CN103142562A - Sustained-release sticking film for treating oral ulcer - Google Patents
Sustained-release sticking film for treating oral ulcer Download PDFInfo
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- CN103142562A CN103142562A CN2013100993185A CN201310099318A CN103142562A CN 103142562 A CN103142562 A CN 103142562A CN 2013100993185 A CN2013100993185 A CN 2013100993185A CN 201310099318 A CN201310099318 A CN 201310099318A CN 103142562 A CN103142562 A CN 103142562A
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- pad pasting
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Abstract
The invention discloses a sustained-release sticking film for treating oral ulcer and relates to the technical field of medical equipment and preparation technology thereof. The sustained-release sticking film is of a circular sheet and provided with a three-layer structure, wherein the upper layer is a sustained-release coating (1) which contacts with an oral ulcer surface, the lower layer is a polyacrylic acid film (3) with a protective effect, a medicament-loaded layer of the middle layer takes bacterial cellulose as a medicament carrier, and a medicament loading substance with a sustained-release effect enters a bacterial cellulose membrane by using a dipping method to obtain a bacterial cellulose/medicament loading substance composite film (2). The sustained-release sticking film disclosed by the invention is good in adhesion, permeability and biocompatibility, large in medicament loading capacity, long in local effect time, capable of relieving pain, promoting wound healing and preventing wound infection. The sustained-release sticking film is suitable for oral traumas of oral ulcers, oral mucosal bites and the like.
Description
Technical field
The present invention relates to medical apparatus and instruments and preparing technical field thereof, particularly a kind of slow release pad pasting for the treatment of oral ulcer.
Background technology
Oral ulcer is that a kind of cause of disease is complicated, common oral mucosa disease that easily recur.In daily life, the oral ulcer that causes because of bite, scald, abrade, scuffing etc. is comparatively common.In case the formation oral ulcer not only affects patient's diet orthobiosis, sometimes even causes general disease.For oral ulcer, clinical symptomatic treatment take local application is as main, and clinical application has the dosage forms such as powder, unguentum, membrane and injection, but how because action time in mouth is shorter, all directly affects the treatment.As powders such as Chinese medicine BINGPENG SAN, it must be applied to the affected part during use, medicine can run off with saliva very soon; Unguentum is difficult to be coated in the affected part; Although membrane commonly used can be affixed on ulcer surface, be very easy to come off, and generally dissolving disappearance within a few minutes, the drug osmotic effect is inadequate.
For dental ulcer treatment paster commonly used at present, Main Problems is: due to the special physiological environment in oral cavity, most plaster time of staying in the oral cavity is short, and the characteristics that are difficult to suitable oral cavity reach lasting active drug concentration at diseased region.In order to extend plaster at intraoral adhesion time, and make physiological make-up and the environment in its suitable oral cavity, often plaster is prepared into the very little thin film with certain flexibility of thickness, but this drug loading that will affect plaster makes diseased region not reach effective drug level.And the plaster with enough drug loading is difficult to be prepared into the less thin film of thickness.Therefore, preparing the thin film plaster that has enough drug loading and have certain flexibility, is the key that solves plaster adhesion property and drug loading contradiction.
As pharmaceutical carrier, Bacterial cellulose is a kind of good biomaterial, has natural three-dimensional net structure with Bacterial cellulose in the present invention; High-tensile and elastic modelling quantity; High-hydrophilic, good ventilative, suction, water permeability.Take Bacterial cellulose as pharmaceutical carrier, utilize its three-dimensional net structure can improve the drug loading of active drug; The rear contact with the oral cavity inner membrance of its suction has good flexibility and affixed property, can be fit to physiological make-up and the environment in oral cavity, extends plaster at intraoral adhesion time.
A kind of slow release pad pasting for the treatment of oral ulcer that the present invention relates to adopts the three-decker design.The upper strata is: the controlled-release coating that contacts with oral ulcer surface; Lower floor is: the polyacrylic acid thin film with protective effect.As pharmaceutical carrier, the medicine carrying material that will have slow releasing function adopts infusion process that it is entered in bacteria cellulose film to the drug-loaded layer in middle level, obtains Bacterial cellulose/medicine carrying material composite membrane with Bacterial cellulose.Slow release pad pasting of the present invention has good adhesiveness, breathability, biocompatibility, and drug loading is large, and the local action time is long, can ease the pain, promotes wound healing, prevent wound infection.Be applicable to oral ulcer, the oral mucosa wound in the oral cavity such as bite.
