CN103156992A - An external application plaster combination for treatment of fracture injuries and a preparation method thereof - Google Patents
An external application plaster combination for treatment of fracture injuries and a preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of application of traditional Chinese medicine, and in particular relates to an external application plaster combination for treatment of fracture injuries and a preparation method thereof. The external application plaster combination is characterized by comprising two parts of, namely traumatology extinction paste, and traumatology bone-setting paste. During the treatment of a fracture injury, different pastes are used at different stages, wherein the traumatology extinction paste is externally applied at the injury position in the early fracture reduction, and before and after a surgery; while the traumatology bone-setting paste is applied in the middle and late period to reduce local swelling and pain of the injury, and effectively promote the healing of the fracture, allowing a patient to perform effective functional training relatively early for prevention and treatment of joint stiffness. Clinical applications have proves that the external application plaster combination which is prepared from pure Chinese medicinal herbs, has advantages of being fast in relieving swelling and pain, short in the recovery period, definite in curative effects, and non-side effects.
Description
Technical field
The invention belongs to the Chinese medicine applied technical field, be specifically related to a kind of Dressed plaster combination for the treatment of fracture and injury and preparation method thereof.
Background technology
Chinese medicinal external application treatment fracture, joint injury can be traced back to the Spring and Autumn and the Warring States Periods, existing treatment fracture, the plaster of joint injury, as SHEXIANG ZHUANGGU GAO, the subsides of strange positive scorching pain, YUNNAN BAIYAO cream etc., mostly prescription is in medication, can not bring into play between Chinese medicine mutually replenish, the effect of promoting blood circulation to remove obstruction in the collateral, circulation of qi promoting blood stasis dispelling, strong muscle granulation promoting.Often with the soft tissue injury of distinct program, the soft tissue injury degree is in injured all more difficult judgements at that time for fracture and injury.No matter manual reduction is fixed or interior the fixing of surgical incision will further be increased the weight of soft tissue injury, cause cutaneous necrosis, inside-fixture and exposed bone.Traditional Therapeutic Method is difficult to early stage reduction and operation because of injured limb swelling, usually causes that at the swelling stage operation postoperative wound healing is bad, and infection and fracture delayed union even do not heal, the adverse consequencess such as joint function disturbance.Although Wicresoft's osteopathy (minimally inVasive plafe osteosynthesis; MIPO) can effectively protect the blood supply of fracture site; but can not alleviate the damage to the blood fortune of bone and soft tissue fully, the complication such as nonunion and infection still have generation.After how making fracture, soft tissue swelling disappears fast, pain relief, and joint function recovery improves clinical healing rate and the bony union rate of fracturing, and is the problem that Orthopedic Clinical must be faced always.The present invention adopts the Dressed plaster for the treatment of fracture and injury, coordinates manual reduction, open reduction treatment fracture and injury, and slow to solve the prior art reducing swelling and alleviating pain, healing period is long, the problem of weak curative effect.
Summary of the invention
The Dressed plaster combination for the treatment of fracture and injury provided by the invention is divided into two doses, be that traumatology disappears and decides cream, SHANGKEJIEGUGAO, the detumescence hemostatic treatment stage disappears with traumatology and decides cream when treatment, uses SHANGKEJIEGUGAO in the bone-setting treatment stage, and the technical scheme that adopts is specific as follows:
One, the Dressed plaster combination for the treatment of fracture and injury, its crude drug forms and weight proportion:
(1), the traumatology for the treatment of fracture and injury detumescence hemostasis disappears and decides cream, it includes the crude drug of following parts by weight:
Lignum Sappan: 10～20g, Fructus Chaenomelis: 10～20g, Radix Achyranthis Bidentatae: 10～20g, Flos Carthami: 25～35g, Radix Notoginseng: 2～10g, Semen Persicae: 10～20g, Olibanum: 5～15g, Myrrha: 5～15g, pyrolusitum: 10～20g, Os Draconis: 10～20g, Radix Asparagi: 10～20g, Pheretima: 25～35g, vomiting nut: 10～20g, ground beetle: 25～35g, Moschus: 1～3g, Radix Dipsaci: 25～35g, catechu: 25～35g, Pyritum: 25～35g.
The optimum weight proportioning of the crude drug that wherein comprises is: Lignum Sappan: 15g, Fructus Chaenomelis: 15g, Radix Achyranthis Bidentatae: 15g, Flos Carthami: 30g, Radix Notoginseng: 6g, Semen Persicae: 15g, Olibanum: 10g, Myrrha: 10g, pyrolusitum: 15g, Os Draconis: 15g, Radix Asparagi: 15g, Pheretima: 30g, vomiting nut: 15g, ground beetle: 30g, Moschus: 3g, Radix Dipsaci: 30g, catechu: 30g, Pyritum: 30g.
