Background technology
Current treatment pharyngalgia type reflux esophagitis, generally adopts: 1, ranitidine: 1. contraindication: to this medicine and other H
2receptor antagonist allergy sufferers, anemia of pregnant woman, women breast-feeding their children, 8 years old following child's forbidding.2. be cautious use of: liver, renal insufficiency person, acute hematoporphyria person, old people are cautious use of.3. can occur headache, dizzy, weak, obnubilation, mental act extremely, insomnia etc.; , after accidental taking medicine, there is the mental symptoms such as disorientation, drowsiness, anxiety in liver, renal insufficiency person and gerontal patient; There is a small amount of generation blurred vision; There is constipation, diarrhoea, feel sick, vomit, suffer from abdominal pain; Can there is erythra, have only a few generation erythema multiforme; Rare arthralgia, myalgia; Rare anaphylactic reaction, shows as rubella, vasodilation, heating, bronchospasm, hypotension, anaphylactic shock, chest pain etc.; Life-time service can cause vitamin B
12lack, male breast is womanlike rare; Cause that renal dysfunction etc., quiet note rear section patient can occur fever sensation of the face sense, dizziness, feel sick, perspiration and gastric irritation.4. this medicine has certain toxicity to liver, therefore in administration process, should monitor patient's changes of liver function.When 5. vein gives this medicine, can there is bradycardia.Therefore should be slow during quiet note, and should make regular check on electrocardiogram in medication process.6. this medicine has certain inhibitory action to bone marrow, and the moderate leukocyte of reversibility or granulocytopenia can occur small number of patients, also occur thrombocytopenia and autoimmune hemolytic anemia.2, aluminium hydroxide: 1. contraindication: have strong basicity digestive juice secretion deficiency or acatharsia person, fracture patient, the hypophosphatemia patients such as bile, pancreatic juice and aluminium hydroxide allergy sufferers is forbidden.2. be cautious use of: the Acute Abdomens such as renal insufficiency person, prolonged constipation person, old people, appendicitis are cautious use of.3. can cause nausea, the symptom such as vomiting, constipation.Take in a large number for a long time, can cause serious constipation, even coproma piece causes intestinal obstruction.4. patients with renal failure long-term taking can cause encephalopathy, dementia and small cell anemia etc.3, omeprazole: 1. contraindication: those who are allergic to this drug, severe renal functional defect person, anemia of pregnant woman, infant patient's forbidding.2. be cautious use of: liver, renal insufficiency person, women breast-feeding their children, gerontal patient should be cautious use of.3. common adverse reactions be diarrhoea, headache, feel sick, stomachache, flatulence and constipation, accidental serum aminotransferase increases, erythra, dizzy, drowsiness, insomnia etc.; Visible chest pain, cardiopalmus, tachycardia or excessively slow, hypertension, periphery edema.Visible microscopic pyuria, albuminuria, hematuria, frequent micturition, urinary system infection, interstitial nephritis, glucose in urine, orchiodynia.Visible hemolytic anemia.Visible erubescence, dry.Rare heliosensitivity, erythema multiforme, Stevens Johnson syndrome, toxicity epidermal necrolysis, alopecia.Rare blurred vision.Rare perspiration increases, hyponatremia, gynecomastia.Rare arthralgia, myalgia, muscular strength weaken.Rare leukopenia, thrombocytopenia, agranulocytosis and pancytopenia.4, cimetidine: 1. contraindication: anemia of pregnant woman, women breast-feeding their children's forbidding.2. be cautious use of: serious heart and respiratory system disease, chronic inflammatory disease are cautious use of as systemic lupus erythematosus (sle) (SLE), encephalosis, renal function injury, hepatic insufficiency, child.3. more common untoward reaction has diarrhoea, dizziness, weak, headache and erythra etc.; When useful agents amount is larger, can