CN103120759A - Supercritical extraction method of conic gymnadenia tuber element - Google Patents
Supercritical extraction method of conic gymnadenia tuber element Download PDFInfo
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- CN103120759A CN103120759A CN2012105943690A CN201210594369A CN103120759A CN 103120759 A CN103120759 A CN 103120759A CN 2012105943690 A CN2012105943690 A CN 2012105943690A CN 201210594369 A CN201210594369 A CN 201210594369A CN 103120759 A CN103120759 A CN 103120759A
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- fructus citri
- citri sarcodactylis
- ginseng
- sarcodactylis ginseng
- skin care
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Abstract
The invention relates to a supercritical extraction method of a conic gymnadenia tuber element, and in particular relates to a method for extracting a natural active ingredient with an anti-aging effect, i.e. the conic gymnadenia tuber element, from a Tibetan medicine conic gymnadenia tuber. According to the invention, through creating a series of new extraction process conditions of pressure, temperature, entrainer and the like and the method, the traditional extraction contradiction of active ingredient purity and extraction rate are solved. Anti-aging medicines, health care products and human hand and face skin care products, which are manufactured through taking the conic gymnadenia tuber element as a basic formula, have the characteristics of nature, safety, transdermal absorption, no side effect and the like.
Description
One, technical field
The present invention is for extracting the active ingredient that human body is had anti-aging effects with supercritical methanol technology from natural Fructus Citri Sarcodactylis ginseng, as the natural effect component of snowy region of defying age medicine, health product and the skin care item of pure natural or difference in functionality prescription, we are referred to as Fructus Citri Sarcodactylis ginseng element with these active ingredients.
Two, background technology
The Tibetan medicine " prosperous drawing " by name of Fructus Citri Sarcodactylis ginseng, the orchid family herbaceos perennial is gained the name because originating in the sacred Buddhist site and being similar to palm.The Fructus Citri Sarcodactylis ginseng is born in snowy region on Qinghai-Tibet 3500 meters for many years, shows preciousness because trophophase is long, is referred to as mystery " Herba Cynomorii " in the Tibetan medicine.What claim in Compendium of Material Medica that they can " YANG invigorating blood deficiency fire, tonifying YANG controlling nocturnal emission with astringent drugs be kept fit beneficial marrow " is top grade.
Prove through modern scientific research: be rich in multiple saponin and eugenol in the Fructus Citri Sarcodactylis ginseng, all have the effect of stronger antioxidation and delaying human body caducity, particularly human body cerebral tissue and skin aging.The present invention extracts the multiple of acquisition and comprehensive Fructus Citri Sarcodactylis ginseng defying age composition, more can work in coordination with to reach antidotal effect:
---daucosterol can suppress lipid peroxidation radical reaction ability and reach antioxidation;
---dioscin can improve activities of antioxidant enzymes, remove free radical, reduces lipid peroxide and generates;
---ribosidoadenine has the old and feeble ability of distinct antibodies table skin peroxidating, and nucleotide has very high radical scavenging activity;
---cupreol has stronger inhibitory action to oxygen-derived free radicals;
---eugenol can suppress xanthine oxidase activity, but and Direct Acquisition superoxides.
Scientific research also proves: be rich in polysaccharide in Rhizoma Gymnadeniae.Beta glucan wherein, except anti-ageing, also has good Transdermal absorption performance because of its straight-chain molecular structure, can promote skin, particularly the synthetic collagen protein of fibrocyte in the hand skin of skin depth, promote wound healing, repairs impaired skin, smooth microgroove, improve skin elasticity and moisten smooth as more aobvious silk.
---β-glucomannoglycan and 16 seed amino acids have good moisture-keeping function;
---aromatic acid and derivant generate black to tryrosinase and have good inhibitory action, thereby have the skin white-skinned face function.
Known water extraction and alcohol extraction method, in the Fructus Citri Sarcodactylis of acquisition ginseng, Saponin, eugenol and cupreol class active ingredient yield are low, and can not take into account and obtain simultaneously multiple required effect active ingredient, can't reject invalid composition.
