CN103211977B

CN103211977B - Traditional Chinese medicine preparation used for treating hyperthyroidism

Info

Publication number: CN103211977B
Application number: CN201310171399.5A
Authority: CN
Inventors: 于文霞; 苏献恩
Original assignee: Individual
Current assignee: Yu Wenxia
Priority date: 2013-03-22
Filing date: 2013-03-22
Publication date: 2014-10-22
Anticipated expiration: 2033-03-22
Also published as: CN103211977A

Abstract

The invention discloses a traditional Chinese medicine preparation used for treating hyperthyroidism. The hyperthyroidism belongs to the categories of goiter and palpitation in the traditional Chinese medicine science. Basic pathogenesis comprises stagnation of liver qi, fire transformation owning to depression, qi and fluid loss, phlegmostagnant blood stasis, overstrain and deficiency of qi and yin due to impairment spleen and qi consumption owning to liver fire. Thus, traditional Chinese medicines abrus herb, fiveleaf akebia fruit, persian veronica, selenitum, dried rehamnnia root, asparagus fern, ophiopogon latifolius, cortex albiziae, tree falsespiraea bark, cornu procaprae gutturosae, concha ostreae, airpotato yam rhizome and clausena lansium kernel are selected and prepared into an orally taken decoction by a medicine preparation room of a hospital (described in the specification), clinical test shows that the total effective rate is 97.2%, and indicators of each treatment group are respectively obviously improved.

Description

A kind of Chinese medicine preparation for the treatment of hyperthyroidism disease

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of hyperthyroidism disease.

Background technology

Hyperthyroidism is called for short hyperthyroidism, is a kind of common endocrinopathy.Bringing out with Nervous and Mental Factors relation of hyperthyroidism disease is the closest, and emotion is not relaxed, irritability stasis, and stagnation of liver-QI with deficiency of the spleen, or pathogenic fire derived from stagnation of liver-QI all can be condensed for disease.Order is prominent to be condensed in eye; The vigorous irascible temperament of liver-fire, irritability; Fire is contained and is consumed impairment of QI the moon; Perverse and unreasonable manner taste are the high Sheng of stomach-fire; To Be Protected from Heat for deficiency of heart-yin, cardiopalmus; Lower and kidney yin, later stage there will be the symptoms such as deficiency of kidney yin, it similarly is that fatal aggravation, case fatality rate occur suddenly on original hyperthyroid basis is high that hyperthyroidism is critically ill, the medicine of doctor trained in Western medicine conventional anti-hyperthyroidism disease in treatment is divided into Thiourea and imidazoles at present, the former is methylthiouracil, propylthiouracil, and the latter is thiamazole and carbimazole.Two class drug mains will stop the synthetic of thyroxin for the activation of inorganic iodine to resist peroxidase, reach therapeutical effect; Drug withdrawal is recurred again, cures the symptoms, not the disease.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of hyperthyroidism disease.Hyperthyroidism belongs to Chinese medicine goiter, goiter, cardiopalmus category.Basic pathogenesis is depression of liver-QI, strongly fragrant and fire-transformation, and cloth, the stagnant blood stasis of expectorant are lost in gas Tianjin; Overstrain impairing the spleen again, liver fire consuming qi and injuring yin and cause deficiency of both QI and YIN.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment hyperthyroidism disease is made up of the Chinese medicine of following weight portion: Herba Abri 5-40 part, Fructus Akebiae 3-15 part, Herba Hemipiliae Flabellatae 1-20 part, Selenitum 3-25 part, Radix Rehmanniae 10-15 part, Radix Asparagi 7-9 part, Radix Ophiopogonis Dracaenoidis 6-28 part, Cortex Albiziae 7-10 part, Cortex Sorbariae Arboreae 4-17 part, Cornu procaprae gutturosae 1-30 part, Concha Ostreae 8-10 part, Rhizoma Dioscoreae Bulbiferae 6-15 part, Semen clausenae lansii 2-10 part.

Preferably, 23 parts of Herba Abris, 9 parts of Fructus Akebiaes, 10 parts of Herba Hemipiliae Flabellataes, 18 parts of Selenitum, 13 parts of Radix Rehmanniae, 8 parts of Radix Asparagis, 17 parts of Radix Ophiopogonis Dracaenoidiss, 8 parts of Cortex Albiziaes, 11 parts of Cortex Sorbariae Arboreaes, 16 parts of Cornu procaprae gutturosaes, 9 parts of Concha Ostreaes, 12 parts of Rhizoma Dioscoreae Bulbiferaes, 6 parts of Semen clausenae lansiis.

