body fluid.Pulmonary tuberculosis is controlled, eak after being ill is thirsty,
Neurasthenia, the liver-yang headache, loss of appetite, lassitude in loin and legs, diabetes."
Yellow grass is spent：Bitter；It is cool in nature.Return lung；Liver；Gallbladder channel.Removing heat from the lung to relieve cough；Clearing liver cholagogic；Analgesic.Cure mainly cough with lung heat；Generate heat chest
Bitterly；Liver and gallbladder damp-heat；Hypochondriac pain；Fever；Apocleisis is greasy；Jaundice；Diarrhea due to damp-heat.
Semen Herpetospermi：Bitter；It is cold in nature.Clearing liver cholagogic；Invigorating the spleen helps fortune.Cure mainly icteric catarrhal jaundice；Cholecystitis；Digestion is not
It is good.
Compared with prior art, the present invention it has the advantages that：
It is mutually auxiliary that the present invention selects the pharmacological property of medicinal material mutually to fit, and suits the remedy to the case for the cause of disease, tonifies the liver and kidney, invigorating the spleen helps fortune, clear liver profit
Courage, the promoting flow of qi and blood circulation, disperse blood stasis and dredge collateral, promote breath and open depression, clearing heat and promoting diuresis, the efficacy of removing toxicity for detumescence effect, good absorption effect is evident in efficacy, nothing
Toxic side effect and clinical adverse are higher to primary biliary cirrhosis cure rate according to clinical verification.
Specific embodiment
The present invention is further elaborated with reference to specific embodiment.
Embodiment 1
The raw material of effective ingredient of the present invention forms and weight is：
20~40 parts of Radix Astragali, 20~40 parts of rigescent hawksbeard root, 20~35 parts of corn stigma, 20~35 parts of rabdosia lophanthide,
15~30 parts of dogwood fruit, shoulder plate return 15~30 parts, 15~30 parts of nutgrass flatsedge, 15~30 parts of holly leaf,
15~25 parts of fiveleaf akebia root, 15~25 parts of lysimachia fortunei maxim, 10~20 parts of Radix Glycyrrhizae, 10~20 parts of Semen sesami nigrum,
10~20 parts of japanese white birch bark, 10~20 parts of frangrant ainsliaea herb, 9~15 parts of Radix Salviae Miltiorrhizae, 9~15 parts of pennywort,
9~15 parts of scarlet swertia herb, 6~12 parts of variegated leaf orchid, 6~12 parts of Rhizoma Chuanxiong, 4~10 parts of Herba Hyperici Patuli,
4~10 parts of common nandina branchlet, 3~9 parts of whorledleaf solomonseal rhizome, yellow grass spend 3~9 parts, 1~5 part of Semen Herpetospermi.
The processing step of process for preparing medicine of the present invention is：
（1）By rigescent hawksbeard root, corn stigma, rabdosia lophanthide, dogwood fruit, shoulder plate return, nutgrass flatsedge, lysimachia fortunei maxim, Semen sesami nigrum, japanese white birch bark, Phnom Penh
Rabbit ear, pennywort, scarlet swertia herb, Herba Hyperici Patuli, common nandina branchlet, yellow grass flower, Semen Herpetospermi are put into after cleaning in container, add in 8-10
Times amount distilled water immersion 4-5 it is small when, heating boil 3-4 it is small when, extract immersion liquid；The 6-8 times of distilled water measured, heating are added in again
Boil 2-3 it is small when, extract immersion liquid；Finally add the 4-6 times of distilled water measured, heating boil 1-2 it is small when, extract immersion liquid；Merge
Immersion liquid three times, filtering, it is spare to obtain filtrate；
（2）Holly leaf, fiveleaf akebia root, variegated leaf orchid, whorledleaf solomonseal rhizome are cleaned and be put into container, the ethyl alcohol for adding in the concentration 80% of 4 times of amounts is molten
