CN103191290A - Pharmaceutical composition for treating nasosinusitis as well as preparation method and application thereof - Google Patents
Pharmaceutical composition for treating nasosinusitis as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a pharmaceutical composition for treating nasosinusitis. The pharmaceutical composition is prepared from the following raw medicinal materials in parts by weight: 16 to 24 parts of dried centipeda or 32 to 48 parts of fresh centipeda, 9 to 15 parts of magnolia flower, 6 to 12 parts of cocklebur fruit, 7 to 13 parts of acorus gramineus, 12 to 18 parts of honeysuckle, 6 to 10 parts of fritillaria, 16 to 24 parts of spina gleditsiae, 7 to 13 parts of angelica dahurica, 6 to 10 parts of divaricate saposhnikovia root, 7 to 13 parts of chastetree fruit, 4 to 8 parts of mint, 7 to 13 parts of ligusticum, 6 to 12 parts of frankincense, 6 to 12 parts of myrrh, 7 to 13 parts of angelica tail, 7 to 13 parts of red peony root, 4 to 8 parts of pangolin, 7 to 13 parts of dried orange peel, 9 to 15 parts of root of Chinese trichosanthes, and 4 to 8 parts of licorice section. The pharmaceutical composition can be used for effectively treating the nasosinusitis, can quickly relieve symptoms, and provides a new choice for clinical medication.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of nasal sinusitis and its production and use.
Background technology
Nasal sinusitis, claim " sinusitis with purulent discharge ", " brain sand ", " sinusitis with purulent discharge ", " brain deep pool " etc. again, be a kind of with turbid nasal discharge, to ooze, measure many as the nether world be the cacorhinia of principal character incessantly, its normal companioned with headache, nasal obstruction, hyposmia, nasal sinuses district pain, the empty dizzy symptom that endlessly waits then for a long time, men and women, old and young all can be ill, is a kind of commonly encountered diseases, frequently-occurring disease.Its etiology and pathogenesis not outside: the evil poison of affection due to external wind and heat, or the exterior attacked by wind and cold violates lung, for a long time and heat-transformation is stopped up and held back lung meridian, impairment of purifying function of the lung causes pathogenic heat to be followed through last steaming, violates and the nose key, burns the nasal sinuses sarolemma and is disease; Or gallbladder heat stagnation, with through last criminal, steam and burn the nose key and send out, because of gallbladder for just dirty, in post fire mutually, its gas lead to brain, if feelings will is not smooth, susceptible to anger is disloyal, gallbladder mistake catharsis, then stagnated QI transforming into fire follows through last criminal, moves hot in brain; Or pathogenic heat violate gallbladder, the gallbladder meridian intenseness of heat, on steam in brain, injure nasal sinuses, burn bright sarolemma, heat refining body fluid and be tears is compeled to ooze under Tianjin to send out and is nasal sinusitis; Or damp-heat in the spleen and stomach, follow stomach through on disturb and send out, the patient causes giving birth in the damp-heat in the spleen and stomach if element is had a liking for delicious food wine sweet wine, dysfunction of the spleen in transportation and transformation, clear YANG failing to ascend then, turbid YIN failing to descend, damp and hot evil poison follow then through last criminal, stop in the poly-hole, burn to decrease sarolemma in the hole and be nasal sinusitis.
Primary disease is suppurative inflammation for the nasal sinuses mucosa in doctor trained in Western medicine, is equivalent to its purulent sinusitis, is more common in after flu, the acute rhinitis.Other, can cause the generation of primary disease as allergic constitution and systemic disease such as anemia, carriage improper (as vertical diving), sewage entered in the hole etc. when the focal infection of contiguous nasal cavity such as hypertrophy of tonsils, adenoid vegetation, the infection of some root of grinding one's teeth in sleep, nose department flesh wound, foreign body penetrated nasal sinuses, swimming, all can cause to infect and fall ill.In addition, as nose diseasess such as diaphragm bending in the nose, middle nasal concha hypertrophy, nasal polyp, tumors, hinder nasal sinuses ventilation, drain, also can cause primary disease.