(2), the SHANGKEJIEGUGAO for the treatment of fracture and injury synthetism, it includes the crude drug of following parts by weight:
Radix Angelicae Sinensis: 55～65g, Rhizoma Chuanxiong: 25～35g, fry ground: 115～125g, the Radix Paeoniae Alba: 25～35g, Olibanum: 25～35g, Myrrha: 25～35g, Pyritum (calcined): 25～35g, Os Draconis (calcined): 25～35g, eupolyphaga: 2～10g, Moschus: 2～6g, Rhizoma Drynariae: 85～95g, Radix Notoginseng: 5～15g, Ramulus Cinnamomi: 25～35g, the Radix Astragali: 85～95g, Radix Codonopsis: 55～65g, Semen Cuscutae: 55～65g, Cortex Acanthopancis: 40～50g, Herba Artemisiae Anomalae: 55～65g, pyrolusitum: 25～35g, Fructus Chaenomelis: 25～35g, Fructus Psoraleae: 55～65g, the Cortex Eucommiae: 25～35g.
The optimum weight proportioning of the crude drug that wherein comprises is: Radix Angelicae Sinensis: 60g, Rhizoma Chuanxiong: 30g, fry ground: 120g, the Radix Paeoniae Alba: 30g, Olibanum: 30g, Myrrha: 30g, Pyritum (calcined): 30g, Os Draconis (calcined): 30g, eupolyphaga: 6g, Moschus: 6g, Rhizoma Drynariae: 90g, Radix Notoginseng: 10g, Ramulus Cinnamomi: 30g, the Radix Astragali: 90g, Radix Codonopsis: 60g, Semen Cuscutae: 60g, Cortex Acanthopancis: 45g, Herba Artemisiae Anomalae: 60g, pyrolusitum: 30g, Fructus Chaenomelis: 30g, Fructus Psoraleae: 60g, the Cortex Eucommiae: 30g.
Two, the preparation method of the Dressed plaster combination for the treatment of fracture and injury:
1, will prepare traumatology disappear decide cream, SHANGKEJIEGUGAO crude drug classifying drying is ground 180 orders into powder, the dress pouch that sieves, wherein bake out temperature is controlled at: 50～60 ℃, Moschus is drying and processing not;
2, classifying drying being ground into powder pack into the standby crude drug of pouch and the Moschus of sieving disappears with the preparation traumatology and decides cream needed raw material medicine composition and percentage by weight carries out proportioning, then pour among container and water and Mel mix and blend, wherein, crude drug: water: the Mel mixing ratio is 3: 1: 0.5, water temperature is controlled at 60～80 ℃, stir, static parking 1～2 hour, encapsulation is traumatology and disappears and decide cream.
3, classifying drying is ground into powder the standby crude drug of pouch of packing into of sieving and carried out proportioning with preparation SHANGKEJIEGUGAO needed raw material medicine composition and percentage by weight thereof, then pour among container and water and Mel mix and blend, wherein, crude drug: water: the Mel mixing ratio is 3: 1: 0.5, water temperature is controlled at 60～80 ℃, stir, static parking 1～2 hour, encapsulation is SHANGKEJIEGUGAO.
4, the traumatology that makes is disappeared decide cream, SHANGKEJIEGUGAO and be encapsulated in the Dressed plaster combination that is treatment fracture and injury of the present invention in a box.
Three, the using method of the Dressed plaster combination for the treatment of fracture and injury
When being diagnosed as fracture and injury, conventional manual reduction, plintlet is fixed, getting traumatology disappears and decides cream, the stand is put in absorbent paper, and outer cladding gauze one deck is then with its outer damage location that spreads on, get final product with 3-4 layer gauze parcel, changed traumatology in every 2 days and disappear and decide cream once, and adjust the clamping plate elasticity, after swelling is disappeared fully, change the SHANGKEJIEGUGAO external application into, namely get SHANGKEJIEGUGAO stand and be put in absorbent paper, outer cladding gauze one deck is then with its outer damage location that spread on, get final product with 3-4 layer gauze parcel, keep being fixed to clinical union of bone.
Bad to the reduction of the fracture, the patient requires operator, first disappears with said method external application traumatology to decide cream, and clamping plate are temporary fixed, and the open reduction of changing one's profession after fracture and injury position swelling is disappeared is fixed, and after the postoperative wound healing, the external application SHANGKEJIEGUGAO is to clinical union of bone.