Summary of the invention
The purpose of this invention is to provide a kind of slow release pad pasting for the treatment of oral ulcer.Relate to a kind of medical apparatus and instruments and preparing technical field thereof.Slow release pad pasting of the present invention has good adhesiveness, breathability, biocompatibility, and drug loading is large, and the local action time is long, can ease the pain, promotes wound healing, prevent wound infection.Be applicable to oral ulcer, the oral mucosa wound in the oral cavity such as bite.
A kind of slow release pad pasting for the treatment of oral ulcer that the present invention relates to, its preparation method is: the medicine carrying material adopts infusion process that it is entered in bacteria cellulose film, obtains Bacterial cellulose/medicine carrying material composite membrane through lyophilization.The macromolecule aqueous solution that will have sustained release performance is coated in the upper epidermis of Bacterial cellulose/medicine carrying material composite membrane, through 30-50 ℃ of drying, forms the controlled-release coating of slow release pad pasting.Polyacrylic acid, phthalic acid ethylene glycol fat and glycerol are dissolved in 75% ethanol water, and are coated in the lower top layer of Bacterial cellulose/medicine carrying material composite membrane, obtain the polyacrylic acid thin layer.The slow release pad pasting of the treatment oral ulcer that obtains has three-decker.The upper strata is: the controlled-release coating that contacts with oral ulcer surface (1); Lower floor is: the polyacrylic acid thin film (3) with protective effect; The drug-loaded layer in middle level is Bacterial cellulose/medicine carrying material composite membrane (2).
As preferred technical scheme:
Wherein, a kind of slow release pad pasting for the treatment of oral ulcer as above, it is characterized in that: described medicine carrying material is: one or more in the middle of Borneolum Syntheticum, artificial Calculus Bovis, dexamethasone acetate, vitamin B2 and the mixture of glycerol, dextrin, carbomer, Polyethylene Glycol and sodium carboxymethyl cellulose.But Borneolum Syntheticum clearing away heat to alleviate pain; But artificial Calculus Bovis's heat-clearing and toxic substances removing; Acetic acid dexamethasone and vitamin B2 topical can alleviate the oral ulcer symptom, promote ulcer healing.The pharmaceutic adjuvants such as one or more of these medicines and glycerol, dextrin, carbomer, Polyethylene Glycol and sodium carboxymethyl cellulose are mixed to get the medicine carrying material.
A kind of slow release pad pasting for the treatment of oral ulcer as above, it is characterized in that: described drug-loaded layer is: the medicine carrying material is dissolved in distilled water, adopt infusion process standing 1-4h in 30-70 ℃, the medicine carrying material is entered in bacteria cellulose film, obtain Bacterial cellulose/medicine carrying material composite membrane through lyophilization.Bacterial cellulose utilizes its three-dimensional net structure can improve the drug loading of active drug as pharmaceutical carrier; The rear contact with the oral cavity inner membrance of its suction has good flexibility and affixed property, can be fit to physiological make-up and the environment in oral cavity, extends plaster at intraoral adhesion time.In addition, common oral cavity sustained release film formulation is all that after being pulverized by medicine and adjuvant, tabletting makes at present, and easy disintegrating is broken in saliva.And take Bacterial cellulose as pharmaceutical carrier, the medicine carrying material in its three-dimensional net structure can form hydrogel with saliva, to reach the slow release of medicine.
A kind of slow release pad pasting for the treatment of oral ulcer as above, it is characterized in that: described controlled-release coating is: one or more in the middle of ethyl cellulose, carboxymethyl cellulose, sodium alginate, hydroxyethyl-cellulose are under 50-70 ℃, be dissolved in distilled water, being mixed with percentage by weight is the macromolecule aqueous solution of 1-5%.Be coated in the upper epidermis of Bacterial cellulose/medicine carrying material composite membrane through coating machine, through 30-50 ℃ of drying, form the controlled-release coating of slow release pad pasting.Controlled-release coating can increase the adhesion of slow release pad pasting, simultaneously when controlled-release coating with after wound contacts, form the gel layer with slow-release function under the moistening of saliva.
