CN103110114A - Beta-alanine-containing composition for endurance increase, and preparation thereof - Google Patents
Beta-alanine-containing composition for endurance increase, and preparation thereof Download PDFInfo
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- CN103110114A CN103110114A CN201110363271XA CN201110363271A CN103110114A CN 103110114 A CN103110114 A CN 103110114A CN 201110363271X A CN201110363271X A CN 201110363271XA CN 201110363271 A CN201110363271 A CN 201110363271A CN 103110114 A CN103110114 A CN 103110114A
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Abstract
The invention provides a beta-alanine-containing composition for endurance increase, and a preparation thereof. The composition for endurance increase is composed of 1000-6000 parts of beta-alanine, 1000-4000 parts of L-carnitine or its pharmaceutically acceptable salt, 1000-4000 parts of taurine and 0.2-30 parts of vitamin B. The invention also provides the preparation of the composition for endurance increase, and a preparation method of the composition for endurance increase.
Description
Technical field
The present invention relates to field of health care products, be specifically related to a kind of composition and preparation thereof that improves endurance.
Background technology
How to improve athletic endurance, delay fatigue occurs and accelerates physical efficiency recovery, is the significant problem of sports science, sports medical science and Nutritional studies all the time.Stamina of speed in endurance is the main quality that consists of locomitivity, is the important content of each sports events training.Stamina of speed not only has key effect to the high strength intermediate item, and sundry item is also had important impact.Project take stamina of speed as main quality mainly contains the winter sports such as track and field, swimming, bicycle, racing boat, boat, speed skating, also need high-caliber stamina of speed quality on many ball and skill intermediate item in addition, the sprint stage of long-time endurance events also needs high-caliber stamina of speed in addition, is the key that improves competitiveness and score achievements.Endurance and fatigue problem are the focuses that coach and sportsman pay close attention to all the time.
Carnosine belongs to dipeptides, and content is very high in the skeletal muscle of mammal, and is synthetic by the carnosine synthetase effect by L-Histidine and Beta-alanine, and Beta-alanine is the synthetic speed limit precursor of carnosine, and carnosine is decomposed by the carnosine kinases.In addition, nerve fiber (as the brain olfactory lobe) and excitable tissue also also have a small amount of carnosine.Dunnett M and Harris RC etc. just studies confirm that since nineteen ninety-five oral Beta-alanine can obviously improve the content of carnosine, and carnosine can cushion H+ and pile up the sour toxicity that causes, strengthens Ca
2+The sensitiveness of passage is alleviated muscular fatigue.The research of recent years is found, replenishes Beta-alanine, improves muscle carnosine content, plays an important role to improving stamina of speed, can improve indiscipline or the individual high-intensity exercise ability of training experience is arranged.
L-cn carries out the oxidation energy supply owing to can promoting aliphatic acid to pass mitochondrial membrane, therefore can promote the burning of body body fat that energy is provided when motion, l-cn can also promote the oxidation utilization of branched-chain amino acid simultaneously, the activity of mitochondria internal respiration enzyme can be changed, thereby the ability of body aerobic oxidation energy supply can be improved.In addition, taurine, B family vitamin are as the coenzyme that energetic supersession participates in, and the energy that can improve in motion generates, and improves the endurance level of body, thereby improves sports achievement, is particularly suitable for the endurance exercise project.
Yet there are no to share about Beta-alanine, l-cn, taurine, B family vitamin and have the relevant report that improves endurance.
Summary of the invention
The invention provides a kind of composition that improves the endurance function that has.
The present invention also provides a kind of preparation that improves endurance function composition that contains.
The present invention also provides a kind of method for preparing the composition that improves endurance.
A kind of composition that improves endurance provided by the invention contains following active component: Beta-alanine, l-cn or its pharmaceutically acceptable salt, taurine, B family vitamin.
Concrete, said composition contains the active component of following weight portion: Beta-alanine 1000-6000 part, l-cn or its pharmaceutically acceptable salt 1000-4000 part, taurine 1000-4000 part and B family vitamin 0.2-30 part.
