CN103142933A - Chinese herba preparation for treating disease of liver and gall in fish and preparation method thereof - Google Patents
Chinese herba preparation for treating disease of liver and gall in fish and preparation method thereof Download PDFInfo
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- CN103142933A CN103142933A CN2013100754220A CN201310075422A CN103142933A CN 103142933 A CN103142933 A CN 103142933A CN 2013100754220 A CN2013100754220 A CN 2013100754220A CN 201310075422 A CN201310075422 A CN 201310075422A CN 103142933 A CN103142933 A CN 103142933A
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Abstract
The invention discloses a Chinese herba preparation for treating disease of liver and gall in fish and a preparation method thereof. The Chinese herba preparation is characterized by comprising the following materials in percentage by weight: 20% of honewort, 12.5% of crude hawthorn, 15% of radix scutellariae, 15% of angelica sinensis, 10% of green tangerine peel, 10% of radix curcumae, 12.5% of rhizome alismatis and 5% of liquorice. The Chinese herba preparation is low in toxic and side effect, has favorable auxiliary function for liver function, has no residues, and has certain therapeutic action on bacterial and viral diseases.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of the Fish liver and gall diseases and preparation method thereof.
Background technology
Due to the needs of economic development, intensive high density culture is grown in modern culture fishery and is occupied critical role, and the thing followed is that various diseases is also more and more.In the Fish high density culture is grown process, because feedstuff is putrid and deteriorated, the feedstuff of throwing something and feeding is too much, the factors such as the deterioration of water quality environment, and the liver of Fish is easy to just occur the fatty damage, because originally this disease does not have sign, so not too easily find, but when can occur under the unexpected variation of weather or water temperature stress, and sudden onset, as bacterial disease toxicity diseases such as secondary infection enteritis, gill rot, hemorrhagic disease, thereby cause heavy losses.
In case liver generation pathological changes or be subject to external damage, it is large that biomembranous permeability becomes, synthetic and the release abnormal of desmoenzyme, AST and ALT are released in blood in a large number, cause the rising of enzymatic activity in blood, therefore it is closely related that the physiological and pathologicals such as the activity change of enzyme and hepatocellular degeneration, necrosis change, reflected the degree of injury of liver.
The problem to be solved in the present invention is how effectively to prevent, treat antibacterial, the viral diseases such as Fish liver and gall diseases and the erythroderma that is caused by its secondary infection, enteritis, gill rot, hemorrhagic disease.
Summary of the invention
The inventor finds Radix Bupleuri treating SHAO YANG disease by mediation, dispersing the stagnated live-QI to relieve the stagnation of QI, antipyretic and anti-inflammatory, well transaminase in anti-liver injury regulating liver-QI fatization, reduction blood; Fructus Crataegi disappear esterified long-pending, dissipating blood stasis is capable stagnant, its main effective ingredient is Crataegolic acid lipolytic enzyme etc., can promote the lipid food digestion, promotes steatolysis, increases copying of liver cell mitochondria; The Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, the liver heat removing function of gallbladder promoting can suppress lipid peroxidation, and the protective wire Mitochondria Membrane promotes the mitochondrial variation that copies with hypertrophy and rough endoplasmic reticulum, enlivens hepatocyte biological oxidation function and protein synthesis; The Chinese Angelica blood replonishing easing the affected liver, relieving spasm to stop pain, blood fat reducing impels liver cell regeneration; The soothing the liver dispelling the stagnated QI of Pericarpium Citri Reticulatae Viride, stagnant long-pending, harmonizing the functional activities of vital QI disappears; Rhizoma Alismatis liver heat removing function of gallbladder promoting; The kidney tonifying diuretic; The clean blood blood fat reducing of Radix Curcumae, effectively Cell protection, prevent the DNA breakage that peroxidating causes; The invigorating middle warmer of Radix Glycyrrhizae emergency, coordinating the actions of various ingredients in a prescription, and can stop fat to be accumulated in liver, suppress fibroplasia.
Thus, the invention provides a kind of Chinese medicine preparation for the treatment of the Fish liver and gall diseases, the parts by weight of each raw material of Chinese medicine are: Radix Bupleuri 15-25%, Fructus Crataegi 10-15%, Radix Scutellariae 10-20%, Radix Angelicae Sinensis 10-20%, Pericarpium Citri Reticulatae Viride 8-12%, Radix Curcumae 8-12%, Rhizoma Alismatis 10-15%, Radix Glycyrrhizae 3-7%.