A kind of slow release pad pasting for the treatment of oral ulcer as above, it is characterized in that: described polyacrylic acid thin film is: polyacrylic acid, phthalic acid ethylene glycol fat and glycerol are under 50-70 ℃, be dissolved in 100ml, in 75% ethanol water, and be coated in the lower top layer of Bacterial cellulose/medicine carrying material composite membrane, through 30-50 ℃ of drying, form the polyacrylic acid thin layer of slow release pad pasting.The polyacrylic acid thin film is thin film water insoluble and that breathability is poor.The polyacrylic acid thin film mainly plays a protective role, and slow down air or saliva enter the female that the slow release pad pasting contacts with ulcer surface in use, extends the adhesion time of slow release pad pasting.Can prevent simultaneously medicine to the offside dissolving of oral mucosa, thereby medicine is infiltrated to ulcer surface.In addition, the polyacrylic acid thin film also can reduce the sense of discomfort of slow release pad pasting in the oral cavity.
A kind of slow release pad pasting for the treatment of oral ulcer as above, it is characterized in that: described slow release pad pasting is round sheet, and thickness is 1-5mm, and diameter is 3-15mm.Preferred scheme is: the slow release pad pasting is round sheet, and the part that contacts with oral ulcer surface depression spherical in shape.When the slow release pad pasting uses, with finger with it by being pressed in the wound surface, the female formation vacuum that at this moment due to pressure, the slow release pad pasting is contacted with ulcer surface.This design more is conducive to the slow release pad pasting and sticks to oral mucosal surface.
Compared with prior art, the invention has the beneficial effects as follows:
1, a kind of slow release pad pasting for the treatment of oral ulcer that the present invention relates to adopts the three-decker design.The slow release pad pasting is round sheet, and the part that contacts with oral ulcer surface depression spherical in shape.This design more is conducive to the slow release pad pasting and sticks to oral mucosal surface.
2, with Bacterial cellulose as pharmaceutical carrier, the medicine carrying material that will have slow releasing function adopts infusion process that it is entered in bacteria cellulose film, obtains Bacterial cellulose/medicine carrying material composite membrane.The hydrogel that the three-dimensional net structure of bacteria cellulose film and saliva form can guarantee sustained release, avoids medicine disintegrate in saliva broken.
3, slow release pad pasting of the present invention has good adhesiveness, breathability, biocompatibility, and drug loading is large, and the local action time is long, can ease the pain, promotes wound healing, prevent wound infection.Be applicable to oral ulcer, the oral mucosa wound in the oral cavity such as bite.
Description of drawings
Accompanying drawing is a kind of structural representation for the treatment of the slow release pad pasting of oral ulcer of the present invention.Wherein 1 is controlled-release coating, the 2nd, and Bacterial cellulose/medicine carrying material composite membrane, the 3rd, polyacrylic acid thin film.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used for explanation the present invention and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims limited range equally.
Embodiment 1:
(1) with the medicine carrying material: the mixture of Borneolum Syntheticum, artificial Calculus Bovis, dexamethasone acetate, vitamin B2 and glycerol, dextrin, carbomer, Polyethylene Glycol and sodium carboxymethyl cellulose is dissolved in the distilled water of 100ml; adopt infusion process standing 1h in 70 ℃; the medicine carrying material is entered in bacteria cellulose film, obtain Bacterial cellulose/medicine carrying material composite membrane through lyophilization.