Liquid, when immersion 1-2 is small, when heating and refluxing extraction 3-4 is small, it is spare to obtain filtrate for filtering；
（3）By astragalus mongholicus tablet plus cooked honey and a little boiling water, mix thoroughly it is slightly bored, put fried in pot to yellow and it is tack-free when, take out
It dries in the air cool, crushing is ground, and is crossed 140 mesh dusting covers, is obtained fine powder, spare；
（4）Net licorice tablet is taken, adds in cooked honey and a little boiling water, it is slightly bored after mixing thoroughly, it puts in frying container, is fried with slow fire depth
Yellow is taken out when tack-free, cools, and crushing is ground, and crosses 140 mesh dusting covers, obtains fine powder, spare；
（5）Danshen Tablets are taken, yellow rice wine is added to mix thoroughly, bored profit is put in pot, fried with slow boiling to saturating, and taking-up cools, and crushing is ground, and crosses 140 mesh
Dusting cover obtains fine powder, spare；
（6）Take the sprinkling of Rhizoma Chuanxiong piece yellow rice wine uniform, slightly bored, it is degree to put stir-fry to micro- coke in pot, and taking-up cools, and crushing is ground, and crosses 140
Mesh dusting cover obtains fine powder, spare；
（7）By step（1）, step（2）The filtrate of gained, with step（3）, step（4）, step（5）, step（6）Middle gained
Fine powder mixes, and after addition refined honey stirs evenly, is prepared as the pill of every 3g.
Usage and dosage：Oral, 3 times a day, 2 tablets each time, with warm water delivery service, 10 days are 1 course for the treatment of, are taken within one hour before meals
With 6 courses for the treatment of.
Embodiment 2
The raw material of effective ingredient of the present invention forms and weight is：
25~35 parts of Radix Astragali, 25~35 parts of rigescent hawksbeard root, 24~30 parts of corn stigma, 24~30 parts of rabdosia lophanthide,
18~25 parts of dogwood fruit, shoulder plate return 18~25 parts, 18~25 parts of nutgrass flatsedge, 18~25 parts of holly leaf,
18~22 parts of fiveleaf akebia root, 18~22 parts of lysimachia fortunei maxim, 12~18 parts of Radix Glycyrrhizae, 12~18 parts of Semen sesami nigrum,
12~18 parts of japanese white birch bark, 12~16 parts of frangrant ainsliaea herb, 10~13 parts of Radix Salviae Miltiorrhizae, 9~12 parts of pennywort,
9~12 parts of scarlet swertia herb, 7~10 parts of variegated leaf orchid, 7~10 parts of Rhizoma Chuanxiong, 5~8 parts of Herba Hyperici Patuli,
5~8 parts of common nandina branchlet, 4~7 parts of whorledleaf solomonseal rhizome, yellow grass spend 4~7 parts, 2~4 parts of Semen Herpetospermi.
The process for preparing medicine processing step and usage and dosage of the present embodiment are same as Example 1.
Embodiment 3
The raw material of effective ingredient of the present invention forms and weight is：
32 parts of Radix Astragali, 30 parts of rigescent hawksbeard root, 28 parts of corn stigma, 26 parts of rabdosia lophanthide,
22 parts of dogwood fruit, shoulder plate return 22 parts, 22 parts of nutgrass flatsedge, 22 parts of holly leaf,
20 parts of fiveleaf akebia root, 20 parts of lysimachia fortunei maxim, 16 parts of Radix Glycyrrhizae, 16 parts of Semen sesami nigrum,
15 parts of japanese white birch bark, 15 parts of frangrant ainsliaea herb, 12 parts of Radix Salviae Miltiorrhizae, 10 parts of pennywort,
10 parts of scarlet swertia herb, variegated leaf are 8 parts blue, 8 parts of Rhizoma Chuanxiong, 7 parts of Herba Hyperici Patuli,
7 parts of common nandina branchlet, 6 parts of whorledleaf solomonseal rhizome, yellow grass spend 6 parts, 3 parts of Semen Herpetospermi.
The process for preparing medicine processing step and usage and dosage of the present embodiment are same as Example 1.