Three, summary of the invention
The present invention adopts supercritical CO
2Extracting process adopts different Extraction techniques, and selective extraction goes out particular actives, and with the different formulations demand of suitable product efficacy, and yield is higher.For example water extract saponin total content is 0.13%, and alcohol extracting method is 0.25%, and supercritical extract saponin total content is 0.68%, has obvious technical advance and higher economic well-being of workers and staff.
Technical scheme of the present invention is, particle diameter is cleaned, dries, is ground into to the Fructus Citri Sarcodactylis ginseng of picking up from the Qinghai-Tibet Platean is 30 purpose granules, closes after putting into supercritical extraction reactor, extraction kettle, separating still, collection still are heated respectively reach 45 ℃ of extraction kettles, 65 ℃ of separating stills when collecting 40 ℃ of stills, are opened CO
2The oxygen pressing system is forced into extraction kettle 30MPa by every Kg raw material 40L/min flow to system, and separating still 12MPa collects still 6MPa, extraction time 60min under this constant temperature and pressure.Then the decompress(ion) gas recovery, take out Fructus Citri Sarcodactylis ginseng active matter.
If adding 90% concentration ethanol 10ml in supercritical extraction is entrainer, Fructus Citri Sarcodactylis ginseng active matter extraction total recovery can reach 7%, far above traditional water extraction and alcohol extracting method, more shows advance and the economic benefit of this method.
Four, the specific embodiment
The present invention will extract gained Fructus Citri Sarcodactylis ginseng element on above abstraction technique basis, defying age medicine, health product, hand and the facial skin care item formula of development different efficacies, and below the invention will be further described with embodiment:
The embodiment 1. anti-brain degeneration Cognexs of Fructus Citri Sarcodactylis ginseng is characterized by Fructus Citri Sarcodactylis ginseng element 12%; Rhizoma Polygonati 10%; The Radix Astragali 9%; Rhodosin 7%; Microcrystalline Cellulose 10%; Soluble starch 52%.This formula has the dementia that good anti-brain is degenerated and caused, improves the effect of brain memory power and respond.
Embodiment 2. Fructus Citri Sarcodactylis ginseng handss are lived the youth quintessence oil, it is characterized by to contain Fructus Citri Sarcodactylis ginseng element 99.8%; 2,6 ditertiary butyl p cresol 0.1%; Propyl p-hydroxybenzoate 0.1%.This formula has quick reparation moisturizing effect, and fragrant atmosphere is graceful.
The embodiment 3. Fructus Citri Sarcodactylis ginsengs brilliant whites U.S. hands stock solution breast of waking up is characterized by and contains Fructus Citri Sarcodactylis ginseng element 10%; Water-solubleazone 5%; Propylene glycol 5%; Glycerol 5%; Isononyl isononanoate 3%; Polydimethylsiloxane 0.5%; Cetearyl glucoside 0.8%; Behenyl alcohol 1%; Hyaluronate sodium 0.05%; EDETATE SODIUM 0.05%; Methylisothiazolinone 0.01%; Deionized water 69.59%.This formula can allow beautiful white light of obscure impaired hand skin instant recovery youth color.
Embodiment 4. Fructus Citri Sarcodactylis ginseng silks are slided and are reproduced the quintessence oil cream, it is characterized by to contain Fructus Citri Sarcodactylis ginseng element 9%; Glycerol 5%; Cyclomethicone 1%; Caprylic/capric triglyceride 4%; Cetearyl alcohol 1.5%; Cetearyl glucoside 2%; 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers 2%; Pantothenylol 1%; Methylisothiazolinone 0.01%; Deionized water 74.49%.This formula can make withered coarse hand skin article for fast moistening, manifests as silk lubricated.
Embodiment 5. Fructus Citri Sarcodactylis ginseng spraying stricture of vagina hands in age films (two-form), it is characterized by: the A agent contains Fructus Citri Sarcodactylis ginseng element 8%; Sodium alginate 3%; Cetearyl glucoside 1%; PEG-100 stearate 0.5%; Glycerol 8%; Methylisothiazolinone 0.01%; Deionized water 79.49%.The B agent contains Fructus Citri Sarcodactylis ginseng element 20%; Calcium chloride 10%, propylene glycol 15%; Vitamin B 0.5%; Vitamin E 0.5%; Methylisothiazolinone 0.01%; Deionized water 53.99%.