Bacterial cellulose/each raw material inventory of medicine carrying material composite membrane:
| Raw material | Deal |
| Borneolum Syntheticum | 0.5g |
| The artificial Calculus Bovis | 1g |
| Dexamethasone acetate | 1g |
| Vitamin B2 | 0.5g |
| Glycerol | 2g |
| Dextrin | 2g |
| Carbomer | 3g |
| Polyethylene Glycol | 3g |
| Sodium carboxymethyl cellulose | 3g |
| Distilled water | 100ml |
(2) with ethyl cellulose and sodium alginate under 70 ℃, be dissolved in distilled water, be mixed with percentage by weight and be 1% ethyl cellulose and sodium alginate mixed aqueous solution.Be coated in the upper epidermis of Bacterial cellulose/medicine carrying material composite membrane through coating machine, through 30 ℃ of dryings, form the controlled-release coating of slow release pad pasting.
(3) polyacrylic acid, phthalic acid ethylene glycol fat and glycerol under 50 ℃, are dissolved in 100ml, in 75% ethanol water, and are coated in the lower top layer of Bacterial cellulose/medicine carrying material composite membrane, through 30 ℃ of dryings, form the polyacrylic acid thin layer of slow release pad pasting.
Each raw material inventory of polyacrylic acid thin layer:
| Raw material | Deal |
| Polyacrylic acid | 0.5g |
| Phthalic acid ethylene glycol fat | 1g |
| Glycerol | 0.5g |
| 75% ethanol | 100ml |
The slow release pad pasting of the treatment oral ulcer that (4) obtains is round sheet, and thickness is 5mm, and diameter is 15mm, and the part that contacts with oral ulcer surface depression spherical in shape.The slow release pad pasting has three-decker.The upper strata is: the controlled-release coating that contacts with oral ulcer surface (1); Lower floor is: the polyacrylic acid thin film (3) with protective effect; The drug-loaded layer in middle level is Bacterial cellulose/medicine carrying material composite membrane (2).
Embodiment 2:
(1) with the medicine carrying material: the mixture of Borneolum Syntheticum, artificial Calculus Bovis, dexamethasone acetate and glycerol, dextrin, carbomer, Polyethylene Glycol and sodium carboxymethyl cellulose is dissolved in the distilled water of 100ml; adopt infusion process standing 4h in 30 ℃; the medicine carrying material is entered in bacteria cellulose film, obtain Bacterial cellulose/medicine carrying material composite membrane through lyophilization.
Bacterial cellulose/each raw material inventory of medicine carrying material composite membrane:
| Raw material | Deal |
| Borneolum Syntheticum | 0.5g |
| The artificial Calculus Bovis | 0.5g |
| Dexamethasone acetate | 1g |
| Glycerol | 1g |
| Dextrin | 2g |
| Carbomer | 3g |
| Polyethylene Glycol | 1g |
| Sodium carboxymethyl cellulose | 4g |
| Distilled water | 100ml |
(2) with carboxymethyl cellulose under 50 ℃, be dissolved in distilled water, be mixed with percentage by weight and be 5% carboxymethyl cellulose aqueous solution.Be coated in the upper epidermis of Bacterial cellulose/medicine carrying material composite membrane through coating machine, through 50 ℃ of dryings, form the controlled-release coating of slow release pad pasting.
(3) polyacrylic acid, phthalic acid ethylene glycol fat and glycerol under 70 ℃, are dissolved in 100ml, in 75% ethanol water, and are coated in the lower top layer of Bacterial cellulose/medicine carrying material composite membrane, through 50 ℃ of dryings, form the polyacrylic acid thin layer of slow release pad pasting.
Each raw material inventory of polyacrylic acid thin layer:
| Raw material | Deal |
| Polyacrylic acid | 1g |
| Phthalic acid ethylene glycol fat | 0.5g |
| Glycerol | 0.5g |
| 75% ethanol | 100ml |
The slow release pad pasting of the treatment oral ulcer that (4) obtains is round sheet, and thickness is 0.5mm, and diameter is 3mm, and the part that contacts with oral ulcer surface depression spherical in shape.The slow release pad pasting has three-decker.The upper strata is: the controlled-release coating that contacts with oral ulcer surface (1); Lower floor is: the polyacrylic acid thin film (3) with protective effect; The drug-loaded layer in middle level is Bacterial cellulose/medicine carrying material composite membrane (2).