One preferred embodiment in, the parts by weight of each raw material of Chinese medicine of this Chinese medicine preparation are: Radix Bupleuri 20%, Fructus Crataegi 12.5%, Radix Scutellariae 15%, Radix Angelicae Sinensis 15%, Pericarpium Citri Reticulatae Viride 10%, Radix Curcumae 10%, Rhizoma Alismatis 12.5%, Radix Glycyrrhizae 5%.
The Chinese medicine preparation of above-mentioned treatment Fish liver and gall diseases can adopt following method preparation:
Above-mentioned various medical herbs are mixed, pulverize, cross 80 eye mesh screens, make powder, then with preparation.
Described preparation can be dosage form on powder, microcapsule, granule, pill, mixture, gel and other pharmaceuticss.
The present invention also provides the usage of the Chinese medicine preparation of above-mentioned treatment Fish liver and gall diseases: mixes bait and throws something and feeds, once measure, and every 1kg body weight, fish, 0.2-0.3g is used in conjunction ten.
In the preferred embodiment of the invention, above-mentioned Chinese medicine preparation is sneaked in feedstuff and throw something and feed.
It is little that the present invention has toxic and side effects, and the function of liver is had good assosting effect, medicine noresidue, bacillary, viral disease are had certain therapeutical effect.
The specific embodiment
Test material: Carassius aurutus gibelio (Carassius auratus gibelio), 300 tails, average weight 50 ± 5g, the long 7 ± 2cm of body supported 1 month temporarily in test chamber, was provided by aquacultural engineering research center, Shanghai; Enrofloxacin (lot number is 20110716) is available from Sangon Biotech (Shanghai) Co., Ltd.; The 50mg/mL enrofloxacin is with reference to the method preparation of (Li Chunyu etc. 2009) such as Li Chunyu; The HITACHI7600-020 automatic clinical chemistry analyzer; Glutamate pyruvate transaminase (ALT), glutamic oxaloacetic transaminase, GOT (AST) test kit are available from Shanghai Shensuo Youfu Medical Diagnosis Products Co., Ltd..
Test method: test is raised and train a week with fish,, mixes various medical herbs in Chinese medicine preparation of the present invention by following 5 embodiment, pulverizes, and crosses 80 eye mesh screens, makes powder, then with it according to every 1kg body weight, fish, the amount of 0.2-0.3g is sneaked in feedstuff and is thrown something and fed.
healthy Carassius aurutus gibelio 210 is trailed machine and is divided into 7 groups of (A, B, Chinese herbal and crude drugs preparations embodiment group), every group of 30 tails are tested, every group each 3 parallel, control group A mouth continuous 30 day every day is filled with isopyknic normal saline, the dosage that experiment group B group and Chinese herbal and crude drugs preparations embodiment group mouth continuous 30 day every day is filled with (by weighing machine) enrofloxacin divide 40mg/kg(we verify out that in laboratory continuous 30 days mouth filling Carassius aurutus gibelio are with the enrofloxacin of 40mg/kg, the serum glutamic oxalacetic transaminase of Carassius aurutus gibelio and glutamate pyruvate transaminase can produce significant change), Chinese herbal and crude drugs preparations embodiment group is thrown something and fed and contain the feedstuff of " Chinese medicine preparation of the present invention " continuous 30 day every day, all the other organize the feedstuff of the normal components of throwing something and feeding.After each is organized continuous 30 days mouths and fills with Carassius aurutus gibelio, with reference to the method for Carassius aurutus gibelio blood sampling, get serum, adopt automatic clinical chemistry analyzer to utilize biuret method and test kit method to carry out respectively the concentration determination of glutamate pyruvate transaminase (ALT), glutamic oxaloacetic transaminase, GOT (AST).The test breeding water is the aeration tap water, and pH value is 7, and water temperature is controlled at 19-21 ℃.
Result of the test: result of the test shows in table 1 and 2, and in process of the test, test group and matched group all occur dead.Experiment group B (enrofloxacin group) continuously mouthful was filled with Carassius aurutus gibelio 40mg/kg enrofloxacin 30 days, the glutamate pyruvate transaminase of Carassius aurutus gibelio and the content of glutamic oxaloacetic transaminase, GOT respectively than matched group increased by 18.82% and 36.56%(P＜0.05).
