CN103142903A - Traditional Chinese medicine preparation for treating psoriasis - Google Patents
Traditional Chinese medicine preparation for treating psoriasis Download PDFInfo
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- CN103142903A CN103142903A CN2013100810095A CN201310081009A CN103142903A CN 103142903 A CN103142903 A CN 103142903A CN 2013100810095 A CN2013100810095 A CN 2013100810095A CN 201310081009 A CN201310081009 A CN 201310081009A CN 103142903 A CN103142903 A CN 103142903A
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Abstract
The invention relates to a traditional Chinese medicine preparation for treating psoriasis. The preparation is a traditional Chinese medicine granule prepared from the following traditional Chinese medicine decoction pieces in parts by weight: 6-20 parts of rhizoma smilacis glabrae, 6-20 parts of radix rehmanniae recen, 6-20 parts of semen coicis, 6-20 parts of lalang grass rhizome, 3-12 parts of cortex dictamni, 1-12 parts of root of common peony, 1-12 parts of angelica sinensis, 1-12 parts of moutan bark, 1-12 parts of fructus kochiae, 1-12 parts of oldenlandia diffusa, 1-10 parts of radix sophorae flavescentis, 1-10 parts of fried gardenia, 1-10 parts of radix clematidis, 1-8 parts of zaocys dhumnade, 1-8 parts of honeycomb, 1-8 parts of radices sileris, 1-8 parts of liquorice and 1-8 parts of lithospermum. The preparation method comprises the following steps of: extracting: respectively taking each Chinese medicine decoction piece, decocting for two times with water, 1-2 hours each time; preparing clear cream: concentrating decocted solution to be required relative density, to obtain the clear cream of each Chinese medicine decoction piece; spraying pelletizing: carrying out spraying pelletizing or spraying drying to the clear creams, preparing to be fine powder, mixing uniformly with auxiliary materials, to obtain traditional Chinese medicine granules; and packaging respectively. The preparation is significant in effect, high in cure rate, low in recurrence rate and low on dosage.
Description
Technical field
The invention belongs to department of dermatologry Chinese medicine preparation category, be specifically related to a kind of psoriatic Chinese medicine preparation for the treatment of.
Background technology
Psoriasis claims again " psoriasis ", is a kind of common chronic dermatosis, the characteristics that intractable arranged and easily recur.Psoriatic prevalence is about 0.123% in China, and patient's physical and mental health is brought great impact.
Psoriatic pathogenesis is very complicated, under the polygenic inheritance background, relates to many-sided reasons such as immunity, inflammation, Cell apoptosis and proliferation, microvascular abnormality, neural Nervous and Mental Factors and neurotransmitter.
In prior art, doctor trained in Western medicine adopts the medicines such as immunosuppressant, hormones, retinoid more for psoriatic treatment, though effective in cure, easily recurrence, and side effect is large.The traditional Chinese medical science claims that psoriasis is “ Bai Mange (b á i b ǐ) ", (" surgery great achievement " proposes “ Bai Mange first " name of disease) thinks many because experiencing ailment said due to cold or exposure, and coagulation skin is strongly fragrant and heat-transformation consumes blood trouble liquid for a long time, and blood-deficiency and wind-dry, skin lose to support and form.Traditional Chinese medical science method in psoriatic treatment is numerous, and individual patients is carried out integral syndrome differentiation treatment, in psoriatic treatment with prevent that the aspect such as recurrence from all obtaining effect preferably.
Over past ten years, on the basis of applicant by institute's internal therapy psoriasis tradition agreement prescriptions of Chinese medicine, on the basis of comprehensive study and clinical observation, to be more suitable for modern's occupation mode, adopted Chinese medicine quality more stable, preparation standard is unified, and the patient is easy to use, the transportation that is easy to carry has the Chinese medicinal granule dosage forms with conspicuous characteristics such as environmental protection.Through Long-term Clinical Observation, effect is remarkable, is suitable for promoting the use of.
Summary of the invention
The application's goal of the invention is to develop a kind of psoriatic Chinese medicine preparation for the treatment of.
Another goal of the invention of the application, on the basis of comprehensive study and clinical observation, to be more suitable for modern's occupation mode, adopted Chinese medicine quality more stable, preparation standard is unified, the patient is easy to use, and the transportation that is easy to carry has the psoriatic Chinese medicinal granule dosage forms for the treatment of with conspicuous characteristics such as environmental protection.
The application's technical scheme is:
Develop a kind of psoriatic Chinese medicine preparation for the treatment of, it is characterized in that:
⑴ the Chinese medicinal granule that made by the prepared slices of Chinese crude drugs of following weight ratio:
6～20 parts of Rhizoma Smilacis Glabraes, 6～20 parts of Radix Rehmanniae, 6～20 parts of Semen Coiciss, 6～20 parts of Rhizoma Imperataes, 3～12 parts of Cortex Dictamni, 1～12 part of Radix Paeoniae Rubra, 1～12 part of Radix Angelicae Sinensis, 1～12 part of Cortex Moutan, 1～12 part of the Fructus Kochiae, 1～12 part of Herba Hedyotidis Diffusae, 1～10 part of Radix Sophorae Flavescentis, 1～10 part of Fructus Gardeniae (parched), 1～10 part of Radix Clematidis, 1～8 part of Zaocys, 1～8 part, Nidus Vespae, 1～8 part of Radix Saposhnikoviae, 1～8 part of 1～8 part, Radix Glycyrrhizae and Radix Arnebiae (Radix Lithospermi);
⑵ the method for making of the psoriatic Chinese medicine preparation of described treatment is characterized in that comprising the steps:
1. extract
In ⑴ item dosage ratio, get respectively each prepared slices of Chinese crude drugs, add the conventional water gaging that decocts, decoct twice, for the first time 1～2h, 1～2h for the second time;
2. clear paste processed
Water decoction is concentrated into the relative density of each prepared slices of Chinese crude drugs regulation, obtains the clear paste of each prepared slices of Chinese crude drugs;
3. spray granulation
With the clear paste that 2. obtains, by pharmacopeia regulation spray granulation or spray drying, make fine powder, add appropriate adjuvant, mixing makes the application's granule, i.e. the Chinese medicinal granule dosage form;
4. pack respectively
With the granule that 4. obtains, by each prepared slices of Chinese crude drugs therapeutic dose packing, standby respectively;
⑶ the application of the psoriatic Chinese medicine preparation of described treatment is characterized in that the application in preparation treatment psoriasis vulgaris medicine preparation.