The symptom of nasal sinusitis can be slightly different because of the difference of its etiology and pathogenesis, as nasal sinusitis due to the wind and heat in the lung meridian, has more existing nose stream yellow thick nasal discharge or sticking white tears, and amount is many, hyposmia, heating, aversion to cold, headache, normal companion's cough, abundant expectoration, red tongue or little red, the little Huang of tongue or white, floating and rapid pulse.And the nasal sinusitis that gallbladder heat stagnation causes is then seen turbid nasal discharge more, and yellow thick as the pus sample, olfactory sensation is poor, headache, heating, bitter taste, dry pharynx, tinnitus, agitation, red tongue, yellow fur, wiry and frequent pulse.The damp and hot nasal sinusitis of sending out of spleen channel, normal disease are seen nose stream yellow thick nasal discharge, and is turbid and amount is many, nasal obstruction, and hyposmia, dizzy nose heave, breast gastral cavity feeling of distension and oppression, yellow urine, red tongue or not red, yellow and greasy fur, slippery and rapid pulse or moisten number.
Nasal sinusitis also has a lot of harm to human body except the misery that symptom own is brought.Nasal sinuses is the gassiness cavity of bones of facial cranium around the nasal cavity, contiguous with vitals such as eye, ear, brains, therefore, nasal sinuses has inflammation just can cause by all means that adjacent tissue and organ produce complication, also can cause the infection of far-end organ by the pus toxic action in the hole.Common person is as the ⑴ ocular complications: be very thin nasal sinuses bone wall more than 2/3 around the orbit wall, also have blood vessel and lymphatic vessel to communicate, when nasal sinuses has inflammation, just can cause complication in the socket of the eye because of the necrosis of bone wall, also can cause ocular infection by the lymph traffic between the nose socket of the eye, as the inflammation of socket of the eye inner tissue, intraorbital abscess, optic neuritis etc.⑵ intracranial complication: the nasal sinuses inflammation can directly involve intracranial by vein, nerve, lymphatic vessel etc., and also can cause the direct destruction of skull and invade and intracranial, and cause meningitis, brain abscess, cavernous sinus thrombophlebitis etc., but even threat to life.⑶ ear infection: during the nasal sinuses inflammation, the purulence nasal mucus can cause the tubule inflammation swelling between ear and the nasopharynx, blocks, and causes catarrhal otitis media, suppurative otitis media etc.⑷ descending infection, common has: 1. pharyngeal infection: can cause pharyngitis, tonsillitis etc.2. the pus nasal mucus can cause the digestive tract pathological changes if swallow, and gastrointestinal dysfunctions such as stomachache, diarrhoea, constipation occur.⑸ empyema in the nasal sinuses: this can become septic focus, causes joint, muscle, heart kidney and nervous system disease, and the child can show as stupid, distraction, and symptoms such as giddy, insomnia, hypomnesis, impatience then appear in the adult.This shows that nasal sinusitis is not only complicated but also serious to the harm of human body, thus should be actively, treatment up hill and dale, can not adopt a casual attitude.
The western medical treatment primary disease, mainly take to use sulfanilamide and antibiotic and so on control to infect, or with the means of operative treatment, but this all can cause the additional injury of drawback due to toxic and side effects and the operation to the patient, the traditional Chinese medical science then can be used the prescription as pharmaceutical composition of the present invention and so on according to the intrinsic determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs rule of being good at of the traditional Chinese medical science, and not only curative effect is good good, stable, and have no side effect, and have suitable advantage.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of nasal sinusitis and its production and use.
The invention provides a kind of pharmaceutical composition for the treatment of nasal sinusitis, it is the preparation that is prepared from by following materials of weight proportions medicine:
The bright product 32-48 of Herba Centipedae dry product 16-24 part or Herba Centipedae part, Flos Magnoliae 9-15 part, Fructus Xanthii 6-12 part, Rhizoma Acori Graminei 7-13 part, Flos Lonicerae 12-18 part, Bulbus Fritillariae Cirrhosae 6-10 part, Spina Gleditsiae 16-24 part, Radix Angelicae Dahuricae 7-13 part, Radix Saposhnikoviae 6-10 part, Fructus Viticis 7-13 part, Herba Menthae 4-8 part, Rhizoma Ligustici 7-13 part, Olibanum 6-12 part, Myrrha 6-12 part, Radix Angelicae Sinensis 7-13 part, Radix Paeoniae Rubra 7-13 part, Squama Manis 4-8 part, Pericarpium Citri Reticulatae 7-13 part, Radix Trichosanthis 9-15 part, Radix Glycyrrhizae uralensis 4-8 part.