Embodiment 1(is preferred)
Radix Bupleuri 20%, Fructus Crataegi 12.5%, Radix Scutellariae 15%, Radix Angelicae Sinensis 15%, Pericarpium Citri Reticulatae Viride 10%, Radix Curcumae 10%, Rhizoma Alismatis 12.5%, Radix Glycyrrhizae 5%.(pulverize, cross 80 eye mesh screens, make powder)
The glutamate pyruvate transaminase of enrofloxacin and Chinese medicine preparation group Carassius aurutus gibelio of the present invention and the content of glutamic oxaloacetic transaminase, GOT respectively than matched group only increased by 8.26% and 1.52%(P 0.05).
The Carassius aurutus gibelio serum glutamic pyruvic transminase that table 1 Chinese medicine preparation of the present invention causes enrofloxacin and the impact of glutamic oxaloacetic transaminase, GOT content
As can be seen from Table 1, Chinese medicine preparation of the present invention has really alleviates the detrimental effect that enrofloxacin causes liver, thereby strengthens the ability of fish body resist the disease.
Embodiment 2
Radix Bupleuri 25%, Fructus Crataegi 10%, Radix Scutellariae 12%, Radix Angelicae Sinensis 14.5%, Pericarpium Citri Reticulatae Viride 10%, Radix Curcumae 10%, Rhizoma Alismatis 12.5%, Radix Glycyrrhizae 5%.(pulverize, cross 80 eye mesh screens, make powder)
The glutamate pyruvate transaminase of enrofloxacin and Chinese medicine preparation group Carassius aurutus gibelio of the present invention and the content of glutamic oxaloacetic transaminase, GOT respectively than matched group only increased by 9.83% and 1.34%(P 0.05).
Embodiment 3
Radix Bupleuri 23%, Fructus Crataegi 11.5%, Radix Scutellariae 15%, Radix Angelicae Sinensis 14%, Pericarpium Citri Reticulatae Viride 10%, Radix Curcumae 10%, Rhizoma Alismatis 12.5%, Radix Glycyrrhizae 4%.(pulverize, cross 80 eye mesh screens, make powder)
The glutamate pyruvate transaminase of enrofloxacin and Chinese medicine preparation group Carassius aurutus gibelio of the present invention and the content of glutamic oxaloacetic transaminase, GOT respectively than matched group only increased by 8.79% and 1.42%(P 0.05).
Embodiment 4
Radix Bupleuri 17%, Fructus Crataegi 13%, Radix Scutellariae 16%, Radix Angelicae Sinensis 15%, Pericarpium Citri Reticulatae Viride 11%, Radix Curcumae 10%, Rhizoma Alismatis 13%, Radix Glycyrrhizae 6%.(pulverize, cross 80 eye mesh screens, make powder)
The glutamate pyruvate transaminase of enrofloxacin and Chinese medicine preparation group Carassius aurutus gibelio of the present invention and the content of glutamic oxaloacetic transaminase, GOT respectively than matched group only increased by 9.85% and 1.36%(P 0.05).
Embodiment 5
Radix Bupleuri 15%, Fructus Crataegi 14%, Radix Scutellariae 17%, Radix Angelicae Sinensis 15%, Pericarpium Citri Reticulatae Viride 10%, Radix Curcumae 10%, Rhizoma Alismatis 14%, Radix Glycyrrhizae 5%.(pulverize, cross 80 eye mesh screens, make powder)
The glutamate pyruvate transaminase of enrofloxacin and Chinese medicine preparation group Carassius aurutus gibelio of the present invention and the content of glutamic oxaloacetic transaminase, GOT respectively than matched group only increased by 9.51% and 1.62%(P 0.05).
The Carassius aurutus gibelio serum glutamic pyruvic transminase that table 2 enrofloxacin+Chinese medicine preparation group of the present invention (embodiment 2-5 group) causes enrofloxacin and the impact of glutamic oxaloacetic transaminase, GOT content
As can be seen from Table 2, Chinese medicine preparation of the present invention has really alleviates the detrimental effect that enrofloxacin causes liver, thereby strengthens the ability of fish body resist the disease.
But, those of ordinary skill in the art will be appreciated that, above embodiment illustrates the present invention, and be not to be used as limitation of the invention, as long as in connotation scope of the present invention, all will drop in claims scope of the present invention variation, the modification of the above embodiment.