Above-mentioned Chinese medicine preparation is characterized in that the relative density that described water decoction is concentrated into each prepared slices of Chinese crude drugs regulation refers to:
1.02～1.10/60～80 ℃ of Rhizoma Imperataes;
1.06～1.14/65 ℃, Rhizoma Smilacis Glabrae, Semen Coicis, Radix Angelicae Sinensis, Cortex Moutan, Radix Sophorae Flavescentis, Radix Clematidis and Radix Glycyrrhizae;
1.08～1.13/65 ℃ of Herba Hedyotidis Diffusaes;
1.10～1.14/65 ℃, Nidus Vespae;
1.10～1.18/65 ℃ of Radix Rehmanniae, Fructus Gardeniae (parched), Zaocys;
1.12～1.17/65 ℃ of Radix Paeoniae Rubra;
1.15～1.20/65 ℃ of Cortex Dictamni, the Fructus Kochiae, Radix Saposhnikoviae and Radix Arnebiae (Radix Lithospermi)s.
Above-mentioned Chinese medicine preparation is characterized in that also can being made by the prepared slices of Chinese crude drugs of following weight ratio:
12～15 parts of Rhizoma Smilacis Glabraes, 12～15 parts of Radix Rehmanniae, 12～15 parts of Semen Coiciss, 12～15 parts of Rhizoma Imperataes, 4～10 parts of Cortex Dictamni, 5～10 parts of Radix Paeoniae Rubra, 5～10 parts of Radix Angelicae Sinensis, 5～10 parts of Cortex Moutans, 5～10 parts of the Fructus Kochiae, 5～10 parts of Herba Hedyotidis Diffusaes, 4～8 parts of Radix Sophorae Flavescentiss, 4～8 parts of Fructus Gardeniae (parched), 4～8 parts of Radix Clematidis, 3～7 parts of Zaocyss, 3～7 parts, Nidus Vespae, 3～7 parts of Radix Saposhnikoviaes, 2～4 parts of 3～7 parts, Radix Glycyrrhizae and Radix Arnebiae (Radix Lithospermi)s.
Above-mentioned Chinese medicine preparation is characterized in that and can also be made by the prepared slices of Chinese crude drugs of following weight ratio:
8～12 parts of Rhizoma Smilacis Glabraes, 8～12 parts of Radix Rehmanniae, 8～12 parts of Semen Coiciss, 8～12 parts of Rhizoma Imperataes, 5～9 parts of Cortex Dictamni, 3～7 parts of Radix Paeoniae Rubra, 3～7 parts of Radix Angelicae Sinensis, 3～7 parts of Cortex Moutans, 3～7 parts of the Fructus Kochiae, 3～7 parts of Herba Hedyotidis Diffusaes, 2～6 parts of Radix Sophorae Flavescentiss, 2～6 parts of Fructus Gardeniae (parched), 2～6 parts of Radix Clematidis, 1～5 part of Zaocys, 1～5 part, Nidus Vespae, 1～5 part of Radix Saposhnikoviae, 1～4 part of 1～5 part, Radix Glycyrrhizae and Radix Arnebiae (Radix Lithospermi).
Psoriasis has another name called " psoriasis ", is a kind of chronic inflammatory disease dermatoses of common and easy recurrence, and its cause of disease is not yet fully clear.According to its Clinical symptoms, generally can be divided into 4 types, homeliness type, pustule type, arthropathica and erythroderma type, wherein, especially common with homeliness type.
The treatment of psoriasis vulgaris should be followed the principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, takes the therapeutic scheme of individuation.According to state of an illness weight, treatment should " be topped bar " to composite treatment step by step from single.If the state of an illness gentlier external used medicine get final product; The slightly heavy system's medication of the state of an illness is in conjunction with external used medicine; The method treatment of adopting the combination of Chinese and Western medicine that is in a bad way is appropriate, as oral medicinal herb, external, then the associating phototherapy etc.Clinical observation shows the comprehensive therapeutic plan that adopts the combination of Chinese and Western medicine, and curative effect is better than simple Chinese medicine or Western medicine.
Psoriasis vulgaris can be controlled the state of an illness well by the Therapeutic Method of the traditional Chinese medical science or the combination of Chinese and Western medicine.We often first reach clinical cure with the method for the combination of Chinese and Western medicine to the treatment of psoriasis vulgaris, and the later stage continues to reduce recurrence with the external washout with traditional Chinese herbs long-term control state of an illness.System's medication had so for a long time both obtained clinical efficacy preferably, had avoided again the side effect of long-term system medication.In psoriasis vulgaris, " psoriasis guttate " is relevant with streptococcal infection, and be better by heat-clearing and detoxifying herb or antibiotic therapy curative effect.Scalp or shank skin lesion, be speckle shape or the more difficult removing of oyster shelly skin lesion.In addition, there are some contraindications in the Drug therapys such as mucosal sites psoriasis external hormone, therefore treatment is also more thorny.Psoriasis vulgaris is not system applies hormone therapy preferably, does not pursue so-called specific drug, not with the large heal with drugs of side effect.Psychological counseling, actively anti-treating tonsillitis, upper respiratory tract infection are of great advantage to the rehabilitation of psoriasis vulgaris.
Chinese medicine thinks, heat in blood, blood stasis, blood deficiency are psoriatic basic pathogenesis, and pathogenic factor is attacked outward, the poly-skin of knot, strongly fragrant heat-transformation of a specified duration, give birth to dry humorously, failure of skin and muscle to be nourished and falling ill.
The psoriasis vulgaris phase of carrying out is main mainly with heat in blood, controls suitable heat-clearing and toxic substances removing, the removing heat from blood speckle dispelling.Take Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi) as monarch drug, be used for the heat in blood poison and contain in the present invention, removing pathogenic heat from blood and toxic substance from the body is arranged, rash doctor skin ulcer, the merit of anti-inflammatory anti-itch; Radix Paeoniae Rubra, Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Rhizoma Imperatae, Cortex Moutan, the Fructus Kochiae, Fructus Gardeniae (parched), Rhizoma Smilacis Glabrae are ministerial drug, to help its promoting blood circulation and cooling blood, the effect of heat-clearing and toxic substances removing; Radix Saposhnikoviae, Radix Clematidis, Cortex Dictamni, Herba Hedyotidis Diffusae, Semen Coicis, Zaocys, Nidus Vespae are adjuvant drug, strengthen heat-clearing and toxic substances removing, the effect of expelling wind and dampness; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making medicine.All medicines share, and play altogether removing heat from blood, invigorate blood circulation, the effect of heat-clearing and toxic substances removing.