In the combination of the Dressed plaster for the treatment of fracture and injury of the present invention, its traumatology disappears and decides Lignum Sappan, Fructus Chaenomelis, Radix Achyranthis Bidentatae, Flos Carthami, Radix Notoginseng, Semen Persicae in cream, relaxing muscles and tendons and activating QI and blood in the collateral, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain; Pyrolusitum: promoting blood circulation and hemostasis, subduing swelling and relieving pain; Pheretima, Olibanum, Myrrha, removing blood stasis, removing obstruction in the collateral to relieve pain; Os Draconis: unsmoothing the sperm and stopping bleeding; Radix Asparagi: anti-inflammation; Vomiting nut, ground beetle, Moschus: promoting blood circulation and stopping pain; Radix Dipsaci: hemostasis, analgesia, promotion tissue regeneration; Catechu, antiinflammatory, analgesic therapy, hemostasis; Pyritum: eliminating stasis to stop pain, reunion of fractured tendons and bones.Above all medicines share plays blood circulation promoting and blood stasis dispelling altogether, removing obstruction in the collateral to relieve pain, the merit of sharp blood detumescence, make fracture and injury surrounding soft tissue blood unobstructed, grain is unfolded, and impels the absorption of damage local stasis of blood, edema, inflammation exudate, alleviate the degeneration of local soft tissue, the contracture of periarticular soft tissues and calcification.
The Dressed plaster combination for the treatment of fracture and injury of the present invention, in its SHANGKEJIEGUGAO, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, the Radix Paeoniae Alba, Fructus Chaenomelis: blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain; Fry ground: beneficial essence is filled out marrow; Olibanum, Myrrha, Pyritum (calcined), removing blood stasis, removing obstruction in the collateral to relieve pain; Os Draconis (calcined): hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing; Eupolyphaga: removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones; Moschus: promoting blood circulation and stopping pain; Rhizoma Drynariae: pain relieving, bone strengthening; Semen Cuscutae: antibacterial, pain relieving; Herba Artemisiae Anomalae: healing up sore and subduing swelling, hemostasis analgesic therapy; Pyrolusitum: promoting blood circulation and hemostasis, subduing swelling and relieving pain; The Cortex Eucommiae, Cortex Acanthopancis kidney-tonifying sperm-generating, Ramulus Cinnamomi, the Radix Astragali, Radix Codonopsis: circulation of qi promoting is enriched blood, the Radix Astragali, benefiting QI and nourishing blood; Fructus Psoraleae: controlling nocturnal emission with astringent drugs gas, bone strengthening marrow, repair the bone conformality.All medicines share altogether to be played, promoting the flow of QI in the collateral by warming the meridian, and spermatogenesis benefit blood, the circulation of qi promoting dissipating blood stasis, adjusting and reinforcing liver and kidney connects the not bone of heavily fortified point, the continuous muscle that does not connect.
The beneficial effect that the present invention treats the Dressed plaster combination of fracture and injury is to take to divide stage by stage the prescription treatment when the treatment fracture and injury, at the early stage reduction of fracture, perioperatively, injury region external application traumatology disappears and decides cream, middle and advanced stage external application SHANGKEJIEGUGAO, can alleviate the damage local swelling, pain is effectively impelled the healing of fracture, make the patient early carry out effective functional exercise, prevention and treatment ankylosis.Through clinical practice prove its have reducing swelling and alleviating pain fast, more the phase short, determined curative effect, pure Chinese medicine is made the advantage that has no side effect.
The specific embodiment
The present invention treats Dressed plaster combination of fracture and injury and preparation method thereof, in conjunction with Pingliang, Gansu Province traditional Chinese medical bone fracture hospital clinical trial, is described further.
One, the technical scheme that adopts:
(1), the Dressed plaster combination raw materials for the treatment of fracture and injury forms and weight proportion:
1, the Dressed plaster combination for the treatment of fracture and injury, wherein said traumatology disappears and decides cream, selects optimum weight part of its crude drug that comprises: Lignum Sappan: 15g, Fructus Chaenomelis: 15g, Radix Achyranthis Bidentatae: 15g, Flos Carthami: 30g, Radix Notoginseng: 6g, Semen Persicae: 15g, Olibanum: 10g, Myrrha: 10g, pyrolusitum: 15g, Os Draconis: 15g, Radix Asparagi: 15g, Pheretima: 30g, vomiting nut: 15g, ground beetle: 30g, Moschus: 3g, Radix Dipsaci: 30g, catechu: 30g, Pyritum: 30g.
2, the Dressed plaster combination for the treatment of fracture and injury, wherein said SHANGKEJIEGUGAO, select optimum weight part of its crude drug that comprises:: Radix Angelicae Sinensis: 60g, Rhizoma Chuanxiong: 30g, fry ground: 120g, the Radix Paeoniae Alba: 30g, Olibanum: 30g, Myrrha: 30g, Pyritum (calcined): 30g, Os Draconis (calcined): 30g, eupolyphaga: 6g, Moschus: 6g, Rhizoma Drynariae: 90g, Radix Notoginseng: 10g, Ramulus Cinnamomi: 30g, the Radix Astragali: 90g, Radix Codonopsis: 60g, Semen Cuscutae: 60g, Cortex Acanthopancis: 45g, Herba Artemisiae Anomalae: 60g, pyrolusitum: 30g, Fructus Chaenomelis: 30g, Fructus Psoraleae: 60g, the Cortex Eucommiae: 30g.