Further, it is the preparation that is prepared from by following materials of weight proportions medicine:
40 parts of the bright product of 20 parts of Herba Centipedae or Herba Centipedae, 12 parts of Flos Magnoliaes, 9 parts of Fructus Xanthii, 10 parts of Rhizoma Acori Graminei, 15 parts of Flos Loniceraes, 8 parts of Bulbus Fritillariae Cirrhosaes, 20 parts of Spina Gleditsiaes, 10 parts of the Radixs Angelicae Dahuricae, 8 parts of Radix Saposhnikoviaes, 10 parts of Fructus Viticises, 6 parts of Herba Menthaes, 10 parts of Rhizoma Ligusticis, 9 parts of Olibanums, 9 parts of Myrrhas, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Paeoniae Rubra, 6 parts of Squama Maniss, 10 parts of Pericarpium Citri Reticulataes, 12 parts of Radix Trichosanthis, 6 parts of Radix Glycyrrhizae uralensiss.
Further, described Spina Gleditsiae is given birth to the product drug effect and is subtracted greatly for frying Spina Gleditsiae, and it is invalid substantially maybe can to say; Bulbus Fritillariae Cirrhosae, stir-baked SQUAMA MANITIS should be ground into powder and take after mixing it with water in this pharmaceutical composition.
Wherein, described pharmaceutical composition be with the water of the medicated powder of crude drug or crude drug or/and ethanol extraction is active component, add the preparation that adjuvant pharmaceutically commonly used or complementary composition are prepared from.
Wherein, described preparation is oral formulations.
Further, described oral formulations is tablet, pill, powder, capsule, granule, oral liquid, drop pill, soft capsule.
The present invention also provides the preparation method of aforementioned pharmaceutical compositions, and it comprises following operating procedure:
(1) weighting raw materials by weight ratio;
(2) get other medical materials except Bulbus Fritillariae Cirrhosae, stir-baked SQUAMA MANITIS, after extracting with water or ethanol water, merge extractive liquid, with the medicinal powder of Bulbus Fritillariae Cirrhosae, stir-baked SQUAMA MANITIS, adds that adjuvant or complementary composition pharmaceutically commonly used are prepared into preparation.This side goes into to fry in shallow oil curative effect with wine heightens.
The present invention also provides the purposes of aforementioned pharmaceutical compositions in the medicine of preparation treatment nasal sinusitis.
Further, described medicine is treatment purulent sinusitis's medicine.
Further, described medicine be treatment because of wind and heat in the lung meridian or wind and cold heat-transformation, gallbladder heat stagnation, spleen channel damp and hot due to the medicine of nasal sinusitis.Its disease sees and is turbid nasal discharge, measures how incessantly, and often with headache, nasal obstruction, hyposmia, red tongue with thin fur is white or yellow, rapid pulse (floating number, stringy and rapid pulse, moisten number, cunning number etc.).
Generally acknowledged that at present " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " the compound compatibility medication is as using military forces " are the most effective several big advantages of science of the traditional Chinese medical science, wherein " the compound compatibility medication is as using military forces " is the original theory of Chinese medicine of very science.Each medicine tight compatibility all linked with one another as arraying troops for battle in the traditional Chinese medical science prescription is its effective means that is better than the Western medicine prescription.The tcm prescription theory is thought, each prescription, not only need to select the suitable appropriate compatibility of medicine according to etiology and pathogenesis, the basic structure that also should meet prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical square tube cross too many levels, many target spots and integrate the biological mechanism of regulating, this illness of nasal sinusitis is regulated and control, can obtain the more lasting also therapeutic effect that has no side effect of green natural more of, the efficacy of a drug better than western medicine result, and this curative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, and prescription of the present invention is just being followed this principle.