The application's method for making is given an example:
The Rhizoma Smilacis Glabrae granule, the Poria prepared slices of Chinese crude drugs that fetch earth add the decoction water gaging and decoct secondary, 2 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, it is 1.06～1.14(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying is granulated, and be get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 15g).
The Radix Rehmanniae granule is got the Radix Rehmanniae prepared slices of Chinese crude drugs, adds to decoct water gaging decoction secondary, 2 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, it is 1.10～1.18(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying is granulated, and be get final product.Every packed 2g(is equivalent to these prepared slices of Chinese crude drugs 5g)
The Semen Coicis granule is got the Semen Coicis prepared slices of Chinese crude drugs, adds the conventional water gaging that decocts and decocts secondary, 1.5 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, it is 1.06～1.14(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying is granulated, and be get final product.Every packed 2g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Rhizoma Imperatae granule is got the Rhizoma Imperatae prepared slices of Chinese crude drugs, adds to decoct water gaging decoction secondary, 2 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, it is 1.02～1.10(60～80 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate amount of auxiliary materials, spray drying is granulated, packing, and get final product.Every packed 1g (being equivalent to these prepared slices of Chinese crude drugs 15g)
The Cortex Dictamni granule is got the Cortex Dictamni prepared slices of Chinese crude drugs and is added decoction water gaging decoction secondary, 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filter, it is 1.15～1.20(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, spray drying is granulated, packing, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Radix Paeoniae Rubra granule is got the Radix Paeoniae Rubra prepared slices of Chinese crude drugs, adds to decoct water gaging decoction secondary, 2 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, it is 1.12～1.17(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, spray drying is granulated, packing, and get final product.Every packed 2g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Radix Angelicae Sinensis granule is got the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, decocts with water twice, and 1.5 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, being concentrated into relative density is 1.06～1.14(65 ℃) clear paste, add appropriate dextrin, mixing, spray drying is granulated, packing, and get final product.Every packed 3g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Cortex Moutan granule is got the Cortex Moutan prepared slices of Chinese crude drugs, adds to decoct water gaging and decoct twice, and each 1.5 hours, collecting decoction filtered, and it is 1.06～1.14(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying is granulated, packing, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g)
Fructus Kochiae granule is got the Fructus Kochiae prepared slices of Chinese crude drugs, adds to decoct water gaging decoction secondary, 2 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, it is 1.15～1.20(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, spray drying is granulated, packing, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Herba Hedyotidis Diffusae grass particle is got the Herba Hedyotidis Diffusae prepared slices of Chinese crude drugs, adds to decoct water gaging decoction secondary, 1.5 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, it is 1.08～1.13(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying, granulate, packing, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 15g)
The Radix Sophorae Flavescentis granule is got the Radix Sophorae Flavescentis prepared slices of Chinese crude drugs, adds to decoct water gaging and decoct secondary, and 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, and it is 1.06～1.14(60～80 ℃ that filtrate is concentrated into relative density) clear paste, spray drying is granulated, packing, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Fructus Gardeniae (parched) granule is got the Fructus Gardeniae (parched) prepared slices of Chinese crude drugs, adds the conventional water gaging that decocts and decocts secondary, 2 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, it is 1.10～1.18(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying is granulated, packing, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Radix Clematidis granule is got Radix Clematidis prepared slices of Chinese crude drugs 10000g, adds to decoct water gaging decoction secondary, 1.5 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, it is 1.06～1.14(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying, granulate, make 1000g, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Zaocys granule is got the Zaocys prepared slices of Chinese crude drugs, adds the conventional water gaging that decocts and decocts secondary, 2 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, it is 1.10～1.18(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying is granulated, packing, and get final product.Every packed 1.5g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Nidus Vespae granule is got the Nidus Vespae prepared slices of Chinese crude drugs, adds to decoct water gaging decoction secondary, 1.5 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, it is 1.10～1.14(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying is granulated, packing, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 5g)
Ledebouriella root granula is got the Radix Saposhnikoviae prepared slices of Chinese crude drugs, adds to decoct water gaging decoction secondary, 2.5 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filter, it is 1.15～1.20(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, spray drying is granulated, packing, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g)
Licorice root particles, the extracting liquorice prepared slices of Chinese crude drugs add the decoction water gaging and decoct secondary, 1.5 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, it is 1.06～1.14(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying is granulated, packing, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 3g)
The Radix Arnebiae (Radix Lithospermi) granule is got the Radix Arnebiae (Radix Lithospermi) prepared slices of Chinese crude drugs, adds the conventional water gaging that decocts and decocts secondary, 2 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, it is 1.15～1.20(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, spray drying is granulated, packing, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g).
Traditional Chinese medical science method in psoriatic treatment is numerous, and individual patients is carried out integral syndrome differentiation treatment, in psoriatic treatment with prevent that the aspect such as recurrence from all obtaining effect preferably.The application is in experimental stage, and the applicant with present technique data treatment psoriasis vulgaris 281 examples (clinical former name claims " gram silver Chinese medicinal granule "), has obtained satisfactory effect by institute's internal therapy; Treat altogether 281 examples, wherein, clinical cure 228 examples, clinical cure rate 81.14%; Produce effects 21 examples, obvious effective rate 7.47%; Effective 26 examples, effective percentage 9.25%; Invalid 6 examples, inefficiency 2.14%.
After gathering, clinical cure rate 81.14%; (produce effects+effectively) clinical effective rate 88.61%.
Advantage of the present invention is:
1. effect is remarkable, cure rate is high, relapse rate is low, dosage is few;
2. easy to use and flexible, standard are unified, meet Chinese medicine standardization, standardization, scientific management expectancy.
The specific embodiment
Below in conjunction with embodiment, invention is further elaborated.
Embodiment 1
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 2000g, Radix Rehmanniae 2000g,, Semen Coicis 2000g,, Rhizoma Imperatae 2000g,, Cortex Dictamni 1200g, Radix Paeoniae Rubra 1200g, Radix Angelicae Sinensis 1200g, Cortex Moutan 1200g, Fructus Kochiae 1200g, Herba Hedyotidis Diffusae 1200g, Radix Sophorae Flavescentis 1000g, Fructus Gardeniae (parched) 1000g, Radix Clematidis 1000g, Zaocys 800g, Nidus Vespae 800g, Radix Saposhnikoviae 800g, Radix Glycyrrhizae 800g and Radix Arnebiae (Radix Lithospermi) 800g.