Preparation method is made decoction by traditional preparation method decocting.

Fang Zhong: Herba Abri, Fructus Akebiae is soothing the liver dissipating blood stasis, regulate the flow of vital energy, promoting blood circulation and stopping pain, heat-clearing and toxic substances removing; Herba Hemipiliae Flabellatae, Selenitum, Radix Rehmanniae, Radix Asparagi nourishing YIN and moistening the lung, nourishing YIN to lower pathogenic fire, softening the hard mass antiinflammatory, clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Radix Ophiopogonis Dracaenoidis, Cortex Albiziae, Cortex Sorbariae Arboreae mind tranquilizing and the heart calming, relieving cough and resolving phlegm, the resolving depression of calming the nerves, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain; Cornu procaprae gutturosae, Concha Ostreae, Rhizoma Dioscoreae Bulbiferae, Semen clausenae lansii suppressing the hyperactive liver to relieve the wind syndrome YANG hyperactivity suppressing, expectorant, the eliminating stagnation of regulating the flow of vital energy.

Clinical data

1, physical data is originally organized the next self-institute hyperthyroidism outpatient service of 142 routine hyperthyroid patients and ward, and " guideline of clinical investigations of new Chinese medicine treatment hyperthyroidism " that all cases is all promulgated with reference to Ministry of Public Health, is divided into two groups at random, treatment group 72 examples, man, 20 examples, female's 52 examples; 18～60 years old age, average 35.6 years old; Onset person's 51 examples, recidivist's 21 examples after drug withdrawal; The course of disease 5 months～3.5 years, average course of disease 1.45 ± 1.25 years; 19 examples that severity Scaling is slight, moderate 40 examples, severe 8 examples, merge leukopenia person 5 examples.Matched group 70 examples, male 22 examples, female's 48 examples; 19～62 years old age, average 33.5 years old; Onset person's 49 examples, recidivist's 21 examples; The course of disease 6 months～4 years, average course of disease 1.85 ± 1.73 years; 14 examples that the state of an illness is slight, moderate 42 examples, severe 8 examples, merge leukopenia person 6 examples.Before two groups of treatments, all do not take Western medicine or more than inactive Western medicine first quarter moon.Two groups of no significant differences (P > 0.05) aspect sex, age, the course of disease, state of an illness weight and Related complication, tool comparability.

2, the selected 142 routine patients of diagnostic criteria all meet hyperthyroidism Western medicine diagnose standard, Syndrome Differentiation of Traditional Chinese Medicine standard and mild symptoms, in, heavy duty standard, and standard in the guideline of clinical investigations of hyperthyroidism " new Chinese medicine treatment " of makeing and issuing with reference to Ministry of Public Health is carried out.

3, Therapeutic Method treatment group is taken Chinese medicine preparation of the present invention, and 1 dose of every day, a point morning and evening takes for twice; Matched group is taken propranolol consumption 30-90mg/d, and two groups of homogeneous are a course for the treatment of in individual month.

4, the standard of formulating in criterion of therapeutical effect is promulgated with reference to Ministry of Public Health " guideline of clinical investigations of new Chinese medicine treatment hyperthyroidism ".Clinic control: transference cure, body weight increases, and pulse frequency is normal, and region thyreoidea trembles and vascular murmur disappears, and goiter is dwindled, and it is normal that every lab testing project is recovered; Effective: cardinal symptom disappears, body weight increases, pulse frequency normal, and region thyreoidea trembles and vascular murmur disappears, and goiter alleviates, serum T ₃, T ₄, FT ₃, FT ₄horizontal normal; Effective: symptom takes a turn for the better, and pulse frequency slows down, and goiter is dwindled, and vascular murmur alleviates, serum T ₃, T ₄, FT ₃, FT ₄horizontal normal; Invalid: symptom, sign, lab testing, be all not improved.

5, the rear curative effect of (1) two group for the treatment of of therapeutic outcome is relatively in table 1.

