CN103156975A - Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, and preparation method thereof - Google Patents
Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, and preparation method thereof Download PDFInfo
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- CN103156975A CN103156975A CN 201110413218 CN201110413218A CN103156975A CN 103156975 A CN103156975 A CN 103156975A CN 201110413218 CN201110413218 CN 201110413218 CN 201110413218 A CN201110413218 A CN 201110413218A CN 103156975 A CN103156975 A CN 103156975A
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Abstract
The invention discloses a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, and a preparation method thereof. The pharmaceutical composition comprises the components of, by weight, 499 parts of salviae miltiorrhizae, 249.5 parts of rhizoma chuanxiong, 249.5 parts of red peony root, 83 parts of saffron, 249.5 parts of peach kernels, 124.75 parts of rhizoma cyperi, 124.75 parts of costus root and 62.4 parts of hawthorn. A solution provided by the invention is an oral liquid preparation of the pharmaceutical composition of pure traditional Chinese medicines. The pharmaceutical composition is prepared based on a composing principle of traditional Chinese medicine formulas, and has the effects of promoting qi to activate blood, relieving depression and resolving blood-stasis, and nourishing blood to dredge vessels. The pharmaceutical composition has the functions for symptoms such as headaches, dizziness, chest pains, palpitations and the like which are caused by qi stagnation and blood stasis of cardiovascular and cerebrovascular diseases such as coronary heart diseases, atherosclerosis, pulmonary heart diseases, multi-infarct dementia and the like. Compared with Lemai granules in a pharmacopeia standard and a conventional solid preparation, the pharmaceutical composition has the advantages of small dosage, good taste, convenience for taking, relatively fast absorption, high bioavailability, stable quality, simple production process, etc.
Description
Technical field
The invention belongs to the ethical goods technical field, relate to oral liquid, particularly a kind of invention liquid and preparation method thereof take the 7 flavor medicines such as Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Flos Carthami, Rhizoma Cyperi, the Radix Aucklandiae, Fructus Crataegi as effective ingredient.
Background technology
The cardiovascular and cerebrovascular diseases such as coronary heart disease, arteriosclerosis, pulmonary heart disease, multiple infarction dementia mostly are mid-aged population, and need Long-term taking medicine.In the Pharmacopoeia of the People's Republic of China, LEMAI KELI and present elderly population corresponding to existing happy arteries and veins sheet oral solid formulation show dysphagia, reach the effective blood drug concentration time long.And the present invention invention has overcome above shortcoming, has that taking dose is little, mouthfeel good, taking convenience, absorption are very fast, the bioavailability advantages of higher.
Summary of the invention
Purpose of the present invention aims to provide a kind of oral liquid for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof, and this invention is a kind of oral liquid of pure Chinese medicine combination, the existing promoting flow of QI and blood of this product, resolving depression blood stasis dispelling, nourishing blood and promoting blood circulation.The effect that is used for headache that the cardiovascular and cerebrovascular diseases such as coronary heart disease, arteriosclerosis, pulmonary heart disease, multiple infarction dementia belong to caused by energy stagnation and blood stasis, dizzy, chest pain, cardio palmus.And the advantages such as taking dose is little, mouthfeel is good, taking convenience, absorption is very fast, bioavailability is high, steady quality, production technology are simple.
Technical scheme of the present invention is: design a kind of liquid oral for the treatment of cardiovascular and cerebrovascular disease, it is characterized in that its composition and weight proportion thereof are: 499 parts of Radix Salviae Miltiorrhizaes, 249.5 parts of Rhizoma Chuanxiongs, 249.5 parts of Radix Paeoniae Rubra, 83 parts of Stigma Crocis, 249.5 parts, Semen Persicae, 124.75 parts of Rhizoma Cyperis, 124.75 parts of the Radix Aucklandiae, 62.4 parts of Fructus Crataegis.
The preparation method of the preparation method invention of the oral liquid of above-mentioned treatment cardiovascular and cerebrovascular disease is characterized in that it comprises the following steps:
1) take raw material by following weight ratio: 499 parts of Radix Salviae Miltiorrhizaes, 249.5 parts of Rhizoma Chuanxiongs, 249.5 parts of Radix Paeoniae Rubra, 83 parts of Stigma Crocis, 249.5 parts, Semen Persicae, 124.75 parts of Rhizoma Cyperis, 124.75 parts of the Radix Aucklandiae, 62.4 parts of Fructus Crataegis;
2) accurately take above-mentioned supplementary material, add 10 times of water gagings and decoct 3 times, each one hour, it was 1.10 ~ 1.30 clear paste that filtrate low temperature (45-50 ℃) is concentrated into relative density;
3) ethanol is added above-mentioned clear paste make to contain the alcohol amount to reach 60%, low temperature (45-50 ℃) is static, precipitate 48 hours, filters recovery ethanol;
4) add 0.5% active carbon, heated 30 minutes, filter;
5) add 1% stevioside, taste masking;
6) adding distil water to total amount, filters, packing, and sterilization gets final product.
