CN103109978A - Amino acid nano-silver liquid as well as preparation method and application thereof in disease-free safe raising of pigs - Google Patents
Amino acid nano-silver liquid as well as preparation method and application thereof in disease-free safe raising of pigs Download PDFInfo
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- CN103109978A CN103109978A CN2013100062287A CN201310006228A CN103109978A CN 103109978 A CN103109978 A CN 103109978A CN 2013100062287 A CN2013100062287 A CN 2013100062287A CN 201310006228 A CN201310006228 A CN 201310006228A CN 103109978 A CN103109978 A CN 103109978A
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Abstract
The invention discloses an amino acid nano-silver liquid as well as a preparation method and an application thereof in disease-free safe raising of pigs. The amino acid nano-silver liquid is prepared by mainly compounding silver sulfate, a cosolvent, an amino acid primary ligand, an amino hetero-ligand, a dispersing agent, a thickening agent, a complexing stabilizer, a pH conditioning agent and deionized water. The amino acid nano-silver liquid has the advantages of having a broad spectrum, high-efficiency and a bactericidal effect, being safe and reliable, being capable of being used for preparation of sterile pig feeds, preventing from serious diseases such as swine influenza and swine fever and disinfecting environments, and being beneficial to realization of the disease-free safe raising of the pigs.
Description
Technical field
The present invention relates to a seed amino acid Nano Silver liquid and method for making thereof and in safety is anosis on raising pigs application.
Background technology
In prior art, swine flu, swine fever etc. are not yet found thoroughly effectively prevention method so far, all can not solve root problem as Chinese herbal medicine preventive treatment, efficient medicine kill bacteria virus method etc.Silver is desirable sterilization, antiviral material, has efficient, wide spectrum, safety, without the large characteristic of the resistance to the action of a drug four, can replace large quantities of bactericide and antivirotic.But due to technical reasons such as high efficiency, security, economy, silver is not widely used in aquaculture at present.Animal can not directly take silver nitrate, because its side effect is very big; If silver nitrate is directly used in the water of raising pigs, because soluble impurity is extremely many, will generate precipitation with silver, cause the high efficiency performance of silver not out.Through retrieval, can prevent that the safety of various swine diseases is anosis raises pigs auxiliary material seldom, silver is used for the method that safety raises pigs has no document and report.
CN1316914C discloses boar Chinese herbal medicine multifunctional feed additive, be herbal decoction piece take folium cortex eucommiae, the fruit of glossy privet, the Radix Astragali, hawthorn and coix seed as raw material, by prepare burden, be pulverized and mixed, alcohol leaching is extracted, water logging is extracted, concentrated ethanol extract, condensed water extract, mix concentrated ethanol extract and aqueous extract, spray-drying and obtain medicinal powder and pack making.CN102018146B provides straw fermenting agent for raising pigs, be the compound formulation of plurality of enzymes preparation, microorganism and Chinese herbal medicine, comprise neutral proteinase, acid protease, phytase, cellulase, zytase, pectase, amylase, saccharomyces cerevisiae, black-koji mould, Li Shi Trichoderma, cordate houttuynia, the Radix Astragali.CN101263803A discloses a kind of method of ecologically raising pigs, is to adopt organic materials such as making bacterial classification and wood chip, corn stalk powder, rice bran, clean earth, salt from the indigenous microorganism of adopting and pig manure urine jointly to ferment.The disclosed technical scheme of above-mentioned document can improve the immunity of pig to a certain extent, avoids swine disease, but can't guarantee the anosis effect of raising pigs of safety.
The inventor being through exploring for many years and study, and selects silver-colored agent without free silver ion as the anosis auxiliary material of raising pigs of safety, successfully solved a difficult problem of using silver-colored agent, developed to be used for the anosis amino acid nano silver material of raising pigs of safety.
Summary of the invention
The invention provides a seed amino acid Nano Silver liquid, solved in the prior art and to lack safety, the problem of the anosis auxiliary material of raising pigs safely and efficiently.
The present invention includes following technical scheme.
