CN103169760A - Medicinal composition for treating chronic conjunctivitis - Google Patents
Medicinal composition for treating chronic conjunctivitis Download PDFInfo
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- CN103169760A CN103169760A CN2013100909378A CN201310090937A CN103169760A CN 103169760 A CN103169760 A CN 103169760A CN 2013100909378 A CN2013100909378 A CN 2013100909378A CN 201310090937 A CN201310090937 A CN 201310090937A CN 103169760 A CN103169760 A CN 103169760A
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Abstract
The invention discloses a medicinal preparation for treating chronic conjunctivitis. The medicinal composition comprises pearl, astragalus and other traditional Chinese medicines, and eye drops can be prepared from the medicinal composition according to clinical requirements. The medicinal composition has an excellent effect for treating or relieving symptoms of chronic conjunctivitis, asthenopia and ocular dryness.
Description
Technical field
The invention discloses a kind of pharmaceutical preparation for the treatment of ocular disease, formed by Chinese medicines such as Margarita and the Radixs Astragali.This pharmaceutical composition for the treatment chronic conjunctivitis, alleviate that eye is dry and astringent has very excellent effect with asthenopia.
Background technology
Chronic conjunctivitis is a kind of chronic oculopathy very occurred frequently, usually recurrence.The conscious eye of patient has gargalesthesia, foreign body sensation and eyestrain.Play interior eyelid section morning and secretions is arranged, eyelid section on daytime visible white foam shape secretions.Conjunctival congestion, a small amount of nipple hypertrophy and folliculus form, take palpebral conjunctiva as main.Do not have blepharoedema and conjunctiva pseudomembrane to form, without the performance of keratitis yet.Inflammation continues with the passing of time person, and conjunctiva can be plump.The staphylococcus aureus causer often infiltrates with ulcerative blepharitis or cornea periphery point-like.
The harm of chronic conjunctivitis is very large, can affect normal work and life during outbreak, if do not note, also can infect to other people.If acute conjunctivitis transfers to chronic, long-term protracted course of disease, have foreign body sensation, eyestrain's discomfort, and is so long-term, has a strong impact on orthobiosis.Serious conjunctivitis also can cause the ptosis, symblepharon etc.Chronic conjunctivitis mainly is divided into infectious and non-infectious two large classes.Infective conjunctivitis is the inflammation that is caused by pathogenic microorganism, and antibacterial, virus, chlamydia, fungus etc. all might be caused a disease.Main and environment and relevant with being accustomed to occur in the harm of chronic conjunctivitis.
Along with the improvement of sanitary condition, the morbidity of infectious chronic conjunctivitis reduces gradually, and noninfective chronic conjunctivitis case is more and more.This is because the reason that causes non-infectious chronic conjunctivitis comprises: the stimulation of dust storm, dust, smog, high light and harmful gas take poor environment and life style as main; Often stay up late, do not have enough sleep, have a liking for cigarette excessively, with the eyestrain etc.Especially long-time operation computer or online are large to eye injury, and on the one hand, the computer asthenopia syndrome can cause the conjunctivitis symptom; On the other hand, the xerophthalmia that causes of computer also can cause or increase the weight of conjunctivitis.Some cosmetics of life-time service or medicament for the eyes are also reasons.
In addition, asthenopia is the common a kind of disease of present ophthalmology, and patient's symptom is varied, and main manifestations is visual disorder, can not be lasting during as close eye, and blurred vision, ghost image, capable overlapping, the word jump of word appear; When seeing again at a distance after seeing closely, need to see clearly gradually a moment.Eye symptom have eye sleepy, keep in dark place, eyelid is heavy, sour swollen sense or pain around difficulty in opening the eyes, eyeball and eye socket, shed tears, foreign body sensation, eye are dry and astringent, saccade etc.Asthenopia also may cause more obstinate headache, giddy, feels sick, lethargy, absent minded, hypomnesis, inappetence, and the symptoms such as neck shoulder aching pain in waist and back and articulations digitorum manus numbness; Diplopia, stereoscopic vision dysfunction, intraocular pressure rising, corneal injury etc. also can appear in minority; There are glaucoma, eye surface or other eye disease patients also can cause or increase the weight of original oculopathy because of asthenopia; In addition, asthenopia also may cause the reduction of senilism and body immunity.