In traditional Chinese medical science traditional theory, nasal sinusitis be by because of wind and heat in the lung meridian or wind and cold heat-transformation, gallbladder heat stagnation, spleen channel is damp and hot is caused that control when wind and heat eliminating or heat clearing away, it is sensible to dehumidify.In the present composition, be monarch drug with the clearing the nasal passage of usurping authority, the Herba Centipedae of controlling nasal sinusitis, and be ministerial drug with Flos Magnoliae, Herba Xanthii, the Rhizoma Acori Graminei with same effect, assist it to direct reach disease institute, with opening the nose key.One group of the Radix Angelicae Dahuricae, Radix Saposhnikoviae, wild pepper, Herba Menthae, Rhizoma Ligustici, wind and heat eliminating not only also can be alleviated the headache due to the nasal sinusitis, and Flos Lonicerae, Radix Trichosanthis, Radix Glycyrrhizae uralensis then can help it to dredge pathogenic heat clearly, so be the adjuvant drug on left road altogether.Bulbus Fritillariae Cirrhosae, Spina Gleditsiae, Pericarpium Citri Reticulatae dehumidifying expelling pus and toxin by strengthening QI, to reduce the thick turbid tears of pus, benefit is the adjuvant drug for right wing with one group of stir-baked SQUAMA MANITIS, Olibanum, Myrrha, Radix Angelicae Sinensis, the Radix Paeoniae Rubra of promoting blood circulation to remove obstruction in the collateral, eliminating stasis and resolving masses again.Though Radix Glycyrrhizae uralensis has antipyretic and antidote functions, also arrogate to oneself coordinating the actions of various ingredients in a prescription, for making medicine.
In the above prescription, it is clearly demarcated that each organizes the flavour of a drug post, complement each other, given full play to the sexology research methodology marrow of analyzing mentally as the exclusive compound compatibility medication of Chinese medicine is structured the formation as row army, so can treat the turbid tears stream empty dizzy nasal sinusitis persistent ailment of oozing incessantly, have a headache, for clinical application provides a kind of new selection.
Specific embodiment
Embodiment 1 preparation of drug combination of the present invention
Get Herba Centipedae dry product 20g, Flos Magnoliae 12g, Fructus Xanthii 9g, Rhizoma Acori Graminei 10g, Flos Lonicerae 15g, Bulbus Fritillariae Cirrhosae 8g fries Spina Gleditsiae 20g, Radix Angelicae Dahuricae 10g, Radix Saposhnikoviae 8g, Fructus Viticis 10g, Herba Menthae 6g, Rhizoma Ligustici 10g, Olibanum 9g, Myrrha 9g, Radix Angelicae Sinensis 10g, Radix Paeoniae Rubra 10 grams, stir-baked SQUAMA MANITIS 6g, Pericarpium Citri Reticulatae 10g, Radix Trichosanthis 12g, Radix Glycyrrhizae uralensis 6g.Each flavour of a drug takes by weighing according to quantity, Bulbus Fritillariae Cirrhosae, stir-baked SQUAMA MANITIS is ground into powder respectively standby, and all the other each liquid medicine are fried in shallow oil after boil, and thermal transfer is little, fry in shallow oil 5 minutes to 8 minutes again, collect decocting liquid; Medicinal residues add water again such as method decocts 2 times, merge each time decocting liquid, are blended into Bulbus Fritillariae Cirrhosae and stir-baked SQUAMA MANITIS end, mix well, and namely get decoction.
Embodiment 2 preparation of drug combination of the present invention
Get Herba Centipedae dry product 16g, Flos Magnoliae 15g, Fructus Xanthii 12g, Rhizoma Acori Graminei 13g, Flos Lonicerae 18g, Bulbus Fritillariae Cirrhosae 10g, Spina Gleditsiae 24g, Radix Angelicae Dahuricae 13g, Radix Saposhnikoviae 10g, Fructus Viticis 13g, Herba Menthae 8g, Rhizoma Ligustici 13g, Olibanum 12g, Myrrha 12g, Radix Angelicae Sinensis 13g, Radix Paeoniae Rubra 13 grams, stir-baked SQUAMA MANITIS 8g, Pericarpium Citri Reticulatae 13g, Radix Trichosanthis 15g, Radix Glycyrrhizae uralensis 8g.Each flavour of a drug takes by weighing according to quantity, Bulbus Fritillariae Cirrhosae, stir-baked SQUAMA MANITIS is ground into powder respectively standby, and all the other each liquid medicine are fried in shallow oil after boil, and thermal transfer is little, fry in shallow oil 5 minutes to 8 minutes again, collect decocting liquid; Medicinal residues add water again such as method decocts 2 times, merge each time decocting liquid, concentrate, and are blended into Bulbus Fritillariae Cirrhosae and stir-baked SQUAMA MANITIS end, add suitable dextrin again, and mixing is granulated, and namely gets granule.
