CN103235015A - Dry chemical test strip for quantitatively testing uric acid - Google Patents
Dry chemical test strip for quantitatively testing uric acid Download PDFInfo
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- CN103235015A CN103235015A CN2012104078843A CN201210407884A CN103235015A CN 103235015 A CN103235015 A CN 103235015A CN 2012104078843 A CN2012104078843 A CN 2012104078843A CN 201210407884 A CN201210407884 A CN 201210407884A CN 103235015 A CN103235015 A CN 103235015A
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- uric acid
- electrode
- enzyme layer
- dielectric base
- test strip
- Prior art date
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- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 title claims abstract description 28
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 229940116269 uric acid Drugs 0.000 title claims abstract description 28
- 238000012360 testing method Methods 0.000 title claims abstract description 18
- 238000007705 chemical test Methods 0.000 title abstract 3
- 108090000790 Enzymes Proteins 0.000 claims abstract description 12
- 102000004190 Enzymes Human genes 0.000 claims abstract description 12
- 238000006243 chemical reaction Methods 0.000 claims abstract description 11
- 238000007650 screen-printing Methods 0.000 claims abstract description 5
- 239000002002 slurry Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 9
- 229910052799 carbon Inorganic materials 0.000 claims description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- 229960005070 ascorbic acid Drugs 0.000 claims description 8
- 235000010323 ascorbic acid Nutrition 0.000 claims description 8
- 239000011668 ascorbic acid Substances 0.000 claims description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- 108090000854 Oxidoreductases Proteins 0.000 claims description 4
- 102000004316 Oxidoreductases Human genes 0.000 claims description 4
- 239000002390 adhesive tape Substances 0.000 claims description 4
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical class [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 claims description 4
- -1 polyethylene terephthalate Polymers 0.000 claims description 4
- 238000012113 quantitative test Methods 0.000 claims description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 238000007639 printing Methods 0.000 claims description 3
- 229910052709 silver Inorganic materials 0.000 claims description 3
- 239000004332 silver Substances 0.000 claims description 3
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 claims description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 2
- GPRSOIDYHMXAGW-UHFFFAOYSA-N cyclopenta-1,3-diene cyclopentanecarboxylic acid iron Chemical compound [CH-]1[CH-][CH-][C-]([CH-]1)C(=O)O.[CH-]1C=CC=C1.[Fe] GPRSOIDYHMXAGW-UHFFFAOYSA-N 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 229960000907 methylthioninium chloride Drugs 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 229920000515 polycarbonate Polymers 0.000 claims description 2
- 239000004417 polycarbonate Substances 0.000 claims description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 2
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 2
- 239000004800 polyvinyl chloride Substances 0.000 claims description 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 2
- KUCOHFSKRZZVRO-UHFFFAOYSA-N terephthalaldehyde Chemical compound O=CC1=CC=C(C=O)C=C1 KUCOHFSKRZZVRO-UHFFFAOYSA-N 0.000 claims description 2
- 229940088598 enzyme Drugs 0.000 abstract description 9
- 230000003647 oxidation Effects 0.000 abstract description 4
- 238000007254 oxidation reaction Methods 0.000 abstract description 4
- 239000000758 substrate Substances 0.000 abstract description 4
- 108010092464 Urate Oxidase Proteins 0.000 abstract description 3
- 229940005267 urate oxidase Drugs 0.000 abstract description 3
- 238000001514 detection method Methods 0.000 abstract description 2
- 238000005516 engineering process Methods 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 abstract description 2
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 238000002848 electrochemical method Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 description 16
- 239000008280 blood Substances 0.000 description 16
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 6
- TYQCGQRIZGCHNB-JLAZNSOCSA-N l-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000008114 Uric Acid Assay Methods 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000004737 colorimetric analysis Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- KYMNSBSWJPFUJH-UHFFFAOYSA-N iron;5-methylcyclopenta-1,3-diene;methylcyclopentane Chemical compound [Fe].C[C-]1C=CC=C1.C[C-]1[CH-][CH-][CH-][CH-]1 KYMNSBSWJPFUJH-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 230000004144 purine metabolism Effects 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention belongs to the technical field of biosensing, and relates to a dry chemical test strip for quantitatively testing uric acid and a preparation method thereof. The dry chemical test strip for quantitatively testing uric acid comprises an insulating substrate, an electrode and an anti-interference enzyme layer which are printed on the insulating substrate by a screen printing technology, and a siphon reaction tank consisting of a double-sided adhesive, a hydrophilic membrane and the enzyme layer. The invention utilizes the electrochemical method to catalyze the oxidation of uric acid, and does not need the participation reaction of urate oxidase, thereby improving the detection accuracy, reducing the cost and measuring the content of uric acid in a short time.