Method for making comprises the steps:
Extract
In the dosage ratio, get respectively each prepared slices of Chinese crude drugs, add the conventional water gaging that decocts, decoct twice, for the first time 1～2h, 1～2h for the second time;
Clear paste processed
Water decoction is concentrated into the relative density of each prepared slices of Chinese crude drugs regulation, obtains the clear paste of each prepared slices of Chinese crude drugs;
Spray granulation
With the clear paste that obtains, by pharmacopeia regulation spray granulation or spray drying, make fine powder, add appropriate adjuvant, mixing makes the application's granule, i.e. the Chinese medicinal granule dosage form;
Pack respectively
With the granule that obtains, by each prepared slices of Chinese crude drugs therapeutic dose packing, standby respectively;
The application of the Chinese medicinal granule agent that the application makes in preparation treatment psoriasis vulgaris medicine preparation.
The relative density that described water decoction is concentrated into each prepared slices of Chinese crude drugs regulation refers to:
1.02～1.10/60～80 ℃ of Rhizoma Imperataes;
1.06～1.14/65 ℃, Rhizoma Smilacis Glabrae, Semen Coicis, Radix Angelicae Sinensis, Cortex Moutan, Radix Sophorae Flavescentis, Radix Clematidis and Radix Glycyrrhizae;
1.08～1.13/65 ℃ of Herba Hedyotidis Diffusaes;
1.10～1.14/65 ℃, Nidus Vespae;
1.10～1.18/65 ℃ of Radix Rehmanniae, Fructus Gardeniae (parched), Zaocys;
1.12～1.17/65 ℃ of Radix Paeoniae Rubra;
1.15～1.20/65 ℃ of Cortex Dictamni, the Fructus Kochiae, Radix Saposhnikoviae and Radix Arnebiae (Radix Lithospermi)s.
Method for making is given an example:
The Rhizoma Smilacis Glabrae granule, the Poria prepared slices of Chinese crude drugs 2000g that fetches earth adds the decoction water gaging and decocts secondary, 2 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, it is 1.06～1.14(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying, granulate, make 1000g, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 15g).
The Radix Rehmanniae granule is got Radix Rehmanniae prepared slices of Chinese crude drugs 2000g, adds to decoct water gaging decoction secondary, 2 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, it is 1.10～1.18(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying, granulate, make 1000g, and get final product.Every packed 2g(is equivalent to these prepared slices of Chinese crude drugs 5g)
The Semen Coicis granule is got Semen Coicis prepared slices of Chinese crude drugs 2000g, adds the conventional water gaging that decocts and decocts secondary, 1.5 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, it is 1.06～1.14(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying, granulate, make 1000g, and get final product.Every packed 2g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Rhizoma Imperatae granule is got Rhizoma Imperatae prepared slices of Chinese crude drugs 2000g, adds to decoct water gaging decoction secondary, 2 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, it is 1.02～1.10(60～80 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate amount of auxiliary materials, spray drying, granulate, make 1000g, packing, and get final product.Every packed 1g (being equivalent to these prepared slices of Chinese crude drugs 15g)
The Cortex Dictamni granule is got Cortex Dictamni prepared slices of Chinese crude drugs 1200g, adds to decoct water gaging decoction secondary, 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filter, it is 1.15～1.20(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, spray drying, granulate, make 1000g, packing, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Radix Paeoniae Rubra granule is got Radix Paeoniae Rubra prepared slices of Chinese crude drugs 1200g, adds to decoct water gaging decoction secondary, 2 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, it is 1.12～1.17(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, spray drying, granulate, make 1000g, packing, and get final product.Every packed 2g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Radix Angelicae Sinensis granule is got Radix Angelicae Sinensis prepared slices of Chinese crude drugs 1200g, decocts with water twice, and 1.5 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, being concentrated into relative density is 1.06～1.14(65 ℃) clear paste, add appropriate dextrin, mixing, spray drying is granulated, and makes 1000g, and get final product.Every packed 3g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Cortex Moutan granule is got Cortex Moutan prepared slices of Chinese crude drugs 1200g, adds to decoct water gaging decoction twice, each 1.5 hours, collecting decoction, filter, it is 1.06～1.14(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying is granulated, and makes 1000g, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g)
Fructus Kochiae granule is got Fructus Kochiae prepared slices of Chinese crude drugs 1200g, adds to decoct water gaging decoction secondary, 2 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, it is 1.15～1.20(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, spray drying, granulate, make 1000g, packing, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Herba Hedyotidis Diffusae grass particle is got Herba Hedyotidis Diffusae prepared slices of Chinese crude drugs 1200g, adds to decoct water gaging decoction secondary, 1.5 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, it is 1.08～1.13(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying, granulate, make 1000g, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 15g)
The Radix Sophorae Flavescentis granule is got Radix Sophorae Flavescentis prepared slices of Chinese crude drugs 1000g, adds to decoct water gaging decoction secondary, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, and it is 1.06～1.14(60～80 ℃ that filtrate is concentrated into relative density) clear paste, spray drying is granulated, and makes 1000g, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Fructus Gardeniae (parched) granule is got Fructus Gardeniae (parched) prepared slices of Chinese crude drugs 1000g, adds the conventional water gaging that decocts and decocts secondary, 2 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, it is 1.10～1.18(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying, granulate, make 1000g, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Radix Clematidis granule is got Radix Clematidis prepared slices of Chinese crude drugs 1000g, adds to decoct water gaging decoction secondary, 1.5 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, it is 1.06～1.14(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying, granulate, make 1000g, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Zaocys granule is got Zaocys prepared slices of Chinese crude drugs 800g, adds the conventional water gaging that decocts and decocts secondary, 2 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, it is 1.10～1.18(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying, granulate, make 1000g, and get final product.Every packed 1.5g(is equivalent to these prepared slices of Chinese crude drugs 10g)
The Nidus Vespae granule is got Nidus Vespae prepared slices of Chinese crude drugs 800g, adds to decoct water gaging decoction secondary, 1.5 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, it is 1.10～1.14(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying, granulate, make 1000g, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 5g)
Ledebouriella root granula is got Radix Saposhnikoviae prepared slices of Chinese crude drugs 800g, adds to decoct water gaging decoction secondary, 2.5 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filter, it is 1.15～1.20(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, spray drying, granulate, make 1000g, packing, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g)
Licorice root particles, extracting liquorice prepared slices of Chinese crude drugs 800g adds the decoction water gaging and decocts secondary, 1.5 hours for the first time, 1 hour for the second time, merge decoction liquor, filter, it is 1.06～1.14(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, mixing, spray drying, granulate, make 1000g, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 3g)
The Radix Arnebiae (Radix Lithospermi) granule is got Radix Arnebiae (Radix Lithospermi) prepared slices of Chinese crude drugs 800g, adds the conventional water gaging that decocts and decocts secondary, 2 hours for the first time, 2 hours for the second time, merge decoction liquor, filter, it is 1.15～1.20(65 ℃ that filtrate is concentrated into relative density) clear paste, add appropriate dextrin, spray drying, granulate, make 1000g, packing, and get final product.Every packed 1g(is equivalent to these prepared slices of Chinese crude drugs 10g).