Above-mentioned disease is easily outbreak repeatedly all, and is obstinate difficult, brings very large misery to the patient.Therefore, seek a kind of pharmaceutical preparation safely and effectively treatment chronic conjunctivitis, to alleviate the dry and astringent and asthenopia of eye be one of pharmaceuticals industry problems of concern.
Summary of the invention
The invention provides a kind of externally-applied medicinal composition for the treatment of ocular disease, have clearing away heat to improve acuity of vision, move back red antipruritic effect, can effectively treat chronic conjunctivitis, alleviating asthenopia, the eye symptom such as dry and astringent.This medicine is not only evident in efficacy, and is free from side effects.
This pharmaceutical composition is made by the component of following weight proportioning: Flos Lonicerae 200-600 part, Radix Astragali 200-600 part, Radix Saposhnikoviae 100-350 part, Margarita 20-70 part, Borneolum Syntheticum 3-14 part.
Preferred pharmaceutical composition is made by the component of following weight proportioning: Flos Lonicerae 250-550 part, Radix Astragali 250-550 part, Radix Saposhnikoviae 150-300 part, Margarita 30-60 part, Borneolum Syntheticum 5-12 part.
Most preferred pharmaceutical composition is made by the component of following weight proportioning: 450 parts of Flos Loniceraes, 450 parts of the Radixs Astragali, 220 parts of Radix Saposhnikoviaes, 40 parts of Margaritas, 8 parts of Borneolum Syntheticums.
In addition, according to the dialectical difference of individual patients, can also carry out some flexible adjustment to above-mentioned prescription, include but not limited to: increase or alleviate part or all of prescription consumption; Delete the part component; Increase or replace some clearing away heat to improve acuity of vision, move back red antipruritic Chinese medicine.Undoubtedly, within these adjustment all should be included in the present invention.
The present invention also comprises the preparation method of aforementioned pharmaceutical compositions.Its preparation method comprises: (a) extracting honeysuckle, the Radix Astragali, Radix Saposhnikoviae three flavor Chinese medicines, filter after water decoction-alcohol sedimentation, and filter, concentrated; (2) crushing pearl is fine powder, adds suitable quantity of water, and hydrochloric acid hydrolysis transfers PH closely neutral, concentrated with sodium hydroxide, and drying is pulverized; (3) add entry and Tween-80 in Borneolum Syntheticum, the emulsifying dissolving; (4) get hyaluronic acid sodium appropriate, with water dissolution; (4) merge above-mentioned all liq, add Margarita powder and sodium chloride, then add distilled water, regulate pH value to neutral with sodium hydroxide; (5) filtering with microporous membrane, sterilization, packing.
Preferred step (a) is: extracting honeysuckle, the Radix Astragali, Radix Saposhnikoviae three flavor Chinese medicines, adding distil water 10-30 doubly decocts and extracts 1-3 time, each 1-3 hour, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.10-1.12 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach 70%, placement is spent the night, filter, decompression filtrate recycling ethanol is to distinguishing the flavor of without alcohol, and adding distil water is adjusted to 12.5ml.Most preferred step (a) is: extracting honeysuckle, the Radix Astragali, Radix Saposhnikoviae three flavor Chinese medicines, 20 times of adding distil waters decoct and extract 2 times, each 1.5 hours, merge decoction liquor, filter, filtrate is concentrated into the clear paste that relative density is 1.10-1.12 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach 70%, placement is spent the night, filter, decompression filtrate recycling ethanol is to distinguishing the flavor of without alcohol, and adding distil water is adjusted to 12.5ml.
Preferred step (b) is: Margarita powder is broken into fine powder, adds the appropriate furnishing pasty state of water, adds 1.2-2.4 and doubly measures hydrochloric acid hydrolysis and make molten, standing demix, filter, filtrate for later use, filtering residue is again with 15% hydrochloric acid solution reflux hydrolysis 12-36 hour, hydrolyzed solution filters, merge hydrolyzed solution twice, heating in water bath drives acid, then transfers pH closely neutral with 10% sodium hydroxide solution, concentrated, be dried and crushed into fine powder.Wherein, in step (b), most preferred hydrochloric acid consumption is 1.8 times of amounts.
In preferred step (e), the addition of sodium chloride is 3.5-12.5g, and most preferred addition is 8.5g.
Content of the present invention also comprises the application of this pharmaceutical composition in preparation treatment chronic conjunctivitis, asthenopia, a dry and astringent medicine.
The present invention is described further by the following examples.
