CN103142770B - Compound houttuynia cordata lotion and preparation method thereof - Google Patents
Compound houttuynia cordata lotion and preparation method thereof Download PDFInfo
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- CN103142770B CN103142770B CN201310078905.6A CN201310078905A CN103142770B CN 103142770 B CN103142770 B CN 103142770B CN 201310078905 A CN201310078905 A CN 201310078905A CN 103142770 B CN103142770 B CN 103142770B
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Abstract
The invention discloses compound houttuynia cordata lotion. The lotion consists of the following components in parts by weight: 120 parts of houttuynia cordata, 80 parts of corydalis tuber, 80 parts of mirabilite, 80 parts of Chinese rhubarb, 60 parts of golden cypress, 60 parts of dandelion, 40 parts of radix sophorae flavescentis, 40 parts of Chinese violet, and 3.0 part of sodium benzoate. The compound houttuynia cordata lotion is reasonable in prescription and has a good effect.
Description
Technical field
The present invention relates to a kind of external anus edge lotion.
Background technology
" ten people's nine hemorrhoid ", anorectal disease is commonly encountered diseases, frequently-occurring disease, and anus edge edema, hyperemia, protuberance or swelling pain are the postoperative common complications of anorectal, incidence rate, up to 50%, has not only increased the weight of incision pain, also affects the healing of otch simultaneously.Existing external anus edge lotion, preparation is complicated, and curative effect is undesirable.
Summary of the invention
The object of the present invention is to provide a kind of formula reasonable, effective compound houttuynin lotion and preparation method thereof.
Technical solution of the present invention is:
A compound houttuynin lotion, is characterized in that: the medicine material by following weight portion is made:
120 parts of Herba Houttuyniae; 80 parts of Rhizoma Corydalis; 80 parts of Mirabilitums; 80 parts of Radix Et Rhizoma Rhei; 60 parts of Cortex Phellodendris, 60 parts of Herba Taraxacis, 40 parts of Radix Sophorae Flavescentiss; 40 parts of Herba Violaes; 3.0 parts of sodium benzoate.
A kind of preparation method of compound houttuynin lotion, it is characterized in that: Herba Houttuyniae, Rhizoma Corydalis, Mirabilitum, Radix Et Rhizoma Rhei, Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Herba Violae eight taste medicines are soaked 4 hours, solid-liquid ratio 1:15, g/ml, decoct 2 times, each 1 hour, merge extractive liquid,, filter after staticly settling 24 hours, discard filtering residue; Filtrate is concentrated, adds sodium benzoate to stir, filter, and adding distil water, subpackage, sterilization, obtains.
Compound houttuynin lotion has the effect of heat-clearing and toxic substances removing, regulating QI to relieve pain, promoting blood circulation and detumescence, dampness removing to stop itchin, washout anus anus edge sufferer part or demibain treatment, and through sick institute, curative effect tool is good.
Modern experimental pharmacology research shows: compound houttuynin lotion has antiinflammatory, detumescence, itching-relieving action.
1, compound houttuynin lotion antiinflammatory action
48 of CI R mices, are divided into 4 groups at random, 12 every group.Matched group (distilled water 2.5ml/kg); The basic, normal, high dosage group (5% of compound houttuynin lotion, 10%, 20% (V/V) 2.5ml/kg), each is organized after Mice Auricle coating 1h, with wet cotton balls, cleaned, give respectively the left ear of mice with 0.05ml/ caused by dimethylbenzene xylene inflammation, ear compares, and puts to death animal after 5min, with card punch (internal diameter 5.8mm), its ears are cut with position homalographic, weigh respectively, the difference of left and right auricle weight of take is its swelling degree, calculates and respectively organizes swelling and inhibitory rate of intumesce (%).Experimental studies results shows: compound houttuynin lotion has the effect of obvious inhibition Mice Auricle inflammatory swelling, its action intensity and dosage positive correlation.The results are shown in Table 1
The impact of table 1. compound houttuynin lotion xylol induced mice auricle inflammatory swelling
（
n=12）
Note: with Normal group comparison, * P < 0.05, * * P < 0.01
2, compound houttuynin lotion detumescence effect
40 of S D rats, are divided into 4 groups at random, 10 every group.Matched group (distilled water 1ml/kg); The basic, normal, high dosage group of compound houttuynin lotion (5%, 10%, 20% (V/V) 1ml/kg).Test the volumetric method mensuration that moves ahead and respectively organize the left back sufficient normal volume of rat (ml), then coating, only causes inflammation in the left back sufficient plantar subcutaneous injection 100% fresh albumen 0.05ml/ of each group rat after 1h, repaste medicine 1 time simultaneously, measure and cause scorching rear 1,2, the left back sufficient volume of 4,6h.The difference that the rat of take causes the sufficient volume in scorching front and back is swelling, calculates swelling and the inhibitory rate of intumesce of respectively organizing different time, respectively organizes the difference of swelling.Experimental studies results shows: compound houttuynin lotion has effect, inhibitory rate of intumesce and the dosage positive correlation of remarkable inhibition rat Ovum Gallus domesticus album pedal swelling.The results are shown in Table 2
Table 2, compound houttuynin lotion on the impact of rat Ovum Gallus domesticus album pedal swelling (
n=10)
Note: △ is histamine phosphate total amount, with matched group comparison, and with Normal group comparison, * P < 0.05, in * * P < 0.01 table, insertion of brackets data are inhibitory rate of intumesce
3, compound houttuynin lotion itching-relieving action
40 of Cavia porcelluss, are divided into 4 groups at random, 10 every group.Matched group (distilled water 1ml/kg); The basic, normal, high dosage group of compound houttuynin lotion (5%, 10%, 20% (V/V), 1ml/kg).List of references, 1d before experiment, to each group right back instep depilation of Cavia porcellus (about 1cm2), coating 1 time, test and abraded right back instep depilation place skin the same day, part repastes medicine 1 time, after last coating, 10min only starts to drip at wound surface place 0.01% histamine phosphate 0.05ml/, then every 3min, press 0.01%, 0.02%, 0.03% ... progressive concentration is only 0.05ml/ at every turn, until occur that the histamine phosphate total amount that Cavia porcellus gives while later licking metapedes is its itch-threshold, record is also respectively organized Cavia porcellus itch-threshold.Experimental studies results shows: compound houttuynin lotion significantly suppresses Cavia porcellus histamine phosphate itch-threshold, its itching-relieving action and dosage positive correlation.The results are shown in Table 3.