(2), the preparation method of the Dressed plaster combination for the treatment of fracture and injury:
1, will prepare traumatology disappear decide cream, SHANGKEJIEGUGAO crude drug classifying drying is ground 180 orders into powder, the dress pouch that sieves, wherein bake out temperature is controlled at: 50～60 ℃, Moschus is drying and processing not;
2, classifying drying being ground into powder pack into the standby crude drug of pouch and the Moschus of sieving disappears with the preparation traumatology and decides cream needed raw material medicine composition and percentage by weight carries out proportioning, then pour among container and water and Mel mix and blend, wherein, crude drug: water: the Mel mixing ratio is 3: 1: 0.5, water temperature is controlled at 60～80 ℃, stir, static parking 1～2 hour, encapsulation is traumatology and disappears and decide cream.
3, classifying drying is ground into powder the standby crude drug of pouch of packing into of sieving and carried out proportioning with preparation SHANGKEJIEGUGAO needed raw material medicine composition and percentage by weight thereof, then pour among container and water and Mel mix and blend, wherein, crude drug: water: the Mel mixing ratio is 3: 1: 0.5, water temperature is controlled at 60～80 ℃, stir, static parking 1～2 hour, encapsulation is SHANGKEJIEGUGAO.
4, traumatology is disappeared decide cream, SHANGKEJIEGUGAO and be encapsulated in the Dressed plaster combination that is treatment fracture and injury of the present invention in a box.
(3), the using method of the Dressed plaster combination for the treatment of fracture and injury
When being diagnosed as fracture and injury, conventional manual reduction, plintlet is fixed, getting traumatology disappears and decides cream, the stand is put in absorbent paper, and outer cladding gauze one deck is then with its outer damage location that spreads on, get final product with 3-4 layer gauze parcel, changed traumatology in every 2 days and disappear and decide cream once, and adjust the clamping plate elasticity, after swelling is disappeared fully, change the SHANGKEJIEGUGAO external application into, namely get SHANGKEJIEGUGAO stand and be put in absorbent paper, outer cladding gauze one deck is then with its outer damage location that spread on, get final product with 3-4 layer gauze parcel, keep being fixed to clinical union of bone.
Bad to the reduction of the fracture, the patient requires operator, first disappears with said method external application traumatology to decide cream, and clamping plate are temporary fixed, and the open reduction of changing one's profession after fracture and injury position swelling is disappeared is fixed, and after the postoperative wound healing, the external application SHANGKEJIEGUGAO is to clinical union of bone.
Two, clinical experiment:
1. data and method
1.1 object of study and grouping: choose radius far-end fracture 4108 examples that in January, 2002 to 2010, year the December emergency treatment was accepted for medical treatment, distal tibial fracture 2438 examples are totally 6546 examples, be divided at random two groups in male 1478 examples of outside far end bone of radius compromise, account for 36%, female's 2630 examples account for 64%, age (31～92 years old), mean age (62.1+1.2 year), traumatogenic reason: traumatic injury 2751 examples account for 67%, traffic accident injury 1355 examples, account for 33%, screening criteria: a) betide the closure radius far-end fracture in 24 hours, the age was more than or equal to 31 years old.B) the fracture typing is A1, A2, B1 and C1 type (AO) typing, and articular step-off or crack be less than 3mm, and the fracture external contracting is less than the capable manual reduction of 5mm, and clamping plate are fixing outward.C) A3, B2, B3, C2 and C3 type fracture CAO typing, dorsal part pulverizing scope surpasses palmar distance 50%, and transverse shift can try manual reduction greater than 1cm and open fracture, clamping plate are fixing outward, and it is fixing that reset failure or patient have requirements of operation person to change in distal radial palmar T-steel plate.in tibiofibula fracture of distal 2438 examples, man's 1658 examples account for 68%, female's 780 examples account for 32%, 16～72 years old age, mean age (35+1.8 year), injure 902 examples by a crashing object, 37%, traffic accident wound 585 examples account for 24%, Falling Injury 511 examples, account for 21%, hard thing wounds 440 examples, account for 18%, open injury 328 examples wherein, press the Ruedi-Allgower typing, I type 560 examples, account for 23%, II type 1518 examples, account for 62.3%, III type 360 examples, account for 14.7%, screening criteria is a) fresh fracture, b) impassivity blood vessel injury before art, c) closure or compound fracture, d) without serious osteoporosis, diabetes, bone tumor.6546 exceptions of choosing the condition of conforming to are divided into two groups at random, and wherein Dressed plaster combination is that traumatology disappears and decides cream, SHANGKEJIEGUGAO group 3723 examples, matched group 3723 examples.The grouping situation sees Table 1.Table 1
The sick kind of table 1, age, sex, classification of fracture situation
1.2 Therapeutic Method
After 1-2-1 radius far-end fracture drug of topical application group is made a definite diagnosis, conventional manual reduction, plintlet is fixed, and the external application traumatology disappears and decides cream.The Colles fracture splint is fixed in palmar chi off normal, the Smith fracture fixation is stretched the chi off normal in dorsal part, take the photograph X-ray film after resetting and check that fracture reduction is to the line situation, changing traumatology in every 2 days later on disappears and decides cream once, adjust the clamping plate elasticity, after swelling is disappeared fully, change the SHANGKEJIEGUGAO external application into, keep being fixed to clinical union of bone, second day begin column finger bends and stretches functional exercise after reduction is fixing simultaneously.Bad to the reduction of the fracture, the patient requires operator, and existing external application traumatology disappears and decides cream, and clamping plate are temporary fixed, and is fixing in the open reduction of changing one's profession after wrist portion swelling is disappeared T-steel plate, and after the postoperative wound healing, the external application SHANGKEJIEGUGAO is to clinical union of bone.