Embodiment 3 preparation of drug combination of the present invention
Get Herba Centipedae dry product 24g, Flos Magnoliae 9g, Fructus Xanthii 6g, Rhizoma Acori Graminei 7g, Flos Lonicerae 12g, Bulbus Fritillariae Cirrhosae 6g, Spina Gleditsiae 16g, Radix Angelicae Dahuricae 7g, Radix Saposhnikoviae 6g, Fructus Viticis 7g, Herba Menthae 4g, Rhizoma Ligustici 7g, Olibanum 6g, Myrrha 6g, Radix Angelicae Sinensis 7g, Radix Paeoniae Rubra 7 grams, stir-baked SQUAMA MANITIS 4g, Pericarpium Citri Reticulatae 7g, Radix Trichosanthis 9g, Radix Glycyrrhizae uralensis 4g.Each flavour of a drug takes by weighing according to quantity, Bulbus Fritillariae Cirrhosae, stir-baked SQUAMA MANITIS is ground into powder respectively standby, and all the other each liquid medicine are fried in shallow oil after boil, and thermal transfer is little, fry in shallow oil 5 minutes to 8 minutes again, collect decocting liquid; Medicinal residues add water again such as method decocts 2 times, merge each time decocting liquid, concentrate, and are blended into Bulbus Fritillariae Cirrhosae and stir-baked SQUAMA MANITIS end, add suitable dextrin again, and mixing is granulated, and tabletting namely gets tablet.
Embodiment 4 preparation of drug combination of the present invention
(1) gets the bright product 40g of Herba Centipedae, Flos Magnoliae 12g, Fructus Xanthii 9g, Rhizoma Acori Graminei 10g, Flos Lonicerae 15g, Bulbus Fritillariae Cirrhosae 8g, Spina Gleditsiae 20g, Radix Angelicae Dahuricae 10g, Radix Saposhnikoviae 8g, Fructus Viticis 10g, Herba Menthae 6g, Rhizoma Ligustici 10g, Olibanum 9g, Myrrha 9g, Radix Angelicae Sinensis 10g, Radix Paeoniae Rubra 10 grams, stir-baked SQUAMA MANITIS 6g, Pericarpium Citri Reticulatae 10g, Radix Trichosanthis 12g, Radix Glycyrrhizae uralensis 6g.Each flavour of a drug takes by weighing according to quantity, Bulbus Fritillariae Cirrhosae, stir-baked SQUAMA MANITIS is ground into powder respectively standby, and all the other each liquid medicine are fried in shallow oil after boil, and thermal transfer is little, fry in shallow oil 5 minutes to 8 minutes again, collect decocting liquid; Medicinal residues add water again such as method decocts 2 times, merge each time decocting liquid, are blended into Bulbus Fritillariae Cirrhosae and stir-baked SQUAMA MANITIS end, mix well, and namely get decoction.
(2) get above-mentioned decoction, leave standstill, get supernatant, after concentrating, drying is pulverized, and is standby; Get an amount of Macrogol 4000, after the fusion, above-mentioned medicated powder is added in the fusion substrate, 75-85 ℃ of insulation down; Adopt various drop pill machine, the drip inside/outside directly reaches and drips the speed appropriateness, and it is splashed in the dimethicone, collects drop pill, namely gets drop pill.
Below specify beneficial effect of the present invention by testing example.
Clinical (outpatient service) treatment situation of test example 1 pharmaceutical composition of the present invention
(1) accepts patient's situation for medical treatment
Patient age and sex scope: mainly in the majority with teenager and child, but the adult is also arranged, there are men and women for sex, possesses following symptom feature (possess part and get final product, needn't also can not fully all possess), accepts 31 examples altogether for medical treatment.