cause gynaecomastia, women's galactorrhea, hyposexuality, sexual impotence, sperm count minimizing etc., can pass through blood-cerebrospinal fluid barrier, there is certain neurotoxicity.Accidental abalienation, the untoward reaction that this product is rare has: anaphylaxis, heating, arthralgia, myalgia, granulocytopenia, thrombocytopenia, interstitial nephritis, hepatotoxicity, bradycardia, tachycardia etc.5, rabeprazole: 1. contraindication: anemia of pregnant woman, women breast-feeding their children's forbidding.2. be cautious use of: anaphylaxis or other untoward reaction persons, the patient of liver dysfunction once occurred while previously using the medicines such as lansoprazole, omeprazole, pantoprazole, gerontal patient should be cautious use of this medicine.3. visible light-sensitive reaction, erythra, pruritus, edema, visual disorder, myalgia, rhinitis.Visible xerostomia, abdominal distention, stomachache, accidentally feel sick, vomiting, constipation, diarrhoea.Rare cardiopalmus, bradycardia, chest pain.Visible dizzy, limbs fatigue, insensitive, accidental headache, rare insomnia, sleepy, grip are low, inarticulateness, lurch.Accidental blood urea nitrogen raises, albuminuria.4. use this medicine can cause erythrocyte, lymphopenia, leukopenia or increase the symptoms such as eosinophilic granulocyte, neutrophilic leukocytosis.5. use this medicine can cause the phenomenons such as propylhomoserin aminotransferase, AST, alkali phosphatase total bilirubin, T-CHOL rising.6. use this medicine likely to cover gastric cancer symptom, therefore should use this medicine on the basis of getting rid of malignant tumor.6, domperidone: 1. contraindication: Patients With Pheochromocytoma, patient with breast cancer, mechanical intestinal obstruction patient, gastrointestinal hemorrhage patient and anemia of pregnant woman's forbidding.2. be cautious use of: 1 years old Infants Below, allergic constitution person, cardiac or hypokalemia patient and the tumor patient of accepting chemotherapy are cautious use of.3. accidental headache, dizziness, drowsiness, asthenia, nervousness etc., extrapyramidal symptoms, epilepsy etc., visible abdominal cramps pain, xerostomia, diarrhoea; Use larger dose can cause non-lactation period lactogenic, can occur arrhythmia, accidental evanescent eruption or pruritus.7, famotidine: 1. contraindication: those who are allergic to this drug, severe renal functional defect person, anemia of pregnant woman, women breast-feeding their children's forbidding.2. be cautious use of: have drug allergy history, liver, renal insufficiency person, infant to be cautious use of.3. can cause constipation, nausea,vomiting,diarrhea, abdominal discomfort, xerostomia, inappetence, parotitis and dysgeusia; Period in a medicine, the detection index of liver function can raise; Most headache, rare has dizziness, confusion, anxiety, paraesthesia, depression, insomnia, general lassitude is unable and drowsiness etc., and rare neutrophilic granulocyte reduces and thrombocytopenia, eosinophilia, and rare libido reduces; Rare erythra, urticaria, alopecia, acne, pruritus, xerosis cutis and flushing; Rare cardiopalmus, bradycardia, atrioventricular block, increased blood pressure, menoxenia, answer monitor ECG to change during medication; Rare toxic epidermal necrolysis; Rare hallucination, epilepsy grand mal, medication should be noted patient clinical performance; Can cause tinnitus; Musculoskeletal pain, comprises muscle cramp and arthralgia; Can cause pars orbitalis edema, facial edema, conjunctival congestion, vasodilation, drug fever, urticaria and erythra etc.8, metoclopramide: can cause that drowsiness, weak, extrapyramidal system syndrome and spirit are uneasy etc.Not yet clear and definite on fetus impact, thus should not be for vomiting during pregnancy, and anemia of pregnant woman is cautious use of.
Summary of the invention
For overcoming above-mentioned shortcoming, the object of the invention is to invent a kind of Chinese medicinal preparation method for the treatment of pharyngalgia type reflux esophagitis.