The clinic trial data
Case is selected
The patient is all my institute's Dermatology Outpatient Department or inpatients, and clinical diagnosis meets psoriasis vulgaris.Wherein M-F is substantially equal, 18～65 years old age, average 38.15 years old; The course of disease 3 months～16 years, average 5.8 years.
Diagnostic criteria
Trunk, extremity differ in size take the dark red speckle of wellability as main, and hypertrophy is obviously plump, conscious little pruritus; Cover the silvery white squama on skin lesion, strike off the thin film that the visible substrate of squama has one deck light, visible petechial hemorrhage under thin film.
Well-defined speckle, coin are to hand size, and number is indefinite, or mutually merge, and slight infiltration is arranged, and color is light red or purple brown.
Diagnostic criteria and Clinical typing standard reference Zhao distinguish the 3rd edition " clinical dermatology " related standards of chief editor.
Standards of Chinese Medical Syndrome Differentiation
The dry exterior syndrome of attacking of wind heat: skin drop shape erythema or red grouper pimple, often accompany laryngopharynx swelling and pain, skin pruritus; Or see scalp squama erythema, scalp itch.Red tip of the tongue, yellow and thin fur, floating and rapid pulse.
Scorching flourishing card (blood-heat syndrome): erythra constantly occurs, development rapidly, color is scarlet, presents the forms such as drop shape, coin shape more, squama increases, acute pruritus, that grabs has a sieve shape petechia; Companion's dry mouth and tougue is had sore throat, and susceptible to lose temper due to restlessness is hard and dry, yellowish or reddish urine.Red tongue, yellow and thin fur, stringy and rolling pulse or number.
Remaining heresy is most, syndrome of wind and dryness due to blood deficiency: the course of disease is more of a specified duration, and erythra is the patch shape more, and color is light red, and squama reduces, and drying is chapped, conscious pruritus; Companion's pharyngoxerosis.Body of the tongue is light red, and tongue is few, deep-thready pulse.
Syndrome of yin deficiency of liver and kidney: with the passing of time disease damage does not move back, companion's soreness of the waist and knees, feel dizzy, Hiccough and deaf, xerostomia, constipation, dark coloured urine, red tongue, few tongue, thready and rapid pulse.
The stagnation of QI-blood card: skin lesion is not healed repeatedly, and erythra is the speckle shape more, and squama is thicker, and color is dark red, and purplish tongue has petechia, ecchymosis, hesitant pulse or thin slow.
Damp and hotly accumulate long-pending card: skin lesion mostly occurs at the gauffer such as axillary fossa, groin position, and erythema is rotten to the corn, and the crust bits are sticking thick, acute pruritus; Or palm sole of the foot erythema, pustule, decortication; Or accompany joint aches, swelling, lower limb are heavy.Red tongue, yellow and greasy fur, rolling pulse.
Inclusive criteria
1. meet above-mentioned diagnostic criteria; 2. the age is at 18-65 outpatient service or the inpatient in year; 3. male or female, skin lesion mainly is distributed in trunk and extremity; 4. in nearly 4 weeks not system used antipsoriatic thing or the psoriatic method of other treatment, do not use Donisolone and vitamin D 3-derivatives in 2 weeks; 5. liver function, renal function, lipid examination are normal; 6. patient's informed consent.
Exclusion standard 1. age＜18 year old or 65 years old; 2. be in the stress state persons such as infection, gestation, childbirth, wound; 3. in nearly 4 weeks, system used antipsoriatic thing or the psoriatic method of other treatment, and Donisolone and vitamin D 3-derivatives external history were arranged in 2 weeks; 4. severe cardiac, liver, kidney disease and insane are arranged.
1. termination and the standard that withdraws from serious adverse events occurs in therapeutic process; 2. run counter to testing program in patient's medication; 3. (comprising that the patient withdraws from voluntarily) lost to follow-up; 4. the patient recalls Informed Consent Form.
Therapeutic Method
Gram silver Chinese medicinal granule, 18 flavor Chinese medicinal granules are respectively got one bag at every turn, mixing in water for oral taking after can distinguishing or mix.Every day twice, after meal half an hour decoction being taken warmly.Take 90 days as a course for the treatment of, carry out therapeutic evaluation after the course for the treatment of.Inactive other related drugs during treatment.The untoward reaction that occurs during the record treatment etc.
Curative effect determinate standard
Carry out skin lesion area (%) and severity scale according to the PASI standards of grading:
Skin lesion area (P): 0 minute: 0%; 1 minute:＜10%; 2 minutes: 10%-29%; 3 minutes: 30%-49%; 4 minutes: 50%-69%; 5 minutes: 70%-89%; 6 minutes: 90%-100%;
Squama (D): 0 minute: without skin lesion; 1 minute: slight; 2 minutes: moderate; 3 minutes: severe; 4 minutes: utmost point severe;
Infiltrate (I): 0 minute: without skin lesion; 1 minute: slight; 2 minutes: moderate; 3 minutes: severe; 4 minutes: utmost point severe;
Erythema (E): 0 minute: without skin lesion; 1 minute: slight; 2 minutes: moderate; 3 minutes: severe; 4 minutes: utmost point severe;
PASI mark=head surface integration * head order of severity divide (D+I+E)+upper limb area divide * the upper limb order of severity divide (D+I+E)+trunk area divide * the trunk order of severity divide (D+I+E)+lower limb area divide * the severe lower extremity degree divides (D+I+E)
Efficacy determination
Clinical cure: state of an illness improvement rate 〉=90%;
Produce effects: state of an illness improvement rate＜90%, but 〉=60%;
Effectively:＜60% but 〉=20%;
Invalid: state of an illness improvement rate＜20%;
* effective percentage adds obvious effective rate calculating with cure rate.
PASI integration * 100% after state of an illness improvement rate (%)=(PASI scoring after PASI scoring-treatment before treatment)/treatment
Model case 1
Certain man, 29 years old, on June 3rd, 2008 was medical.Suffer from psoriasis 2 years, and in many ways cured curative effect undesirable.When examining, trunk, extremity have generalized erythema, on cover squama, pruritus, red tongue, yellow fur, stringy pulse.This is flourishing the levying of interior-heat, controls suitable heat-clearing and toxic substances removing, and removing heat from blood moves back speckle.Use gram silver Chinese medicinal granule for oral administration, every day twice, after meal half an hour decoction being taken warmly.