Symptom feature:
The symptom of nasal sinusitis can be slightly different because of the difference of its etiology and pathogenesis, as nasal sinusitis due to the wind and heat in the lung meridian, has more existing nose stream yellow thick nasal discharge or sticking white tears, and amount is many, hyposmia, heating, aversion to cold, headache, normal companion's cough, abundant expectoration, red tongue or little red, the little Huang of tongue or white, floating and rapid pulse.And the nasal sinusitis that gallbladder heat stagnation causes is then seen turbid nasal discharge more, and yellow thick as the pus sample, olfactory sensation is poor, headache, heating, bitter taste, dry pharynx, tinnitus, agitation, red tongue, yellow fur, wiry and frequent pulse.The damp and hot nasal sinusitis of sending out of spleen channel, normal disease are seen nose stream yellow thick nasal discharge, and is turbid and amount is many, nasal obstruction, and hyposmia, dizzy nose heave, breast gastral cavity feeling of distension and oppression, yellow urine, red tongue or not red, yellow and greasy fur, slippery and rapid pulse or moisten number.In addition, also can be from its symptom feature of the fine analysis of nasal sinusitis institute this symptom of companioned with headache:
Nasal sinusitis is equivalent to the purulent sinusitis of doctor trained in Western medicine, and nasal sinuses is the general name of maxillary sinus, sinus frontalis, sieve hole, sphenoid sinus, and each Dou Jun has opening and communicates with nasal cavity.Headache one disease of occurring together in the nasal sinusitis is though the degree difference all has following characteristics: I. and headache is often with symptoms such as nasal obstruction, rhinorrhea, olfactory disordeies.II. have a headache intersexuality and location characteristics sometimes, this anatomical position with them is relevant: the ⑴ frontal sinusitis: show as frons pain, and at forehead geisoma place tenderness is arranged, pain is heavy the morning, and noon is the most acute, alleviates in the afternoon, then all disappears to evening.⑵ maxillary sinusitis: be frons pain also, the morning is light, and afternoon is heavy, at geisoma and buccal portion tenderness can be arranged, and acute person is sometimes with the above-listed pain of grinding one's teeth in sleep.⑶ sphenoiditis: at the eye rear portion and a deep pain, also can cause rise morning gently, afternoon heavy occipitalia pain.⑷ ethmoiditis: the nose bridge at place, angle can have tenderness or pain within the eye, and it is lighter to have a headache, and the headache character of anterior ethmoid sinus inflammation is similar to frontal sinusitis sometimes, and the headache character of posterior ethmoid sinus inflammation is similar with sphenoiditis sometimes.III. headache can alleviate after rest, nose drops, steam suction or nasal airflow, drain improve, and in cough, bow bend over, headache increases the weight of firmly or when shaking head suddenly, smoking, drink, excited headache is increased the weight of.
(2) treatment standard
Recovery from illness: the complete obiteration of above-mentioned symptom characteristics, check does not see that index of correlation is unusual.
Evident in efficacy: above-mentioned symptom obviously alleviates, and test rating has certain degree to improve simultaneously.
Certain effect is arranged: patient's symptom alleviates to some extent, or index has improvement slightly.
Invalid: symptom remains unchanged, and index not to be improved.
(3) Therapeutic Method
1, embodiment 1 made decoction takes 200 to 400ml at every turn, or the daily used rice bowl of having a meal 1 bowl (child dose by age cuts down according to the circumstance, take medicine by the preceding method dosing of cutting down according to the circumstance, add a day clothes number of times but need to drink), every about 6 hours, take once, at least obey every day 3 times, take according to quantity on time.
2, note also science conditioning daily life, observe some necessary points for attention, as:
⑴ actively take exercises, health invigorating, preventing cold.
⑵ note striking a proper balance between work and rest, and is sure not overworked and the health resistance against diseases is descended.
⑶ active treatment adjacent tissue organ lesion, amygdala inflammation etc. are to anxious nasal sinusitis also timely active treatment, in order to avoid with the passing of time delay transfers chronic sinusitis to or other deteriorated cases take place.