Pharyngalgia type reflux esophagitis refers to, due to stomach or the anti-esophagus that flows into of intestinal contents, cause the inflammation of distal esophagus mucosa.< < Medical Treasures of the Golden Chamber > > is called regurgitation.At < < vomiting sound of vomiting diarrhea, sick > > points out: " eating in the morning but vomiting out in the evening, vomiting out in the morning what eaten at last night, indigested food stagnated in the stomach, name is said regurgitation ".Its card be eat after, stop in stomach and do not change, towards trencherman's vomiting at night, dusk, trencherman was towards telling, and the dysphagic > > of < < Jing Yue's complete work says: " regurgitation person, eats still can enter; enter and instead go out, therefore say regurgitation.
etiology and pathogenesis:it is the higher-pressure region of long 2~5 centimetres that lower esophageal is crossed diaphragm segment, and this place's pressure is high at the bottom of compared with stomach, though it is anatomically without sphincteral structure, plays the barrier action of sphincter sample between esophagus stomach function regulating, therefore be called lower esophageal sphincter.When intragastric pressure increases, the pressure of LES is also along with increasing, to avoid stomach, the anti-esophagus that flows into of intestinal contents.LES is subject to the adjusting of vagus nerve and hormone.Drink, smoking, all can make the miopragia of LES, cause the anti-esophagus that flows to of gastrointestinal contents.So the hydrochloric acid in gastric juice and pepsin, the cholate in gallbladder, pancreatic juice and LYSOLECITHIN SUNLECITHIN A etc. can be damaged mucous membrane of esophagus, cause esophagitis.Mucous membrane of esophagus is subject to anti-stream after thing infringement, and the squamous cell on mucosa top layer comes off, and basal layer cell hypertrophy, thickens, and produces more new cell with the compensatory cells of superficial layer coming off, therefore jejune epithelial increasing proportion in mucosa.In addition, blood vessel mastoid process hypertrophy, blood tube bundle and the teleneuron of following extend, and even can reach the surface of epithelium.Because these change, the visible mucous membrane of esophagus of endoscope is hyperemia, edema, crisp and easy hemorrhage, rotten to the corn, shallow table ulcer, or with exudate, mucosa is graininess sometimes, or has white macula.Innate excess of YANG in the body, pathogenic heat is attacked, and causes primary disease.
clinical manifestation:pharyngalgia weight.Under normal circumstances, Esophagus has keratinization top layer, the epithelial cell attenuation on keratinization top layer or come off completely, heart burn.Burn feeling can involve to neck, interscapular region, ear, two upper arm even, and Chang Yu occurs after the meal soon, or, strenuous exercise anteflexion at trunk, lies on the back or occur during lateral position.Instead flow compared with severe one, when trunk is anteflexion or lie in bed, often have the stomach of acidity or bitterness or intestinal contents to overflow into oral cavity.Along with the progress of the course of disease, burn feeling attack times reduces, and engenders acataposis.When swallowing food, have intermittent obstruction sense, severe one can be with swallowing pain.Red tongue, yellow fur, rapid pulse.
its technical scheme:get Herba Androsaces umbellatae 6 weight portions, Herba hylotelephii erythrosticti 3 weight portions, Folium et cacumen Breyniae Fruticosae 3 weight portions, Phymatopsis hastata (Thunb.) Kitag. 5 weight portions, Rhizoma Belamcandae 3 weight portions, Lasiosphaera Seu Calvatia 5 weight portions (cloth bag), Calyx Seu Fructus Physalis 2 weight portions, Radix Sophorae Tonkinensis 6 weight portions, Fructus Canarii 3 weight portions, Rhizoma Paridis 1 weight portion, Herba Potentillae Discoloris 4 weight portions, Radix Berberidis 5 weight portions, Herba Bidentis Bipinnatae 4 weight portions, Herba Cayatiae Japonicae 3 weight portions, TUOPANGEN 2 weight portions, Radix Stellariae 6 weight portions, Herba Oxalidis Corniculatae 6 weight portions, Fructus rhamni (Rhamnus davurica Pall.) 6 weight portions, Herba veronicastri villosuli 6 weight portions, Herba Meliloti Suaveolentis 3 weight portions, Herba cassiae occidentalis 6 weight portions, Cortex Alstoniae scholaris 6 weight portions, Herba Lophatheri 12 weight portions, Semen phaseoli radiati 18 weight portions, Flos Chrysanthemi 12 weight portions and Radix Glycyrrhizae 9 weight portions, above 26 taste Chinese medicines are put into 1500 ml waters, soak 30 minutes, then slow fire is fried 30 minutes, boil medicine altogether 360 milliliters of liquid of filter and remove residue, fried medicinal liquid is the Chinese medicine for the treatment of pharyngalgia type reflux esophagitis.