One seed amino acid Nano Silver liquid belongs to many ligands of amino acid Nano Silver, it is characterized in that: mainly made by the raw material of following proportioning:
Silver sulfate: 0.005%～0.5%;
Cosolvent: ethanol or glycerine, 5%～20%;
Amino acid master ligand: contain four seed amino acids, comprise three kinds of lysines, tryptophan, methionine, and any in following amino acid: phenylalanine, threonine, isoleucine, leucine, knot propylhomoserin, histidine, arginine, 0.01%～5%, being equal in weight of above-mentioned four seed amino acids;
Amino different ligand: 2-mercapto imidazoline or thiosemicarbazides, 0.01%～5%;
Dispersant: polyvinylpyrrolidone or TX-100,1%～5%;
Thickener: any in gelatin, carboxymethyl cellulose, polyvinyl alcohol, 1%～5%;
Complexing stabilizing agent: NH
4KHPO
4Or NH
4CI, 0.01%～1%;
Acid-base modifier: H
3PO
4And ammoniacal liquor, 0.005%～0.5%;
Deionized water: 75%～90%.
The preparation method of above-mentioned amino acid nanometer silvering solution is characterized in that: mainly comprise the steps:
(1) silver sulfate is dissolved in deionized water;
(2) amino acid master ligand, amino different ligand and dispersant are dissolved in respectively in deionized water, first amino acid master ligand and amino different ligand solution are successively added in plastics or glass container, stir, then add dispersant to stir;
(3) silver sulfate solution in step (1) is added dropwise in equipment and solution in step (2), constantly stirs, react approximately 24h, sampling splashes in NaCI liquid till do not precipitate, and gets amino acid nanometer silvering solution crude product;
(4) thickener is dissolved in deionized water, then in (3) the gained solution that under agitation adds step;
(5) start stirring, add water-soluble complexing stabilizing agent in step (4) gained solution, get amino acid nanometer silvering solution;
(6) add soda acid conditioning agent adjust pH, stir, add at last cosolvent and deionized water to desired concn, stir, get amino acid Nano Silver liquid product.
The present invention is used for preparing the purposes of aseptic pig feed, prevention swine disease, environment disinfected.
Be the amino acid nanometer silvering solution that adds 0.005～0.05ppm in pig feed when preparing aseptic pig feed, for example the amino acid nanometer silvering solution 1～10ml with 500ppm adds in the 100kg pig feed; At first be to admix in the animals ' protein forage raw material after the dilution of amino acid nanometer silvering solution, then add mineral feed raw material and even; Then add the few vegetable raw material of water content and mixing; Then add remaining vegetable raw material, raw materials of feed additives and other raw materials and mixing; Again trace element and water are added mixing; Add at last vitamins raw material and mixing.
The prevention swine disease is the amino acid nanometer silvering solution that adds 0.005～0.05ppm in the drinking water of pig, for example the amino acid nanometer silvering solution of 500ppm is added 10000～20000 times of the drinking water dilutions of pig after feeding to pig.
The disinfection of environment is the amino acid nanometer silvering solution of 0.05～0.5ppm is sprayed or rinse the cultivation place, for example 1000～10000 times of the amino acid nanometer silvering solution dilutions of 500ppm is sprayed afterwards or rinsed the cultivation place.
Beneficial effect of the present invention: have wide spectrum, efficient sterilizing effect, safe and reliable, can be used for the preparation of aseptic pig feed, the serious diseases such as preventing swine influenza, swine fever carry out disinfection to environment, are conducive to realize safety, anosis raising pigs.During at formula feed with for pig drinking-water, the concentration of Nano Silver all is not more than 0.05ppm, meets the relevant regulations of WHO.Show according to other evidence materials, described by Chemical Industry Press's " nano-antibacterial technology ", the silver-colored filter that fills on the ionization silver water purifier of selling on American market and aircraft, in the rear water of its processing, silver content is not all higher than 0.05ppm.
The specific embodiment
Further describe technical scheme of the present invention below in conjunction with embodiment.
