CN103211100A - Feed additive for improving immunoglobulin content in sow colostrum - Google Patents
Feed additive for improving immunoglobulin content in sow colostrum Download PDFInfo
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- CN103211100A CN103211100A CN2013101459049A CN201310145904A CN103211100A CN 103211100 A CN103211100 A CN 103211100A CN 2013101459049 A CN2013101459049 A CN 2013101459049A CN 201310145904 A CN201310145904 A CN 201310145904A CN 103211100 A CN103211100 A CN 103211100A
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Abstract
The invention provides a feed additive for improving the immunoglobulin content in sow colostrum. The feed additive comprises the following ingredients by weight percent: 16.7-32.3% of calcium chloride, 3.3-17.7% of ammonium chloride, 16.7-33.3% of citric acid, 0.7-2% of magnesium sulfate, 0.1-0.3% of ligustrum lucidum polysaccharide, 0.3-0.7% of saccharin sodium salt, 1.0-2.0% of powdered rice hull, and 11.7-61.2% of zeolite powder. The additive can improve the immunoglobulin content in the serum of a sow in latter half of gestation and the immunoglobulin content in post-partum colostrum to further improve the immunity of a piglet in suckling period and weaning period and reduce piglet diarrhea.
Description
Technical field
The invention belongs to agriculture herding application, be specifically related to a kind of feed addictive that improves immunoglobulin content in the sow colostrum.
Background technology
At present, every sow average year of China provides 15 of number pigs weaned average out to, far below the average level of developed country more than 20.The many advanced pig farm of Europe, Canada and the U.S. can reach every sow provides 30 weanling pigs every year.China pig farm sow year productivity is low, and is except serious with sow breeding difficulty disease, outside the strong son of birth is few, also low in close relations with the suckling pig survival rate.In recent years, virus diarrhea takes place with interior piglet in China's many pig farms 10 ages in days, and the morbidity scope spreads all over the whole nation, longer duration, and outbreak repeatedly, incidence of disease height, the death rate is also higher.A lot of for this reason people control with medicine, but produce little effect.Under this background, the relevant expert points out: reduce the diarrhoea of piglet in 10 days, improve the suckling pig survival rate, except the health in delivery room, temperature and humidity, must pay close attention to sow, pay close attention to milk, pay close attention to disease-resistant nutritive and maternal antibody in the sow milk.
Lack immunoglobulin (Ig) in the blood during newborn piglet birth, must could obtain passive immunity by sucking colostrum after the birth, thereby resist the invasion and attack of pathogen.Therefore we can say that colostrum is the material base of piglet life.That summarizes says that colostrum has the function of three aspects to newborn piglet: one provides the nutritional substance of energy and biosynthesis precursor; Two provide special and non-specific immunoprotection defense function; The 3rd, pass on source of parents neural and endocrine conditioning signal.The piglet life be it is essential maternal antibody, i.e. first Ruzhong immunoglobulin content.
Sow gestation later stage daily ration nutrient and active component affect immunoglobulin content in the sow colostrum.This seminar is through exploring for many years, through various composite tests, find by immunomodulator first and reconcile sow cylinder electrolyte or ionic equilibrium simultaneously, guarantee the metabolic normal operation of sow body cell before childbirth, thereby strengthen the immunity and the anti-stress ability of body, can improve the immunoglobulin content in the sow colostrum, improve the resistance against diseases of piglet, effect is remarkable.
Summary of the invention
Based on above weak point, the present invention is to provide a kind of feed addictive that improves immunoglobulin content in the sow colostrum, this additive can improve in the sow gestation later stage serum immunoglobulin content and divide immunoglobulin content in the puerperium colostrum, and then improve lactation and weaning period pigling immunity, reduce grice diarrhoea.
The present invention adopts following technology: a kind of feed addictive that improves immunoglobulin content in the sow colostrum, weight percentage is as follows: calcium chloride 16.7%-32.3%, ammonium chloride 3.3%-17.7%, citric acid 16.7%-33.3%, magnesium sulfate 0.7%-2%, Fructus Ligustri Lucidi polysaccharide 0.1%-0.3%, saccharin sodium 0.3%-0.7%, powdered rice hulls 1.0%-2.0% and zeolite powder 11.7%-61.2%.