Take 90 days as a course for the treatment of, after the course for the treatment of, erythra all disappears.With preventing so far without recurrence.
Model case 2
Certain man, 33 years old.Because of skin erythema, squama, pruritus 8 years, increase the weight of to come medical on June 1st, 2009 in 1 year.The patient had history of psoriasis 8 years, and beginning skin only has several places erythema, pruritus.Erythra developed to whole body from taking the psoriatic special effect Chinese of mailing treatment (for the warming and recuperating the kidney-YANG Chinese drug-treated group such as Radix Ginseng, Cornu Cervi Pantotrichum become) state of an illness aggravation after half a year in 2005.When examining, erythra has spreaded all over scalp, trunk, extremity, and face also is dispersed in erythema, pruritus, red tongue, yellow fur, stringy pulse.This is the card of excessive noxious heat, and controlling should heat-clearing and toxic substances removing, and removing heat from blood moves back speckle, uses gram silver Chinese medicinal granule for oral administration, every day twice, after meal half an hour decoction being taken warmly.Take 90 days as a course for the treatment of, after two courses for the treatment of, erythra all disappears.With preventing so far without recurrence.
Model case 3
Certain female, 23 years old, skin erythema, pruritus 3 years, medical on August 5th, 2008, when medical, extremity, trunk have extensive Semen Glycines great red spot, cover the silvery white squama on erythema, pruritus, laryngopharynx swelling and pain, red tip of the tongue, yellow and thin fur, floating pulse.This attacks the card of table for wind heat, controlling should the wind and heat dispersing detoxifcation.Use gram silver Chinese medicinal granule for oral administration, every day twice, after meal half an hour decoction being taken warmly.
Take 90 days as a course for the treatment of, after the course for the treatment of, erythra all disappears.With preventing so far without recurrence.
Embodiment 2
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 600g, Radix Rehmanniae 800g, Semen Coicis 600g, Rhizoma Imperatae 600g, Cortex Dictamni 400g, Radix Paeoniae Rubra 500g, Radix Angelicae Sinensis 400g, Cortex Moutan 500g, Fructus Kochiae 400g, Herba Hedyotidis Diffusae 500g, Radix Sophorae Flavescentis 400g, Fructus Gardeniae (parched) 200g, Radix Clematidis 400g, Zaocys 300g, Nidus Vespae 100g, Radix Saposhnikoviae 300g, Radix Glycyrrhizae 200g and Radix Arnebiae (Radix Lithospermi) 400g.
All the other are with embodiment 1.
Embodiment 3
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 800g, Radix Rehmanniae 2000g, Semen Coicis 800g, Rhizoma Imperatae 2000g, Cortex Dictamni 300g, Radix Paeoniae Rubra 900g, Radix Sophorae Flavescentis 100g, Fructus Gardeniae (parched) 800g, Radix Clematidis 1000g, Zaocys 300g, Nidus Vespae 500g, Radix Saposhnikoviae 300g, Radix Glycyrrhizae 300g and Radix Arnebiae (Radix Lithospermi) 100g.
All the other are with embodiment 1.
Embodiment 4
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 2000g, Radix Rehmanniae 1500g, Semen Coicis 2000g, Rhizoma Imperatae 800g, Cortex Dictamni 500g, Radix Paeoniae Rubra 2000g, Radix Angelicae Sinensis 900g, Cortex Moutan 400g, Fructus Kochiae 100g, Herba Hedyotidis Diffusae 500g, Radix Sophorae Flavescentis 600g, Fructus Gardeniae (parched) 400g, Radix Clematidis 400g, Zaocys 100g, Nidus Vespae 700g, Radix Saposhnikoviae 100g, Radix Glycyrrhizae 300g and Radix Arnebiae (Radix Lithospermi) 800g.
All the other are with embodiment 1.
Embodiment 5
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 1500g, Radix Rehmanniae 1500g, Semen Coicis 1500g, Rhizoma Imperatae 1500g, Cortex Dictamni 400g, Radix Paeoniae Rubra 1000g, Radix Angelicae Sinensis 1000g, Cortex Moutan 500g, Fructus Kochiae 1200g, Herba Hedyotidis Diffusae 900g, Radix Sophorae Flavescentis 200g, Fructus Gardeniae (parched) 100g, Radix Clematidis 600g, Zaocys 100g, Nidus Vespae 800g, Radix Saposhnikoviae 700g, Radix Glycyrrhizae 100g and Radix Arnebiae (Radix Lithospermi) 100g.
All the other are with embodiment 1.
Embodiment 6
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 800g, Radix Rehmanniae 1200g, Semen Coicis 1500g, Rhizoma Imperatae 2000g, Cortex Dictamni 300g, Radix Paeoniae Rubra 900g, Radix Angelicae Sinensis 1200g, Cortex Moutan 1200g, Fructus Kochiae 1200g, Herba Hedyotidis Diffusae 100g, Radix Sophorae Flavescentis 400g, Fructus Gardeniae (parched) 200g, Radix Clematidis 1000g, Zaocys 300g, Nidus Vespae 300g, Radix Saposhnikoviae 800g, Radix Glycyrrhizae 300g and Radix Arnebiae (Radix Lithospermi) 400g.
All the other are with embodiment 1.
Embodiment 7
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 2000g, Radix Rehmanniae 1500g, Semen Coicis 2000g, Rhizoma Imperatae 600g, Cortex Dictamni 900g, Radix Paeoniae Rubra 400g, Radix Angelicae Sinensis 500g, Cortex Moutan 1000g, Fructus Kochiae 900g, Herba Hedyotidis Diffusae 400g, Radix Sophorae Flavescentis 400g, Fructus Gardeniae (parched) 600g, Radix Clematidis 100g, Zaocys 300g, Nidus Vespae 100g, Radix Saposhnikoviae 300g, Radix Glycyrrhizae 300g and Radix Arnebiae (Radix Lithospermi) 100g.
Embodiment 8
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 1500g, Radix Rehmanniae 800g, Semen Coicis 1200g, Rhizoma Imperatae 800g, Cortex Dictamni 1000g, Radix Paeoniae Rubra 500g, Radix Angelicae Sinensis 900g, Cortex Moutan 400g, Fructus Kochiae 1200g, Herba Hedyotidis Diffusae 1000g, Radix Sophorae Flavescentis 800g, Fructus Gardeniae (parched) 800g, Radix Clematidis 200g, Zaocys 300g, Nidus Vespae 800g, Radix Saposhnikoviae 100g, Radix Glycyrrhizae 300g and Radix Arnebiae (Radix Lithospermi) 400g.