Description
Technical field
The invention belongs to the biosensor technique field, relate to dry chemistry test paper slip of a kind of quantitative test uric acid and preparation method thereof.
Background technology
Uric acid is the final product of purine metabolism in the human body, does not have physiological function in human body.Under the normal condition, mainly by renal excretion.The content of uric acid be clinical in the amount of normal measurement.The serum uric acid assay is having important meaning aspect ventilation, ACVD, disease in heart failure, kidney trouble and the diabetes diagnosis, so the important index of the quantitative measurement of uric acid in the serum as clinical detection.In addition, blood uric acid measure also with leukaemia, coronary heart disease, etc. diagnosis and observation have certain meaning.As seen, the blood uric acid assay more and more be applied to clinical among, for clinical diagnosis with observe disease reliable foundation is provided, and to the clinical important role that played.
The measuring method of uric acid mainly is the micro photo electric tintmeter made from the photoelectric colorimetry principle in the blood, it is by the uric acid specific reaction in enzyme and the blood, linking chromogenic reaction again makes strip or reagent produce change color, inspect the change color of bar by anaclasis, according to the height of the depth reaction uric acid concentration of change color.Adopt the biochemical instruments of photoelectric colorimetry, owing to must adopt optical component, the cost of instrument is very high, reagent or strip need urate oxidase and hydrogen peroxidase, increased the cost of reagent, and reaction rate is affected by the external environment bigger, and the hydrogen peroxide of production easily and the substance reactions such as ascorbic acid in the blood influences the uric acid measurement precision.For example Chinese patent CN1456892A discloses a kind of whole blood uric acid concentration test strip, adopts photochemical method to carry out quantitatively, because the amount of utilizing urate oxidase oxidation uric acid to produce hydrogen peroxide is determined the content of uric acid.Because ascorbic acid reacts with hydrogen peroxide and chromogen substance easily in the blood, thereby influence the precision of uric acid measurement.、
Therefore the object of the present invention is to provide a kind of direct catalytic oxidation uric acid of redox material that utilizes, and utilize the method for ascorbic acid oxidase oxidation ascorbic acid eliminating interference to come the convenient dry chemistry test paper slip of quick and precisely measuring uric acid content in the blood, only need the blood of trace just can measure the content of uric acid in the blood at short notice with the coupling of miniature galvanochemistry biochemical instruments.
Summary of the invention
Technical matters to be solved by this invention provides a kind of dry chemistry test paper slip that can make things convenient for uric acid content in the fast detecting blood, and the present invention only needs the blood of trace just can measure the content of uric acid in the blood at short notice.
The dry chemistry test paper slip of quantitative test uric acid of the present invention comprises dielectric base, is printed on electrode and anti-interference enzyme layer on the dielectric base by screen printing technique, the siphon reaction tank that is made of double faced adhesive tape and hydrophilic film and enzyme layer.
Described dielectric base is characterized in that described material is Polyvinylchloride, poly-terephthaldehyde's ester, polycarbonate, polyethylene terephthalate.
Described electrode is made of a working electrode and a contrast electrode at least, by screen printing technique carbon slurry and silver slurry is printed on the dielectric base.
Described working electrode carbon slurry is characterized in that comprising 1-20 part of electron mediator by weight, organic solvent such as cyclohexane, cyclohexanone or acetone 10-20 part, carbon slurry 60-89 part.
Described electron mediator is ferrocene derivatives such as ferrocenecarboxylic acid, ferrocene methanol etc. or the potassium ferricyanide, methylene blue etc.
Described anti-interference enzyme layer is characterized in that every dry chemistry test paper slip contains the ascorbic acid oxidase of 1U-10U by printing or being coated on the electrode.