the advantage of this invention:we's 26 taste Chinese medicines, all can buy in pharmacy, make simply, and the herb liquid toxic and side effects of making is little, short treating period, and cure rate is high.Monarch, just right.In the time of application Chinese medicine, untoward reaction, anaphylaxis and the toxic reaction of having avoided Western medicine antibacterials to cause.Herba Androsaces umbellatae, Herba hylotelephii erythrosticti, Folium et cacumen Breyniae Fruticosae, Phymatopsis hastata (Thunb.) Kitag., Rhizoma Belamcandae, Lasiosphaera Seu Calvatia, Calyx Seu Fructus Physalis, Radix Sophorae Tonkinensis, Fructus Canarii, Rhizoma Paridis, Herba Potentillae Discoloris, Radix Berberidis, Herba Bidentis Bipinnatae, Herba Cayatiae Japonicae, TUOPANGEN, above 15 taste medical instruments have resolving toxin and disinhibiting the throat, heat-clearing and toxic substances removing, the effect of reducing swelling and alleviating pain, cooling blood for hemostasis, vanishing sputum and dispelling knot, removing toxic substances and promoting subsidence of swelling, lowering the adverse-rising QI to resolve phlegm.In the process for the treatment of pharyngalgia type reflux esophagitis, play primary treatment effect, therefore be monarch drug.Radix Stellariae, Herba Oxalidis Corniculatae, Fructus rhamni (Rhamnus davurica Pall.), Herba veronicastri villosuli, Herba Meliloti Suaveolentis, Herba cassiae occidentalis, Cortex Alstoniae scholaris, Herba Lophatheri, Semen phaseoli radiati, above 9 taste medical instruments have the effect of heat clearing and damp drying, eliminating fire and detoxication, cooling blood for hemostasis, reducing swelling and alleviating pain, clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain.In the process for the treatment of pharyngalgia type reflux esophagitis, can assist principal agent performance therapeutical effect, therefore be ministerial drug.Flos Chrysanthemi: be slightly cold; Sweet, bitter; Return lung, Liver Channel.Dispelling wind and heat pathogens, suppressing the hyperactive liver improving eyesight.The all medicines of this taste medicine energy rate focus of going directly, therefore be adjuvant drug.Radix Glycyrrhizae: sweet, flat.Enter 12 warps.Spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.Can entangle the bias of all medicines, can alleviate again the toxicity of all medicines, therefore for making medicine.Herba Androsaces umbellatae, Herba hylotelephii erythrosticti, Folium et cacumen Breyniae Fruticosae, Phymatopsis hastata (Thunb.) Kitag., Rhizoma Belamcandae, Lasiosphaera Seu Calvatia, Calyx Seu Fructus Physalis, Radix Sophorae Tonkinensis, Fructus Canarii, Rhizoma Paridis, Herba Potentillae Discoloris, Radix Berberidis, Herba Bidentis Bipinnatae, Herba Cayatiae Japonicae, TUOPANGEN, Radix Stellariae, Herba Oxalidis Corniculatae, Fructus rhamni (Rhamnus davurica Pall.), Herba veronicastri villosuli, Herba Meliloti Suaveolentis, Herba cassiae occidentalis, Cortex Alstoniae scholaris, Herba Lophatheri, Semen phaseoli radiati, Flos Chrysanthemi, Radix Glycyrrhizae, above 26 taste medicines, there is resolving toxin and disinhibiting the throat, heat-clearing and toxic substances removing, the effect of reducing swelling and alleviating pain, cooling blood for hemostasis, vanishing sputum and dispelling knot, removing toxic substances and promoting subsidence of swelling, eliminating fire and detoxication, eliminating stasis to stop pain.Monarch, compatibility is proper, is the optimum formula for the treatment of pharyngalgia type reflux esophagitis.Herba Androsaces umbellatae: pungent, bitter, be slightly cold.Enter lung, liver, spleen channel.