Preferably, said composition contains the active component of following weight portion: Beta-alanine 4000-6000 part, l-cn or its pharmaceutically acceptable salt 2000-4000 part, taurine 2000-4000 part and B family vitamin 1-20 part.
In above-mentioned composition:
Described weight portion can be the known unit of weights of field of medicaments such as μ g, mg, g, kg, or its multiple, as 100mg, 10g etc.;
Described l-cn pharmaceutically acceptable salt is selected from one or more in L-carnitine-L-tartrate, l-cn fumarate or L-carnitine hydrochloride;
Described B family vitamin comprises Cobastab
1, Cobastab
2, Cobastab
6, one or more in nicotinic acid, pantothenic acid;
The present invention also provides the preparation that contains above-mentioned raising endurance composition, is comprised of the composition that improves endurance and pharmaceutically acceptable carrier or diluent.
The described preparation that contains composition is solid pharmaceutical preparation or liquid preparation; Described solid pharmaceutical preparation is tablet, hard capsule, granule, pulvis or soft capsule; Described liquid preparation is oral liquid.
Described pharmaceutically acceptable carrier or diluent are selected from one or more in xylitol, D-sorbite, isomalt, isomaltoketose, sweet mellow wine, ethanol, microcrystalline cellulose, lactose, HPMC, soybean oil or dolomol.
The present invention also provides a kind of method for preparing the composition that improves endurance, comprises the following steps:
1) take Beta-alanine, taurine, l-cn or its pharmaceutically acceptable salt, B family vitamin raw material, sieve, standby;
2) with step 1) in active component in add pharmaceutically acceptable carrier or diluent, mix according to the equivalent method of progressively increasing, be prepared into conventional formulation.
Usage and dosage: every day, oral or Instant Drinks were 1-4 time, each 1-3 grain or sheet or bag, every, bag or sheet to contain Beta-alanine 0.1-6.0g, contain l-cn 0.1-4.0g, contain taurine 0.1-4.0g, contain B family vitamin 0.02-30mg.
A kind of composition for antifatigue provided by the invention has the following advantages:
Carnosine belongs to dipeptides, and content is very high in the skeletal muscle of mammal, and is synthetic by the carnosine synthetase effect by L-Histidine and Beta-alanine, and Beta-alanine is the synthetic speed limit precursor of carnosine, and carnosine is decomposed by the carnosine kinases.In addition, nerve fiber (as the brain olfactory lobe) and excitable tissue also also have a small amount of carnosine.Dunnett M and Harris RC etc. just studies confirm that since nineteen ninety-five oral Beta-alanine can obviously improve the content of carnosine, and carnosine can cushion H+ and pile up the sour toxicity that causes, strengthens Ca
2+The sensitiveness of passage is alleviated muscular fatigue.The research of recent years is found, replenishes Beta-alanine, improves muscle carnosine content and plays an important role to improving stamina of speed, can improve indiscipline or the individual high-intensity exercise ability of training experience is arranged.
L-cn carries out the oxidation energy supply owing to can promoting aliphatic acid to pass mitochondrial membrane, therefore can promote the burning of body body fat that energy is provided when motion, l-cn can also promote the oxidation utilization of branched-chain amino acid simultaneously, the activity of mitochondria internal respiration enzyme can be changed, thereby the ability of body aerobic oxidation energy supply can be improved.
In addition, taurine, B family vitamin are as the coenzyme that energetic supersession participates in, and the energy that can improve in motion generates, and improves the endurance level of body, thereby improves sports achievement, is particularly suitable for the endurance exercise project.
Confirm through overtesting: Beta-alanine, l-cn and taurine, B family vitamin share and can improve human tolerance, alleviate Fatique after Sports, have synergistic function.
The specific embodiment
Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Be in order to further illustrate realizability of the present invention for the buying producer of Beta-alanine and l-cn, but should be used for limiting the scope of the invention.
Raw material Beta-alanine of the present invention available from Jia Kang source, Beijing Bioisystech Co., Ltd, l-cn available from Shenyang Keshuo Nutrition Technology Co., Ltd..