⑷ diet is suitable light and nutritious, gives up tobacco and wine, eats the product of pungent stimulation at ordinary times less, then should not eat fully during one's sickness.
⑸ if when diving swimming in summer, and the improper or swimming back of posture is blowing the nose firmly, sewage is entered in the nasal sinuses and diseases induced, so need add attention.
⑹ if when go hemostasis with packs because of epistaxis, and wadding can not be kept somewhere of a specified duration, otherwise not only can cause local excitation or pollution, also can hinder ventilate drain and bring out primary disease of Dou Kou.
⑺ note cleaning nasal cavity, removes the nasal mucus that accumulates, and keeps nasal meatus unobstructed.Should also be noted that the blowing the nose method, nasal cavity has secretions and has a stuffy nose and avoid firmly blowing the nose when weighing, in order to avoid the contrary pleasant key of evil poison causes ear key disease.
⑻ actively prevent and treat odontopathy, can reduce the morbidity of odontogenic maxillary sinusitis.
(4) therapeutic outcome
In medicine composite for curing primary disease men and women, old and young patient 31 examples of the present invention (mainly in the majority with child and teenager), obtained preferable curative effect between many decades.Treatment time, difference according to the difference of concrete conditions such as each conditions of patients weight, physical strength and slightly to some extent, generally alleviating in various degree can be arranged on 3rd to 1 all left and right sides symptom, 2 thoughtful 8 its cardinal symptoms of all left and right sides then can disappear substantially or part disappears, by above-mentioned science conditioning daily life, sincerely abide by points for attention, can receive preferable therapeutic effect, and can stop to cause and close on or the complication of histoorgan far away.
By above-mentioned treatment standard, among the 31 routine patients, 14 example recoveries from illness are arranged, cure rate is 45.1%; 4 examples are evident in efficacy, are 12.9%; 5 examples have certain effect, are 16.1%; 8 routine DeGrains (invalid) account for 25.9%.Total effective rate is 74.1%.
Model case
The patient, the woman, 11 years old, the student, disease is seen heating, aversion to cold, headache, cough expectorant is more, and the sticking white tears of nose stream be again thick yellow thick nasal discharge sometimes, and amount is many as leak as gush, and if nasal obstruction stuffiness, olfactory sensation be mistake, and anosmia is weak, inappetence, body of the tongue is little red, the little Huang of tongue, floating and rapid pulse.Look it, nasal mucosa swelling, hyperemia, nasal cavity has a large amount of sticking pus tears.Be anxious nasal sinusitis due to typical wind and heat in the lung meridian.Bestow pharmaceutical composition of the present invention (embodiment 1 preparation), and advise science conditioning and the points for attention of its method of administration of sternly abiding by above-mentioned " Therapeutic Method " it " 1 " and " 2 ".Infant was taken medicine only 2 days, and heating, aversion to cold, headache, cough symptom just alleviate to some extent, and the many symptoms of tears only have any to extenuate slightly, and tongue is still little red, but yellow fur is few, and pulse condition is also gentle slightly.Namely advise it to continue to take, the conditioning as before.To after this, each symptom continues slowly to alleviate day by day, and about having approximately 10, the thickness nasal mucus namely eliminates substantially, and all the other symptoms are also lost entirely, and more not having far and near histoorgan has complication to occur.Back health check-up, the no abnormality seen index.
Xian fang Huoming Yin comes from " married woman's good recipe is annotated in the school ", has heat-clearing and toxic substances removing, relieving swelling and disintegrating mass, and the effect of promoting blood circulation and stopping pain can be used for treating nasal sinusitis.During the early-stage Study, with the positive contrast of Xian fang Huoming Yin, in order to prove the drug activity of pharmaceutical composition of the present invention, the result is as follows:
1. in identical treatment time, the cure rate of using pharmaceutical composition of the present invention exceeds about 19% than the former side of Xian fang Huoming Yin, and rate evident in efficacy also exceeds about 23% than the former side of Xian fang Huoming Yin, and this treatment effect that shows pharmaceutical composition of the present invention is better.