Clinical data：
1st, case selection
40 clinical observations of patients with primary biliary cirrhosis that selection our hospital makes a definite diagnosis, patient are randomly divided into two groups.Treatment group
20, wherein male 3, women 17,36~63 years old age, average age 47.6 years old.Control group 20, wherein male 2,
Women 18,39~64 years old age, average age 48.2 years old.Two groups of qualifications and record of service are basically identical, and no significant difference is comparable.
2nd, therapy
Treatment group patient takes drug of the present invention, takes orally, 3 times a day, 2 tablets each time, one hour before meals with warm water delivery service, 10 days
For 1 course for the treatment of, 6 courses for the treatment of are taken；Control group gives ursodesoxycholic acid capsule oral, once a grain (250mg), once a day,
10 days are 1 course for the treatment of, take 6 courses for the treatment of.
3rd, efficacy determination：
Observation item symptom integral changes, clinical cardinal symptom include it is weak, receive poor, abdominal distension and pruitus, score standard is joined
According to by《New Chinese medicine guideline of clinical investigations (tentative)》Middle clinical features degree is divided into 4 grades：Asymptomatic is 0 point, gently
It spends for 1 point, moderate is 2 points, and severe is 3 points；(2) liver function index changes：TBIL、ALT、ALP、γ-GT；(3) two groups of treatments
Period adverse reaction.
（1）It is effective：Clinical symptoms are obviously improved or disappear, symptom integral reduce more than 70%, liver function recovery 70% with
Upper person；
（2）It improves：Clinical symptoms are obviously improved or disappear, and symptom integral reduces more than 30%, more than 50% person of liver function recovery；
（3）It is invalid：Symptom is same to treat preceding no significant difference.
4th, treatment results
Treatment effectiveness evaluation is carried out according to clinical the standard of curative effect evaluation of working out：Effective 13 in treatment group, improve 5, invalid 2
Example, total effective rate 90%, have no adverse reaction case during medication；Effective 8 in control group, improve 7, it is invalid 5, total effective
Rate 75%, diarrhea 1 during medication, nausea 2, itch 1.
The above results show that the therapeutic effect for the treatment of group is significantly better than control group, and takes Chinese medicine and have no adverse reaction.
Model case is illustrated：
1st, Zhao's ××, female, 47 years old.The patient began with breathes hard before January, stomach is received depressed, and occur together heat, skin moderate xanthochromia etc.
Symptom carrys out institute's interrogation, is diagnosed as primary biliary cirrhosis, after taking 4 courses for the treatment of of Chinese medicine of the present invention, above-mentioned symptom
It is substantially reduced, it follows the doctor's advice after continuing to take 1 course for the treatment of of Chinese medicine of the present invention, above-mentioned symptom completely disappears, and has fully recovered.
2nd, what ××, female, 58 years old.Patient because it is weak, receive poor, pruitus with progressive jaundice admission in January, examine
Break as primary biliary cirrhosis, after taking 6 courses for the treatment of of Chinese medicine of the present invention, above-mentioned symptom completely disappears, and has fully recovered.
Primary biliary cirrhosis (primary biliary cirrhosis, PBC) is that a kind of autoimmune is slow
Property intrahepatic cholestasis disease, onset concealment, atypical symptom, Chinese medicine this disease has certain advantage, of the invention
Chinese medicine is suited the remedy to the case according to the cause of disease, in side holly leaf, dogwood fruit, Semen sesami nigrum, whorledleaf solomonseal rhizome, rigescent hawksbeard root can tonify the liver and kidney, invigorating the spleen profit
It is wet；Radix Astragali can invigorating qi for strengthening superficies, diuresis in side；Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, nutgrass flatsedge can promoting blood circulation, promote breath and open depression, dispelling wind and arresting itching in side；Side
Middle variegated leaf orchid, fiveleaf akebia root can the promoting flow of qi and blood circulation, dispelling wind and removing obstruction in the meridians, inducing diuresis for removing edema；Corn stigma, yellow grass flower, scarlet swertia herb, herpetospermum pedunculosum in side
Can clear liver cholagogic, invigorating the spleen of son helps fortune；Rabdosia lophanthide in side, lysimachia fortunei maxim, frangrant ainsliaea herb, shoulder plate return, Herba Hyperici Patuli, common nandina branchlet, birch
Wood skin, pennywort can clearing heat and promoting diuresis, removing toxicity for detumescence, dispersing the stagnated liver-QI and dredging collaterals；Radix Glycyrrhizae can coordinating the drug actions of a prescription in side；All medicines share can play altogether in side
Tonify the liver and kidney, invigorating the spleen helps fortune, clearing liver cholagogic, the promoting flow of qi and blood circulation, disperse blood stasis and dredge collateral, promote breath and open depression, clearing heat and promoting diuresis, the efficacy of removing toxicity for detumescence
Effect, good absorption effect is evident in efficacy, has no toxic side effect and clinical adverse, hard to primary biliary liver according to clinical verification
It is higher to change cure rate.
