CN103181956B - Percutaneous absorption plaster for treating degenerative osteoarthropathy - Google Patents
Percutaneous absorption plaster for treating degenerative osteoarthropathy Download PDFInfo
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- CN103181956B CN103181956B CN201110456186.8A CN201110456186A CN103181956B CN 103181956 B CN103181956 B CN 103181956B CN 201110456186 A CN201110456186 A CN 201110456186A CN 103181956 B CN103181956 B CN 103181956B
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Abstract
The invention discloses a percutaneous absorption plaster for treating degenerative osteoarthropathy, which is prepared by the following raw materials: 0.01-0.3 parts of mylabris, 0.3-6 parts of monkshood, 0.5-15 parts of Aconitum kusnezoffii, 1-3 parts of rhizoma corydalis and 1-3 parts of Ligusticum wallichii; 2) extracting the raw materials by an ethanol aqueous solution to obtain an extract product; and 3) adding a percutaneous penetration enhancer to prepare the percutaneous absorption plaster. By using a percutaneous targeting drug delivery system, the percutaneous absorption plaster enables long-time continuous drug delivery, can keep necessary plasma concentration, overcome the adverse influence on human body when the plasma concentration reaches a peak value after oral drug administration, the first pass effect can be avoided, the percutaneous absorption plaster has little harm to liver and kidney, and the simultaneous treatment of principal and subordinate symptoms can be reached.
Description
Technical field
The invention belongs to medical art, relate to a kind of percutaneous absorption patch for the treatment of degeneration osteoarthrosis pain.
Background technology
Degenerative osteoarthritis, also known as hypertrophiarthritis, refers to that some old peoples usually have lumbago, skelalgia, arthralgia.Because it is more common in old people, thus also referred to as senile arthritis.Senescent deterioration is the main cause causing degenerative osteoarthritis.After person in middle and old age, all can there is degeneration change in all histoorgans; Bone and joint tissue no exception, degeneration change, be especially apt to occur in the joint of load-bearing and the joint of multi-activity.Excessive heavy burden or some joint of excessive use, can promote the generation that degeneration changes.In addition, as intra-articular fracture, diabetes, long-term use the factors such as adrenocortical hormone irrelevantly, all can promote the formation that degeneration change and accelerate the development that already present degeneration changes.
Rarity Chinese medicine as China plays huge effect in the treatment of disease, wherein: Mylabris (MYLABRIS) is the dry body of Meloidae insecticide Mylabris phalarata Mylabris phalerata Pallas or yellow black mylabris cichorii Mylabris cichorii Linnaeus.Its function cures mainly: removing blood stasis Xiao Disorder, and counteracting toxic substances phagedenoma, draws red foaming.Yong Yu mass in the abdomen lump, stubborn dermatitis for many years, scrofula, wart, carbuncle is not burst, the dead flesh of malignant boil.Radix Aconiti (RADIXACONITI) is the parent root of ranunculaceae plant Ka Shi Aconitum carmichjaelii Debx. AconitumcarmichaeliDebx..Its function cures mainly: expelling wind and removing dampness, antalgic.Have a pain for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type.Radix Aconiti Kusnezoffii (RADIXACONITIKUSNEZOFFII), another name: Caput Anas domestica, medicine sheep Artemisia, Caput Gallus domesticus grass, Kusnezoff Monkshood Root.For the tuber of ranunculaceae plant Aconitum kusnezoffii Reichb Aconitumkusnezoffii Reichb..Its function cures mainly: expelling wind and removing dampness, antalgic.Have a pain for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type, narcotic analgesic.Said medicine has some to limit time for oral administration, and such as: Mylabris is very toxic, take orally and be cautious use of, anemia of pregnant woman is forbidden.Therefore, need badly a kind of little to human body side effect, again can the medicine of anticancer analgetic.Rhizoma Corydalis acrid in the mouth, hardship, warm in nature.There is promoting blood circulation to remove blood stasis, the function of promoting the circulation of QI pain relieving.For whole body each portion qi depression to blood stasis pain, dysmenorrhea, amenorrhea, lump in the abdomen, postpartum stagnation, injury from falling down, hernia is had a pain.Rhizoma Chuanxiong has blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Effect of wind-expelling pain-stopping, cures mainly: medicine first choice for the treatment of headache.Menoxenia; Amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; Lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; Ulcer sores.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of percutaneous absorption patch for the treatment of degeneration osteoarthrosis pain is provided.