All the other are with embodiment 1.
Embodiment 9
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 1200g, Radix Rehmanniae 600g, Semen Coicis 800g, Rhizoma Imperatae 1500g, Cortex Dictamni 1200g, Radix Paeoniae Rubra 100g, Radix Angelicae Sinensis 1000g, Cortex Moutan 500g, Fructus Kochiae 1200g, Herba Hedyotidis Diffusae 900g, Radix Sophorae Flavescentis 600g, Fructus Gardeniae (parched) 1000g, Radix Clematidis 800g, Zaocys 300g, Nidus Vespae 700g, Radix Saposhnikoviae 100g, Radix Glycyrrhizae 300g and Radix Arnebiae (Radix Lithospermi) 400g.
All the other are with embodiment 1.
Embodiment 10
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 600g, Radix Rehmanniae 1200g, Semen Coicis 600g, Rhizoma Imperatae 1200g, Cortex Dictamni 900g, Radix Paeoniae Rubra 1000g, Radix Angelicae Sinensis 400g, Cortex Moutan 100g, Fructus Kochiae 500g, Herba Hedyotidis Diffusae 1200g, Radix Sophorae Flavescentis 600g, Fructus Gardeniae (parched) 600g, Radix Clematidis 1000g, Zaocys 100g, Nidus Vespae 700g, Radix Saposhnikoviae 300g, Radix Glycyrrhizae 500g and Radix Arnebiae (Radix Lithospermi) 400g.
All the other are with embodiment 1.
Embodiment 11
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 800g, Radix Rehmanniae 1500g, Semen Coicis 1200g, Rhizoma Imperatae 2000g, Cortex Dictamni 1000g, Radix Paeoniae Rubra 1200g, Radix Angelicae Sinensis 1200g, Cortex Moutan 500g, Fructus Kochiae 1200g, Herba Hedyotidis Diffusae 1000g, Radix Sophorae Flavescentis 800g, Fructus Gardeniae (parched) 200g, Radix Clematidis 800g, Zaocys 300g, Nidus Vespae 800g, Radix Saposhnikoviae 700g, Radix Glycyrrhizae 100g and Radix Arnebiae (Radix Lithospermi) 200g.
All the other are with embodiment 1.
Embodiment 12
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 1200g, Radix Rehmanniae 2000g, Semen Coicis 1500g, Rhizoma Imperatae 800g, Cortex Dictamni 500g, Radix Paeoniae Rubra 900g, Radix Angelicae Sinensis 100g, Cortex Moutan 400g, Fructus Kochiae 900g, Herba Hedyotidis Diffusae 900g, Radix Sophorae Flavescentis 200g, Fructus Gardeniae (parched) 600g, Radix Clematidis 600g, Zaocys 700g, Nidus Vespae 300g, Radix Saposhnikoviae 800g, Radix Glycyrrhizae 300g and Radix Arnebiae (Radix Lithospermi) 800g.
All the other are with embodiment 1.
Embodiment 13
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 1500g, Radix Rehmanniae 1200g, Semen Coicis 800g, Rhizoma Imperatae 1200g, Cortex Dictamni 1200g, Radix Paeoniae Rubra 500g, Radix Angelicae Sinensis 500g, Cortex Moutan 900g, Fructus Kochiae 500g, Herba Hedyotidis Diffusae 400g, Radix Sophorae Flavescentis 200g, Fructus Gardeniae (parched) 400g, Radix Clematidis 400g, Zaocys 700g, Nidus Vespae 800g, Radix Saposhnikoviae 700g, Radix Glycyrrhizae 300g and Radix Arnebiae (Radix Lithospermi) 100g.
All the other are with embodiment 1.
Embodiment 14
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 1200g, Radix Rehmanniae 1500g, Semen Coicis 1500g, Rhizoma Imperatae 1500g, Cortex Dictamni 400g, Radix Paeoniae Rubra 400g, Radix Angelicae Sinensis 400g, Cortex Moutan 1200g, Fructus Kochiae 100g, Herba Hedyotidis Diffusae 500g, Radix Sophorae Flavescentis 200g fries Cape jasmine 600g, Radix Clematidis 800g, Zaocys 500g, Nidus Vespae 500g, Radix Saposhnikoviae 500g, Radix Glycyrrhizae 200g and Radix Arnebiae (Radix Lithospermi) 300g.
All the other are with embodiment 1.
Embodiment 15
The prepared slices of Chinese crude drugs consist of:
Rhizoma Smilacis Glabrae 2000g, Radix Rehmanniae 2000g, Semen Coicis 600g, Rhizoma Imperatae 600g, Cortex Dictamni 1200g, Radix Paeoniae Rubra 100g, Radix Angelicae Sinensis 900g, Cortex Moutan 1200g, Fructus Kochiae 1200g, Herba Hedyotidis Diffusae 100g, Radix Sophorae Flavescentis 400g, Fructus Gardeniae (parched) 1000g, Radix Clematidis 1000g, Zaocys 300g, Nidus Vespae 500g, Radix Saposhnikoviae 700g, Radix Glycyrrhizae 100g and Radix Arnebiae (Radix Lithospermi) 800g.All the other are with embodiment 1.
Claims (4)
1. treat psoriatic Chinese medicine preparation for one kind, it is characterized in that:
⑴ the Chinese medicinal granule that made by the prepared slices of Chinese crude drugs of following weight ratio:
6～20 parts of Rhizoma Smilacis Glabraes, 6～20 parts of Radix Rehmanniae, 6～20 parts of Semen Coiciss, 6～20 parts of Rhizoma Imperataes, 3～12 parts of Cortex Dictamni, 1～12 part of Radix Paeoniae Rubra, 1～12 part of Radix Angelicae Sinensis, 1～12 part of Cortex Moutan, 1～12 part of the Fructus Kochiae, 1～12 part of Herba Hedyotidis Diffusae, 1～10 part of Radix Sophorae Flavescentis, 1～10 part of Fructus Gardeniae (parched), 1～10 part of Radix Clematidis, 1～8 part of Zaocys, 1～8 part, Nidus Vespae, 1～8 part of Radix Saposhnikoviae, 1～8 part of 1～8 part, Radix Glycyrrhizae and Radix Arnebiae (Radix Lithospermi);
⑵ the method for making of the psoriatic Chinese medicine preparation of described treatment is characterized in that comprising the steps:
1. extract
In ⑴ item dosage ratio, get respectively each prepared slices of Chinese crude drugs, add the conventional water gaging that decocts, decoct twice, for the first time 1～2h, 1～2h for the second time;
2. clear paste processed
Water decoction is concentrated into the relative density of each prepared slices of Chinese crude drugs regulation, obtains the clear paste of each prepared slices of Chinese crude drugs;
3. spray granulation
With the clear paste that 2. obtains, by pharmacopeia regulation spray granulation or spray drying, make fine powder, add appropriate adjuvant, mixing makes the application's granule, i.e. Chinese medicinal granule;
4. pack respectively
With the granule that 4. obtains, by each prepared slices of Chinese crude drugs therapeutic dose packing, standby respectively;
⑶ the application of the psoriatic Chinese medicine preparation of described treatment is characterized in that the application in preparation treatment psoriasis vulgaris medicine preparation.