During use, first A agent hands film is applied on the back of the hand, palm or wrist 5～10 minutes, then spray B agent spray, keep after film forming, whole hands film being peeled in 5～10 minutes, the high-visible the back of the hand skin stricture of vagina that is engraved on film, and by contrasting the standard hands skin stricture of vagina of all ages and classes and health status, make skin age and the aging state of hands as can be known, the nursing of suiting the medicine to the illness.This formula moistens fast impaired hand skin and repairs, and reappears youthful vigor.
Embodiment 6. Fructus Citri Sarcodactylis are joined the exfoliation scrubbing cream, it is characterized by to contain Fructus Citri Sarcodactylis ginseng element 8%; Glycerol 21.99%; Sorbitol glycosides polyoxyethylene (20) ether monolaurate 5%; Sucrose 60%; Silicon dioxide 5%; Methylisothiazolinone 0.01%.The gentle hand aging cutin of removing of this formula, the degree of depth is nourished, and reappears beautiful tender in vain.
The insured wet hand cream of embodiment 7. Fructus Citri Sarcodactylis is characterized by and contains Fructus Citri Sarcodactylis ginseng element 7%; Trimethyl glycine 5%; Cetearyl alcohol 2.5%; Glycerol 5%; Propylene glycol 3%; Polydimethylsiloxane 2%; Cetearyl glucoside 1.8%; 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers 2%; Methyl hydroxybenzoate 0.2%; Propyl hydroxybenzoate 0.1%; Diazolidinyl urea 0.3%; Deionized water 71.1%.This formula has stronger moistening effect, makes skin plentiful soft and smooth, and is not oily oiliness.
The embodiment 8. freeze proof warm hands of Fructus Citri Sarcodactylis ginseng are white, it is characterized by to contain Fructus Citri Sarcodactylis ginseng element 7%; Vanillyl butyl ether 0.1%; Cetearyl alcohol 2.5%; Glycerol 5%; Propylene glycol 3%; Polydimethylsiloxane 2%; Cetearyl glucoside 2%; 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers 2%; Methyl hydroxybenzoate 0.2%; Propyl hydroxybenzoate 0.1%; Diazolidinyl urea 0.3%; Deionized water 75.8%.This formula can make the hand of catching a cold or freezing return rapidly dim profit and protect, and replys youth gloss.
Embodiment 9. Fructus Citri Sarcodactylis ginseng handss are consoled the not old honey of parents, it is characterized by to contain Fructus Citri Sarcodactylis ginseng element 7%; Polydimethylsiloxane cross linked polymer (reaching) dimethiconol (reaching) cyclohexyl methyl siloxanes 8%; Cetearyl alcohol 3%; Glycerol 5%; Propylene glycol 3%; Cetearyl glucoside 1.5%; 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers 2.5%; Methyl hydroxybenzoate 0.2%; Propyl hydroxybenzoate 0.1%; Diazolidinyl urea 0.3%; Deionized water 69.4%.This formula has Transdermal absorption, deeply preserving moisture, smooths microgroove, recovers the effect of slow down aging, gloss full of vitality.
SPA hands film is provided special care in embodiment 10. Fructus Citri Sarcodactylis ginseng oxygen supplement, it is characterized by to contain Fructus Citri Sarcodactylis ginseng element 5%; Fructus Citri Sarcodactylis ginseng extracting solution 20%; Polyacrylic acid 2.5%, 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers 1%; Lauryl glucoside 10%; Perfluor (different) butyl methyl ether 8%, butanediol 5%, EDETATE SODIUM 0.05%, triethanolamine 2%, Methylisothiazolinone 0.01%; Deionized water 46.44%.This formula can divide and nutrition for rapidly hand skin delivery of supplemental oxygen, shines the skin vigor.
Claims (13)
1. the plain extracting process of Fructus Citri Sarcodactylis ginseng, is characterized in that extracting the multiple active matter that human body is had anti-aging effects with the super method of facing from the Fructus Citri Sarcodactylis ginseng.
2. extracting process as claimed in claim 1, the method is included in extraction kettle pressure 30Mpa, temperature 45 C; Separating still pressure 12Mpa, 65 ℃ of temperature; Collect still pressure 6Mpa, 40 ℃ of temperature; Extraction time 60 minutes, CO
2Flow is under every Kg raw material 40L/min specific process conditions, the multiple activity of fighting against senium thing in the Fructus Citri Sarcodactylis ginseng fully to be extracted.