After 1-2-2 tibiofibula fracture of distal drug of topical application group was made a definite diagnosis, Therapeutic selection was to pass through calcaneal traction before operation, and manual reduction, super ankle clamping plate are fixing outward, and be fixing in Wicresoft's anatomical form distal tibial steel plate stage by stage.The manual reduction fracture reduction can continue conservative non-operative treatment to the good person of line, and the external application traumatology disappears and decides cream, and after the postoperative wound healing, the external application SHANGKEJIEGUGAO is to clinical union of bone.
The 1-2-3 matched group, the reduction of the fracture, fixing, operation method disappears with the external application traumatology and decides the cream group, all adopts lifting affected limb before art, uses hemorrhage, the Comprehensive Treatments such as detumescence medicine (mannitol or Sodium Aescinate), not external application traumatology disappears and decides cream and SHANGKEJIEGUGAO.
1.3 the standard of curative effect evaluation
Clinical healing rate and all patients of bony union rate the 4th week, the 10th week check x-ray after fracture in the 1-3-1 special time, with the part without tenderness, without vertically knocking pain and abnormal movement, X-ray film shows that fracture line is fuzzy, there is continuous callus to pass through fracture line, after fixing except solution, upper limb is put down forward and is stretched, and the heavy 1kg of extension reaches 1min and is considered as clinical healing; To have all standard of clinical healing, x-ray shows the seriality callus by fracture line, and fracture line disappears or approaches to disappear and is considered as bony union.After two groups of patients are fractured, the clinical healing rate in 4 weeks and the situation of the bony union rate in 10 weeks of fracturing compare, and observing disappears decides cream, JIEGU GAO to the impact of union of fracture.
After the 1-3-2 pain scores adopts visual simulation method (Visual analog scale VAS) observation patient to hinder, 1,4,10 all pain scores compare two groups of patient's pain situations, and get rid of by the specialist possibility that Other diseases causes pain.
The 1-3-3 wrist joint function was estimated all patients and adopt Cartland and the remaining deformity/subjective assessment of Vverley carpal joint standards of grading/objective evaluation/complication when 4,8,12 week, finger function carries out the wrist joint function evaluation, that total points 100 minutes, comprehensive score can be divided into is excellent, good, can, differ from four grades.
The 1-3-4 ankle joint function estimate all patients in 4,8,12 whens week according to the Mazur evaluation criteria.Carry out the ankle joint function evaluation, total points 100 minutes, can be divided into excellent, good, can, differ from 4 grades.
The 1-3-5 limb swelling disappears time and limbs week to measure two groups of patients all in fracture and injury at that time through variation, hinders rear 5 days, hinders rear 10 days mensuration, observes traumatology and disappears and decide cream to the disappear impact of degree of limb swelling.
In 1-3-6 statistical analysis literary composition, the data spss13.0 carries out statistical procedures, VAS scoring between two groups, Cartland, the scoring of Werley carpal joint, Mazur ankle joint scoring acceptance rate, 4 all clinical healings and 10 all clinical healing situations adopt the X 2 test analysis, and two groups of patients hinder limb wound swelling in the rear 7 days situation that disappears and contrast employing t check analysis
2, result
Clinical healing rate and bony union rate in the 2-1 special time, the combination of application Dressed plaster, be that traumatology disappears and decides that 4 all clinical healing situations and 10 all bony union rates all are better than matched group after cream, JIEGU GAO group fracture, (P＜0.05) difference has statistical significance, prompting can effectively improve in the combination of different time points Dressed plaster, clinical healing rate and bony union rate in the distal radius special time see Table 2.