The specific embodiment
Embodiment 1
Prescription: 200 parts of Flos Loniceraes, 600 parts of the Radixs Astragali, 100 parts of Radix Saposhnikoviaes, 70 parts of Margaritas, 14 parts of Borneolum Syntheticums.
Method for making: extracting honeysuckle, the Radix Astragali, Radix Saposhnikoviae three flavor Chinese medicines, 10 times of adding distil waters decoct and extract 1 time, extracted 3 hours, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.10-1.12 (50 ℃), adding ethanol makes and contains alcohol amount and reach 70%, placement is spent the night, and filters, and decompression filtrate recycling ethanol is to distinguishing the flavor of without alcohol, adding distil water is adjusted to 12.5ml, and medicinal liquid is standby.Margarita powder is broken into fine powder, adds the appropriate furnishing pasty state of water, adds 1.2 times of amount hydrochloric acid hydrolysiss and makes molten, standing demix filters filtrate for later use, filtering residue is again with 15% hydrochloric acid solution reflux hydrolysis 12 hours, hydrolyzed solution filters, and merges twice hydrolyzed solution, and heating in water bath drives acid, transfer pH closely neutral with 10% sodium hydroxide solution again, concentrated, be dried and crushed into fine powder, standby.Separately get hyaluronic acid sodium 0.1g, add a small amount of water dissolution; Separately get ethyl hydroxybenzoate 0.1g, add 70 ℃ of hot water and dissolve in right amount; Borneolum Syntheticum adds a small amount of water and Tween-80 0.03ml grinding makes the emulsifying dissolving.The three flavor herb liquids such as above-mentioned three kinds of liquid and above-mentioned Flos Lonicerae are merged, and mixing adds Margarita hydrolysis xeraphium and sodium chloride 3.5g successively, be stirred to dissolve, adding distil water to 1000ml, is regulated pH value to 6.0-6.5 with 10% sodium hydroxide solution, mixing again, filter, filter with microporous filter membrane (0.2 μ m), flowing steam sterilization 30 minutes filters under aseptic condition again, packing, and get final product.
Embodiment 2
Prescription: 600 parts of Flos Loniceraes, 200 parts of the Radixs Astragali, 350 parts of Radix Saposhnikoviaes, 20 parts of Margaritas, 3 parts of Borneolum Syntheticums.
Method for making: extracting honeysuckle, the Radix Astragali, Radix Saposhnikoviae three flavor Chinese medicines, 30 times of adding distil waters decoct and extract 3 times, each 1 hour, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.10-1.12 (50 ℃), adding ethanol makes and contains alcohol amount and reach 70%, placement is spent the night, and filters, and decompression filtrate recycling ethanol is to distinguishing the flavor of without alcohol, adding distil water is adjusted to 12.5ml, and medicinal liquid is standby.Margarita powder is broken into fine powder, adds the appropriate furnishing pasty state of water, adds 2.4 times of amount hydrochloric acid hydrolysiss and makes molten, standing demix filters filtrate for later use, filtering residue is again with 15% hydrochloric acid solution reflux hydrolysis 36 hours, hydrolyzed solution filters, and merges twice hydrolyzed solution, and heating in water bath drives acid, transfer pH closely neutral with 10% sodium hydroxide solution again, concentrated, be dried and crushed into fine powder, standby.Separately get hyaluronic acid sodium 0.9g, add a small amount of water dissolution; Separately get ethyl hydroxybenzoate 0.5g, add 80 ℃ of hot water and dissolve in right amount; Borneolum Syntheticum adds a small amount of water and Tween-80 0.3ml grinding makes the emulsifying dissolving.The three flavor herb liquids such as above-mentioned three kinds of liquid and above-mentioned Flos Lonicerae are merged, and mixing adds Margarita hydrolysis xeraphium and sodium chloride 12.5g successively, be stirred to dissolve, adding distil water to 1000ml, is regulated pH value to 6.0-6.5 with 10% sodium hydroxide solution, mixing again, filter, filter with microporous filter membrane (0.2 μ m), flowing steam sterilization 30 minutes filters under aseptic condition again, packing, and get final product.
Embodiment 3
Prescription: 250 parts of Flos Loniceraes, 250 parts of the Radixs Astragali, 300 parts of Radix Saposhnikoviaes, 30 parts of Margaritas, 12 parts of Borneolum Syntheticums.
Method for making: with embodiment 1.