3. the Fructus Citri Sarcodactylis anti-brain degeneration Cognex of ginseng and the serial hand skin care item of Fructus Citri Sarcodactylis ginseng, contain the Fructus Citri Sarcodactylis ginseng element by the method extraction of claim 1.
4. Fructus Citri Sarcodactylis as claimed in claim 3 is joined plain medicine, and it is the anti-brain degeneration Cognex of a kind of Fructus Citri Sarcodactylis ginseng, it is characterized by Fructus Citri Sarcodactylis ginseng element 12%; Rhizoma Polygonati 10%; The Radix Astragali 9%; Rhodosin 7%; Microcrystalline Cellulose 10%; Soluble starch 52%.
5. Fructus Citri Sarcodactylis as claimed in claim 3 is joined the hand skin care item, and it is that a kind of Fructus Citri Sarcodactylis ginseng hands is lived the youth quintessence oil, it is characterized by to contain Fructus Citri Sarcodactylis ginseng element 99.8%; 2,6 ditertiary butyl p cresol 0.1%; Propyl p-hydroxybenzoate 0.1%.
6. Fructus Citri Sarcodactylis as claimed in claim 3 ginseng hand skin care item, it is a kind of Fructus Citri Sarcodactylis ginseng brilliant white U.S. hands stock solution breast of waking up, and it is characterized by to contain Fructus Citri Sarcodactylis ginseng element 10%; Water-solubleazone 5%; Propylene glycol 5%; Glycerol 5%; Isononyl isononanoate 3%; Polydimethylsiloxane 0.5%; Cetearyl glucoside 0.8%; Behenyl alcohol 1%; Hyaluronate sodium 0.05%; EDETATE SODIUM 0.05%; Methylisothiazolinone 0.01%; Deionized water 69.59%.
7. Fructus Citri Sarcodactylis as claimed in claim 3 ginseng hand skin care item, it is the sliding quintessence oil cream that reproduces of a kind of Fructus Citri Sarcodactylis ginseng silk, it is characterized by to contain Fructus Citri Sarcodactylis ginseng element 9%; Glycerol 5%; Cyclomethicone 1%; Caprylic/capric triglyceride 4%; Cetearyl alcohol 1.5%; Cetearyl glucoside 2%; 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers 2%; Pantothenylol 1%; Methylisothiazolinone 0.01%; Deionized water 74.49%.
8. Fructus Citri Sarcodactylis as claimed in claim 3 is joined the hand skin care item, and it is a kind of Fructus Citri Sarcodactylis ginseng spraying stricture of vagina hands in age film (two-form), it is characterized by the A agent and contains Fructus Citri Sarcodactylis ginseng element 8%; Sodium alginate 3%; Cetearyl glucoside 1%; PEG-100 stearate 0.5%; Glycerol 8%; Methylisothiazolinone 0.01%; Deionized water 79.49%.The B agent contains Fructus Citri Sarcodactylis ginseng element 20%; Calcium chloride 10%, propylene glycol 15%; Vitamin B 0.5%; Vitamin E 0.5%; Methylisothiazolinone 0.01%; Deionized water 53.99%.
9. Fructus Citri Sarcodactylis as claimed in claim 3 is joined the hand skin care item, and it is a kind of Fructus Citri Sarcodactylis ginseng exfoliation scrubbing cream, it is characterized by to contain Fructus Citri Sarcodactylis ginseng element 8%; Glycerol 21.99%; Sorbitol glycosides polyoxyethylene (20) ether monolaurate 5%; Sucrose 60%; Silicon dioxide 5%; Methylisothiazolinone 0.01%.
10. Fructus Citri Sarcodactylis as claimed in claim 3 is joined the hand skin care item, and it is the insured wet hand cream of a kind of Fructus Citri Sarcodactylis, it is characterized by to contain Fructus Citri Sarcodactylis ginseng element 7%; Trimethyl glycine 5%; Cetearyl alcohol 2.5%; Glycerol 5%; Propylene glycol 3%; Polydimethylsiloxane 2%; Cetearyl glucoside 1.8%; 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers 2%; Methyl hydroxybenzoate 0.2%; Propyl hydroxybenzoate 0.1%; Diazolidinyl urea 0.3%; Deionized water 71.1%.
