CN103127281A - 一种治疗痤疮的药物 - Google Patents

一种治疗痤疮的药物 Download PDF

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CN103127281A
CN103127281A CN2011103728426A CN201110372842A CN103127281A CN 103127281 A CN103127281 A CN 103127281A CN 2011103728426 A CN2011103728426 A CN 2011103728426A CN 201110372842 A CN201110372842 A CN 201110372842A CN 103127281 A CN103127281 A CN 103127281A
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CN103127281B (zh
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张文龙
郭玉华
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Lanzhou Holyshine Pharmaceutical Co ltd
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JILIN SECOND RONGFU MILITARY HOSPITAL
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Abstract

本发明涉及一种治疗痤疮的药物，具体的说是一种治疗ⅢⅣ级痤疮疾病的“面痤净胶囊”。该药物由大黄、陈皮、丹参、西咪替丁、维生素B6经煎煮、浓缩、制粒、干燥、灭菌，包装等工艺步骤制备而成，本发明药物具有抗菌消炎，活血化瘀，调节脂类代谢，减少皮脂腺分泌，与外用药联用，内外结合治疗发挥协同作用，对ⅢⅣ级痤疮疾病有显著的治疗效果。

Description

一种治疗痤疮的药物
技术领域
本发明涉及一种治疗皮肤病的药物，具体的说是一种治疗Ⅲ、Ⅳ级痤疮疾病的药物“面痤净胶囊”。
背景技术
痤疮是多种因素导致的毛囊皮脂腺慢性炎症性皮肤病，目前西医治疗痤疮方法内服的药物主要是抗生素，以抗菌消炎为主，但有些药物含有四环霉素。如果长期服用，无形中会加重肝、肾的负担，对孕妇尤其有禁忌。
维A酸类药物治疗，由于动物和人的皮肤结构差异及对维A酸刺激的敏感性不同所致。所以有关动物维A酸局部给药的安全性令人堪忧。
中医主要采用清热祛风、凉血利湿的方法，但上述方法在治疗上存在片面性的问题，而且有副作用。
发明内容
本发明的目的是为了克服现有技术的不足，提供一种治疗效果好，无副作用的治疗Ⅲ、Ⅳ级痤疮疾病的中西复方制剂。
本发明的目的是这样实现的：本发明药物是由下列重量配比的原料药制成的
西咪替丁6～7份、维生素B6  0.5～1份、大黄30～32份、 丹参120～128份、陈皮24～26份；
制备方法如下：将处方量净中药材大黄、陈皮、丹参混合，加水煎煮两次，第一次加水为中药材量6倍，时间30分钟；第二次加水为中药材量4倍，时间60分钟；分次过滤，合并滤液，减压蒸馏浓缩至密度为1.30稠膏；加入已混匀的西咪替丁、维生素B6原料药粉搅拌均匀，在70-80oC干燥，粉碎成细粉，过80目筛，混合均匀，分装成每粒0.4g的1000粒胶囊，即得到本发明的产品。
本发明产品的剂型为胶囊剂，内容物为棕色粉末，略有芳香气味，包装规格为60粒/瓶，服用方法为饭后温开水送服，口服一次6粒，早晚各一次。
本发明药物具有抗菌消炎，活血化瘀，调节脂类代谢，减少皮脂腺分泌，与外用药联用，内外结合治疗发挥协同作用，对Ⅲ Ⅳ级痤疮疾病有显著的治疗效果。
临床治疗效果：
    该治疗痤疮（粉刺）的药物面痤净胶囊是胶囊制剂，该药具有抗菌消炎，活血化瘀，调节脂质代谢，减少皮脂分泌，与外用药联用，内外结合治疗发挥协同作用，对Ⅱ、Ⅲ、Ⅳ级痤疮有显著的治疗效果。
一、病例选择
    1.1  100例皮肤病患者，均来自我院门诊皮肤科，诊断标准符合临床皮肤病学有关寻常痤疮诊断。痤疮患者（且采取pillshurv分类法）、Ⅱ、Ⅲ、Ⅳ度痤疮患者列为对象。100例痤疮患者；其中男性55例，年龄：14—32岁；女性45例， 年龄：14—30岁。
 1.2 治疗方法
采取随机开放式试验，不设对照组。使用本发明药面痤净胶囊，一天2次，口服，一次6粒，饭后温开水送服。疗程8周，对治疗的患者于2周、4周、6周、8周各复诊随访1次，记录粉刺、丘疹脓疱、囊肿的变化，在第8周末评价疗效。 
二、诊断标准
2.1痤疮分级，采用采取pillshurv分类法；皮损表现Ⅰ、Ⅱ、Ⅲ、Ⅳ。颜面部为主。
Ⅰ级主要皮损是粉刺，皮损总数在10—30个：
Ⅱ级主要皮损是粉刺，并有丘疹和脓包，皮损总数在31—50个：
Ⅲ级丘疹和脓包较多，皮损总数在51—100个：
Ⅳ级皮损数目>100个，并可见结节囊肿数目在3个以上。
2.2疗效判定标准
根据治疗前后皮损总数减少的百分率判定疗效标准：基本痊愈：皮肤损害消退率≥95%，无新发疹；显效：皮肤损害消退率≥70%—94%；
有效：皮肤损害消退率≥50%—69%；无效：皮肤损害消退率不足50%。
总有效率为基本治愈率与显效率例数之和占所有病例数百分比。
  2.3疗效观察结果见表：
病种分类 例  数 痊 愈 显 效 有 效 无 效 痊愈率 总有效率
痤疮 100 64 23 9   4 60.0% 87.0%
    从表中可以看出，该药对治疗痤疮治愈60例，治愈率64%；显效23例，显效率23%；有效9例，有效率9%；无效率4%。
 三、讨论：痤疮是青年人好发的一种常见皮肤病，痤疮的病因与激素代谢和皮脂腺分泌旺盛有关。在粉刺棒状杆菌等作用下引起局部炎症。该药具有抗菌消炎，活血化瘀，调节脂质代谢，减少皮脂分泌，与外用药联用，内外结合治疗发挥协同作用，对Ⅲ、Ⅳ级痤疮有显著的治疗效果。
具体实施方式
按原料重量配比称取大黄312g、丹参1250g、陈皮250g，加水煎煮两次,第一次加水为10.872kg，时间30分钟；第二次加水2.848kg，时间60分钟；分次过滤，合并滤液，减压蒸馏浓缩至密度为1.30稠膏；加入已混匀的西咪替丁62.5g、维生素B65g原料药粉搅拌均匀，在70-80oC干燥，粉碎成细粉，过80目筛。混合均匀，分装成每粒0.4g的1000粒胶囊，即得到本发明的产品，最后包装成规格为60粒/瓶的小瓶。

