CN103202936B - 用于治疗慢性胃炎的中药汤剂 - Google Patents
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Abstract
本发明涉及中药配方领域，具体地说是一种用于治疗慢性胃炎的中药汤剂，其特征是原料药组成以重量百分比计为：白芍8～12％，石菖蒲8～11％，延胡索9～14％，炙甘草8～12％，香附7～9％，炒黄芩8～11％，枳实6～9％，白术7～10％，当归7～10％，山楂4～7％，蒲公英3～5％，金银花3～6％，菟丝子1～3％。本发明原料成本低，依从性好，无毒副作用，可抗菌消炎，增强防护因子，调节抗体免疫功能，能有效治疗慢性胃炎。
Description
技术领域
本发明涉及一种中成药制剂，具体地说是一种用于治疗慢性胃炎的中药汤剂。
背景技术
众所周知，慢性胃炎系指不同病因引起的各种慢性胃粘膜炎性病变，也是现代人群多发病之一，其发病率在各种胃病中居首位，男女老少均可罹患，病程长，易复发，对健康影响甚大。慢性胃炎的症状主要表现在：1、上腹疼痛：占85％，多为隐痛，半数以上与饮食有关，空腹时比较舒适，饭后不适。常因进冷食、硬食、辛辣或其它刺激性食物引起症状或使症状加重，有的与天气寒冷有关。2、饱胀，暖气：50％左右患者存在，慢性胃炎患者因受舒张功能障碍，进食虽不多但觉过饱患者进少量食物，甚至空腹时，都觉上腹饱胀。3、食欲不振，乏力：有的病人在进食后会出现腹胀、嗳气的症状，食欲不佳，自动限制日常饮食，这样导致了体重下降而出现消瘦、乏力的情况。4、恶心，反酸：慢性胃炎的炎症累及胃幽门管附近时，可引起幽门管的功能失调。当胃蠕动波推动食物到达幽门时，幽门不是处于开放状态，以便食物通过，到达十二指肠，而是仍紧紧关闭，使胃腔压力升高，反射性刺激呕吐中枢，使人感到恶心。治疗慢性胃炎一般采用克拉霉素、阿莫西林或四环素、甲硝唑，药物的毒性和不良反应的较强，且病情复发率高。
发明内容
本发明的目的就是为了克服上述现有的技术不足，提供一种用于治疗慢性胃炎的中药汤剂，原料成本低，依从性好，无毒副作用，可抗菌消炎，增强防护因子，调节抗体免疫功能，能有效治疗慢性胃炎。
本发明解决上述技术问题采用的技术方案是：一种用于治疗慢性胃炎的中药汤剂，其特征是原料药组成以重量百分比计为：白芍8～12％，石菖蒲8～ 11％，延胡索9～14％，炙甘草8～12％，香附7～9％，炒黄芩8～11％，枳实6～9％，白术7～10％，当归7～10％，山楂4～7％，蒲公英3～5％，金银花3～6％，菟丝子1～3％。
本发明原料成本低，依从性好，无毒副作用，可抗菌消炎，增强防护因子，调节抗体免疫功能，能有效治疗慢性胃炎。
具体实施方式
下面结合实施例对本发明作进一步的描述：
实施例一：采用白芍、石菖蒲、延胡索、炙甘草、香附、炒黄芩、枳实、白术、当归、山楂、蒲公英、金银花、菟丝子为原料药制备而成，其组分(重量％)每付为白芍10、石菖蒲10、延胡索10、炙甘草10、香附11、炒黄芩8、枳实8、白术8、当归9、山楂6、蒲公英4、金银花4、菟丝子2。取上述13味原料总重量为186克，在室温下将13种中草药加水至800～1000ml，浸泡30～50分钟，然后用武火煮沸文火煎熬90～100分钟左右，去渣得滤液200ml，药渣再加水250～300ml，煎熬30～40分钟，去渣得滤液100ml，共得300ml左右药汁，即制得用于治疗慢性胃炎的中药汤剂。装入无菌玻璃瓶内，密封瓶盖备用，每日1剂分早晚2次口服，每次空腹口服150ml左右，服用后临床症状体征消失，再巩固疗效服用1周。