Embodiment 3:
(1) with the medicine carrying material: the mixture of Borneolum Syntheticum, dexamethasone acetate and glycerol, dextrin, carbomer, Polyethylene Glycol and sodium carboxymethyl cellulose is dissolved in the distilled water of 100ml, adopt infusion process standing 3h in 50 ℃, the medicine carrying material is entered in bacteria cellulose film, obtain Bacterial cellulose/medicine carrying material composite membrane through lyophilization.
Bacterial cellulose/each raw material inventory of medicine carrying material composite membrane:
| Raw material | Deal |
| Borneolum Syntheticum | 1g |
| Dexamethasone acetate | 2g |
| Glycerol | 1g |
| Dextrin | 1g |
| Carbomer | 2g |
| Polyethylene Glycol | 2g |
| Sodium carboxymethyl cellulose | 4g |
| Distilled water | 100ml |
(2) with hydroxyethyl-cellulose under 60 ℃, be dissolved in distilled water, be mixed with percentage by weight and be 2% carboxymethyl cellulose aqueous solution.Be coated in the upper epidermis of Bacterial cellulose/medicine carrying material composite membrane through coating machine, through 40 ℃ of dryings, form the controlled-release coating of slow release pad pasting.
(3) polyacrylic acid, phthalic acid ethylene glycol fat and glycerol under 60 ℃, are dissolved in 100ml, in 75% ethanol water, and are coated in the lower top layer of Bacterial cellulose/medicine carrying material composite membrane, through 40 ℃ of dryings, form the polyacrylic acid thin layer of slow release pad pasting.
Each raw material inventory of polyacrylic acid thin layer:
| Raw material | Deal |
| Polyacrylic acid | 3g |
| Phthalic acid ethylene glycol fat | 0.5g |
| Glycerol | 0.5g |
| 75% ethanol | 100ml |
The slow release pad pasting of the treatment oral ulcer that (4) obtains is round sheet, and thickness is 3mm, and diameter is 10mm, and the part that contacts with oral ulcer surface depression spherical in shape.The slow release pad pasting has three-decker.The upper strata is: the controlled-release coating that contacts with oral ulcer surface (1); Lower floor is: the polyacrylic acid thin film (3) with protective effect; The drug-loaded layer in middle level is Bacterial cellulose/medicine carrying material composite membrane (2).
Embodiment 4:
(1) with the medicine carrying material: the mixture of artificial Calculus Bovis, dexamethasone acetate, vitamin B2 and glycerol, dextrin, carbomer, Polyethylene Glycol and sodium carboxymethyl cellulose is dissolved in the distilled water of 100ml; adopt infusion process standing 2h in 60 ℃; the medicine carrying material is entered in bacteria cellulose film, obtain Bacterial cellulose/medicine carrying material composite membrane through lyophilization.
Bacterial cellulose/each raw material inventory of medicine carrying material composite membrane:
| Raw material | Deal |
| The artificial Calculus Bovis | 1g |
| Dexamethasone acetate | 1g |
| Vitamin B2 | 1g |
| Glycerol | 2g |
| Dextrin | 2g |
| Carbomer | 3g |
| Polyethylene Glycol | 1g |
| Sodium carboxymethyl cellulose | 2g |
| Distilled water | 100ml |
(2) with carboxymethyl cellulose and sodium alginate under 70 ℃, be dissolved in distilled water, be mixed with percentage by weight and be 3% carboxymethyl cellulose and sodium alginate mixed aqueous solution.Be coated in the upper epidermis of Bacterial cellulose/medicine carrying material composite membrane through coating machine, through 30 ℃ of dryings, form the controlled-release coating of slow release pad pasting.
(3) polyacrylic acid, phthalic acid ethylene glycol fat and glycerol under 60 ℃, are dissolved in 100ml, in 75% ethanol water, and are coated in the lower top layer of Bacterial cellulose/medicine carrying material composite membrane, through 50 ℃ of dryings, form the polyacrylic acid thin layer of slow release pad pasting.