2. after the patient's administration to close body constitution, find the former side's of Xian fang Huoming Yin treatment time than long 2 week～4 weeks of the present invention pharmaceutical composition, this course for the treatment of that shows pharmaceutical composition of the present invention is shorter.
In sum, pharmaceutical composition of the present invention can effectively be treated nasal sinusitis, and catabasis symptom quickly is for clinical application provides a kind of new selection.
Claims (10)
1. pharmaceutical composition for the treatment of nasal sinusitis, it is characterized in that: it is the preparation that is prepared from by following materials of weight proportions medicine:
The bright product 32-48 of Herba Centipedae dry product 16-24 part or Herba Centipedae part, Flos Magnoliae 9-15 part, Fructus Xanthii 6-12 part, Rhizoma Acori Graminei 7-13 part, Flos Lonicerae 12-18 part, Bulbus Fritillariae Cirrhosae 6-10 part, Spina Gleditsiae 16-24 part, Radix Angelicae Dahuricae 7-13 part, Radix Saposhnikoviae 6-10 part, Fructus Viticis 7-13 part, Herba Menthae 4-8 part, Rhizoma Ligustici 7-13 part, Olibanum 6-12 part, Myrrha 6-12 part, Radix Angelicae Sinensis 7-13 part, Radix Paeoniae Rubra 7-13 part, stir-baked SQUAMA MANITIS 4-8 part, Pericarpium Citri Reticulatae 7-13 part, Radix Trichosanthis 9-15 part, Radix Glycyrrhizae uralensis 4-8 part.
2. pharmaceutical composition according to claim 1, it is characterized in that: it is the preparation that is prepared from by following materials of weight proportions medicine:
40 parts of the bright product of 20 parts of Herba Centipedae or Herba Centipedae, 12 parts of Flos Magnoliaes, 9 parts of Fructus Xanthii, 10 parts of Rhizoma Acori Graminei, 15 parts of Flos Loniceraes, 8 parts of Bulbus Fritillariae Cirrhosaes, 20 parts of Spina Gleditsiaes, 10 parts of the Radixs Angelicae Dahuricae, 8 parts of Radix Saposhnikoviaes, 10 parts of Fructus Viticises, 6 parts of Herba Menthaes, 10 parts of Rhizoma Ligusticis, 9 parts of Olibanums, 9 parts of Myrrhas, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Paeoniae Rubras, 6 parts of stir-baked SQUAMA MANITISs, 10 parts of Pericarpium Citri Reticulataes, 12 parts of Radix Trichosanthis, 6 parts of Radix Glycyrrhizae uralensiss.
3. pharmaceutical composition according to claim 1 and 2 is characterized in that: described Spina Gleditsiae is for frying Spina Gleditsiae.
4. according to any described pharmaceutical composition of claim 1-3, it is characterized in that: described pharmaceutical composition be with the water of the medicated powder of crude drug or crude drug or/and ethanol extraction is active component, add the preparation that adjuvant pharmaceutically commonly used or complementary composition are prepared from.
5. pharmaceutical composition according to claim 4, it is characterized in that: described preparation is oral formulations.
6. pharmaceutical composition according to claim 5, it is characterized in that: described oral formulations is tablet, pill, drop pill, powder, capsule, soft capsule, granule, oral liquid.
7. the described preparation of drug combination method of claim 1, it is characterized in that: it comprises following operating procedure:
(1) weighting raw materials by weight ratio;
(2) get other medical materials except Bulbus Fritillariae Cirrhosae, stir-baked SQUAMA MANITIS, after extracting with water or ethanol water, merge extractive liquid, with the medicinal powder of Bulbus Fritillariae Cirrhosae, stir-baked SQUAMA MANITIS, adds that adjuvant or complementary composition pharmaceutically commonly used are prepared into preparation.
8. the purposes of any described pharmaceutical composition of claim 1-6 in the medicine of preparation treatment nasal sinusitis.
9. purposes according to claim 8 is characterized in that: described medicine is treatment purulent sinusitis's medicine.
10. purposes according to claim 8 is characterized in that: described medicine be treatment because of wind and heat in the lung meridian or wind and cold heat-transformation, gallbladder heat stagnation, spleen channel damp and hot due to the medicine of nasal sinusitis.
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