Technical scheme of the present invention is summarized as follows:
Treat a percutaneous absorption patch for degeneration osteoarthrosis pain, make as follows:
(1) following raw material is taken by weight: Mylabris 0.01 ~ 0.3 part; Radix Aconiti 0.3 ~ 6 part; Radix Aconiti Kusnezoffii 0.5 ~ 15 part; Rhizoma Corydalis 1 ~ 3 part; Rhizoma Chuanxiong 1 ~ 3 part;
(2) described raw material ethanol water is extracted, obtain extract; (3) add transdermal penetration enhancer and make patch.
Described Mylabris is 0.03 ~ 0.24 part, and described Radix Aconiti is 0.5 ~ 4 part, and described Radix Aconiti Kusnezoffii is 1.5 ~ 12 parts, and described unit acts like a bully 2 parts; Described Rhizoma Chuanxiong 2 parts.
The concentration expressed in percentage by volume of described ethanol water is 40%-90%.
Described transdermal penetration enhancer is Borneolum Syntheticum, Oleum Caryophylli, Oleum menthae, wintergreen oil or propylene glycol.
A kind of percutaneous absorption patch for the treatment of degeneration osteoarthrosis pain of the present invention, owing to adopting transdermal targeting drug delivery system, add pharmaceutically acceptable adjuvant, make rubber-emplastrum or cataplasma, can long-time continuous administration, maintain necessary blood drug level, harmful effect when blood drug level reaches peak value after can overcoming oral administration, human body caused, and avoid first pass effect, liver, kidney are endangered little, and reach treating both the principal and secondary aspects of a disease.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further illustrated.
Embodiment 1
Treat a percutaneous absorption patch for degeneration osteoarthrosis pain, make as follows:
(1) following raw material is taken by weight: Mylabris 0.1 part; Radix Aconiti 3 parts; Radix Aconiti Kusnezoffii 7 parts; Rhizoma Corydalis 2 parts; Rhizoma Chuanxiong 2 parts;
(2) be that 60% ethanol water extracts by raw material concentration expressed in percentage by volume, obtain extract; (3) add Borneolum Syntheticum and make rubber-emplastrum.
Embodiment 2
Treat a percutaneous absorption patch for degeneration osteoarthrosis pain, make as follows:
(1) following raw material is taken by weight: Mylabris 0.03 part; Radix Aconiti 0.3 part; Radix Aconiti Kusnezoffii 15 parts; Rhizoma Corydalis 1 part; Rhizoma Chuanxiong 2 parts;
(2) be that 75% ethanol water extracts by raw material concentration expressed in percentage by volume, obtain extract;
(3) add Oleum Caryophylli and make subsides rubber-emplastrum.
Embodiment 3
Treat a percutaneous absorption patch for degeneration osteoarthrosis pain, make as follows:
(1) following raw material is taken by weight: Mylabris 0.24 part; Radix Aconiti 0.5 part; Radix Aconiti Kusnezoffii 0.5 part; Rhizoma Corydalis 2 parts; Rhizoma Chuanxiong 3 parts;
(2) be that 40% ethanol water extracts by raw material concentration expressed in percentage by volume, obtain extract;
(3) add Oleum menthae and make rubber-emplastrum.
Embodiment 4
Treat a percutaneous absorption patch for degeneration osteoarthrosis pain, make as follows:
(1) following raw material is taken by weight: Mylabris 0.01 part; Radix Aconiti 4 parts; Radix Aconiti Kusnezoffii 1.5 parts; Rhizoma Corydalis 1 part; Rhizoma Chuanxiong 2 parts;
(2) be that 70% ethanol water extracts by raw material concentration expressed in percentage by volume, obtain extract;
(3) add wintergreen oil and make cataplasma.