Embodiment 1: capsule:
1, prescription (weight): Beta-alanine 10000g, l-cn 40000g, taurine 10000g, Cobastab
120g, Cobastab
240g, Cobastab
640g, dolomol 600g prepare 120000.
2, preparation method:
1) Beta-alanine, l-cn, taurine, Cobastab
1, Cobastab
2, Cobastab
6, dolomol, cross respectively 40 mesh sieves, standby;
2) take each supplementary material according to proportioning, then mix by the equivalent method of progressively increasing, pour in the capsule-filling mould can capsule, polishing, packing into.
3) specification: contain Beta-alanine 0.084g, l-cn 0.333g, taurine 0.083g, B family vitamin 0.00083g in every capsules.
4) instructions of taking: take each 4 every day 3 times.
Embodiment 2: pulvis
1, prescription (weight): Beta-alanine 6000g, L-carnitine-L-tartrate (containing l-cn 68%) 1470g, taurine 4000g, Cobastab
11g, Cobastab
21g, nicotinic acid 2g, pantothenic acid 30g, isomaltoketose 8500g prepare 2000 bags.
2, preparation method:
1) Beta-alanine, L-carnitine-L-tartrate, taurine, Cobastab
1, Cobastab
2, nicotinic acid, pantothenic acid, isomaltoketose crosses respectively 40 mesh sieves, and is standby;
2) take above-mentioned supplementary material according to proportioning, then mix packing by the equivalent method of progressively increasing.
3) specification: every bag contains Beta-alanine 3g, l-cn 0.5g, taurine 2g, B family vitamin 0.0155g.
4) instructions of taking: take each 1 bag every day 2 times.
Embodiment 3: tablet
1, prescription (weight): Beta-alanine 40000g, L-carnitine-L-tartrate (containing l-cn 68%) 29400g, taurine 40000g, Cobastab
1100g, nicotinic acid 200g, pantothenic acid 300g, lactose 50000g, microcrystalline cellulose 8400g, dolomol 1600g prepare 160000.
2, preparation method:
1) Beta-alanine, L-carnitine-L-tartrate (containing l-cn 68%), taurine, Cobastab
1, nicotinic acid, pantothenic acid, lactose, microcrystalline cellulose, dolomol crosses respectively 40 mesh sieves, and is standby;
2) take above-mentioned supplementary material (except dolomol) according to proportioning, then mix by the equivalent method of progressively increasing, make water as adhesive, softwood processed, with above-mentioned softwood granulation in the oscillating granulator of 14 eye mesh screens, particle is inserted in multi-functional boiling drier, 50 ℃ of fluidized dryings approximately 40 minutes, control pellet moisture 5%, then whole grain adds dolomol in particle, total mixed, compressing tablet, packing;
3, specification: every contains Beta-alanine 0.25g, contains l-cn 0.125g, contains taurine 0.25g, contains B family vitamin 0.00375g.
4, taking dose: every day 4 times, each serving with 4.
Embodiment 4: capsule:
1, prescription (weight): Beta-alanine 50000g, l-cn 20000g, taurine 20000g, Cobastab
2100g, Cobastab
6200g, dolomol 600g prepare 200000.
2, preparation method:
1) Beta-alanine, l-cn, taurine, Cobastab
2, Cobastab
6, dolomol crosses respectively 40 mesh sieves, and is standby;
2) take above-mentioned supplementary material according to proportioning, then mix by the equivalent method of progressively increasing, pour in the capsule-filling mould can capsule, polishing, packing into.
3, specification: contain Beta-alanine 0.25g, l-cn 0.1g, taurine 0.1g, B family vitamin 0.0015g in every capsules.
4, instructions of taking: take each 5 every day 4 times.
Experimental example: human experimentation
1, experimental subjects and method
1.1 experimental subjects
Take 54 man's dash of certain sport university to sportsman's (18.5 ± 0.67 years old mean age) as research object.