Claims (4)
1. a kind of medicine pill for primary biliary cirrhosis, which is characterized in that the effective ingredient is made
Raw material forms and parts by weight are：
20~40 parts of Radix Astragali, 20~40 parts of rigescent hawksbeard root, 20~35 parts of corn stigma, 20~35 parts of rabdosia lophanthide,
15~30 parts of dogwood fruit, shoulder plate return 15~30 parts, 15~30 parts of nutgrass flatsedge, 15~30 parts of holly leaf,
15~25 parts of fiveleaf akebia root, 15~25 parts of lysimachia fortunei maxim, 10~20 parts of Radix Glycyrrhizae, 10~20 parts of Semen sesami nigrum,
10~20 parts of japanese white birch bark, 10~20 parts of frangrant ainsliaea herb, 9~15 parts of Radix Salviae Miltiorrhizae, 9~15 parts of pennywort,
9~15 parts of scarlet swertia herb, 6~12 parts of variegated leaf orchid, 6~12 parts of Rhizoma Chuanxiong, 4~10 parts of Herba Hyperici Patuli,
4~10 parts of common nandina branchlet, 3~9 parts of whorledleaf solomonseal rhizome, yellow grass spend 3~9 parts, 1~5 part of Semen Herpetospermi.
2. a kind of medicine pill for primary biliary cirrhosis according to claim 1, which is characterized in that be made
The raw material of the effective ingredient forms and parts by weight are：
25~35 parts of Radix Astragali, 25~35 parts of rigescent hawksbeard root, 24~30 parts of corn stigma, 24~30 parts of rabdosia lophanthide,
18~25 parts of dogwood fruit, shoulder plate return 18~25 parts, 18~25 parts of nutgrass flatsedge, 18~25 parts of holly leaf,
18~22 parts of fiveleaf akebia root, 18~22 parts of lysimachia fortunei maxim, 12~18 parts of Radix Glycyrrhizae, 12~18 parts of Semen sesami nigrum,
12~18 parts of japanese white birch bark, 12~16 parts of frangrant ainsliaea herb, 10~13 parts of Radix Salviae Miltiorrhizae, 9~12 parts of pennywort,
9~12 parts of scarlet swertia herb, 7~10 parts of variegated leaf orchid, 7~10 parts of Rhizoma Chuanxiong, 5~8 parts of Herba Hyperici Patuli,
5~8 parts of common nandina branchlet, 4~7 parts of whorledleaf solomonseal rhizome, yellow grass spend 4~7 parts, 2~4 parts of Semen Herpetospermi.
