CN103146626B - 一种治疗乳腺癌的基因工程菌及其构建方法和应用 - Google Patents
一种治疗乳腺癌的基因工程菌及其构建方法和应用 Download PDFInfo
- Publication number
- CN103146626B CN103146626B CN201310062253.7A CN201310062253A CN103146626B CN 103146626 B CN103146626 B CN 103146626B CN 201310062253 A CN201310062253 A CN 201310062253A CN 103146626 B CN103146626 B CN 103146626B
- Authority
- CN
- China
- Prior art keywords
- vnp20009
- genetically engineered
- methioninase
- engineered bacterium
- breast cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y404/00—Carbon-sulfur lyases (4.4)
- C12Y404/01—Carbon-sulfur lyases (4.4.1)
- C12Y404/01011—Methionine gamma-lyase (4.4.1.11)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (2)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310062253.7A CN103146626B (zh) | 2013-02-28 | 2013-02-28 | 一种治疗乳腺癌的基因工程菌及其构建方法和应用 |
US14/766,558 US9816083B2 (en) | 2013-02-28 | 2014-02-27 | Genetically engineered bacterium for treatment of breast cancer, method for constructing the bacterium, and applications thereof |
PCT/CN2014/072652 WO2014131363A1 (zh) | 2013-02-28 | 2014-02-27 | 一种治疗乳腺癌的基因工程菌及其构建方法和应用 |
AU2014223112A AU2014223112B2 (en) | 2013-02-28 | 2014-02-27 | Genetically engineered bacterium for treatment of breast cancer, method for constructing the bacterium, and applications thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310062253.7A CN103146626B (zh) | 2013-02-28 | 2013-02-28 | 一种治疗乳腺癌的基因工程菌及其构建方法和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103146626A CN103146626A (zh) | 2013-06-12 |
CN103146626B true CN103146626B (zh) | 2014-12-31 |
Family
ID=48544949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310062253.7A Active CN103146626B (zh) | 2013-02-28 | 2013-02-28 | 一种治疗乳腺癌的基因工程菌及其构建方法和应用 |
Country Status (4)
Country | Link |
---|---|
US (1) | US9816083B2 (zh) |
CN (1) | CN103146626B (zh) |
AU (1) | AU2014223112B2 (zh) |
WO (1) | WO2014131363A1 (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103146626B (zh) | 2013-02-28 | 2014-12-31 | 南京华贞生物医药科技有限公司 | 一种治疗乳腺癌的基因工程菌及其构建方法和应用 |
CN103961721B (zh) * | 2014-04-30 | 2018-10-23 | 广州华津医药科技有限公司 | 减毒鼠伤寒沙门氏菌及其基因工程菌在制备治疗前列腺癌的药物上的应用 |
CN105983103A (zh) * | 2015-03-17 | 2016-10-05 | 广州华津医药科技有限公司 | 基因工程菌vnp20009-m在制备预防和治疗癌症转移的药物上的应用 |
CN106474489B (zh) * | 2015-08-31 | 2019-08-16 | 广州华津医药科技有限公司 | 减毒鼠伤寒沙门氏菌基因工程菌在制备治疗肝癌药物上的应用 |
CN107115533A (zh) * | 2017-04-01 | 2017-09-01 | 广州华津医药科技有限公司 | 基因工程菌vnp20009‑m在制备治疗恶性肉瘤药物中的应用 |
CN106913883A (zh) * | 2017-04-01 | 2017-07-04 | 广州华津医药科技有限公司 | 基因工程菌vnp20009‑m在制备预防和治疗肺癌药物中的应用 |
CN109112154B (zh) * | 2018-08-02 | 2021-11-19 | 南昌大学 | 重组减毒鼠伤寒沙门氏菌pcDNA3.3c-Caspase-3-Gala-VNP20009的构建方法及功能验证方法 |
US20210403571A1 (en) | 2018-11-15 | 2021-12-30 | Erytech Pharma | Synergistic combinations of methionine depletion agents and immune checkpoint modulators |
CN112220917A (zh) * | 2020-10-16 | 2021-01-15 | 广东工业大学 | 一种用于治疗恶性肿瘤的联合用药物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1879890A (zh) * | 1995-06-07 | 2006-12-20 | 抗癌公司 | 蛋氨酸酶在抗蛋氨酸和抗高半胱氨酸的化学治疗中的应用 |
CA2470411C (en) * | 2001-12-31 | 2015-07-07 | Anticancer, Inc. | System for monitoring bacterial tumor treatment |
JP2008504822A (ja) | 2004-06-29 | 2008-02-21 | アンチキャンサー インコーポレーテッド | 癌選択的栄養要求株 |
CN103146626B (zh) | 2013-02-28 | 2014-12-31 | 南京华贞生物医药科技有限公司 | 一种治疗乳腺癌的基因工程菌及其构建方法和应用 |
-
2013
- 2013-02-28 CN CN201310062253.7A patent/CN103146626B/zh active Active
-
2014
- 2014-02-27 US US14/766,558 patent/US9816083B2/en active Active
- 2014-02-27 AU AU2014223112A patent/AU2014223112B2/en active Active