1.2 experiment grouping
Grouping: 90 experimenters are divided into 3 groups at random:
Blank group (N=18) is taken placebo, 4/day;
Experimental group 1 is taken embodiments of the invention 1, takes every day 3 times, and each 4 (contain Beta-alanine 0.084g, l-cn 0.333g, taurine 0.083g, B family vitamin 0.00083g in every capsules.)；
Experimental group 2 is taken embodiments of the invention 2, takes each 1 bag (every bag contains Beta-alanine 3g, l-cn 0.5g, taurine 2g, B family vitamin 0.0155g) every day 2 times;
Experimental group 3 is taken embodiments of the invention 3, and every day 4 times is each serving with 5 (every contains Beta-alanine 0.25g, contains l-cn 0.125g, contains taurine 0.25g, contains B family vitamin 0.00375g);
Experimental group 4 is taken embodiments of the invention 4, and every day 4 times is each serving with 4 (containing Beta-alanine 0.25g, l-cn 0.1g, taurine 0.1g, B family vitamin 0.0015g) in every capsules;
All took continuously for 8 weeks.Whole experimental session, and prohibit food and the medicine that takes other raising endurance.
1.3 experimental technique
Venous blood when requiring the experimenter to come the laboratory on an empty stomach before test to get peace and quiet, carry out exercise load (moving) before motion on the Monark power meter, first limber up 1min (0 load), then begin with 50W power, increasing load progressively, reach 70%Hrmax (measured by trial test and draw) about 3 minutes, after this namely no longer increase load, continue 60 minutes to pedal.Centre of motion rate adopts the monitoring of Polar table.Control temperature and the humidity in laboratory.The experimenter tests after taking 8 all nutriment again.
1.4 index and method
Test index: in motion, get ear blood 1 per half an hour, surveys lactic acid.After immediate postexercise, motion, measurement in the 3rd, 9,15 minute recovers heart rate, gets ear blood survey lactic acid.Second day extracting vein blood in early morning is measured serum superoxide dismutases (SOD) vigor.
Method of testing: blood lactic acid adopts YSI 1500SPORT LACTATEANALYZER to measure, and method is Enzyme Electrode; Serum superoxide dismutases (SOD) vigor adopts xanthine oxidase to measure, and determining instrument is 721 type spectrophotometers.
1.5 result statistics
Data are processed and are adopted SPSS10.0 software, all data to represent with means standard deviation, adopt variance and the pairing T method of inspection.
2 experimental results
2.1 the comparison of blood lactate concentration
Table 1: blood lactate concentration (unit: mmol/L)
Compare with the blank group,
*P＜0.05;
*P＜0.01.
Find out from table 1 result:
Immediate postexercise, the blood lactate concentration of experimental group significantly lower than with blank group (p＜0.05);
3min after motion finishes compares with the blank group, and the blood lactate concentration of experimental group is significantly lower than blank group (P＜0.01); The level when blood lactate concentration of experimental group returns to peace and quiet.
15min after motion finishes, the level when blank group just returns to peace and quiet.
Lactic acid is the product that in motion process, energy substance catabolism obtains in body, and a large amount of acidic materials accumulation cause muscle, joint acid swollen and spiritual tired.Take the experimental group sample, help to accelerate the removing speed of blood lactic acid in body, be conducive to extend exercise tolerance, improve locomitivity.
2.2 motion finishes to recover in rear 3 minutes the comparison of heart rate
After immediate postexercise and motion, the heart rate of 3min test subject, the results are shown in Table 2.
Table 2: motion finishes the rear 3 minutes hearts rate that recover (inferior/as to divide)
After the heart rate that after motion finishes, 3min recovers and motion finish, at once heart rate is compared,
*Expression p＜0.05;
* *Expression p＜0.01.
As can be seen from Table 2:
Motion finishes rear 3 minutes, and each experimental group heart rate and immediate postexercise relatively heart rate recover extremely significantly (P＜0.01), and blank group heart rate recovers significantly obviously (P＜0.05).