The preparation of pig feed need be decided by different growth phases, different weight and the DIFFERENT FEED raw material of pig, the formula that neither one is fixing, but common formulation principle and compound method are arranged.When preparation, animal feed raw material such as fish meal, bone meal etc. the most easily carry disease germs, Ying Xianyu sterilization, sterilization, and the raw material that moisture is few is first mixed, and mixed after washy raw material, simple vitamins feed addictive adds at last.Auxiliary material in the present invention in pig feed and drinking-water are the amino acid nano silver material, and these auxiliary material belong to many ligands amino acid Nano Silver complex compound, and its characteristics are: in material, without freely silver-colored, security is high, good dispersion, and sterilization valid density is extremely low.As everyone knows, silver is very big to the complexation propensity of amino, and when amino fully surrounded silver and forms network structure or chelate structure, silver just was fixed, and can not freely discharge.Only have when encountering electronegative free bacterium, virus, silver with powerful positive charge just can discharge, bacterium, virus are lived in binding, destroy its sulfydryl and take amino as main DNA, RNA, it is suffocated and die, then silver can dissociate out again, drops among the next round sterilization, Infinite Cyclic, the oligodynamic effect of the silver that Here it is often says.Simultaneously, silver also can destroy bacterium, viral electric transmission and cell membrane, the kill bacteria that works from many aspects, virus.Amino acid master ligand in the present invention and amino different ligand synergy make silver generate many ligands amino acid Nano Silver complex compound, and this complex compound does not contain free silver ion, more single ligand complexe stable in properties many, therefore safely many; This Nano Silver complex compound is that size is between 1～10nm than macromolecular structure.
The compound method of pig feed: respectively with mineral feed raw material and animals ' protein forage raw material stoving and cooling; Amino acid nanometer silvering solution is admixed in the animals ' protein forage raw material, then added mineral feed raw material and even; Then add the few vegetable raw material of water content and mixing; Then add remaining vegetable raw material, raw materials of feed additives and other raw materials and mixing; Again trace element and water are added mixing; Add at last vitamins raw material and mixing.By the feed of this compound method preparation, except as also preventing various swine diseases aseptic feed.
Embodiment 1
Take various raw materials according to following formula: silver sulfate 204g, ethanol 40kg, lysine 140g, tryptophan 140g, methionine 140g, histidine 140g, 2-mercapto imidazoline 205g, polyvinylpyrrolidone 2.5kg, carboxymethyl cellulose 2.2kg, NH
4Cl60g adds deionized water and cosolvent ad pond om 200kg, and phosphoric acid or ammoniacal liquor are made acid-base modifier, add use according to the pH value.
The preparation method:
Silver sulfate is dissolved in deionized water, is dissolved in respectively amino acid master ligand and amino different ligand in deionized water; Again main ligand and amino different ligand are stirred in glass-lined kettle, then will be dissolved in dispersant in deionized water and add and stir; Again silver sulfate solution is added dropwise in front step equipment and solution, the reaction 24h, until the sampling splash into do not precipitate in NaCl liquid till; Again thickener is dissolved in deionized water, more under agitation adds in front step solution; With water-soluble solution complexing stabilizing agent, add in front step solution again, stir; Again with ammoniacal liquor or phosphoric acid adjust pH to 6.8～7.2; Add at last cosolvent and deionized water ad pond om, stir, get concentration 500ppm amino acid nanometer silvering solution 200kg.
Embodiment 2
30～60kg growing and fattening pigs aseptic feed formula: corn 30kg, rice bran 10kg, soya-bean cake 8.5kg, fish meal 1.5kg, copper sulphate 25g, ferrous sulfate 15g, zinc sulfate 10g, manganese sulfate 10g, cobaltous sulfate 30mg, sodium selenite 5mg, KI 100mg, sodium chloride 500g, Paris white 100g, 500ppm amino acid nanometer silvering solution 4ml.
Compound method: with the fish meal oven dry, cooling; Again the nanometer silvering solution is added water approximately 100ml add in fish meal and be even; Add again Paris white and even; Again with corn, bran powder and even; Again with soya-bean cake and even; Add again sodium chloride and trace element and even; At last cobaltous sulfate and sodium selenite are dissolved in respectively in the 100ml deionized water, with front material and even; Again KI is dissolved in the 100ml deionized water, with front material and even.