- 2014-02-27 WO PCT/CN2014/072652 patent/WO2014131363A1/zh active Application Filing
Non-Patent Citations (1)
Title |
---|
周易明 等.减毒鼠伤寒沙门氏菌作为肿瘤基因治疗载体的低毒性和靶向性研究.《复旦学报(医学版)》.2008,第35卷(第3期),336-341. * |
Also Published As
Publication number | Publication date |
---|---|
US20150376593A1 (en) | 2015-12-31 |
AU2014223112B2 (en) | 2017-03-02 |
WO2014131363A1 (zh) | 2014-09-04 |
CN103146626A (zh) | 2013-06-12 |
US9816083B2 (en) | 2017-11-14 |
AU2014223112A1 (en) | 2015-08-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103146626B (zh) | 一种治疗乳腺癌的基因工程菌及其构建方法和应用 | |
CN103656684B (zh) | 减毒鼠伤寒沙门氏菌及其基因工程菌在制备治疗胰腺癌的药物上的应用 | |
CN103961721A (zh) | 减毒鼠伤寒沙门氏菌及其基因工程菌在制备治疗前列腺癌的药物上的应用 | |
CN105983103A (zh) | 基因工程菌vnp20009-m在制备预防和治疗癌症转移的药物上的应用 | |
US11318172B2 (en) | Use of genetically engineered bacterium of attenuated Salmonella typhimurium in for treating liver cancer | |
CN105177045B (zh) | 表达人白介素15的重组溶瘤腺病毒及其构建方法 | |
Xu et al. | Tumor-associated fibroblast-conditioned medium promotes tumor cell proliferation and angiogenesis | |
Bunnell et al. | The effect of obesity on adipose-derived stromal cells and adipose tissue and their impact on cancer | |
CN112190717B (zh) | 减毒鼠伤寒沙门氏菌及其基因工程菌在制备治疗急性白血病的药物上的应用 | |
Yu et al. | Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in vitro and in vivo | |
CN102688228B (zh) | 含有芹菜素及芹菜素类衍生物和冬凌草甲素及冬凌草甲素类衍生物的药物组合物及其应用 | |
US9439934B1 (en) | Application of an attenuated salmonella typhimurium, its genetically engineered bacterium in preparing drugs for the treatment of prostate cancer | |
Yue et al. | Taraxacum mongolicum polysaccharide promotes white adipocyte browning by regulating miR-134-3p via Akt/GSK-3β signalling | |
CN102940651B (zh) | 一种利用肿瘤靶向性细菌激活前药的方法及其应用 | |
CN103800905A (zh) | 联合应用c-MET抑制剂与丁酸钠治疗癌症的方法 | |
CN103710311A (zh) | 一种稳定分泌表达il-24重组蛋白的细胞株及其构建和应用 | |
CN116603065B (zh) | Pcbp2抑制剂在制备促进模拟禁食饮食治疗胆囊癌的药物中的应用 | |
CN110638839A (zh) | 重组沙门氏菌vnp20009-m在制备治疗骨肉瘤的药物中的应用 | |
CN115089570B (zh) | 一种治疗肿瘤的药物组合物及其制剂和应用 | |
CN102559753A (zh) | Il-24和osm双基因共表达重组质粒和重组腺病毒以及应用 | |
CN117122704A (zh) | 基因工程菌sgn1在制备治疗小细胞肺癌药物中的应用 | |
CN116262137A (zh) | 一种同时杀伤肿瘤和改善免疫微环境的抗肿瘤联合用药物 | |
CN104830864B (zh) | 作用于PNPO基因的shRNA构建及其用途 | |
CN113082211A (zh) | 一种治疗npm1突变急性髓系白血病的药物组合物及其应用 | |
CN103623431B (zh) | miR181s在制备治疗急性肠炎药物中的应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160829 Address after: 510075 Guangdong, Guangzhou, new Guangzhou knowledge city, Phoenix Road 2, building 8, No. three, No. 2416 Patentee after: Guangzhou Huajin Pharmaceutical Technology Co., Ltd. Address before: 211100, No. 118 East Tianyuan Road, Jiangning District, Jiangsu, Nanjing Patentee before: Nanjing SinoGen Biomedical Technology Co., Ltd. |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A genetically engineered bacterium for treating breast cancer and its construction method and Application Effective date of registration: 20220530 Granted publication date: 20141231 Pledgee: Bank of China Limited Guangzhou Development Zone Branch Pledgor: Guangzhou Huajin Pharmaceutical Technology Co.,Ltd. Registration number: Y2022980006677 |
|
CP02 | Change in the address of a patent holder | ||
CP02 | Change in the address of a patent holder |
Address after: 510535 Room 101, building C5, No. 11, Kaiyuan Avenue, Huangpu District, Guangzhou, Guangdong Patentee after: Guangzhou Huajin Pharmaceutical Technology Co.,Ltd. Address before: 510075 Building 2, No. 8, Fenghuang Third Road, Zhongxin Guangzhou Knowledge City, Guangzhou, Guangdong 2416 Patentee before: Guangzhou Huajin Pharmaceutical Technology Co.,Ltd. |