Claims (1)

1.一种治疗痤疮的药物，其特征在于：它是由下列重量配比的原料药制成：
西咪替丁6～7份、维生素B6  0.5～1份、大黄30～32份、  丹参120～128份、陈皮24～26份；
制备方法如下：将处方量净中药材大黄、陈皮、丹参混合，水煎煮两次，第一次加水为中药材量6倍，时间30分钟；第二次加水为中药材量4倍，时间60分钟；分次过滤，合并滤液，减压蒸馏浓缩至密度为1.30稠膏；加入已混匀的西咪替丁、维生素B6原料药粉搅拌均匀，在70～80oC干燥，粉碎成细粉，过80目筛，混合均匀，分装成每粒0.4g的1000粒胶囊，即得到本发明的产品。
CN201110372842.6A 2011-11-22 2011-11-22 一种治疗痤疮的药物 Active CN103127281B (zh)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1188671A (zh) * 1998-02-13 1998-07-29 韩德五 双利肝冲剂及其制备方法
JP2004161623A (ja) * 2002-11-11 2004-06-10 Noevir Co Ltd 水性スティック状抗アクネ用組成物
CN101049315A (zh) * 2006-04-05 2007-10-10 马学荣 一种寻常痤疮药配方
CN101468070A (zh) * 2007-12-27 2009-07-01 天津天阜康生物技术发展有限公司 一种治疗痤疮的药物组合及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1188671A (zh) * 1998-02-13 1998-07-29 韩德五 双利肝冲剂及其制备方法
JP2004161623A (ja) * 2002-11-11 2004-06-10 Noevir Co Ltd 水性スティック状抗アクネ用組成物
CN101049315A (zh) * 2006-04-05 2007-10-10 马学荣 一种寻常痤疮药配方
CN101468070A (zh) * 2007-12-27 2009-07-01 天津天阜康生物技术发展有限公司 一种治疗痤疮的药物组合及其制备方法

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Title
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