3. a kind of medicine pill for primary biliary cirrhosis according to claim 1, which is characterized in that be made
The raw material of the effective ingredient forms and parts by weight are：
32 parts of Radix Astragali, 30 parts of rigescent hawksbeard root, 28 parts of corn stigma, 26 parts of rabdosia lophanthide,
22 parts of dogwood fruit, shoulder plate return 22 parts, 22 parts of nutgrass flatsedge, 22 parts of holly leaf,
20 parts of fiveleaf akebia root, 20 parts of lysimachia fortunei maxim, 16 parts of Radix Glycyrrhizae, 16 parts of Semen sesami nigrum,
15 parts of japanese white birch bark, 15 parts of frangrant ainsliaea herb, 12 parts of Radix Salviae Miltiorrhizae, 10 parts of pennywort,
10 parts of scarlet swertia herb, variegated leaf are 8 parts blue, 8 parts of Rhizoma Chuanxiong, 7 parts of Herba Hyperici Patuli,
7 parts of common nandina branchlet, 6 parts of whorledleaf solomonseal rhizome, yellow grass spend 6 parts, 3 parts of Semen Herpetospermi.
4. the preparation method of a kind of medicine pill for primary biliary cirrhosis, which is characterized in that including following technique
Step：
（1）By rigescent hawksbeard root, corn stigma, rabdosia lophanthide, dogwood fruit, shoulder plate return, nutgrass flatsedge, lysimachia fortunei maxim, Semen sesami nigrum, japanese white birch bark, Phnom Penh
Rabbit ear, pennywort, scarlet swertia herb, Herba Hyperici Patuli, common nandina branchlet, yellow grass flower, Semen Herpetospermi are put into after cleaning in container, add in 8-10
Times amount distilled water immersion 4-5 it is small when, heating boil 3-4 it is small when, extract immersion liquid；The 6-8 times of distilled water measured, heating are added in again
Boil 2-3 it is small when, extract immersion liquid；Finally add the 4-6 times of distilled water measured, heating boil 1-2 it is small when, extract immersion liquid；Merge
Immersion liquid three times, filtering, it is spare to obtain filtrate；
（2）Holly leaf, fiveleaf akebia root, variegated leaf orchid, whorledleaf solomonseal rhizome are cleaned and be put into container, the ethyl alcohol for adding in the concentration 80% of 4 times of amounts is molten
Liquid, when immersion 1-2 is small, when heating and refluxing extraction 3-4 is small, it is spare to obtain filtrate for filtering；
（3）By astragalus mongholicus tablet plus cooked honey and a little boiling water, mix thoroughly it is slightly bored, put fried in pot to yellow and it is tack-free when, take out
It dries in the air cool, crushing is ground, and is crossed 140 mesh dusting covers, is obtained fine powder, spare；
（4）Net licorice tablet is taken, adds in cooked honey and a little boiling water, it is slightly bored after mixing thoroughly, it puts in frying container, is fried with slow fire depth
Yellow is taken out when tack-free, cools, and crushing is ground, and crosses 140 mesh dusting covers, obtains fine powder, spare；
（5）Danshen Tablets are taken, yellow rice wine is added to mix thoroughly, bored profit is put in pot, fried with slow boiling to saturating, and taking-up cools, and crushing is ground, and crosses 140 mesh
Dusting cover obtains fine powder, spare；
（6）Take the sprinkling of Rhizoma Chuanxiong piece yellow rice wine uniform, slightly bored, it is degree to put stir-fry to micro- coke in pot, and taking-up cools, and crushing is ground, and crosses 140
Mesh dusting cover obtains fine powder, spare；
（7）By step（1）, step（2）The filtrate of gained, with step（3）, step（4）, step（5）, step（6）Middle gained
Fine powder mixes, and after addition refined honey stirs evenly, is prepared as the pill of every 3g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810041794.4A CN108042732A (en) | 2018-01-17 | 2018-01-17 | A kind of medicine pill and preparation method for primary biliary cirrhosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810041794.4A CN108042732A (en) | 2018-01-17 | 2018-01-17 | A kind of medicine pill and preparation method for primary biliary cirrhosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108042732A true CN108042732A (en) | 2018-05-18 |
Family
ID=62127610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810041794.4A Pending CN108042732A (en) | 2018-01-17 | 2018-01-17 | A kind of medicine pill and preparation method for primary biliary cirrhosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108042732A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239618A (en) * | 2012-02-13 | 2013-08-14 | 北京亚东生物制药有限公司 | Traditional Chinese medicine composition for treating chronic hepatitis and cirrhosis and preparation method thereof |
