CN103127300B - 一种熏蒸治疗腰椎间盘突出症的中药组合物 - Google Patents
一种熏蒸治疗腰椎间盘突出症的中药组合物 Download PDFInfo
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Abstract
本发明公开了一种熏蒸治疗腰椎间盘突出症的中药组合物，由原料和辅料制备而成，按重量份计所述的原料为：马钱子5-10份、麻黄5-10份、牛膝15-22份、草乌15-22份、桑寄生10-16份、威灵仙10-16份、当归7-12份、玄参7-12份、川断7-12份。本发明熏洗中药组合物配合推拿治疗腰椎间盘突出症的效果明显，能缓解腰肌痉挛，舒筋通络，收到了满意的疗效，而且无痛苦，复发率低，容易为患者接受。
Description
技术领域
本发明属于中医药技术领域，具体涉及一种熏蒸治疗腰椎间盘突出症的中药组合物。
背景技术
腰椎间盘突出症(1umbar；,nterevrtehra disc herniation，LIDH)又称“腰椎间盘纤维环破裂症”，是指纤维环破裂后髓核突出，刺激和压迫腰部神经根或马尾神经造成腰腿疼痛、麻木的一种临床常见疾病。LIDH属于中医“腰腿痛”、“痹证”范畴，其发病主要由肾虚邪犯、气滞血瘀所致，素体不足或长期劳损，致肾气不足，腰为肾之府，腰部气血筋脉失养；跌扑损伤，外邪乘袭，引起局部气滞血瘀，不通则痛。目前，腰椎间盘突出症多以非手术治疗为主，临床常用推拿、牵引、针灸、药物等治疗，但都由于疗效不稳定和患者惧怕疼痛而疗效欠佳。
发明内容
本发明的目的在于提供一种疗效显著不复发、治疗时无痛苦的熏蒸治疗腰椎间盘突出症的中药组合物。
本发明的目的是这样实现的：
本发明一种熏蒸治疗腰椎间盘突出症的中药组合物，由原料和辅料制备而成，按重量份计所述的原料为：马钱子5-10份、麻黄5-10份、牛膝15-22份、草乌15-22份、桑寄生10-16份、威灵仙10-16份、当归7-12份、玄参7-12份、川断7-12份。
优选地，本发明熏蒸治疗腰椎间盘突出症的中药组合物，按重量份计所述的原料为：马钱子8份、麻黄8份、牛膝18份、草乌18份、桑寄生13份、威灵仙13份、当归10份、玄参10份、川断10份。
进一步优选地，上述的熏蒸治疗腰椎间盘突出症的中药组合物，其中所述的辅料包括防腐剂。
再进一步优选地，上述的熏洗治疗腰椎间盘突出症的中药组合物，其中所述的防腐剂为羟苯乙酯。
本发明熏洗治疗腰椎间盘突出症的中药组合物的制备方法包括如下步骤：称取马钱子5-10份、麻黄5-10份、牛膝15-22份、草乌15-22份、桑寄生10-16份、威灵仙10-16份、当归7-12份、玄参7-12份和川断7-12份，洗净去杂，晾干，粉碎成颗粒，加入药材重量10-15倍量的水煎煮1-1.5h，过滤，收集滤液；再在药渣中加入药材重量8-10倍量的水煎煮0.5-1h，过滤，收集滤液，将两次滤液合并，浓缩至溶液体积∶药材重量=1∶2的药物浸膏，然后按常规加入95%的乙醇进行醇沉，慢加快搅，使溶液的乙醇浓度达到70%，置冰箱冷藏过夜。第2日将醇沉液抽滤，收集滤液，回收乙醇，得到浓度为溶液体积∶药材重量=1∶1的药物浸膏，并按重量百分比0.1%加入防腐剂羟苯乙酯，最后加水稀释，分装即可。
根据中医药史料记载，本发明选用的上述中药材的药理活性和来源如下：
马钱子：通络止痛，消肿散结，治疗小儿麻痹后遗症，腰椎间盘突出症，三叉神经痛，类风湿性关节炎，跌打损伤、瘀血疼痛，风寒湿痹、全身关节拘急、麻木，癌肿等。选用马钱科植物马钱 Strychnos nuxvomica L. 的干燥成熟种子，泡制方法采用油炙，即净马钱子在植物油中炸至膨胀内部棕黄色时取出入药。