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Herba hylotelephii erythrosticti: bitter, sour, cold.Enter the heart, liver, kidney, large intestine channel, heat-clearing and toxic substances removing, cooling blood for hemostasis.Folium et cacumen Breyniae Fruticosae: hardship, cold.Enter large intestine, Liver Channel.Heat-clearing and toxic substances removing, removing stasis to stop bleeding.Goose slaps full star grass: hardship, and cool.Enter lung, liver, kidney channel.Heat-clearing and toxic substances removing, reducing heat in the blood and treating stranguria.Rhizoma Belamcandae: hardship, cold.Enter lung, Liver Channel.Resolving toxin and disinhibiting the throat, vanishing sputum and dispelling knot.Lasiosphaera Seu Calvatia (cloth bag): pungent, flat.Enter lung meridian.Removing heat from the lung and relieving sorethroat, removing toxic substances and promoting subsidence of swelling, astringing to arrest bleeding.Calyx Seu Fructus Physalis: bitter, sour, cold.Enter the heart, lung, kidney, urinary bladder channel.Heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling, lowering the adverse-rising QI to resolve phlegm, inducing diuresis for treating stranguria syndrome.Radix Sophorae Tonkinensis: hardship, cold.Enter the heart, lung, stomach warp.Heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling.Fructus Canarii: sweet, puckery, sour, flat.Enter lung meridian.Removing heat from the lung and relieving sorethroat, removing toxic substances.Rhizoma Paridis: micro-hardship, cool.Slightly poisonous.Enter Liver Channel, heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.Herba Potentillae Discoloris: sweet, micro-hardship, flat.Enter liver, spleen, large intestine channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis.Radix Berberidis: hardship, cold.Enter lung, liver, large intestine channel.Heat-clearing and toxic substances removing, bowel relieving dysentery relieving.Herba Bidentis Bipinnatae: hardship, is slightly cold.Enter lung, famous scenic spot, stomach, large intestine channel.Heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, bowel relieving antidiarrheal.Herba Cayatiae Japonicae: sour, bitter, cold.Enter liver, spleen, urinary bladder channel.Heat-clearing and toxic substances removing, removing heat from blood detumescence, diuresis.TUOPANGEN: bitter, pungent, micro-sweet, cool.Enter lung, Liver Channel.Clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling.Radix Stellariae: sweet, bitter, be slightly cold.Enter liver, stomach warp.Reducing the asthenic fever, asthenia, clearing heat in indigestion.Herba Oxalidis Corniculatae: sour, micro-puckery, cold.Enter lung, stomach warp.Clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating, cooling blood for hemostasis.Fructus rhamni (Rhamnus davurica Pall.): sweet, bitter, cold.Enter liver,kidney,spleen three warps.Clearing away heat-damp and promoting diuresis, invigorating the spleen for dissipating phlegm.Herba veronicastri villosuli: pungent, bitter, cold.Enter liver, lung, kidney three warps.Heat-clearing and toxic substances removing, the capable water of dampness removing, eliminating stasis to stop pain.Herba Meliloti Suaveolentis: pungent, bitter, cool, nontoxic.Enter liver, spleen, stomach warp.Heat-clearing and toxic substances removing, heat clearing and damp drying, inducing diuresis for treating stranguria syndrome.Herba cassiae occidentalis: hardship, cold.Enter lung, liver, stomach warp.Relieving cough and asthma, liver heat removing and eyesight improving, stomach function regulating help digestion, subduing swelling and detoxicating, inducing diuresis for treating stranguria syndrome, relieving constipation by purgation.Cortex Alstoniae scholaris: bitter, light, cold.Enter lung, Liver Channel.Heat-clearing and toxic substances removing, hemostasia and detumescence.Herba Lophatheri: sweet, light, cold.Enter the heart, stomach, kidney, small intestine meridian.Relieving restlessness, heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, Qinghua heat-phlegm clear away heart-fire.Semen phaseoli radiati: sweet, cold.Enter the heart, spleen, stomach, lung meridian.Heat-clearing and toxic substances removing, relieve heat and thirst, inducing diuresis to remove edema, QI invigorating skin moistening, the thick intestinal of clearing stomach.Flos Chrysanthemi: be slightly cold; Sweet, bitter; Return lung, Liver Channel.Dispelling wind and heat pathogens, suppressing the hyperactive liver improving eyesight.Radix Glycyrrhizae: sweet, flat.Enter 12 warps.Spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.