CN103239580B - Chinese medicine external application preparation for treating radioactive skin damage - Google Patents
Chinese medicine external application preparation for treating radioactive skin damage Download PDFInfo
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- CN103239580B CN103239580B CN201310171397.6A CN201310171397A CN103239580B CN 103239580 B CN103239580 B CN 103239580B CN 201310171397 A CN201310171397 A CN 201310171397A CN 103239580 B CN103239580 B CN 103239580B
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Abstract
The invention discloses a Chinese medicine external application preparation for treating radioactive skin damage. The radioactive skin damage belongs to the category of 'burn' in the traditional Chinese medicine, is caused by excessive heat toxicity, impairment of yin owning to heat evil and blood heat accumulation and shows on skin, such as erythema, stagnation of qi and blood and burning pain owning to blocking of channels. Therefore, Chinese medicines such as stellaria media, haloragis micrantha, field cowpea root, souliea vaginata, rubiaceae randia depauperata, scutellaria baicalensis, brucea javanica, red peony root, loosestrife, tree falsespiraea bark, humifuse euphorbia herb, pinellia cordata and rhaphiolepis indica are selected in the Chinese medicine external application preparation disclosed by the invention and are prepared into an external smearing preparation by a drug manufacturing room of a hospital (described in the specification), and clinical tests show that the total effective rate is 94.7% and a better curative effect is achieved.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of external application of Chinese medicine preparation for the treatment of radioactive skin injury.
background technology
Radiotherapy is one of primary treatment means of malignant tumor.In Patients During Radiotherapy, be subject to the normal skin according to position to be easy to cause radiation injury, main manifestations for radiation wild in rubescent, the dryness desquamation of local skin, then occur oozing out, vesicle and the different epithelium of degree peel off very ulcer, patient all feels obvious causalgia.Radiation skin injury, it is radiocurable common complication, according to statistics, tumor radiotherapy patient skin the rate of injury is 91.4%, the incidence rate that is seriously forced to therapy discontinued because damaging is 58.1%, and to acute skin, effectively prevention and treatment are carried out in reaction, can reduce patient's misery, can guarantee the seriality for the treatment of, and then increase radiotherapeutic effect.
summary of the invention
The external application of Chinese medicine preparation that the object of this invention is to provide a kind for the treatment of radioactive skin injury.Radiation skin injury, belongs to Chinese medicine " burn " category, and radiation skin injury is because pyretic toxicity is crossed Sheng, and fire-toxin is strongly fragrant in skin, and intenseness of heat meat is rotten, thereby produces desquamation ulcer; YIN damaged by pathogenic heat, strongly fragrant and see desquamation, pruritus due to heat in pyretic toxicity; Thermal man's nutrient blood, heat mixing with blood, in skin, there is erythema in outgoing; Blood loses and to make moist, coagulation of QI-blood, and meridians block and cause causalgia.
The object of the invention is to be achieved through the following technical solutions, the external application of Chinese medicine preparation of this treating radioactive skin injury is made by the Chinese medicine of following weight portion: Herba malachii aquatici 5-15 part, Herba Haloragidis Micranthae 1-15 part, Radix Vignae yunnanensis 10-13 part, Rhizoma soulieae vaginatae 3-10 part, Cortex berberidis dasystachyae 8-14 part, Radix Scutellariae 7-15 part, Fructus Bruceae 8-20 part, Radix Paeoniae Rubra 10-12 part, Herba Lythri Salicariae 9-20 part, Cortex Sorbariae Arboreae 6-15 part, Herba Euphorbiae Humifusae 10-25 part, Rhizoma pinelliae cordatae 3-10 part, Ramulus et Folium Raphiolepis indicae 5-35 part.
Preferably, 10 parts of Herba malachii aquaticis, 8 parts of Herba Haloragidis Micranthae, 11 parts of Radix Vignae yunnanensis, 7 parts of Rhizoma soulieae vaginataes, 12 parts of Cortex berberidis dasystachyaes, 11 parts of Radix Scutellariaes, 14 parts of Fructus Bruceaes, 11 parts of Radix Paeoniae Rubra, 15 parts of Herba Lythri Salicariae, 11 parts of Cortex Sorbariae Arboreaes, 17 parts of Herba Euphorbiae Humifusaes, 6 parts of Rhizoma pinelliae cordatae, 17 parts of Ramulus et Folium Raphiolepis indicaes.