Curative effect comparison after table 1 liang group treatment

With relatively P < 0.05 of matched group

Two groups of comparisons, treatment group group clinic control, total effective rate, apparently higher than matched group, have statistical significance (P < 0.05).

Before and after (2) two groups of treatments, the variation of heart rate and body weight is relatively in table 2.

The variation comparison of heart rate and body weight before and after table 2 liang group treatment

With the front relatively P < 0.05 for the treatment of; With relatively P < 0.05. of matched group.

As can be seen from Table 2, more all see that decreased heart rate, body weight increase before and after two groups of treatments, hyperthyroidism exponential integral obviously declines, and statistical procedures difference has significance (P < 0.05); Between treatment group and matched group, compare heart rate, body weight change difference, without significance (P < 0.05); Treatment group hyperthyroidism exponential integral declines obvious compared with matched group, and between two groups, difference has significance (P < 0.05); Show that the clinical symptoms such as treatment group patient hypermetabolism syndrome, thyromegaly and body weight obviously improve, have good clinical efficacy.

Serum T before and after (3) two groups of treatments ₃, T ₄, FT ₃, FT ₄, TSH variation relatively in table 3.

Serum T before and after table 3 liang group treatment ₃, T ₄, FT ₃, FT ₄, TSH variation comparison

With the front relatively P < 0.05 for the treatment of, with relatively P < 0.05 of matched group

As can be seen from Table 3, T after treatment group treatment ₃, T ₄, FT ₃, FT ₄, be all decreased significantly, statistical procedures difference has significance (P < 0.05), and fall is all obviously better than matched group (P < 0.05), TSH obviously rises, with treatment before relatively have significant difference (P < 0.05), rise and seem to be also better than matched group, but statistical procedures no significant difference (P < 0.05); The flat high content that can reduce thyroxin in patient body of prompting, thus feedback improves the TSH level of pituitary, shows that treatment group also has good curative effect.

Detailed description of the invention

Embodiment mono-: take Herba Abri 23g, Fructus Akebiae 9g, Herba Hemipiliae Flabellatae 10g, Selenitum 18g, Radix Rehmanniae 13g, Radix Asparagi 8g, Radix Ophiopogonis Dracaenoidis 17g, Cortex Albiziae 8g, Cortex Sorbariae Arboreae 11g, Cornu procaprae gutturosae 17g, Concha Ostreae 9g, Rhizoma Dioscoreae Bulbiferae 12g, Semen clausenae lansii 6g.Make decoction by traditional preparation method decocting.

Embodiment bis-: take Herba Abri 40g, Fructus Akebiae 3g, Herba Hemipiliae Flabellatae 20g, Selenitum 3g, Radix Rehmanniae 10g, Radix Asparagi 7g, Radix Ophiopogonis Dracaenoidis 28, Cortex Albiziae 10g, Cortex Sorbariae Arboreae 4g, Cornu procaprae gutturosae 5g, Concha Ostreae 10g, Rhizoma Dioscoreae Bulbiferae 6g, Semen clausenae lansii 2g.Make decoction by traditional preparation method decocting.

Embodiment tri-: take Herba Abri 5g, Fructus Akebiae 15g, Herba Hemipiliae Flabellatae 1g, Selenitum 25g, Radix Rehmanniae 15g, Radix Asparagi 9g, Radix Ophiopogonis Dracaenoidis 6g, Cortex Albiziae 7g, Cortex Sorbariae Arboreae 17g, Cornu procaprae gutturosae 30g, Concha Ostreae 8g, Rhizoma Dioscoreae Bulbiferae 15g, Semen clausenae lansii 10g.Make decoction by traditional preparation method decocting.

Claims

1. treat a Chinese medicine preparation for hyperthyroidism disease, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: 23 parts of Herba Abris, 9 parts of Fructus Akebiaes, 10 parts of Herba Hemipiliae Flabellataes, 18 parts of Selenitum, 13 parts of Radix Rehmanniae, 8 parts of Radix Asparagis, 17 parts of Radix Ophiopogonis Dracaenoidiss, 8 parts of Cortex Albiziaes, 11 parts of Cortex Sorbariae Arboreaes, 16 parts of Cornu procaprae gutturosaes, 9 parts of Concha Ostreaes, 12 parts of Rhizoma Dioscoreae Bulbiferaes, 6 parts of Semen clausenae lansiis.