4 all clinical healings and 10 all clinical healing situations (example) after table 2 fracture
Annotate:
*P＜0.05
The 2-2 pain scores, Dressed plaster group VAS marks significantly lower than matched group (P＜0.05), and pain degree is lighter, and the wrist ankle joint function is recovered also comparatively fully, and (P＜0.05) sees Table 3.
Table 3 liang group patient VAS scoring Cartland and the scoring of Werley carpal joint scoring Mazur ankle joint
Annotate:
*P＜0.05
2-3 hinders limb swelling regression time and degree: the Dressed plaster group is hindered limb swelling regression time in advance, and degree (P＜0.05) in advance sees Table 4
Table 4 a liang group patient hinders between rear 7 days of limb wound swelling paracmasis and the degree situation
Annotate:
*P＜0.0.
The 2-4 principle:
(1) B﹠J damage is commonly encountered diseases, frequently-occurring disease, and the patient when medical sign very remarkable, the X-ray film finding is also quite clear and definite, there is no difficulty in the majority of cases diagnosis.Closed fracture patient is complete because of skin soft tissue, and swelling pressure can not get discharging, so local swelling is serious, easily forms blister.Postoperative skin necrosis whether occurs and the wound healing situation depends on opportunity of operation.In early injury 12h, mostly the swelling of onset is what Fracture Hematoma and Limb Shortening caused.After 8-12h, swelling is mainly that the Intradermal edema causes, but by different blister type indirect Estimation skins, the degree of soft tissue injury.Simultaneously, due to fixing major limitation the activity in joint, muscle does not move, vein and lymphatic vessel are retarded by silt, the slow tissue edema that circulates, the pulp fibers albumen that oozes out forms adhesion between joint capsule, pleat and synovial membrane opisthotonos and muscle, leave over joint function disturbance.Bartlree etc. think and relate to the articular surface of ankle setting board of skeleton end fracture, the intercalation of distinct program is arranged, be comminuted, unstability, the articular surface cartilage injury, articular surface is uneven, the serious soft tissue injury of general normal merging, when swelling was not disappeared fully, reduction and operation can increase the weight of soft tissue injury, and curative effect is often not good enough.And easily produce the myometrial suture difficulty in art, the infection of incisional wound of postoperative secondary, disruption of wound, bone and inside-fixture expose.Radius far-end fracture uses simple Gypsum Fibrosum or clamping plate are fixing outward, because the set time extends, usually can cause carpal joint stiff, unable, increases the weight of osteoporosis; The syndromes such as Sudeck atrophy even can occur, operative treatment is also inapplicable to the relatively poor old people of part physical condition, and it is large to have wound, easy infection, produce the shortcomings such as soft tissue irritation and wearing and tearing, after fracture, osteoporosis also can cause interior fixedly hold to descend, even loose shift.so how to reduce in a short time soft tissue injury after patient's fracture and injury, the swelling that the fracture site hematoma causes, especially before performing the operation, the distal tibial fracture person how to impel as early as possible local swelling to disappear, reduction, impel as soon as possible fracture heals in early days after operation, recover function of joint is the difficult problem that Orthopedic Clinical solves always, in the present invention, early stage external application traumatology disappears and decides cream, clinical healing rate and the bony union rate in 10 weeks in later stage external application SHANGKEJIEGUGAO group 4 weeks after fracture obviously improve (P＞0.05), the Dressed plaster combination that proves this treatment fracture and injury plays union of fracture and impels effect, can shorten healing time and limb brake time, allow the patient to remove as early as possible the outer functional exercise of fixedly carrying out, alleviate the untoward reaction that limb brake produces.And from Cartland and the scoring of Werley carpal joint, Mazur ankle joint function appraisal result, the Dressed plaster group obviously is better than matched group (P＜0.05) to the recovery of wrist, ankle joint function.
(2) after fracture or joint injury, hemorrhage owing to organizing, body fluid oozes out, traumatic inflammatory reaction, the stimulation generation pain some patients were sharp ache that the spasm of muscle, local vein and lymphatic vessel are retarded by silt and are formed local swelling and fracture end, the general more difficult alleviation of medicine.After this problem VAS appraisal result demonstration external application traumatology disappears and decides cream, patient's pain perception obviously alleviates, degree is far below matched group (P＞0.05), this medicine to fracture and injury after pain obvious mitigation is arranged: we think main and realize fracture town's pain effect to fracture patient by three kinds of approach.A) to the direct effect inhibition of pain of nerve, b) alleviate the stimulation c that soft tissue swelling forms) by manual reduction and traction, loosening of soft tissue alleviates the pain that the film sexual stimulus produces after the reduction of the fracture.
(3) clinical practice Dressed plaster combined therapy fracture, take to divide stage by stage the prescription treatment when the treatment fracture and injury, at the early stage reduction of fracture, perioperatively, injury region external application traumatology disappears and decides cream, middle and advanced stage external application SHANGKEJIEGUGAO has embodied the dialectical thought that treats of the traditional Chinese medical science.