The method that test strips of the present invention and eliminating ascorbic acid disturb is not limited to the present invention, this method is except can be used for the present invention, can also be implemented in the dry chemistry test paper slip of measuring other blood parameters, as glucose, blood ketone, cholesterol, triglyceride etc.
Description of drawings
Fig. 1 is test strips structural representation of the present invention.
1. substrate 2 carbon slurry working electrode 3 silver medals are starched contrast electrode 4 enzyme layers 5 double faced adhesive tape 6 hydrophilic film
Fig. 2 measures the graph of a relation of uric acid dry chemistry test paper slip strength of current and uric acid concentration for the invention process.
Embodiment
Following examples are intended to illustrate the present invention rather than limitation of the invention further.
5g dimethyl ferrocene is dissolved in the cyclohexanone solution of 15g and is stirred to abundant dissolving, adding 80g carbon pulp grinder tool, to stir the 20min mixing standby.
Polyester film is cut into the substrate of 90X300cm in advance, puts into baking box after cleaning with secondary water at 60 ℃ of oven dry 15min, standby after cooling.
Deployed carbon slurry is printed 80 ℃ of oven dry 30min in 250 purpose half tones.
The Ag/AgCl slurry is printed 75 ℃ of oven dry 15min in 250 purpose half tones.
The enzyme slurry that 10g is contained the ascorbic acid oxidase of 2ku prints in 200 purpose water-based half tones, 45 ℃ of oven dry 15min.
Double faced adhesive tape (5) and hydrophilic film (6) are attached to the siphon reaction zone that enzyme slurry Printing Zone (4) constitutes, cut the test strips of the wide 6mm of growth 30mm.
Concentration is respectively 0.05,0.1,0.2,0.4,0.6 the whole blood of 0.8,1.0,1.2mmol/L enters test strips siphon reaction zone by siphon, utilize electrochemical workstation under the 0.3V condition, measure electric current and time relationship in the strength of current at 10s place, the result as shown in Figure 2.
Claims (6)
1. the dry chemistry test paper slip of a quantitative test uric acid comprises dielectric base, is printed on electrode and anti-interference enzyme layer on the dielectric base by screen printing technique, the siphon reaction tank that is made of double faced adhesive tape and hydrophilic film and enzyme layer.
2. dielectric base as claimed in claim 1 is characterized in that described material is Polyvinylchloride, poly-terephthaldehyde's ester, polycarbonate, polyethylene terephthalate.
3. electrode as claimed in claim 1 is made of a working electrode and a contrast electrode at least, by screen printing technique carbon slurry and silver slurry is printed on the dielectric base.
4. working electrode carbon slurry as claimed in claim 3 is characterized in that comprising 1-20 part of electron mediator by weight, organic solvent such as cyclohexane, cyclohexanone or acetone 10-20 part, carbon slurry 60-89 part.
5. electron mediator as claimed in claim 4 is ferrocene derivatives such as ferrocenecarboxylic acid, ferrocene methanol etc. or the potassium ferricyanide, methylene blue etc.