The heart rate resume speed is fast, shows that experimental group experimenter exercise tolerance is good, and locomitivity is strong.Therefore can find out, experimental group experimenter's antifatigue effect is better than blank group.
2.3 oxidation resistance test result
Serum superoxide dismutases (SOD) vigor of m seq difference experiments of measuring group 1, experimental group 2, blank group, control group 1 and control group 2 after experiment, experimental result sees Table 3.
Table 3: the rear impact on 4 groups of experimenter's oxidation resistances of experiment
Compare with early morning on the previous day,
*P＜0.05;
As shown in Table 3, the SOD vigor in five groups of experimenter mornings next day is all high than morning on the previous day, but each experimental group is significantly higher than the previous day (P＜0.05), and blank group is without significant difference.Show, this patent obtains composition and can effectively promote body SOD to raise, and has strengthened the ability of body Green Tea Extract.
3, conclusion
From whole experimentation, composition provided by the invention has the effect of Synergistic, and experimenter's blood lactic acid resume speed is accelerated, and it is also fast that heart rate recovers, and this is all the key factor that is conducive to extend exercise tolerance, is conducive to the raising of locomitivity.Motion can cause that the body free radical increases, and too much free radical can cause some important metabolic enzymes because of the cross-linked polymeric inactivation, causes a series of pathological change, causes the ability to work of human body descend and produce tired.Therefore, accelerate the removing speed of free radical, improve the anti-oxidative defense function, significant to improving locomitivity.
Although, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements, all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
- One kind improve endurance contain the Beta-alanine composition, it is characterized in that, said composition is comprised of Beta-alanine, l-cn or its pharmaceutically acceptable salt, taurine and B family vitamin.
- 2. composition according to claim 1; it is characterized in that, said composition is comprised of the raw material of following weight portion: Beta-alanine 1000-6000 part, l-cn or its pharmaceutically acceptable salt 1000-4000 part, taurine 1000-4000 part, B family vitamin 0.2-30 part.
- 3. composition according to claim 2; it is characterized in that, said composition is comprised of the raw material of following weight portion: Beta-alanine 4000-6000 part, l-cn or its pharmaceutically acceptable salt 2000-4000 part, taurine 2000-4000 part, B family vitamin 1-20 part.
- 4. according to claim 1,2 or 3 described compositions, is characterized in that, described l-cn comprises one or more in pharmaceutically acceptable salt L-carnitine-L-tartrate, l-cn fumarate or L-carnitine hydrochloride.
- 5. according to claim 1,2 or 3 described compositions, is characterized in that, described B family vitamin comprises Cobastab 1, Cobastab 2, Cobastab 6, one or more in nicotinic acid, pantothenic acid.
- 6. contain the preparation of the described raising endurance of claim 1-5 any one composition, it is characterized in that, formed by described composition and pharmaceutically acceptable carrier or diluent.
- 7. preparation according to claim 6, is characterized in that, described preparation is selected from solid pharmaceutical preparation or liquid preparation.
- 8. preparation according to claim 7, is characterized in that, described solid pharmaceutical preparation is tablet, granule, hard shell capsules, soft capsule or pulvis.
- 9. preparation according to claim 8, it is characterized in that, described pharmaceutically acceptable carrier or diluent are selected from one or more in xylitol, D-sorbite, isomalt, isomaltoketose, sweet mellow wine, water, microcrystalline cellulose, lactose, HPMC, dolomol.
- 10. the described composition of claim 1-4 any one or the described preparation of the claim 5-8 any one application in the health products of the anti-endurance of preparation.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108514114A (en) * | 2018-03-27 | 2018-09-11 | 西安交通大学 | Composition for relieving physical fatigue and purposes based on chondriosome nutrient theory |
| CN116138450A (en) * | 2023-03-03 | 2023-05-23 | 山东深海生物科技股份有限公司 | Sports nutritional composition containing 5-aminolevulinic acid or derivative thereof, and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112021573A (en) * | 2020-05-26 | 2020-12-04 | 上海轻姿健康管理有限公司 | Sports nutritional composition for improving endurance |
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