(4) show through pharmacological evaluation, the present invention treats the Dressed plaster combination of fracture and injury, and its unguentum contains the bioactive peptide of multiple bone metabolism, has the adjusting bone metabolism, stimulated osteoblastic proliferation, and foot makes callus formation, induces new bone formation, promotes fracture repair; Can reduce the local capillary permeability of fracture, reduce inflammatory exudation, foot advances the recovery of local blood fortune obstacle, and the blood circulation that improves the callus part has detumescence effect for osteocyte provides good blood for environment.
3, beneficial effect of the present invention is
(1) Dressed plaster for the treatment of fracture and injury of the present invention combination, be divided into two doses, be that traumatology disappears and decides cream, SHANGKEJIEGUGAO, when treatment, the detumescence hemostatic treatment stage disappears with traumatology decides cream, use SHANGKEJIEGUGAO in the bone-setting treatment stage, coordinate manual reduction or open reduction internal fixation treatment extremities joint fracture and injury, show through the clinical comparison treatment, at radius far-end fracture, can obviously alleviate the damage local swelling in tibiofibula fracture of distal therapeutic process, pain, effectively impel union of fracture, can make the patient early carry out effective functional exercise, prevention and treatment ankylosis, embodied the Overall View of orthopedics department internal and external application, the principle that meets the minimally-invasive treatment fracture.
(2) Dressed plaster for the treatment of fracture and injury of the present invention combination, its reasonable recipe, preparation is simple, and is easy to use, is easy to carry.
(4) Dressed plaster for the treatment of fracture and injury of the present invention combination, its treatment with fracture and injury is divided into two stages, disappear with traumatology decide cream, SHANGKEJIEGUGAO treats respectively, perfect combination, kept to greatest extent periosteum, and intramembranous ossification is the basis that bone is repaired, union of fracture is fast.As long as there is the good manual reduction technology fully can be at Grass-roots Hospital.
In the present invention, the Dressed plaster combination for the treatment of fracture and injury, early stage external application traumatology disappears and decides cream, clinical healing rate and the bony union rate in 10 weeks in later stage external application SHANGKEJIEGUGAO group 4 weeks after fracture obviously improve (P＞0.05), the Dressed plaster combination that proves this treatment fracture and injury plays union of fracture and impels effect, can shorten healing time and limb brake time, allow the patient to remove as early as possible the outer functional exercise of fixedly carrying out, alleviate the untoward reaction that limb brake produces.And from the scoring of Cartland and Werley carpal joint, Mazur ankle joint function appraisal result, the Dressed plaster group obviously is better than matched group (P＜0.05 to the recovery of wrist, ankle joint function., have good social benefit.
Claims (3)
1. the Dressed plaster combination for the treatment of fracture and injury is characterized in that: this plaster combination is divided into two doses, and namely traumatology disappears and decides cream and SHANGKEJIEGUGAO;
Described traumatology disappears and decides cream, and its crude drug composition and weight proportion thereof are as follows:
Lignum Sappan: 10～20g, Fructus Chaenomelis: 10～20g, Radix Achyranthis Bidentatae: 10～20g, Flos Carthami: 25～35g, Radix Notoginseng: 2～10g, Semen Persicae: 10～20g, Olibanum: 5～15g, Myrrha: 5～15g, pyrolusitum: 10～20g, Os Draconis: 10～20g, Radix Asparagi: 10～20g, Pheretima: 25～35g, vomiting nut: 10～20g, ground beetle: 25～35g, Moschus: 1～3g, Radix Dipsaci: 25～35g, catechu: 25～35g, Pyritum: 25～35g;
Described traumatology disappears and decides cream, and its optimum feed stock forms and weight proportion is: Lignum Sappan: 15g, Fructus Chaenomelis: 15g, Radix Achyranthis Bidentatae: 15g, Flos Carthami: 30g, Radix Notoginseng: 6g, Semen Persicae: 15g, Olibanum: 10g, Myrrha: 10g, pyrolusitum: 15g, Os Draconis: 15g, Radix Asparagi: 15g, Pheretima: 30g, vomiting nut: 15g, ground beetle: 30g, Moschus: 3g, Radix Dipsaci: 30g, catechu: 30g, Pyritum: 30g;
Described SHANGKEJIEGUGAO, its crude drug composition and weight proportion thereof are as follows:
Radix Angelicae Sinensis: 55～65g, Rhizoma Chuanxiong: 25～35g, fry ground: 115～125g, the Radix Paeoniae Alba: 25～35g, Olibanum: 25～35g, Myrrha: 25～35g, Pyritum (calcined): 25～35g, Os Draconis (calcined): 25～35g, eupolyphaga: 2～10g, Moschus: 2～6g, Rhizoma Drynariae: 85～95g, Radix Notoginseng: 5～15g, Ramulus Cinnamomi: 25～35g, the Radix Astragali: 85～95g, Radix Codonopsis: 55～65g, Semen Cuscutae: 55～65g, Cortex Acanthopancis: 40～50g, Herba Artemisiae Anomalae: 55～65g, pyrolusitum: 25～35g, Fructus Chaenomelis: 25～35g, Fructus Psoraleae: 55～65g, the Cortex Eucommiae: 25～35g,
Described SHANGKEJIEGUGAO, its optimum feed stock forms and weight proportion is: Radix Angelicae Sinensis: 60g, Rhizoma Chuanxiong: 30g, fry ground: 120g, the Radix Paeoniae Alba: 30g, Olibanum: 30g, Myrrha: 30g, Pyritum (calcined): 30g, Os Draconis (calcined): 30g, eupolyphaga: 6g, Moschus: 6g, Rhizoma Drynariae: 90g, Radix Notoginseng: 10g, Ramulus Cinnamomi: 30g, the Radix Astragali: 90g, Radix Codonopsis: 60g, Semen Cuscutae: 60g, Cortex Acanthopancis: 45g, Herba Artemisiae Anomalae: 60g, pyrolusitum: 30g, Fructus Chaenomelis: 30g, Fructus Psoraleae: 60g, the Cortex Eucommiae: 30g.