2. according to Chinese medicine preparation claimed in claim 1, it is characterized in that the relative density that described water decoction is concentrated into each prepared slices of Chinese crude drugs regulation refers to:
1.02～1.10/60～80 ℃ of Rhizoma Imperataes;
1.06～1.14/65 ℃, Rhizoma Smilacis Glabrae, Semen Coicis, Radix Angelicae Sinensis, Cortex Moutan, Radix Sophorae Flavescentis, Radix Clematidis and Radix Glycyrrhizae;
1.08～1.13/65 ℃ of Herba Hedyotidis Diffusaes;
1.10～1.14/65 ℃, Nidus Vespae;
1.10～1.18/65 ℃ of Radix Rehmanniae, Fructus Gardeniae (parched), Zaocys;
1.12～1.17/65 ℃ of Radix Paeoniae Rubra;
1.15～1.20/65 ℃ of Cortex Dictamni, the Fructus Kochiae, Radix Saposhnikoviae and Radix Arnebiae (Radix Lithospermi)s.
3. according to Chinese medicine preparation claimed in claim 1, it is characterized in that being made by the prepared slices of Chinese crude drugs of following weight ratio:
12～15 parts of Rhizoma Smilacis Glabraes, 12～15 parts of Radix Rehmanniae, 12～15 parts of Semen Coiciss, 12～15 parts of Rhizoma Imperataes, 4～10 parts of Cortex Dictamni, 5～10 parts of Radix Paeoniae Rubra, 5～10 parts of Radix Angelicae Sinensis, 5～10 parts of Cortex Moutans, 5～10 parts of the Fructus Kochiae, 5～10 parts of Herba Hedyotidis Diffusaes, 4～8 parts of Radix Sophorae Flavescentiss, 4～8 parts of Fructus Gardeniae (parched), 4～8 parts of Radix Clematidis, 3～7 parts of Zaocyss, 3～7 parts, Nidus Vespae, 3～7 parts of Radix Saposhnikoviaes, 2～4 parts of 3～7 parts, Radix Glycyrrhizae and Radix Arnebiae (Radix Lithospermi)s.
4. according to Chinese medicine preparation claimed in claim 1, it is characterized in that being made by the prepared slices of Chinese crude drugs of following weight ratio:
8～12 parts of Rhizoma Smilacis Glabraes, 8～12 parts of Radix Rehmanniae, 8～12 parts of Semen Coiciss, 8～12 parts of Rhizoma Imperataes, 5～9 parts of Cortex Dictamni, 3～7 parts of Radix Paeoniae Rubra, 3～7 parts of Radix Angelicae Sinensis, 3～7 parts of Cortex Moutans, 3～7 parts of the Fructus Kochiae, 3～7 parts of Herba Hedyotidis Diffusaes, 2～6 parts of Radix Sophorae Flavescentiss, 2～6 parts of Fructus Gardeniae (parched), 2～6 parts of Radix Clematidis, 1～5 part of Zaocys, 1～5 part, Nidus Vespae, 1～5 part of Radix Saposhnikoviae, 1～4 part of 1～5 part, Radix Glycyrrhizae and Radix Arnebiae (Radix Lithospermi).
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405477A (en) * | 2013-07-09 | 2013-11-27 | 安徽济人药业有限公司 | Mantis egg-case formula granules, and preparation method and quality control method thereof |
| CN103520655A (en) * | 2013-10-25 | 2014-01-22 | 梁轶聪 | Traditional Chinese medicine composition for treating psoriasis vulgaris and preparation method thereof |
| CN104027672A (en) * | 2014-07-06 | 2014-09-10 | 华菊 | Traditional Chinese medicine composition for treating psoriasis |
| CN106692637A (en) * | 2017-02-27 | 2017-05-24 | 南通良春中医医院有限公司 | Traditional Chinese medicine formula for treating psoriasis vulgaris |
| EP3363450A4 (en) * | 2015-10-15 | 2019-04-10 | Guangdong Provincial Hospital Of Chinese Medicine | Traditional chinese medicine composition for treating psoriasis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101716291A (en) * | 2009-11-17 | 2010-06-02 | 王茂基 | Oral traditional Chinese medicine for treating skin diseases |
-
2013
- 2013-03-14 CN CN201310081009.5A patent/CN103142903B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101716291A (en) * | 2009-11-17 | 2010-06-02 | 王茂基 | Oral traditional Chinese medicine for treating skin diseases |
Non-Patent Citations (1)
| Title |
|---|
| 荣显会等: "中医辨证治疗寻常型银屑病的现状", 《光明中医》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405477A (en) * | 2013-07-09 | 2013-11-27 | 安徽济人药业有限公司 | Mantis egg-case formula granules, and preparation method and quality control method thereof |
| CN103520655A (en) * | 2013-10-25 | 2014-01-22 | 梁轶聪 | Traditional Chinese medicine composition for treating psoriasis vulgaris and preparation method thereof |
| CN103520655B (en) * | 2013-10-25 | 2015-06-03 | 王竞鹏 | Traditional Chinese medicine composition for treating psoriasis vulgaris and preparation method thereof |
| CN104027672A (en) * | 2014-07-06 | 2014-09-10 | 华菊 | Traditional Chinese medicine composition for treating psoriasis |
| EP3363450A4 (en) * | 2015-10-15 | 2019-04-10 | Guangdong Provincial Hospital Of Chinese Medicine | Traditional chinese medicine composition for treating psoriasis |
| CN106692637A (en) * | 2017-02-27 | 2017-05-24 | 南通良春中医医院有限公司 | Traditional Chinese medicine formula for treating psoriasis vulgaris |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103142903B (en) | 2014-07-16 |
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