Preparation method, by above-mentioned Chinese medicine, is placed in medicine pot, adds clear water appropriate, is fried open 30min after soaking 2h, dense decocting to 100mL, after filtration, standby after embedding, sterilizing.
In side: Herba malachii aquatici, Herba Haloragidis Micranthae, Radix Vignae yunnanensis heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Rhizoma soulieae vaginatae, Radix Scutellariae, Cortex berberidis dasystachyae, Fructus Bruceae heat clearing and damp drying, eliminating fire and detoxication, anti-inflammation, cooling blood for hemostasis; Radix Paeoniae Rubra, Herba Lythri Salicariae clearing away heat and cooling blood, eliminating stasis to stop pain; Cortex Sorbariae Arboreae, Herba Euphorbiae Humifusae promoting blood circulation to remove blood stasis, removing toxic substances and promoting subsidence of swelling; Rhizoma pinelliae cordatae, Ramulus et Folium Raphiolepis indicae pain relieving clots absorbing, antiinflammatory removing the necrotic tissue.
Clinical data
1, all patients of physical data are in December, 2008-2009 year June in the court or outer court's row radiotherapy, and after radiotherapy, occur the patient of acute II degree, III degree dermoreaction, include case totally 132 examples in, male 85 examples, female's 47 examples; Age 35-75 year, breast carcinoma 40 examples, tumor of head and neck 69 examples, other 23 examples; Skin injury degree: II degree 72 examples, III degree 60 examples.
2, the variation of pain degree after observation index and method 24h; The variation of skin lesion size; Moist sepage dwell time; The edema extinction time.Pain degree adopts VAS (0～100mm) the patient point system of testing oneself; Standards of grading are by International Union Against Cancer (UICC) acute radiation reaction standards of grading evaluation radiation skin injury degree.0 degree is for unchanged; I degree is that vesicle forms, slight erythema, and depilation, dryness skin lesion, perspires and reduces; II degree is obvious erythema, the moist skin lesion of speckle shape, neutral edema; III degree is the moist skin lesion of amalgamation, pitting edema; IV degree is necrosis, ulcer, hemorrhage.
3, criterion of therapeutical effect is formulated with reference to relevant in 1997 < < new Chinese medicine guideline of clinical investigations > > " guideline of clinical investigations of new Chinese medicine treatment burn and scald ".Clinical recovery: the healing of skin ulcer face, General Symptoms disappears; Effective: the healing of the total skin ulcer face of II degree is more than 90%, or the healing of III degree skin ulcer face is more than 50%, and General Symptoms disappears; Effective: the healing of the total skin ulcer face of II degree is more than 50%, or the healing of III degree skin ulcer face is more than 30%, and General Symptoms disappears; Invalid: do not reach above-mentioned standard, skin ulcer face does not infect not to be controlled.
4, first local skin lesion is processed during this group of Therapeutic Method patient treatment, with aseptic 0.9% sodium chloride solution, cleaned wound surface, affected part sepage, decortication, slough are cleaned, then embrocate external application of Chinese medicine preparation, 3～5 times/d every 2 weeks is 1 course for the treatment of.
5, therapeutic outcome (1) in various degree skin injury patient clinical efficacy analysis (example) in Table 1.
Table 1 is skin injury patient clinical efficacy analysis (example) in various degree
Clinical recovery 55 examples after treatment, effective 43 examples, effective 27 examples, invalid 7 examples, effective percentage 94.7%.
(2) the moist sepage dwell time of skin injury patient, edema extinction time compare in Table 2 in various degree.
Table 2 is the moist sepage dwell time of skin injury patient, edema extinction time comparison (x ± s, d) in various degree
Average (2.14 ± 1.39) d of moist sepage dwell time, edema extinction time average (3.16 ± 1.35) d, refers to table 2.Pain index comparison, the front average pain index 82.13 ± 10.34 for the treatment of, after 24h, average pain index 20.42 ± 8.14, compares t=52.62, P=0.000 before and after treatment.
The specific embodiment
Embodiment mono-: take Herba malachii aquatici 10g, Herba Haloragidis Micranthae 8g, Radix Vignae yunnanensis 11g, Rhizoma soulieae vaginatae 7g, Cortex berberidis dasystachyae 12g, Radix Scutellariae 11g, Fructus Bruceae 14g, Radix Paeoniae Rubra 11g, Herba Lythri Salicariae 15g, Cortex Sorbariae Arboreae 11g, Herba Euphorbiae Humifusae 17g, Rhizoma pinelliae cordatae 6g, Ramulus et Folium Raphiolepis indicae 20g, by above-mentioned Chinese medicine, be placed in medicine pot, add clear water appropriate, after soaking 2h, be fried open 30min, dense decocting to 100mL, after filtration, standby after embedding, sterilizing.