The present invention has promoting flow of QI and blood, resolving depression blood stasis dispelling, nourishing blood and promoting blood circulation.The effect that is used for headache that the cardiovascular and cerebrovascular diseases such as coronary heart disease, arteriosclerosis, pulmonary heart disease, multiple infarction dementia belong to caused by energy stagnation and blood stasis, dizzy, chest pain, cardio palmus.
Advantage of the present invention is: the present invention is a kind of pure Chinese medicine combination oral liquid.Have that taking dose is little, mouthfeel good, taking convenience, the advantage such as absorption is very fast, bioavailability is high, steady quality, production technology are simple.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, but not as limitation of the present invention.The part that is not described in detail in the present embodiment is to adopt prior art, and industry standard or known approaches.
Embodiment
Oral liquid of described this treatment cardiovascular and cerebrovascular disease and preparation method thereof, it adopts following steps to make:
1) by following weight ratio weighting raw materials: 499 parts of Radix Salviae Miltiorrhizaes, 249.5 parts of Rhizoma Chuanxiongs, 249.5 parts of Radix Paeoniae Rubra, 83 parts of Stigma Crocis, 249.5 parts, Semen Persicae, 124.75 parts of Rhizoma Cyperis, 124.75 parts of the Radix Aucklandiae, 62.4 parts of Fructus Crataegis;
2) accurately take above-mentioned raw materials, add 10 times of water gagings and decoct 3 times, each one hour, it was 1.10 ~ 1.30 clear paste that filtrate low temperature (45-50 ℃) is concentrated into relative density;
3) ethanol is added above-mentioned clear paste make to contain the alcohol amount to reach 60%, low temperature (45-50 ℃) is static, precipitate 48 hours, filters recovery ethanol;
4) add 0.5% active carbon, heated 30 minutes, filter;
5) add 1% stevioside, taste masking;
6) adding distil water to total amount, filters, packing, and sterilization gets final product.
Claims (2)
1. a liquid oral for the treatment of cardiovascular and cerebrovascular disease, is characterized in that its composition and weight proportion thereof are: 499 parts of Radix Salviae Miltiorrhizaes, 249.5 parts of Rhizoma Chuanxiongs, 249.5 parts of Radix Paeoniae Rubra, 83 parts of Stigma Crocis, 249.5 parts, Semen Persicae, 124.75 parts of Rhizoma Cyperis, 124.75 parts of the Radix Aucklandiae, 62.4 parts of Fructus Crataegis.
2. the preparation method of the preparation method of the oral liquid of above-mentioned treatment cardiovascular and cerebrovascular disease invention is characterized in that it comprises the following steps:
1) take raw material by following weight ratio: 499 parts of Radix Salviae Miltiorrhizaes, 249.5 parts of Rhizoma Chuanxiongs, 249.5 parts of Radix Paeoniae Rubra, 83 parts of Stigma Crocis, 249.5 parts, Semen Persicae, 124.75 parts of Rhizoma Cyperis, 124.75 parts of the Radix Aucklandiae, 62.4 parts of Fructus Crataegis;
2) accurately take above-mentioned supplementary material, add 10 times of water gagings and decoct 3 times, each one hour, it was 1.10 ~ 1.30 clear paste that 45-50 ℃ of filtrate low temperature are concentrated into relative density;
3) ethanol is added above-mentioned clear paste make to contain the alcohol amount to reach 60%, 45-50 ℃ of low temperature are static, precipitates 48 hours, filter recovery ethanol;
4) add 0.5% active carbon, heated 30 minutes, filter;
5) add 1% stevioside, taste masking;
6) adding distil water to total amount, filters, packing, and sterilization gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110413218 CN103156975A (en) | 2011-12-10 | 2011-12-10 | Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110413218 CN103156975A (en) | 2011-12-10 | 2011-12-10 | Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103156975A true CN103156975A (en) | 2013-06-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201110413218 Pending CN103156975A (en) | 2011-12-10 | 2011-12-10 | Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690735A (en) * | 2013-12-19 | 2014-04-02 | 贵州景峰注射剂有限公司 | Lemai pill composition |
| CN106937991A (en) * | 2017-02-14 | 2017-07-11 | 四川双鑫生物科技有限公司 | It is a kind of to be used to treat decoction medicine of cardiovascular and cerebrovascular disease and preparation method thereof |
-
2011
- 2011-12-10 CN CN 201110413218 patent/CN103156975A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690735A (en) * | 2013-12-19 | 2014-04-02 | 贵州景峰注射剂有限公司 | Lemai pill composition |
| CN106937991A (en) * | 2017-02-14 | 2017-07-11 | 四川双鑫生物科技有限公司 | It is a kind of to be used to treat decoction medicine of cardiovascular and cerebrovascular disease and preparation method thereof |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130619 |