2. method for the preparation of the combination of the Dressed plaster of the described treatment fracture and injury of claim 1 is characterized in that comprising following steps:
(1), will prepare the traumatology crude drug classifying drying of deciding cream, SHANGKEJIEGUGAO that disappears and grind 180 orders into powder, the dress pouch that sieves, wherein bake out temperature is controlled at: 50～60 ℃, Moschus is drying and processing not;
(2), classifying drying being ground into powder pack into the standby crude drug of pouch and the Moschus of sieving disappears with the preparation traumatology and decides the required crude drug formula of cream and percentage by weight carries out proportioning, then pour among container and water and Mel mix and blend, wherein, crude drug: water: the Mel mixing ratio is 3: 1: 0.5, water temperature is controlled at 60～80 ℃, stir, static parking 1～2 hour, encapsulation is traumatology and disappears and decide cream;
(3), classifying drying is ground into powder the standby crude drug of pouch of packing into of sieving and carried out proportioning with formula and the percentage by weight thereof of preparation SHANGKEJIEGUGAO needed raw material medicine, then pour among container and water and Mel mix and blend, wherein, crude drug: water: the Mel mixing ratio is 3: 1: 0.5, water temperature is controlled at 60～80 ℃, stir, static parking 1～2 hour, encapsulation is SHANGKEJIEGUGAO;
(4), the traumatology that makes is disappeared decide cream, SHANGKEJIEGUGAO and be encapsulated in the Dressed plaster combination that is treatment fracture and injury of the present invention in a box.
3. the Dressed plaster for the treatment of fracture and injury as claimed in claim 1 combination, its using method be, disappears with traumatology in the detumescence hemostatic treatment stage and decide cream, uses SHANGKEJIEGUGAO in the bone-setting treatment stage.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104474463A (en) * | 2014-11-26 | 2015-04-01 | 陈红芹 | Nursing plaster for recovering postpartum fracture |
| CN106138299A (en) * | 2016-06-30 | 2016-11-23 | 罗荣娟 | Traumatic injury plaster and preparation method thereof |
| CN109125676A (en) * | 2018-11-07 | 2019-01-04 | 李辉青 | For the Chinese medicine composition of bone disease treatment, bone setting powder and its preparation method and application |
| CN116236523A (en) * | 2023-02-01 | 2023-06-09 | 姜劲挺 | System for promoting absorption of Shangke Xiaojing ointment |
-
2011
- 2011-12-13 CN CN201110416807XA patent/CN103156992A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 李天顺等: "伤科消定膏、伤科接骨膏对四肢骨折损伤的临床疗效观察", 《2011年甘肃省中医药学会学术年会论文集》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104474463A (en) * | 2014-11-26 | 2015-04-01 | 陈红芹 | Nursing plaster for recovering postpartum fracture |
| CN106138299A (en) * | 2016-06-30 | 2016-11-23 | 罗荣娟 | Traumatic injury plaster and preparation method thereof |
| CN109125676A (en) * | 2018-11-07 | 2019-01-04 | 李辉青 | For the Chinese medicine composition of bone disease treatment, bone setting powder and its preparation method and application |
| CN116236523A (en) * | 2023-02-01 | 2023-06-09 | 姜劲挺 | System for promoting absorption of Shangke Xiaojing ointment |
| CN116236523B (en) * | 2023-02-01 | 2023-11-17 | 姜劲挺 | System for promoting absorption of Shangke Xiaojing ointment |
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Application publication date: 20130619 |