麻黄：发汗散寒，宣肺平喘，利水消肿。多用于风寒表实证，胸闷喘咳，风水浮肿，风湿痹痛，阴疽，痰核。选用为麻黄科植物草麻黄 Ephedra sinica Stapf，中麻黄Ephedra intermedia Schrenk et C. A. Mey. 或木贼麻黄Ephedra equisetina Bge. 的草质茎。
牛膝：补肝肾、强筋骨、活血通经、引火（血）下行、利尿通淋。主治腰膝酸痛、下肢痿软、血滞经闭、痛经、产后血瘀腹痛、症瘕、胞衣不下、热淋、血淋、跌打损伤、痈肿恶疮、咽喉肿痛。选用苋科植物牛膝的根。
草乌：搜风胜湿，散寒止痛，开痰，消肿。治风寒湿痹，中风瘫痪，破伤风，头风，脘腹冷痛，痰癖，气块，冷痢，喉痹，痈疽，疔疮，瘰疬。选用毛茛科植物北乌头 Aconitum kusnezoffii Reichb. 的干燥块根。
桑寄生：补肝肾；强筋骨；祛风湿；安胎。主腰膝酸痛；筋骨痿弱；肢体偏枯；风湿痹痛；头错目眩；胎动不安，崩漏下血。用于风湿痹痛，腰膝酸软，筋骨无力，崩漏经多，妊娠漏血，胎动不安；高血压。选用桑寄生科植物桑寄生 Taxillus chinensis (DC.) Danser的干燥带叶茎枝。
威灵仙：祛风除湿，通络止痛，消痰水，散癖积。主治痛风顽痹、风湿痹痛，肢体麻木，腰膝冷痛，筋脉拘挛，屈伸不利，脚气，疟疾，症瘕积聚，破伤风，扁桃体炎，诸骨鲠咽。选用毛茛科植物威灵仙 Clematis chinensis Osbeck、棉团铁线莲 Clematis hexapetala Pall. 或东北铁线莲 Clematis manshurica Rupr. 的干燥根及根茎。
当归：补血活血，调经止痛，润肠通便。用于血虚萎黄、眩晕心悸、月经不调、经闭痛经、虚寒腹痛、肠燥便秘、风湿痹痛、跌扑损伤、痈疽疮疡。选用伞形科植物当归Angelica sinensis (Oliv.) Diels 的干燥根。
玄参：清热凉血，泻火解毒，滋阴。主治温邪入营，内陷心包，温毒发斑，热病伤阴、舌绛烦渴、津伤便秘、骨蒸劳嗽、目赤、咽痛、瘰疬、白喉、痈肿疮毒。选自双子叶植物玄参科Scrophulariaceae 玄参Scrophularia ningpoensisHemsl. 的干燥根。
川断：又名续断，补肝肾；强筋骨；调血脉；续折伤；止崩漏。用于腰背酸痛；肢节痿痹；跌扑创伤、损筋折骨、胎动漏红、血崩、遗精、带下、痈疽疮肿。酒续断多用于风湿痹痛，跌扑损伤。盐续断多用于腰膝酸软。选用多年生草本植物川续断的根。
本发明涉及的熏洗中药组合物具有促进局部血液循环，改善局部新陈代谢和营养状态的作用，有利于改善局部炎症、充血、水肿，从而减轻对神经根的压迫，达到缓解甚至消除腰腿痛症状。尤其是，该中药组合物配合推拿治疗腰椎间盘突出症的效果明显，能缓解腰肌痉挛，舒筋通络，收到了满意的疗效，而且无痛苦，复发率低，容易为患者接受。
具体实施方式
以下是本发明的具体实施例，对本发明的技术方案做进一步作描述，但是本发明的保护范围并不限于这些实施例。凡是不背离本发明构思的改变或等同替代均包括在本发明的保护范围之内。
实施例1
生药处方：马钱子80克、麻黄80克、牛膝180克、草乌180克、桑寄生130克、威灵仙130克、当归100克、玄参100克、川断100克。
制备工艺：称取上述中药材原料，洗净去杂，晾干，粉碎成颗粒，加入药材重量10-15倍量的水煎煮1-1.5h，过滤，收集滤液；再在药渣中加入药材重量8-10倍量的水煎煮0.5-1h，过滤，收集滤液，将两次滤液合并，浓缩至溶液体积∶药材重量=1∶2的药物浸膏，然后按常规加入95%的乙醇进行醇沉，慢加快搅，使溶液的乙醇浓度达到70%，置冰箱冷藏过夜。第2日将醇沉液抽滤，收集滤液，回收乙醇，得到浓度为溶液体积∶药材重量=1∶1的药物浸膏，并按重量百分比0.1%加入防腐剂羟苯乙酯，最后加水稀释至2升，按每袋100毫升分装。