Embodiment bis-: take Herba malachii aquatici 5g, Herba Haloragidis Micranthae 15g, Radix Vignae yunnanensis 10g, Rhizoma soulieae vaginatae 3g, Cortex berberidis dasystachyae 14g, Radix Scutellariae 7g, Fructus Bruceae 8g, Radix Paeoniae Rubra 12g, Herba Lythri Salicariae 20g, Cortex Sorbariae Arboreae 6g, Herba Euphorbiae Humifusae 10g, Rhizoma pinelliae cordatae 3g, Ramulus et Folium Raphiolepis indicae 35g, preparation method is with embodiment mono-.
Embodiment tri-: take Herba malachii aquatici 15g, Herba Haloragidis Micranthae 1g, Radix Vignae yunnanensis 13g, Rhizoma soulieae vaginatae 10g, Cortex berberidis dasystachyae 8g, Radix Scutellariae 15g, Fructus Bruceae 20g, Radix Paeoniae Rubra 10g, Herba Lythri Salicariae 9g, Cortex Sorbariae Arboreae 15g, Herba Euphorbiae Humifusae 25g, Rhizoma pinelliae cordatae 10g, Ramulus et Folium Raphiolepis indicae 5g, preparation method is with embodiment mono-.
Claims (2)
1. an external application of Chinese medicine preparation for treating radioactive skin injury, is characterized in that this external application of Chinese medicine preparation made by the Chinese medicine of following weight portion: Herba malachii aquatici 5-15 part, Herba Haloragidis Micranthae 1-15 part, Radix Vignae yunnanensis 10-13 part, Rhizoma soulieae vaginatae 3-10 part, Cortex berberidis dasystachyae 8-14 part, Radix Scutellariae 7-15 part, Fructus Bruceae 8-20 part, Radix Paeoniae Rubra 10-12 part, Herba Lythri Salicariae 9-20 part, Cortex Sorbariae Arboreae 6-15 part, Herba Euphorbiae Humifusae 10-25 part, Rhizoma pinelliae cordatae 3-10 part, Ramulus et Folium Raphiolepis indicae 5-35 part.
2. the external application of Chinese medicine preparation of a kind for the treatment of radioactive skin injury according to claim 1, is characterized in that this external application of Chinese medicine preparation made by the Chinese medicine of following weight portion: 10 parts of Herba malachii aquaticis, 8 parts of Herba Haloragidis Micranthae, 11 parts of Radix Vignae yunnanensis, 7 parts of Rhizoma soulieae vaginataes, 12 parts of Cortex berberidis dasystachyaes, 11 parts of Radix Scutellariaes, 14 parts of Fructus Bruceaes, 11 parts of Radix Paeoniae Rubra, 15 parts of Herba Lythri Salicariae, 11 parts of Cortex Sorbariae Arboreaes, 17 parts of Herba Euphorbiae Humifusaes, 6 parts of Rhizoma pinelliae cordatae, 17 parts of Ramulus et Folium Raphiolepis indicaes.
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103877386B (en) * | 2014-04-10 | 2018-04-27 | 李贵新 | It is a kind of to dress agent and preparation method thereof for skin reactions |
| CN103877387A (en) * | 2014-04-10 | 2014-06-25 | 陈玉 | Nursing medicine for skin injury after radiotherapy |
| CN103920029B (en) * | 2014-04-10 | 2016-05-11 | 威海市妇女儿童医院 | A kind of pharmaceutical composition that prevents dermoreaction after radiotherapy |
| CN105031709B (en) * | 2015-08-28 | 2017-12-15 | 重庆医科大学附属永川医院 | A kind of preparation method of medical use hydrocolloid dressing |
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Non-Patent Citations (3)
| Title |
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| 放射性皮炎的治疗护理进展;邱圣红;《临床医学工程》;20120131;第19卷(第1期);第149-150页 * |
| 胡艳,等.金虎膏预防放射性皮肤损伤的病理学机制探讨.《时珍国医国药》.2012,第23卷(第1期),第252-253页. * |
| 邱圣红.放射性皮炎的治疗护理进展.《临床医学工程》.2012,第19卷(第1期),第149-150页. |
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