Claims (6)
1. Chinese medicine preparation for the treatment of the Fish liver and gall diseases, it is characterized in that: the parts by weight of each raw material of Chinese medicine are: Radix Bupleuri 15-25%, Fructus Crataegi 10-15%, Radix Scutellariae 10-20%, Radix Angelicae Sinensis 10-20%, Pericarpium Citri Reticulatae Viride 8-12%, Radix Curcumae 8-12%, Rhizoma Alismatis 10-15%, Radix Glycyrrhizae 3-7%.
2. the Chinese medicine preparation of the Fish liver and gall diseases for the treatment of according to claim 1, it is characterized in that, the parts by weight of each raw material of Chinese medicine are: Radix Bupleuri 20%, Fructus Crataegi 12.5%, Radix Scutellariae 15%, Radix Angelicae Sinensis 15%, Pericarpium Citri Reticulatae Viride 10%, Radix Curcumae 10%, Rhizoma Alismatis 12.5%, Radix Glycyrrhizae 5%.
3. the Chinese medicine preparation for the treatment of Fish liver and gall diseases according to claim 1 and 2, is characterized in that said preparation is: the dosage form on powder, microcapsule, granule, pill, mixture, gel or other pharmaceuticss.
4. the preparation method of the Chinese medicine preparation for the treatment of Fish liver and gall diseases described according to aforementioned arbitrary claim, is characterized in that the method is: described various medical herbs are mixed, pulverize, cross 80 eye mesh screens, make powder.
5. the Chinese medicine preparation for the treatment of according to claim 1 and 2 Fish liver and gall diseases is characterized in that its usage is: mixes bait and throws something and feeds, and amount once, every 1kg body weight, fish, 0.2-0.3g is used in conjunction ten.
6. the Chinese medicine preparation for the treatment of Fish liver and gall diseases according to claim 5, is characterized in that, described Chinese medicine preparation is sneaked in feedstuff and thrown something and fed.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103330089A (en) * | 2013-07-13 | 2013-10-02 | 肖玲 | Special compound feed for carassius auratus gibelio and preparation method of compound feed |
| CN106509337A (en) * | 2016-10-15 | 2017-03-22 | 广西润爽生态农业科技有限公司 | Feed additive capable of preventing and treating diseases in liver and gallbladder of fish and preparation method of feed additive |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1207314A (en) * | 1998-04-28 | 1999-02-10 | 叶坦 | Chinese medicine for treating hepatitis B |
| CN1907462A (en) * | 2006-08-07 | 2007-02-07 | 张庆存 | Traditional Chinese medicine composition for treating hepatitis and fatty liver |
| CN101971933A (en) * | 2010-11-12 | 2011-02-16 | 沈阳农业大学 | Disease-resistant health-care compound Chinese herbal medicinal feed additive for dairy cattle in perinatal period and feeding method |
| CN102114224A (en) * | 2010-10-21 | 2011-07-06 | 孔祥军 | Traditional Chinese compound for treating fatty liver |
| CN102755594A (en) * | 2012-07-19 | 2012-10-31 | 杨国兴 | Traditional Chinese medicine composition for treating acute and chronic hepatitis B and preparation method thereof |
-
2013
- 2013-03-08 CN CN2013100754220A patent/CN103142933A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1207314A (en) * | 1998-04-28 | 1999-02-10 | 叶坦 | Chinese medicine for treating hepatitis B |
| CN1907462A (en) * | 2006-08-07 | 2007-02-07 | 张庆存 | Traditional Chinese medicine composition for treating hepatitis and fatty liver |
| CN102114224A (en) * | 2010-10-21 | 2011-07-06 | 孔祥军 | Traditional Chinese compound for treating fatty liver |
| CN101971933A (en) * | 2010-11-12 | 2011-02-16 | 沈阳农业大学 | Disease-resistant health-care compound Chinese herbal medicinal feed additive for dairy cattle in perinatal period and feeding method |
| CN102755594A (en) * | 2012-07-19 | 2012-10-31 | 杨国兴 | Traditional Chinese medicine composition for treating acute and chronic hepatitis B and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103330089A (en) * | 2013-07-13 | 2013-10-02 | 肖玲 | Special compound feed for carassius auratus gibelio and preparation method of compound feed |
| CN106509337A (en) * | 2016-10-15 | 2017-03-22 | 广西润爽生态农业科技有限公司 | Feed additive capable of preventing and treating diseases in liver and gallbladder of fish and preparation method of feed additive |
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Application publication date: 20130612 |