The present invention also has following feature:
1, aforesaid a kind of preparation method who improves the feed addictive of immunoglobulin content in the sow colostrum is as follows:
(1) calcium chloride, ammonium chloride, citric acid, magnesium sulfate, Fructus Ligustri Lucidi polysaccharide, saccharin sodium are ground into 60 purpose particles;
(2) zeolite powder and powdered rice hulls are ground into 40 purpose particles;
(3) with the above-mentioned raw materials composition in the ratio weighing in the prescription, be put into mixture homogeneity then smaller or equal to stirring in 5% the stainless steel mixer 5-10 minute, by quantitative package finished product.
2, aforesaid a kind of application that improves the feed addictive of immunoglobulin content in the sow colostrum to childbirth period, is added this feed addictive of weight percentage 3% sow gestation the 95th day in perfect compound feed.
Product of the present invention can make that immunoglobulin G content improves 15.93%-32.05% in 107 days serum of sow gestation, immunoglobulin A content improves 28.57%-64.29%, immunoglobulin M content improves immunoglobulin G content raising 19.95%-36.34% in 25.93%-92.59% and the childbirth sow serum on the same day, immunoglobulin A content improves 38.10%-76.19%, and immunoglobulin M content improves 34.48%-96.55%.Make immunoglobulin G content raising 26.27%-36.04% in the branch puerperium colostrum, immunoglobulin A content improves 21.43%-60.71%, and immunoglobulin M content improves 29.41%-44.12%.And then the raising pigling immunity, make piglet lactation (0-25d) diarrhoea incidence reduce 49.85%-74.85%, make weaned piglet phase (wean back 0-15 days) diarrhea rate reduce 49.49%-64.33%.
The specific embodiment
Embodiment 1
A kind of feed addictive that improves immunoglobulin content in the sow colostrum adds 3% in latter half of gestation (95 days-childbirth of gestation) Sow Diet, it is by following formulated.Each component and percentage by weight are:
Calcium chloride 16.7%, ammonium chloride 3.3%, citric acid 16.7%, magnesium sulfate 0.7%, Fructus Ligustri Lucidi polysaccharide 0.1%, saccharin sodium 0.3%, powdered rice hulls 1%, zeolite powder 61.2%.Calcium chloride, ammonium chloride, citric acid, magnesium sulfate, Fructus Ligustri Lucidi polysaccharide, saccharin sodium are ground into 60 purpose particles; Zeolite powder and powdered rice hulls are ground into 40 purpose particles; The above-mentioned raw materials composition in the ratio weighing in the prescription, is put into mixture homogeneity then smaller or equal to stirring in 5% the stainless steel mixer 5-10 minute, by quantitative package finished product.
The sow material is with reference to U.S. NRC (1998) sow heavy in pig and sow in lactation nutritional need, the swine rearing standard of the Ministry of Agriculture 2004 promulgation and " Chinese feed ingredient and nutritive value table (2009 the 20th edition) " are prepared, control group is pressed the widely used corn-dregs of beans in present pig farm-wheat bran type in-pig diet recipe (%): corn 65.84, dregs of beans 13.3, wheat bran 18.0, calcium monohydrogen phosphate 1.05, stone flour 1.08, salt 0.4, Choline Chloride (50%) 0.1, microelement pre-mix material 0.2%, vitamin premix 0.03% adds up to 100.0%.
Test group substitutes in the control group diet 0.92% stone flour (equivalent substitution calcium amount) and 2.08% corn with a kind of feed addictive that improves immunoglobulin content in the sow colostrum 3% of the present invention.Finish from the sow gestation childbirth (about 114 days) that began to feed in 95 days.