Embodiment 4
Prescription: 550 parts of Flos Loniceraes, 550 parts of the Radixs Astragali, 150 parts of Radix Saposhnikoviaes, 60 parts of Margaritas, 5 parts of Borneolum Syntheticums.
Method for making: with embodiment 2.
Embodiment 5
Prescription: 450 parts of Flos Loniceraes, 450 parts of the Radixs Astragali, 220 parts of Radix Saposhnikoviaes, 40 parts of Margaritas, 8 parts of Borneolum Syntheticums.
Method for making: three flavors such as Flos Lonicerae, the Radix Astragali, Radix Saposhnikoviae, 20 times of adding distil waters decoct and extract 2 times, each 1.5 hours, merge decoction liquor, filter, filtrate is concentrated into the clear paste that relative density is 1.10-1.12 (50 ℃), adding ethanol makes and contains alcohol amount and reach 70%, placement is spent the night, and filters, and decompression filtrate recycling ethanol is to distinguishing the flavor of without alcohol, adding distil water is adjusted to 12.5ml, and medicinal liquid is standby.Margarita powder is broken into fine powder, adds the appropriate furnishing pasty state of water, adds 1.8 times of amount hydrochloric acid hydrolysiss and makes molten, standing demix filters filtrate for later use, filtering residue is again with 15% hydrochloric acid solution reflux hydrolysis 24 hours, hydrolyzed solution filters, and merges twice hydrolyzed solution, and heating in water bath drives acid, transfer pH closely neutral with 10% sodium hydroxide solution again, concentrated, be dried and crushed into fine powder, standby.Separately get hyaluronic acid sodium 0.5g, add a small amount of water dissolution; Separately get ethyl hydroxybenzoate 0.3g, add 70-80 ℃ of hot water and dissolve in right amount; Borneolum Syntheticum adds a small amount of water and Tween-80 0.1ml grinding makes the emulsifying dissolving.The medicinal liquids such as above-mentioned three kinds of liquid and above-mentioned Flos Lonicerae are merged, and mixing adds Margarita hydrolysis xeraphium and sodium chloride 8.5g successively, be stirred to dissolve, adding distil water to 1000ml, is regulated pH value to 6.0-6.5 with 10% sodium hydroxide solution, mixing again, filter, filter with microporous filter membrane (0.2 μ m), flowing steam sterilization 30 minutes filters under aseptic condition again, packing, and get final product.
Embodiment 6
The present invention has carried out animal experiment research to the pharmaceutical composition for preparing in above-described embodiment 1-5, and result shows the present invention to chronic conjunctivitis, asthenopia and eye is dry and astringent that very excellent therapeutic effect arranged.
70 of healthy adult White Rabbits, male and female half and half, the art of sunkening cord under the row bulbar conjunctiva in the upper ball conjunctiva apart from limbus of corneae 2mm place after general anesthesia, the end of a thread does not expose.Above-mentioned laboratory animal is divided into chloromycetin positive controls, model control group, embodiment 1-5 group, gives respectively the pharmaceutical preparation of Chloramphenicol Eye Drop, normal saline, embodiment 1-5.10 eyes of every group of 10 animals are responsible for conjunctival sac in postoperative beginning in 24 hours by the special messenger and are dripped medicine, and each 1, eyes are passive closed one's eyes 10 seconds, every day 4 times, 1 week of the course for the treatment of.
Form observation group by 2～3 people, double-blind method is observed, every day torch naked eyes and fluorescence staining slit lamp observation, record, unified charting quantizes score.The score standard sees the following form.Every Index for examination meter 0,1,2,3 minute, the comprehensive criterion of curative effect: 0～015 is divided into healing, and 1～115 is divided into produce effects, and 2～215 are divided into improvement, are invalid more than 215 minutes.Total effective rate=cure rate+obvious effective rate.
Experimental result is as follows:
Claims (10)
1. externally-applied medicinal composition for the treatment of ocular disease, made by the component of following weight proportioning:
Flos Lonicerae 200-600 part, Radix Astragali 200-600 part, Radix Saposhnikoviae 100-350 part, Margarita 20-70 part, Borneolum Syntheticum 3-14 part.
2. pharmaceutical composition as described in claim 1, is characterized in that, made by the component of following weight proportioning:
Flos Lonicerae 250-550 part, Radix Astragali 250-550 part, Radix Saposhnikoviae 150-300 part, Margarita 30-60 part, Borneolum Syntheticum 5-12 part.