| CN103356956A (en) * | 2013-06-27 | 2013-10-23 | 毛德文 | Traditional Chinese medicine composition for treating autoimmune liver disease and preparation method thereof |
| CN106668696A (en) * | 2017-03-10 | 2017-05-17 | 江志杰 | Traditional Chinese medicine preparation for treating primary biliary cirrhosis |
-
2018
- 2018-01-17 CN CN201810041794.4A patent/CN108042732A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239618A (en) * | 2012-02-13 | 2013-08-14 | 北京亚东生物制药有限公司 | Traditional Chinese medicine composition for treating chronic hepatitis and cirrhosis and preparation method thereof |
| CN103356956A (en) * | 2013-06-27 | 2013-10-23 | 毛德文 | Traditional Chinese medicine composition for treating autoimmune liver disease and preparation method thereof |
| CN106668696A (en) * | 2017-03-10 | 2017-05-17 | 江志杰 | Traditional Chinese medicine preparation for treating primary biliary cirrhosis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103520572B (en) | A kind of Chinese medicine composition being used for the treatment of atopic dermatitis and preparation method thereof | |
| CN104666579A (en) | Traditional Chinese medicine composition for treating gonarthromeningitis and preparation method of traditional Chinese medicine composition | |
| CN104324125B (en) | Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method thereof | |
| CN103933498A (en) | Drug for treatment of chronic atrophic gastritis and preparation method thereof | |
| CN103520655A (en) | Traditional Chinese medicine composition for treating psoriasis vulgaris and preparation method thereof | |
| CN107596197A (en) | A kind of strongly fragrant tea of tonifying Qi solution and preparation method thereof | |
| CN101164600A (en) | Medicine for treating acne and whelk | |
| CN103495072B (en) | Traditional Chinese medicine composition treating bronchiectasia disease and preparation method thereof | |
| CN110302332A (en) | A kind of Chinese medicine composition and preparation method thereof for treating intestinal cancer | |
| CN105233188A (en) | Traditional Chinese medicine composition for treating liver cancer and application of traditional Chinese medicine composition | |
| CN105125792A (en) | Traditional Chinese medicinal decoction for treating female mastitis and preparation method of decoction | |
| CN104043058A (en) | Traditional Chinese medicinal preparation for treating kidney deficiency type lumbar disc herniation and preparation method thereof | |
| CN103893603B (en) | The medicine of a kind of therapeutic radiation rectitis and preparation method | |
| CN103212026B (en) | A kind of Chinese medicine for the treatment of cholelithiasis and preparation method thereof and instructions of taking | |
| CN106038995A (en) | Traditional Chinese medicine granules for treating perioral dermatitis and preparation method | |
| CN108042732A (en) | A kind of medicine pill and preparation method for primary biliary cirrhosis | |
| CN104666475A (en) | Coptis chinensis and donkey-hide gelatin composition for treating sicca syndrome and application of coptis chinensis and donkey-hide gelatin composition | |
| CN104623304A (en) | Lotion for treating chronic skin ulcer caused by damp-heat and toxicity accumulation and preparation method of lotion | |
| CN103860948A (en) | Traditional Chinese medicine for treating acute mastitis caused by qi stagnation and heat congestion and preparation method thereof | |
| CN103800890B (en) | A kind of medicine and preparation method for the treatment of menoxenia | |
| CN103520644B (en) | Traditional Chinese medicine composition used for treating phlegm stagnation type hyperlipidaemia and preparation method of composition | |
| CN107854662A (en) | A kind of Chinese medicine preparation for treating cirrhotic ascites and preparation method thereof | |
| CN105726823A (en) | Chinese herbal preparation for treating allergic rhinitis and preparation method of Chinese herbal preparation | |
| CN104740403A (en) | Medicine for treating blood-insufficiency and yin-deficiency recurrent oral ulceration and preparation method thereof | |
| CN107812087A (en) | It is a kind of to treat Chinese medicine composition increased under band and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180518 |