Embodiment 5
Treat a percutaneous absorption patch for degeneration osteoarthrosis pain, make as follows:
(1) following raw material is taken by weight: Mylabris 0.3 part; Radix Aconiti 6 parts; Radix Aconiti Kusnezoffii 12 parts; Rhizoma Corydalis 2 parts; Rhizoma Chuanxiong 1 part;
(2) be that 90% ethanol water extracts by raw material concentration expressed in percentage by volume, obtain extract;
(3) add propylene glycol and make cataplasma.
Embodiment 6
Experiment: degenerative osteoarthritis patient, 31 people, age 61-77 year, male 24 people, female 7 people, lumbago, skelalgia, arthralgia, be affixed on sore spot by rubber-emplastrum prepared by embodiments of the invention 1, every day one pastes.Stick latter 30 minutes, 31 people all feel pain relief, and stick latter 60 minutes, wherein 27 people feel that pain disappears.
Claims (3)
1. treat a percutaneous absorption patch for degeneration osteoarthrosis pain, it is characterized in that making as follows:
(1) following raw material is taken by weight: Mylabris 0.01 ~ 0.3 part; Radix Aconiti 0.3 ~ 6 part; Radix Aconiti Kusnezoffii 0.5 ~ 15 part; Rhizoma Corydalis 1 ~ 3 part; Rhizoma Chuanxiong 1 ~ 3 part;
(2) described raw material ethanol water is extracted, obtain extract; (3) add transdermal penetration enhancer and make patch; The concentration expressed in percentage by volume of described ethanol water is 40%-90%.
2. a kind of percutaneous absorption patch for the treatment of degeneration osteoarthrosis pain according to claim 1, it is characterized in that described Mylabris is 0.03 ~ 0.24 part, described Radix Aconiti is 0.5 ~ 4 part, and described Radix Aconiti Kusnezoffii is 1.5 ~ 12 parts, and described unit acts like a bully 2 parts; Described Rhizoma Chuanxiong 2 parts.
3. a kind of percutaneous absorption patch for the treatment of degeneration osteoarthrosis pain according to claim 1 and 2, is characterized in that described transdermal penetration enhancer is Borneolum Syntheticum, Oleum Caryophylli, Oleum menthae, wintergreen oil or propylene glycol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110456186.8A CN103181956B (en) | 2011-12-30 | 2011-12-30 | Percutaneous absorption plaster for treating degenerative osteoarthropathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110456186.8A CN103181956B (en) | 2011-12-30 | 2011-12-30 | Percutaneous absorption plaster for treating degenerative osteoarthropathy |
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| Publication Number | Publication Date |
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| CN103181956A CN103181956A (en) | 2013-07-03 |
| CN103181956B true CN103181956B (en) | 2015-04-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201110456186.8A Expired - Fee Related CN103181956B (en) | 2011-12-30 | 2011-12-30 | Percutaneous absorption plaster for treating degenerative osteoarthropathy |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306756A (en) * | 2014-09-28 | 2015-01-28 | 苏州市天灵中药饮片有限公司 | Plaster for treating osteoarthritis and preparation method thereof |
| CN109288888A (en) * | 2018-12-19 | 2019-02-01 | 廖俞森 | A kind of medicament composing prescription for treating osteoarthropathy |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101229229A (en) * | 2008-02-02 | 2008-07-30 | 崔建平 | Anticancer analgesic percutaneous absorption preparation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101229229A (en) * | 2008-02-02 | 2008-07-30 | 崔建平 | Anticancer analgesic percutaneous absorption preparation |
Non-Patent Citations (2)
| Title |
|---|
| 活血行气的延胡索;园丁;《药物与人》;20081231(第10期);第44页，左栏第3段 * |
| 骨痹疼痛的治疗体会;刘宝琴;《中国现代医生》;20091031;第47卷(第30期);第121-122页 * |
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| CN103181956A (en) | 2013-07-03 |
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Effective date of registration: 20151209 Address after: Guizhou Heping District, Tianjin City Road 300000 Building No. 1, No. 405 pik Patentee after: Cui Jianping Address before: 300384 B101 room, 7 Alex Hua Tian Road, Tianjin Huayuan Industrial Park, Binhai New Area Patentee before: SANCA MEDICAL TECHNOLOGY (TIANJIN) Co.,Ltd. |
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Granted publication date: 20150429 Termination date: 20211230 |