11. Fructus Citri Sarcodactylis ginseng hand skin care item as claimed in claim 3, it is the freeze proof warm hand frost of a kind of Fructus Citri Sarcodactylis ginseng, it is characterized by to contain Fructus Citri Sarcodactylis ginseng element 7%; Vanillyl butyl ether 0.1%; Cetearyl alcohol 2.5%; Glycerol 5%; Propylene glycol 3%; Polydimethylsiloxane 2%; Cetearyl glucoside 2%; 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers 2%; Methyl hydroxybenzoate 0.2%; Propyl hydroxybenzoate 0.1%; Diazolidinyl urea 0.3%; Deionized water 75.8%.
12. Fructus Citri Sarcodactylis ginseng hand skin care item as claimed in claim 3, it is that a kind of Fructus Citri Sarcodactylis ginseng hands is consoled the not old honey of parents, it is characterized by to contain Fructus Citri Sarcodactylis ginseng element 7%; Polydimethylsiloxane cross linked polymer (reaching) dimethiconol (reaching) cyclohexyl methyl siloxanes 8%; Cetearyl alcohol 3%; Glycerol 5%; Propylene glycol 3%; Cetearyl glucoside 1.5%; 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers 2.5%; Methyl hydroxybenzoate 0.2%; Propyl hydroxybenzoate 0.1%; Diazolidinyl urea 0.3%; Deionized water 69.4%.
13. Fructus Citri Sarcodactylis ginseng hand skin care item as claimed in claim 3, it is that SPA hands film is provided special care in the oxygen supplement of a kind of Fructus Citri Sarcodactylis ginseng, it is characterized by to contain Fructus Citri Sarcodactylis ginseng element 25%; Polyacrylic acid 2.5%, 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers 1%; Lauryl glucoside 10%; Perfluor (different) butyl methyl ether 8%, butanediol 5%, EDETATE SODIUM 0.05%, triethanolamine 2%, Methylisothiazolinone 0.01%; Deionized water 46.44%.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105859816A (en) * | 2016-05-03 | 2016-08-17 | 浙江大学 | Method for extracting beta-sitosterol and beta-daucosterol from hemp seeds, application and product |
| CN106344436A (en) * | 2016-08-31 | 2017-01-25 | 苏州菲博特环保科技有限公司 | Skin-tendering, moisturizing and cutin-eliminating hand membrane and preparation method thereof |
| CN113208944A (en) * | 2021-05-17 | 2021-08-06 | 广东一方制药有限公司 | Skin care composition and skin care product with moisturizing effect |
-
2012
- 2012-12-28 CN CN201210594369.0A patent/CN103120759B/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 薛楠 等: "藏药佛手参本草及功用考证", 《中药材》, vol. 32, no. 11, 30 November 2009 (2009-11-30), pages 1778 - 1780 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105859816A (en) * | 2016-05-03 | 2016-08-17 | 浙江大学 | Method for extracting beta-sitosterol and beta-daucosterol from hemp seeds, application and product |
| CN105859816B (en) * | 2016-05-03 | 2018-04-10 | 浙江大学 | Method, application and the product of Sitosterolum and β daucosterols are extracted in fructus cannabis |
| CN106344436A (en) * | 2016-08-31 | 2017-01-25 | 苏州菲博特环保科技有限公司 | Skin-tendering, moisturizing and cutin-eliminating hand membrane and preparation method thereof |
| CN113208944A (en) * | 2021-05-17 | 2021-08-06 | 广东一方制药有限公司 | Skin care composition and skin care product with moisturizing effect |
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| CN103120759B (en) | 2016-05-04 |
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Effective date of registration: 20190910 Address after: 518000 Information Building of Baoyunda Logistics Center, Fuhua Community, Xixiang Street, Baoan District, Shenzhen City, Guangdong Province 408 Patentee after: Shenzhen Sapphire Industry Co., Ltd. Address before: 518034, room 3101, Huafeng building, No. 6006 Shennan Road, Shenzhen, Guangdong, Futian District Patentee before: Huang Yun Hu |
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