Embodiment 3
Formula for pig forage in 15～30 kilograms: corn 29kg, jowar 5kg, wheat bran 4kg, soya-bean cake 10kg, fish meal 1.5kg, bone meal 0.5kg, salt 250g, EDTACu16g, ferrous sulfate 10g, zinc sulfate 8g, manganese sulfate 6g, cobaltous sulfate 25mg, sodium selenite 5mg, 500ppm amino acid nanometer silvering solution 4ml.
Compound method: with fish meal, bone meal oven dry, cooling; Again the nanometer silvering solution is added water approximately 100ml add its neutralization even; Again with corn, jowar, wheat bran and even; Again with soya-bean cake and even; Again with salt and trace element and even; Again cobaltous sulfate is dissolved in the 100ml deionized water, with aforementioned material and even, at last sodium selenite is dissolved in 100ml water, with aforementioned material and even.
Embodiment 4
Agent of feed for pregnancy sow formula: corn 53kg, rice chaff 12.5kg, dregs of beans 5.1kg, wheat bran 15kg, rice bran cake 12kg, bone meal 0.7kg, salt 0.4kg, lysine 200g, methionine 180g, cystine 210g, calcium lactate 300g, sodium dihydrogen phosphate 300g, 500ppm nanometer silvering solution 8ml.
Compound method: with the bone meal oven dry, cooling; Again the nanometer silvering solution is added water approximately 100ml add its neutralization even; Again with corn, rice chaff, wheat bran and even; Again with dregs of beans, rice bran cake and even; Again with salt and even; Add again calcium lactate, sodium dihydrogen phosphate and even; Add at last lysine, methionine, cystine and even.
Embodiment 5
After only needing during the prevention swine disease to add the drinking water of pig to dilute 20000 times 500ppm amino acid nanometer silvering solution, feeding gets final product to pig.
Embodiment 6
During to the environment disinfected sterilization to the disinfection in cultivation place (pigsty, road etc.), can be with approximately 2000 times of 500ppm amino acid nanometer silvering solution dilutions, spray or rinse the place.
The described method of embodiment 1～6 is cultivated unit at following three carry out safe pig-keeping experiment, and with common pig cultivation method as a comparison, add up sick pig quantity, acquired results is as shown in table 1:
The safe pig-keeping experiment result of table 1
As can be seen from Table 1, adopt amino acid nanometer silvering solution of the present invention, and be used in safe raising pigs by the method for the invention, can greatly reduce the quantity of disease pig, effectively realize raising pigs safely.
Claims (6)
1. a seed amino acid Nano Silver liquid, belong to many ligands of amino acid Nano Silver, it is characterized in that: mainly made by the raw material of following proportioning:
Silver sulfate: 0.005%～0.5%;
Cosolvent: ethanol or glycerine, 5%～20%;
Amino acid master ligand: contain four seed amino acids, comprise three kinds of lysines, tryptophan, methionine, and any in following amino acid: phenylalanine, threonine, isoleucine, leucine, knot propylhomoserin, histidine, arginine, 0.01%～5%, being equal in weight of above-mentioned four seed amino acids;
Amino different ligand: 2-mercapto imidazoline or thiosemicarbazides, 0.01%～5%;
Dispersant: polyvinylpyrrolidone or TX-100,1%～5%;
Thickener: any in gelatin, carboxymethyl cellulose, polyvinyl alcohol, 1%～5%;
Complexing stabilizing agent: NH
4KHPO
4Or NH
4Cl, 0.01%～1%;
Acid-base modifier: H
3PO
4And ammoniacal liquor, 0.005%～0.5%;
Deionized water: 75%～90%.