3. the pharmaceutical composition described in claim 1-2, is characterized in that, made by the component of following weight proportioning:
450 parts of Flos Loniceraes, 450 parts of the Radixs Astragali, 220 parts of Radix Saposhnikoviaes, 40 parts of Margaritas, 8 parts of Borneolum Syntheticums.
4. the pharmaceutical composition described in claim 1-3, its preparation method comprises:
(a) extracting honeysuckle, the Radix Astragali, Radix Saposhnikoviae three flavor Chinese medicines, water decoction-alcohol sedimentation filters, and is concentrated;
(b) crushing pearl is fine powder, adds suitable quantity of water, and hydrochloric acid hydrolysis transfers PH closely neutral, concentrated with sodium hydroxide, and drying is pulverized;
(c) add entry and Tween-80 in Borneolum Syntheticum, the emulsifying dissolving;
(d) get Hyaluronic Acid and receive in right amount, with water dissolution;
(e) combining step (a), (c) and the liquid that (d) obtains, the Margarita powder that adds step (b) to obtain, and add sodium chloride, distilled water, regulate pH value to neutral with sodium hydroxide;
(f) filtering with microporous membrane, sterilization, packing.
5. the preparation method of pharmaceutical composition as described in claim 4, its step (a) is: extracting honeysuckle, the Radix Astragali, Radix Saposhnikoviae three flavor Chinese medicines, adding distil water 10-30 is doubly, decoct and extract 1-3 time, each 1-3 hour, collecting decoction filtered, filtrate is concentrated into the clear paste that relative density is 1.10-1.12 (50 ℃), add ethanol and make and contain alcohol amount and reach 70%, placement is spent the night, and filters, decompression filtrate recycling ethanol is to distinguishing the flavor of without alcohol, and adding distil water is adjusted to 12.5ml.
6. the pharmaceutical composition described in claim 4,5, its step (a) is: extracting honeysuckle, the Radix Astragali, Radix Saposhnikoviae three flavor Chinese medicines, 20 times of adding distil waters, decoct and extract 2 times, each 1.5 hours, merge decoction liquor, filter, filtrate is concentrated into the clear paste that relative density is 1.10-1.12 (50 ℃), add ethanol and make and contain alcohol amount and reach 70%, placement is spent the night, and filters, decompression filtrate recycling ethanol is to distinguishing the flavor of without alcohol, and adding distil water is adjusted to 12.5ml.
7. the preparation method of pharmaceutical composition as described in claim 4, its step (b) is: Margarita powder is broken into fine powder, adds the appropriate furnishing pasty state of water, add 1.2-2.4 and doubly measure hydrochloric acid hydrolysis and make moltenly, standing demix filters, filtrate for later use, with 15% hydrochloric acid solution reflux hydrolysis 12-36 hour, hydrolyzed solution filtered filtering residue, merges twice hydrolyzed solution again, heating in water bath drives acid, transfer pH closely neutral, concentrated with 10% sodium hydroxide solution again, be dried and crushed into fine powder.
8. in the preparation method of the pharmaceutical composition described in claim 4,7, its step (b), the hydrochloric acid consumption is 1.8 times of amounts.
9. the preparation method of pharmaceutical composition as described in claim 4, in its step (e), the addition of sodium chloride is 3.5-12.5g.
10. the application of the pharmaceutical composition described in claim 1-9 in preparation treatment chronic conjunctivitis, asthenopic medicine.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109771528A (en) * | 2018-12-28 | 2019-05-21 | 曲沃李时珍医药科技有限公司 | A kind of improvement eye is dry, eye is puckery, asthenopia cold compress eye sticker and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1730022A (en) * | 2005-08-18 | 2006-02-08 | 北京市眼科研究所 | Medicine for treating chronic conjunctivitis |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1730022A (en) * | 2005-08-18 | 2006-02-08 | 北京市眼科研究所 | Medicine for treating chronic conjunctivitis |
Non-Patent Citations (1)
| Title |
|---|
| 李浩博，等: "中医药治疗免疫性结膜炎概况", 《湖南中医杂志》, vol. 28, no. 4, 31 July 2012 (2012-07-31), pages 179 - 180 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109771528A (en) * | 2018-12-28 | 2019-05-21 | 曲沃李时珍医药科技有限公司 | A kind of improvement eye is dry, eye is puckery, asthenopia cold compress eye sticker and preparation method thereof |
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Application publication date: 20130626 |