Sow serum testing result (seeing Table 1) shows, in in-pig later stage feed, add 3% feedstuff additive product of the present invention, compare with control group, make that immunoglobulin G (IgG) content improves 15.93% (P＜0.05) in 107 days serum of sow gestation, immunoglobulin A (IgA) content improves 28.57% (P＜0.05), immunoglobulin M (IgM) content improves 25.93% (P＜0.05), makes immunoglobulin G (IgG) content raising 19.95% (P＜0.05) in the sow gestation serum on the same day, immunoglobulin A (IgA) content improves 38.10% (P＜0.05), immunoglobulin M (IgM) content improves 34.48% (P＜0.05).3% feedstuff additive product of the present invention is added in explanation in in-pig later stage feed can improve sow immunity.
Table 1 in-pig serum immunoglobulin level
| Project group | Control group | Test group |
| Gestation 107 days | ? | ? |
| IgG(g/L) | 5.21±0.53 b | 6.04±0.76 a |
| IgA(g/L | 0.28±0.08 b | 0.36±0.07 a |
| IgM(g/L) | 0.27±0.02 b | 0.34±0.07 a |
| Gave a birth the same day | ? | ? |
| IgG(g/L) | 3.66±0.70 b | 4.39±0.60 a |
| IgA(g/L) | 0.21±0.02 b | 0.29±0.01 a |
| IgM(g/L) | 0.29±0.05 b | 0.39±0.07 a |
The different letter representation significant differences (P＜0.05) of colleague's shoulder motes.
Farrowing colostrum on same day testing result (seeing Table 2) shows, in in-pig later stage feed, add 3% feedstuff additive product of the present invention, make immunoglobulin G in the sow colostrum (IgG) content raising 26.27%, immunoglobulin A (IgA) content raising 21.43%, immunoglobulin M (IgM) content improve 29.41%.3% feedstuff additive product of the present invention is added in explanation in in-pig later stage feed can significantly improve immunoglobulin level in the sow colostrum.Because lack immunoglobulin (Ig) in the blood during newborn piglet birth, must could obtain passive immunity by sucking colostrum after the birth, thereby resist the invasion and attack of pathogen.Therefore explanation is added 3% feedstuff additive product of the present invention and can be improved the piglet immunological function in in-pig later stage feed.
Immunoglobulin level in table 2 sow colostrum
| Project group | Control group | Test group |
| IgG(g/L) | 13.93±1.26 b | 17.59±1.68 a |
| IgA(g/L) | 0.28±0.03 b | 0.34±0.02 a |
| IgM(g/L) | 0.34±0.05 b | 0.44±0.06 a |
The different letter representation significant differences (P＜0.05) of colleague's shoulder motes.
Result's (seeing Table 3) that piglet lactation (0-25d) and weaning period (wean back 0-15 days) diarrhea rate is measured shows, in in-pig later stage feed, add 3% feedstuff additive product of the present invention, compare with control group, make piglet lactation (0-25d) diarrhoea incidence reduce 49.85%, make the weaned piglet phase (wean back 0-15 days) (0-25d) diarrhea rate reduced 49.49%.3% feedstuff additive product of the present invention is added in explanation in in-pig later stage feed can improve the piglet immunological function, reduces the grice diarrhoea incidence.
Table 3 grice diarrhoea rate (%)
| Project group | Control group | Test group |
| Lactation (0-25d) | 20.36±5.21 a | 10.21±4.21 b |
| Weaning period (wean back 0-15 age in days) | 30.45±7.21 a | 15.38±3.21 b |
The different letter representation significant differences (P＜0.05) of colleague's shoulder motes.
Embodiment 2
A kind of feed addictive that improves immunoglobulin content in the sow colostrum adds 3% in latter half of gestation (95 days-childbirth of gestation) Sow Diet, it is by following formulated.Each component and percentage by weight are: calcium chloride 32.3%, ammonium chloride 17.7%, citric acid 33.3%, magnesium sulfate 2%, Fructus Ligustri Lucidi polysaccharide 0.3%, saccharin sodium 0.7%, powdered rice hulls 2%, zeolite powder 11.7%.Calcium chloride, ammonium chloride, citric acid, magnesium sulfate, Fructus Ligustri Lucidi polysaccharide, saccharin sodium are ground into 60 purpose particles; Zeolite powder and powdered rice hulls are ground into 40 purpose particles; The above-mentioned raw materials composition in the ratio weighing in the prescription, is put into mixture homogeneity then smaller or equal to stirring in 5% the stainless steel mixer 5-10 minute, by quantitative package finished product.