2. the preparation method of amino acid nanometer silvering solution as described in right 1, is characterized in that: mainly comprise the steps:
(1) silver sulfate is dissolved in deionized water;
(2) amino acid master ligand, amino different ligand and dispersant are dissolved in respectively in deionized water, first amino acid master ligand and amino different ligand solution are successively added in plastics or glass container, stir, then add dispersant to stir;
(3) silver sulfate solution in step (1) is added dropwise in container and solution in step (2), constantly stirs, react approximately 24h, sampling splashes in NaCl liquid till do not precipitate, and gets amino acid nanometer silvering solution crude product;
(4) thickener is dissolved in deionized water, then in (3) the gained solution that under agitation adds step;
(5) start stirring, add water-soluble complexing stabilizing agent in step (4) gained solution, get amino acid nanometer silvering solution;
(6) add soda acid conditioning agent adjust pH, stir, add at last cosolvent and deionized water to desired concn, stir, get amino acid Nano Silver liquid product.
3. the purposes of amino acid nanometer silvering solution as described in claim 1-3, is characterized in that: the purposes that is used for preparing aseptic pig feed, prevention swine disease, environment disinfected.
4. the purposes of amino acid nanometer silvering solution as claimed in claim 4, is characterized in that: be the amino acid nanometer silvering solution that adds 0.005～0.05ppm in pig feed during the aseptic pig feed of preparation; At first be to admix in the animals ' protein forage raw material after the dilution of amino acid nanometer silvering solution, then add mineral feed raw material and even; Then add the few vegetable raw material of water content and mixing; Then add remaining vegetable raw material, raw materials of feed additives and other raw materials and mixing; Again trace element and water are added mixing; Add at last vitamins raw material and mixing.
5. the purposes of amino acid nanometer silvering solution as claimed in claim 4 is characterized in that: the prevention swine disease is the amino acid nanometer silvering solution that adds 0.005～0.05ppm in the drinking water of pig.
6. the purposes of amino acid nanometer silvering solution as claimed in claim 4 is characterized in that: the disinfection of environment is that the amino acid nanometer silvering solution with 0.05～0.5ppm sprays or rinses the cultivation place.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109965120A (en) * | 2019-04-28 | 2019-07-05 | 长沙绿叶生物科技有限公司 | A kind of feed addictive of prevention and control African swine fever disease |
| CN111631230A (en) * | 2020-07-10 | 2020-09-08 | 深圳市源兴医药股份有限公司 | Silver ion air disinfectant and preparation method thereof |
| RU2779305C2 (en) * | 2020-07-19 | 2022-09-06 | Андрей Аркадьевич Варич | Pesticide and agrochemical based on silver ions and copper ions in chelate form |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101076322A (en) * | 2004-02-26 | 2007-11-21 | 塔斯克制品知识产权控股公司 | Antimicrobial composition for pre-harvest and post-harvest treatment of plants and animals |
| CN101161728B (en) * | 2007-09-21 | 2010-11-17 | 东华大学 | Gelatin-Ag nano compound having bacteriostasis efficacy and preparation method thereof |
| CN102178069A (en) * | 2010-07-06 | 2011-09-14 | 新疆农业大学 | Application of microbial ecological agent in production of cows |
| CN102090418A (en) * | 2010-12-21 | 2011-06-15 | 河南惠尔纳米科技有限公司 | Nano-Ag antibacterial agent and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109965120A (en) * | 2019-04-28 | 2019-07-05 | 长沙绿叶生物科技有限公司 | A kind of feed addictive of prevention and control African swine fever disease |
| CN111631230A (en) * | 2020-07-10 | 2020-09-08 | 深圳市源兴医药股份有限公司 | Silver ion air disinfectant and preparation method thereof |
| RU2779305C2 (en) * | 2020-07-19 | 2022-09-06 | Андрей Аркадьевич Варич | Pesticide and agrochemical based on silver ions and copper ions in chelate form |
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Effective date of registration: 20220104 Address after: 519000 room 32, building a, Meida garden, Meidu new village, Jinwan District, Zhuhai City, Guangdong Province Patentee after: Hu Keju Patentee after: Hu Deyi Address before: 563000 facade of a-1-20, Changzheng business city, Hong Kong Road, Huichuan, Zunyi City, Guizhou Province Patentee before: Guizhou Lidegao Science & Technology Development Co.,Ltd. Patentee before: Hu Keju |