本发明白芍养血柔肝，缓中止痛，敛阴收汗。治胸腹胁肋疼痛，泻痢腹痛，自汗盗汗，阴虚发热，月经不调，崩漏，带下；石菖蒲化湿开胃，开窍豁痰，醒神益智。用于脘痞不饥、噤口下痢、神昏癫痫、健忘耳聋；延胡索活血，利气，止痛。用于胸胁、脘腹疼痛，经闭痛经，产后瘀阻，跌扑肿痛；炙甘草补脾和胃，益气复脉。用于脾胃虚弱，倦怠乏力，心动悸，脉结代；香附能够理气解郁，止痛调经。临床常用于治疗肝胃不和，气郁不舒，胸腹胁肋胀痛，痰饮痞满，月经不调，崩漏带下等等；炒黄芩清热燥湿，泻火解毒，止血，安胎。用于湿温、暑温胸闷呕恶，湿热痞满，泻痢，黄疸，肺热咳嗽，高热烦渴，血热吐衄，痈肿疮毒，胎动不安；枳实行气消痞，消积化痰.还可治疗胃扩张，胃下垂等；白术具有健脾益气，燥湿利水，止汗，安胎的功效。用于脾虚食少，腹胀泄 泻，痰饮眩悸，水肿，自汗，胎动不安；当归可补血活血，调经止痛，润肠通便。用于血虚萎黄、眩晕心悸、月经不调、经闭痛经、虚寒腹痛、肠燥便秘、风湿痹痛、跌扑损伤、痈疽疮疡；山楂消食积，散瘀血，驱绦虫；治肉积，癥瘕，痰饮，痞满，吞酸，泻痢，肠风，腰痛，疝气产后儿枕痛，恶露不尽，小儿乳食停滞。消食健胃，行气散瘀。用于肉食积滞、胃烷胀满、泻痢腹痛、瘀血经闭、产后瘀阻、心腹刺痛、疝气疼痛、高血脂症；蒲公英性味甘、苦、寒，具有清热解毒、消痈散结、消炎、凉血、利尿、利胆、轻泻、健胃；金银花性寒，具有清热解毒、疏散风热的作用。金银花有清热解毒、疏利咽喉、消暑除烦的作用。可治疗暑热症、泻痢、流感、疮疖肿；菟丝子用于肾虚阳痿，遗精尿频，带下，腰痛；肝肾不足，视物昏花，视力减退，脾肾虚弱，便溏腹泻，肝肾虚损，胎动不安。诸药合用，共奏清热化湿理气，湿祛热清，脾健胃和，本发明具有抗菌、抗炎、促进胃肠运动、削弱损伤因子、减少对胃粘膜的损害、增强防护因子、加强胃粘膜屏障作用、调整免疫功能等作用，临床应用治疗慢性胃炎取得很好疗效。
本发明各原料还可按下表所列比例(重量百分比)混合的实施例来实现，其煎熬程序、口服方法与实施例一相同，其含量如下表所示。
下面结合我院，即山东省荣成市第二人民医院进行的临床试验对本发明作进一步、详细地描述：
1.病例选择：本组84例，男41例，女43例，年龄20-68岁，平均年龄40±2岁，病程2月至35年，平均8±1.2年。
2.诊断标准：慢性胃炎“诊断标准参照2006年上海中华医学会消化病学会中国慢性胃炎参考意见”拟定。全部病例均经上消化道钡餐透视或电子胃 镜检查及胃黏膜活检诊断为慢性浅表性胃炎，实验室HP检测均阳性，临床表现不同程度消化不良，厌食，与进食有关的上腹部疼痛，病程迁延。体征：可伴有上腹部轻度压痛。中医辨证标准：依据《中药新药临床研究指导原则》的标准制定。主症：胃脘疼痛，胃脘痞胀，纳呆；次症：口苦或口臭或口粘，大便溏，渴不欲饮，舌质淡，苔黄腻，脉弦涩或弦滑。具备主症1项，次症2项和相应舌脉即可诊断。
3.病例排除标准：a、胃及十二指肠溃疡、胃黏膜有异型增生或疑有恶性病变。b、消化道出血或胃肠手术后者。c、恶性肿瘤患者。
4.疗效标准：参照《中药新药临床研究指导原则》制定。痊愈：临床症状消失，HP检测阴性，胃镜和组织管检查提示，活动性炎症消失，粘膜可有轻度慢性炎症；显效：临床症状基本消失，HP检测阴性，胃镜和组织学检查提示活动性炎症基本消失，粘膜慢性炎症下降一个等级；有效：主要症状减轻，HP检测弱阳性或阳性，胃镜和组织学检查提示活动性炎症无明显改变；无效：无变化或恶化者。
5.治疗方法：每次服用本发明汤剂150ml，每日早晚各一次，空腹温服，服用十天为一疗程，连续服用本发明五个疗程。
6.治疗结果：本发明治疗84例，服药三个疗程，临床治愈18例(21.43％)，显效44例(52.38％)，有效18例(21.43％)，无效4例(4.76％)总有效率为95.24％。
Claims (1)
1.一种用于治疗慢性胃炎的中药汤剂，其特征是：原料药组成以重量百分比计为，白芍8～12％，石菖蒲8～11％，延胡索9～14％，炙甘草8～12％，香附7～9％，炒黄芩8～11％，枳实6～9％，白术7～10％，当归7～10％，山楂4～7％，蒲公英3～5％，金银花3～6％，菟丝子1～3％。
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