The sow material is with reference to U.S. NRC (1998) sow heavy in pig and sow in lactation nutritional need, the swine rearing standard of the Ministry of Agriculture 2004 promulgation and " Chinese feed ingredient and nutritive value table (2009 the 20th edition) " are prepared, control group is pressed the widely used corn-dregs of beans in present pig farm-wheat bran type in-pig diet recipe (%): corn 65.84, dregs of beans 13.3, wheat bran 18.0, calcium monohydrogen phosphate 1.05, stone flour 1.08, salt 0.4, Choline Chloride (50%) 0.1, microelement pre-mix material 0.2%, vitamin premix 0.03% adds up to 100.0%.
Test group substitutes in the control group diet 0.92% stone flour (equivalent substitution calcium amount) and 2.08% corn with a kind of feed addictive that improves immunoglobulin content in the sow colostrum 3% of the present invention.Finish from the sow gestation childbirth (about 114 days) that began to feed in 95 days.
Sow serum testing result (seeing Table 4) shows, in in-pig later stage feed, add 3% feedstuff additive product of the present invention, compare with control group, make that immunoglobulin G (IgG) content improves 32.05% (P＜0.05) in 107 days serum of sow gestation, immunoglobulin A (IgA) content improves 64.29% (P＜0.05), immunoglobulin M (IgM) content improves 92.59% (P＜0.05), makes immunoglobulin G (IgG) content raising 36.34% (P＜0.05) in the Farrowing serum on the same day, immunoglobulin A (IgA) content improves 76.19% (P＜0.05), immunoglobulin M (IgM) content improves 96.55% (P＜0.05).3% feedstuff additive product of the present invention is added in explanation in in-pig later stage feed can improve sow immunity.
Table 4 in-pig serum immunoglobulin level
| Project group | Control group | Test group |
| Gestation 107 days | ? | ? |
| IgG(g/L) | 5.21±0.53 b | 6.88±1.30 a |
| IgA(g/L) | 0.28±0.08 b | 0.46±0.10 a |
| IgM(g/L) | 0.27±0.02 b | 0.52±0.11 a |
| Gave a birth the same day | ? | ? |
| IgG(g/L) | 3.66±0.70 b | 4.99±0.77 a |
| IgA(g/L) | 0.21±0.02 b | 0.37±0.05 a |
| IgM(g/L) | 0.29±0.05 b | 0.57±0.09 a |
The different letter representation significant differences (P＜0.05) of colleague's shoulder motes.
Farrowing colostrum on same day testing result (seeing Table 5) shows, in in-pig later stage feed, add 3% feedstuff additive product of the present invention, make immunoglobulin G in the sow colostrum (IgG) content raising 36.04%, immunoglobulin A (IgA) content raising 60.71%, immunoglobulin M (IgM) content improve 44.12%.3% feedstuff additive product of the present invention is added in explanation in in-pig later stage feed can improve immunoglobulin level in the sow colostrum.Because lack immunoglobulin (Ig) in the blood during newborn piglet birth, must could obtain passive immunity by sucking colostrum after the birth, thereby resist the invasion and attack of pathogen.Therefore explanation is added 3% feedstuff additive product of the present invention and can be improved the piglet immunological function in in-pig later stage feed.
Immunoglobulin level in table 5 sow colostrum
| Project group | Control group | Test group |
| IgG(g/L) | 13.93±1.26 b | 18.95±1.41 a |
| IgA(g/L) | 0.28±0.03 b | 0.45±0.07 a |
| IgM(g/L) | 0.34±0.05 b | 0.49±0.17 a |
The different letter representation significant differences (P＜0.05) of colleague's shoulder motes.
Result's (seeing Table 6) that piglet lactation (0-25d) and weaning period (wean back 0-15 days) diarrhea rate is measured shows, in in-pig later stage feed, add 3% feedstuff additive product of the present invention, make piglet lactation (0-25d) diarrhoea incidence reduce by 74.85%, make the weaned piglet phase (wean back 0-15 days) (0-25d) diarrhea rate reduced 64.33%.3% feedstuff additive product of the present invention is added in explanation in in-pig later stage feed can improve the piglet immunological function, reduces the grice diarrhoea incidence.