Each raw material inventory of polyacrylic acid thin layer:
| Raw material | Deal |
| Polyacrylic acid | 2g |
| Phthalic acid ethylene glycol fat | 0.5g |
| Glycerol | 1g |
| 75% ethanol | 100ml |
The slow release pad pasting of the treatment oral ulcer that (4) obtains is round sheet, and thickness is 2mm, and diameter is 12mm, and the part that contacts with oral ulcer surface depression spherical in shape.The slow release pad pasting has three-decker.The upper strata is: the controlled-release coating that contacts with oral ulcer surface (1); Lower floor is: the polyacrylic acid thin film (3) with protective effect; The drug-loaded layer in middle level is Bacterial cellulose/medicine carrying material composite membrane (2).
Claims (7)
1. slow release pad pasting for the treatment of oral ulcer, it is characterized in that: the slow release pad pasting has three-decker, and the upper strata is the controlled-release coating that contacts with oral ulcer surface; Lower floor is the polyacrylic acid thin film with protective effect; The middle level is that drug-loaded layer is comprised of Bacterial cellulose/medicine carrying material composite membrane.
2. the slow release pad pasting of the treatment oral ulcer of claim 1, its medicine carrying material adopts infusion process that it is entered in bacteria cellulose film, obtain Bacterial cellulose/medicine carrying material composite membrane as drug-loaded layer through lyophilization, the macromolecule aqueous solution that will have sustained release performance is coated in the upper epidermis of Bacterial cellulose/medicine carrying material composite membrane, form the controlled-release coating of slow release pad pasting, polyacrylic acid is coated in the lower top layer of Bacterial cellulose/medicine carrying material composite membrane, obtain the polyacrylic acid thin layer, the slow release pad pasting of the treatment oral ulcer that makes has three-decker.
3. as claim 1, a kind of slow release pad pasting for the treatment of oral ulcer is characterized in that: described medicine carrying material is: Borneolum Syntheticum, artificial Calculus Bovis, dexamethasone acetate, vitamin B
2Central one or more and the mixture of glycerol, dextrin, carbomer, Polyethylene Glycol and sodium carboxymethyl cellulose.
4. as claim 1, a kind of slow release pad pasting for the treatment of oral ulcer, it is characterized in that: described drug-loaded layer is: the medicine carrying material is dissolved in distilled water, adopt infusion process standing 1-4h in 30-70 ℃, the medicine carrying material is entered in bacteria cellulose film, obtain Bacterial cellulose/medicine carrying material composite membrane through lyophilization.
5. as claim 1, a kind of slow release pad pasting for the treatment of oral ulcer, it is characterized in that: described controlled-release coating is: one or more in the middle of ethyl cellulose, carboxymethyl cellulose, sodium alginate, hydroxyethyl-cellulose are under 50-70 ℃, be dissolved in distilled water, being mixed with percentage by weight is the macromolecule aqueous solution of 1-5%; Be coated in the upper epidermis of Bacterial cellulose/medicine carrying material composite membrane through coating machine, through 30-50 ℃ of drying, form the controlled-release coating of slow release pad pasting.
6. as claim 1, a kind of slow release pad pasting for the treatment of oral ulcer, it is characterized in that: described polyacrylic acid thin film is: polyacrylic acid, phthalic acid ethylene glycol fat and glycerol are under 50-70 ℃, be dissolved in 100ml, in 75% ethanol water, and be coated in the lower top layer of Bacterial cellulose/medicine carrying material composite membrane, through 30-50 ℃ of drying, form the polyacrylic acid thin layer of slow release pad pasting.
7. as claim 1, a kind of slow release pad pasting for the treatment of oral ulcer is characterized in that: described slow release pad pasting is round sheet, and thickness is 1-5mm, and diameter is 3-15mm; Preferred scheme is: the slow release pad pasting is round sheet, and the part that contacts with oral ulcer surface depression spherical in shape.