6. anti-interference enzyme layer as claimed in claim 1 is characterized in that every dry chemistry test paper slip contains the ascorbic acid oxidase of 1U-10U by printing or being coated on the electrode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104078843A CN103235015A (en) | 2012-10-24 | 2012-10-24 | Dry chemical test strip for quantitatively testing uric acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104078843A CN103235015A (en) | 2012-10-24 | 2012-10-24 | Dry chemical test strip for quantitatively testing uric acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103235015A true CN103235015A (en) | 2013-08-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012104078843A Pending CN103235015A (en) | 2012-10-24 | 2012-10-24 | Dry chemical test strip for quantitatively testing uric acid |
Country Status (1)
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104330448A (en) * | 2014-10-31 | 2015-02-04 | 桂林中辉科技发展有限公司 | High-sensitivity electrode type uric acid test paper and manufacturing method thereof |
| CN104777194A (en) * | 2015-04-21 | 2015-07-15 | 苏州市玮琪生物科技有限公司 | Anti-interference sensing electrode and microfluidics test paper runner flow velocity control method |
| CN105486734A (en) * | 2015-12-29 | 2016-04-13 | 东莞市青麦田数码科技有限公司 | Uric acid detecting device based on smartphone |
| CN105572199A (en) * | 2015-12-17 | 2016-05-11 | 三诺生物传感股份有限公司 | Working electrode biological reactant and electrode type test strip |
| CN106596535A (en) * | 2016-12-12 | 2017-04-26 | 中国科学院苏州生物医学工程技术研究所 | Blood uric acid detection test paper |
| CN108195833A (en) * | 2016-12-08 | 2018-06-22 | 苏州百源基因技术有限公司 | A kind of uric acid detection device |
| CN108303454A (en) * | 2018-02-23 | 2018-07-20 | 南京鱼跃软件技术有限公司 | A kind of uric acid electrochemical sensor |
| CN111189899A (en) * | 2020-01-10 | 2020-05-22 | 杭州联晟生物科技有限公司 | Test strip for detecting creatinine by electrochemical method and preparation method thereof |
| CN112858422A (en) * | 2019-11-12 | 2021-05-28 | 北京怡成生物电子技术股份有限公司 | Electrochemical uric acid test strip for removing interference of ascorbic acid and manufacturing and application thereof |
| CN114235925A (en) * | 2021-12-17 | 2022-03-25 | 南京晶捷生物科技有限公司 | Anti-interference electrochemical uric acid test paper and preparation method thereof |
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| CN102507670A (en) * | 2011-09-30 | 2012-06-20 | 长沙三诺生物传感技术股份有限公司 | Electrochemical uric acid test strip and manufacturing method thereof |
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| CN101246175A (en) * | 2007-02-14 | 2008-08-20 | 胡军 | Silk screen printing method for producing blood sugar test paper |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104330448A (en) * | 2014-10-31 | 2015-02-04 | 桂林中辉科技发展有限公司 | High-sensitivity electrode type uric acid test paper and manufacturing method thereof |
| CN104777194B (en) * | 2015-04-21 | 2017-10-27 | 苏州市玮琪生物科技有限公司 | Anti-interference sensing electrode and micro-fluidic test paper runner flow rate control method |
| CN104777194A (en) * | 2015-04-21 | 2015-07-15 | 苏州市玮琪生物科技有限公司 | Anti-interference sensing electrode and microfluidics test paper runner flow velocity control method |
| CN105572199A (en) * | 2015-12-17 | 2016-05-11 | 三诺生物传感股份有限公司 | Working electrode biological reactant and electrode type test strip |
| CN105486734A (en) * | 2015-12-29 | 2016-04-13 | 东莞市青麦田数码科技有限公司 | Uric acid detecting device based on smartphone |
| CN108195833A (en) * | 2016-12-08 | 2018-06-22 | 苏州百源基因技术有限公司 | A kind of uric acid detection device |
| CN106596535A (en) * | 2016-12-12 | 2017-04-26 | 中国科学院苏州生物医学工程技术研究所 | Blood uric acid detection test paper |
| CN106596535B (en) * | 2016-12-12 | 2019-06-25 | 中国科学院苏州生物医学工程技术研究所 | Blood uric acid Test paper |
| CN108303454A (en) * | 2018-02-23 | 2018-07-20 | 南京鱼跃软件技术有限公司 | A kind of uric acid electrochemical sensor |
| CN112858422A (en) * | 2019-11-12 | 2021-05-28 | 北京怡成生物电子技术股份有限公司 | Electrochemical uric acid test strip for removing interference of ascorbic acid and manufacturing and application thereof |
| CN112858422B (en) * | 2019-11-12 | 2022-12-20 | 北京怡成生物电子技术股份有限公司 | Electrochemical uric acid test strip for removing interference of ascorbic acid and manufacturing and application thereof |
| CN111189899A (en) * | 2020-01-10 | 2020-05-22 | 杭州联晟生物科技有限公司 | Test strip for detecting creatinine by electrochemical method and preparation method thereof |
| CN114235925A (en) * | 2021-12-17 | 2022-03-25 | 南京晶捷生物科技有限公司 | Anti-interference electrochemical uric acid test paper and preparation method thereof |
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Application publication date: 20130807 |