实施例2
生药处方：马钱子50克、麻黄80克、牛膝220克、草乌150克、桑寄生160克、威灵仙150克、当归70克、玄参120克、川断120克。
制备工艺：称取上述中药材原料，洗净去杂，晾干，粉碎成颗粒，加入药材重量10-15倍量的水煎煮1-1.5h，过滤，收集滤液；再在药渣中加入药材重量8-10倍量的水煎煮0.5-1h，过滤，收集滤液，将两次滤液合并，浓缩至溶液体积∶药材重量=1∶2的药物浸膏，然后按常规加入95%的乙醇进行醇沉，慢加快搅，使溶液的乙醇浓度达到70%，置冰箱冷藏过夜。第2日将醇沉液抽滤，收集滤液，回收乙醇，得到浓度为溶液体积∶药材重量=1∶1的药物浸膏，并按重量百分比0.1%加入防腐剂羟苯乙酯，最后加水稀释至2升，按每袋100毫升分装。
实施例3
生药处方：马钱子100克、麻黄50克、牛膝150克、草乌220克、桑寄生100克、威灵仙100克、当归120克、玄参70克、川断70克。
制备工艺：称取上述中药材原料，洗净去杂，晾干，粉碎成颗粒，加入药材重量10-15倍量的水煎煮1-1.5h，过滤，收集滤液；再在药渣中加入药材重量8-10倍量的水煎煮0.5-1h，过滤，收集滤液，将两次滤液合并，浓缩至溶液体积∶药材重量=1∶2的药物浸膏，然后按常规加入95%的乙醇进行醇沉，慢加快搅，使溶液的乙醇浓度达到70%，置冰箱冷藏过夜。第2日将醇沉液抽滤，收集滤液，回收乙醇，得到浓度为溶液体积∶药材重量=1∶1的药物浸膏，并按重量百分比0.1%加入防腐剂羟苯乙酯，最后加水稀释至2升，按每袋100毫升分装。
临床应用例
将85例腰椎间盘突出症患者随机分为两组。试验组43例，男性28例，女性15例；对照组42例，男性28例，女性14例。两组患者在性别、年龄、疾病程度等比较无统计学差异。
对照组患者按如下方法进行推拿治疗：首先按揉腰及下肢，用掌根自上而下用力按揉患侧腰骶部、臀部及下肢后外侧肌肉3-5遍，以腰部为重点；继而用拇指或肘尖点压腰阳关、肾俞、居髎、环跳、承扶、委中、承山及阿是穴；接着弹拨腰部椎体两侧肌肉3-5次；拳叩腰臀部，双手握拳，以拳背叩击双侧肾俞、大肠俞、环跳、秩边等处，先轻后重，轻重交替，各叩击3O次；最后以滚法和抖法放松腰部和腿部肌肉结束。每次30分钟，每天1次，连续推拿治疗3周。
试验组患者除按上述方法进行推拿治疗外，并按如下方法进行熏蒸治疗：取本发明实施例制备的中药组合物1包，加入中药熏蒸仪，患者躺于熏蒸仪床上，熏蒸腰部约20-30分钟，每天1次，连续熏蒸治疗3周。
疗效评价标准：
痊愈：腰腿痛消失，直腿抬高7O°以上，能恢复正常工作；
好转：腰腿疼痛减轻，腰部活动功能改善；
未愈：症状体征无改善。
两组的治疗结果见表1：
表1 试验组与对照组疗效统计结果
由表1可以看出试验组治疗有效率明显高于对照组。
Claims (3)
1.一种熏蒸治疗腰椎间盘突出症的中药组合物，由原料和辅料制备而成，其特征在于：按重量份计所述的原料为：马钱子8份、麻黄8份、牛膝18份、草乌18份、桑寄生13份、威灵仙13份、当归10份、玄参10份、川断10份。
2.根据权利要求1所述的熏蒸治疗腰椎间盘突出症的中药组合物，其特征在于：所述的辅料包括防腐剂。
3.如权利要求2所述的熏洗治疗腰椎间盘突出症的中药组合物，其特征在于：所述的防腐剂为羟苯乙酯。
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