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| CN201310099318.5A CN103142562B (en) | 2013-03-26 | 2013-03-26 | Sustained-release sticking film for treating oral ulcer |
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|---|---|---|---|
| CN201310099318.5A CN103142562B (en) | 2013-03-26 | 2013-03-26 | Sustained-release sticking film for treating oral ulcer |
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| CN103142562A true CN103142562A (en) | 2013-06-12 |
| CN103142562B CN103142562B (en) | 2015-03-25 |
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Cited By (15)
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| CN106109445A (en) * | 2016-06-22 | 2016-11-16 | 佛山市高明绿化纳新材料有限公司 | A kind of long-acting slow-release film for treating oral ulcer and preparation method thereof |
| CN107412200A (en) * | 2017-04-27 | 2017-12-01 | 哈尔滨乾佰纳生物药业有限公司 | A kind of spacetabs type stomatocace film with bioadhesive and preparation method thereof |
| CN108159024A (en) * | 2018-01-26 | 2018-06-15 | 西安交通大学 | A kind of sustained release pad pasting for treating canker sore and preparation method thereof |
| CN108478921A (en) * | 2018-05-01 | 2018-09-04 | 柴传程 | Oral cavity is sustained pack |
| CN108785496A (en) * | 2018-09-03 | 2018-11-13 | 解智强 | A kind of canker sore sustained release pad pasting and preparation method thereof |
| CN110025830A (en) * | 2019-04-29 | 2019-07-19 | 振德医疗用品股份有限公司 | A kind of sustained release antibacterial type artificial dermis model and its construction method |
| CN110151998A (en) * | 2019-05-15 | 2019-08-23 | 南京华开生物科技有限公司 | A kind of canker sore repair membrane and preparation method thereof |
| GB2575625A (en) * | 2018-06-22 | 2020-01-22 | Church & Dwight Co Inc | Oral care compositions comprising benzocaine and mucoadhesive thin films formed therefrom |
| CN111249328A (en) * | 2020-03-13 | 2020-06-09 | 河南护理职业学院 | Compound oral ulcer film and preparation method thereof |
| CN112007006A (en) * | 2020-08-07 | 2020-12-01 | 山东省药学科学院 | A pharmaceutical composition for treating oral ulcer, and its preparation method |
| CN112274282A (en) * | 2020-12-07 | 2021-01-29 | 中日友好医院(中日友好临床医学研究所) | Medicine-carrying orthodontic anchorage nail |
| CN112451137A (en) * | 2020-12-07 | 2021-03-09 | 中日友好医院(中日友好临床医学研究所) | Just abnormal anchorage nail of medicine carrying convenient to remove |
| CN113713113A (en) * | 2021-09-28 | 2021-11-30 | 四川大学 | Composition for treating oral mucosa diseases and preparation method thereof |
| CN114983982A (en) * | 2022-05-30 | 2022-09-02 | 浙江大学 | Slow-release type dental ulcer hydrogel ulcer plaster |
| CN115737605A (en) * | 2022-11-24 | 2023-03-07 | 杭州归领医疗器械有限公司 | Oral ulcer membrane with sandwich structure and lasting viscosity and preparation method thereof |
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Cited By (25)
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| CN106109445A (en) * | 2016-06-22 | 2016-11-16 | 佛山市高明绿化纳新材料有限公司 | A kind of long-acting slow-release film for treating oral ulcer and preparation method thereof |
| CN107412200A (en) * | 2017-04-27 | 2017-12-01 | 哈尔滨乾佰纳生物药业有限公司 | A kind of spacetabs type stomatocace film with bioadhesive and preparation method thereof |
| CN107412200B (en) * | 2017-04-27 | 2018-07-24 | 哈尔滨乾佰纳生物药业有限公司 | A kind of slow-release stomatocace film and preparation method thereof with bioadhesive |
| CN108159024B (en) * | 2018-01-26 | 2020-10-27 | 西安交通大学 | Sustained-release patch for treating oral ulcer and preparation method thereof |
| CN108159024A (en) * | 2018-01-26 | 2018-06-15 | 西安交通大学 | A kind of sustained release pad pasting for treating canker sore and preparation method thereof |
| CN108478921A (en) * | 2018-05-01 | 2018-09-04 | 柴传程 | Oral cavity is sustained pack |
| GB2575625A (en) * | 2018-06-22 | 2020-01-22 | Church & Dwight Co Inc | Oral care compositions comprising benzocaine and mucoadhesive thin films formed therefrom |
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| CN108785496A (en) * | 2018-09-03 | 2018-11-13 | 解智强 | A kind of canker sore sustained release pad pasting and preparation method thereof |
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