The impact of table 3, compound houttuynin lotion Dui Dui Cavia porcellus histamine phosphate itch-threshold (
n=10)
Note: △ is histamine phosphate total amount, with matched group comparison, and with Normal group comparison, * P < 0.05, * * P < 0.01.
Below in conjunction with embodiment, the invention will be further described.
The specific embodiment
Herba Houttuyniae 120g, Rhizoma Corydalis 80g, Mirabilitum 80g, Radix Et Rhizoma Rhei 80g, Cortex Phellodendri 60g, Herba Taraxaci 60g, Radix Sophorae Flavescentis 40g, Herba Violae 40g, eight taste medicines are soaked to (solid-liquid ratio 1:15, g/ml) 4 hours, decoct 2 times, each 1 hour, merge extractive liquid,, filter after staticly settling 24 hours, discard filtering residue.Filtrate is concentrated into 900-950ml, adds sodium benzoate 3.0g to stir, and filters, and adding distil water is to 1000ml, and subpackage, sterilizes, and obtains.
Quality standard:
Specification: 200ml/ bottle
Character: this product is light brown liquid, has a small amount of precipitation.
Check: relative density: should be not less than 1.02; PH value: 7.0-7.5.
Differentiate: get this product 5ml in test tube, drip sulfurous acid test solution, displaing amaranth.
Consumption usage: every day 2 times, anus edge washout (1:1 dilution); Demibain (each 50ml adds appropriate warm water).
Storage: the airtight storage in shady and cool place.
Effect duration: six months.
Claims (2)
1. a compound houttuynin lotion, is characterized in that: the medicine material by following weight portion is made:
120 parts of Herba Houttuyniae; 80 parts of Rhizoma Corydalis; 80 parts of Mirabilitums; 80 parts of Radix Et Rhizoma Rhei; 60 parts of Cortex Phellodendris, 60 parts of Herba Taraxacis, 40 parts of Radix Sophorae Flavescentiss; 40 parts of Herba Violaes; 3.0 parts of sodium benzoate.
2. the preparation method of a compound houttuynin lotion claimed in claim 1, it is characterized in that: Herba Houttuyniae, Rhizoma Corydalis, Mirabilitum, Radix Et Rhizoma Rhei, Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Herba Violae eight taste medicines are soaked 4 hours, solid-liquid ratio 1:15, g/ml, decoct 2 times, each 1 hour, merge extractive liquid,, filter after staticly settling 24 hours, discard filtering residue; Filtrate is concentrated, adds sodium benzoate to stir, filter, and adding distil water, subpackage, sterilization, obtains.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310078905.6A CN103142770B (en) | 2013-03-13 | 2013-03-13 | Compound houttuynia cordata lotion and preparation method thereof |
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| CN201310078905.6A CN103142770B (en) | 2013-03-13 | 2013-03-13 | Compound houttuynia cordata lotion and preparation method thereof |
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| CN103142770A CN103142770A (en) | 2013-06-12 |
| CN103142770B true CN103142770B (en) | 2014-08-27 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1097604A (en) * | 1993-07-21 | 1995-01-25 | 黄勇 | Fumigating and washing hemorrhoid curing powder and preparation method thereof |
| CN102233085A (en) * | 2010-10-01 | 2011-11-09 | 刘叙光 | External application drug for treating skin diseases |
-
2013
- 2013-03-13 CN CN201310078905.6A patent/CN103142770B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1097604A (en) * | 1993-07-21 | 1995-01-25 | 黄勇 | Fumigating and washing hemorrhoid curing powder and preparation method thereof |
| CN102233085A (en) * | 2010-10-01 | 2011-11-09 | 刘叙光 | External application drug for treating skin diseases |
Non-Patent Citations (8)
| Title |
|---|
| 平川洗剂配合手术减压治疗肛肠术后肛缘水肿;陈冰璞等;《山东医药》;20091231;第49卷(第04期);第38页 * |
| 方克勤.痔瘘熏洗方坐浴治疗肛门疾患临床观察.《新疆中医药》.2000,第18卷(第03期), |
| 痔瘘熏洗剂在肛肠病术后中的应用;黄继承;《中国中医药信息杂志》;20090131;第16卷(第01期);第73-74页 * |
| 痔瘘熏洗方坐浴治疗肛门疾患临床观察;方克勤;《新疆中医药》;20001231;第18卷(第03期);第23-24页 * |
| 谢红等.鱼腥草注射剂治疗头皮银屑病疗效观察.《现代医药卫生》.2009,第25卷(第19期), |
| 陈冰璞等.平川洗剂配合手术减压治疗肛肠术后肛缘水肿.《山东医药》.2009,第49卷(第04期), |
| 鱼腥草注射剂治疗头皮银屑病疗效观察;谢红等;《现代医药卫生》;20091231;第25卷(第19期);第2904-2905页 * |
| 黄继承.痔瘘熏洗剂在肛肠病术后中的应用.《中国中医药信息杂志》.2009,第16卷(第01期), |
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