Table 6 grice diarrhoea rate
| Project group | Control group | Test group |
| Lactation (0-25d) | 20.36±5.21 a | 5.12±2.21 b |
| Weaning period (wean back 0-7 age in days) | 30.45±7.21 a | 10.86±4.35 b |
The different letter representation significant differences (P＜0.05) of colleague's shoulder motes.
Claims (3)
1. feed addictive that improves immunoglobulin content in the sow colostrum, it is characterized in that, weight percentage is as follows: calcium chloride 16.7%-32.3%, ammonium chloride 3.3%-17.7%, citric acid 16.7%-33.3%, magnesium sulfate 0.7%-2%, Fructus Ligustri Lucidi polysaccharide 0.1%-0.3%, saccharin sodium 0.3%-0.7%, powdered rice hulls 1.0%-2.0% and zeolite powder 11.7%-61.2%.
2. a kind of preparation method who improves the feed addictive of immunoglobulin content in the sow colostrum according to claim 1 is characterized in that method is as follows:
(1) calcium chloride, ammonium chloride, citric acid, magnesium sulfate, Fructus Ligustri Lucidi polysaccharide, saccharin sodium are ground into 60 purpose particles;
(2) zeolite powder and powdered rice hulls are ground into 40 purpose particles;
(3) with the above-mentioned raw materials composition in the ratio weighing in the prescription, be put into mixture homogeneity then smaller or equal to stirring in 5% the stainless steel mixer 5-10 minute, by quantitative package finished product.
3. a kind of application that improves the feed addictive of immunoglobulin content in the sow colostrum according to claim 1 to childbirth period, is added this feed addictive of weight percentage 3% sow gestation the 95th day in perfect compound feed.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104171500A (en) * | 2014-07-02 | 2014-12-03 | 中泰和（北京）科技发展有限公司 | Sow feed additive capable of improving immunity of piglets and using method thereof |
| WO2018199749A1 (en) * | 2017-04-25 | 2018-11-01 | Nutreco Nederland B.V. | Composition contaning a chloride salt for use in pregnant animals |
| CN111418724A (en) * | 2020-03-25 | 2020-07-17 | 浙江省农业科学院 | Feed additive for preventing, relieving or treating postpartum infection of sow and application thereof |
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| JP4854226B2 (en) * | 2005-07-05 | 2012-01-18 | 神協産業株式会社 | Feed additives |
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| JPH06303918A (en) * | 1993-04-23 | 1994-11-01 | Smith Kline Biichiyamu Nippon Zenyaku Kk | Feed additive composition for swine and poultry |
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| CN1493203A (en) * | 2003-09-05 | 2004-05-05 | 刘蒙榕 | High content immunoglobulin roaster colostrum feed |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104171500A (en) * | 2014-07-02 | 2014-12-03 | 中泰和（北京）科技发展有限公司 | Sow feed additive capable of improving immunity of piglets and using method thereof |
| WO2018199749A1 (en) * | 2017-04-25 | 2018-11-01 | Nutreco Nederland B.V. | Composition contaning a chloride salt for use in pregnant animals |
| WO2018199748A1 (en) * | 2017-04-25 | 2018-11-01 | Nutreco Nederland B.V. | Calcium binder for use in preventing stillbirth |
| CN110785177A (en) * | 2017-04-25 | 2020-02-11 | 纽崔克Ip资产有限公司 | Composition for pregnant animals comprising chloride salts |
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| RU2767187C2 (en) * | 2017-04-25 | 2022-03-16 | НЮТРЕКО АйПи ЭССЕТС Б.В. | Calcium-binding agent for use in preventing stillbirth |
| CN111418724A (en) * | 2020-03-25 | 2020-07-17 | 浙江省农业科学院 | Feed additive for preventing, relieving or treating postpartum infection of sow and application thereof |
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| CN103211100B (en) | 2014-05-14 |
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