CN103100079A - Compound medicine for treating infantile diarrhea and preparation method of compound medicine - Google Patents
Compound medicine for treating infantile diarrhea and preparation method of compound medicine Download PDFInfo
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- CN103100079A CN103100079A CN2013100656232A CN201310065623A CN103100079A CN 103100079 A CN103100079 A CN 103100079A CN 2013100656232 A CN2013100656232 A CN 2013100656232A CN 201310065623 A CN201310065623 A CN 201310065623A CN 103100079 A CN103100079 A CN 103100079A
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Abstract
The invention relates to a medicine for treating infantile diarrhea, and in particular relates to a compound medicine for treating infantile diarrhea and a preparation method of the compound medicine. The medicine disclosed by the invention is prepared by taking glucurone, tannalbin and compound diphenoxylate as raw materials. The preparation method disclosed by the invention comprises the steps of evenly mixing the raw materials to prepare 100-120 meshes of powder, sterilizing and disinfecting, bagging and then sealing to obtain the medicine. The medicine for treating infantile diarrhea has the advantages of good curative effect, quick effect and no toxic and side effects.
Description
Technical field
The present invention relates to treat the medicine of infantile diarrhea, especially a kind of compound medicine for the treatment of infantile diarrhea.
Background technology
Infantile diarrhea is common clinically a kind of frequently-occurring disease, it is the syndrome of dyspepsia digestive system, its cause of disease has infectious diarrhea and two kinds of noninfectious diarrheas, symptom to have acute and chronic diarrhea, although the sort of diarrhoea, Therapeutic Method mostly is now, fluid therapy+antibiotherapy, medicine commonly used has " dioctahedral smectite, Medilac-Vita, Mi Ya, Birid Triple Viable, gentamycin " etc., but the problems such as what can produce effect and is slow, and the course of disease is long, and expense is many.
Summary of the invention
The objective of the invention is to make up the deficiencies in the prior art, the compound medicine of the treatment infantile diarrhea that provide a kind of good effect, instant effect, has no side effect.
Medicine of the present invention is that the crude drug by following parts by weight prepares:
Glucurolactone 50-400 tannalbin 300-2000
Compound Di Fen Nuo Zhi 2.5-20.
The concrete preparation method of above-mentioned each component being made medicine of the present invention is:
With the mentioned component mix homogeneously, make 100-120 order ground powder, after sterilizing, in the bag of packing into, sealing gets final product.
Every bag of 50 mg, each 50 mg of consumption, twice on the one is oral.
In prescription of the present invention, tannalbin, oral after in intestinal in conjunction with tryptic effect, to intestinal mucosa have the convergence and protective effect.Glucuronic acid lactone can be combined with liver and enteral noxious substance, the growth and breeding that destroys antibacterial generates nontoxic glucuronide conjugate, noxious substance is discharged with urine, in the time of also treatment can being suffered from diarrhoea simultaneously, drug toxicity one urine of the same age used comes external, thereby reach good effect, Compound Di Fen Nuo Zhi can be eliminated the enterokinesia reflection, and alleviates the moisture absorption that enterokinesia promotes enteral.Obvious antidiarrheal effect has been played in three medicine combinations.
For further investigating clinical efficacy and the safety of medicine of the present invention, select 120 routine infantile diarrhea patients to carry out clinical observation to the curative effect of medicine of the present invention, 120 routine cases are divided into two groups at random, matched group 60 examples, treatment group 60 examples.All cases all is diagnosed as infantile diarrhea according to the diagnostic criteria in (Chinese diarrhoeal diseases diagnoses and treatment scheme (trying) in October, 1993 Beijing).
Matched group uses doctor trained in Western medicine common medicine dioctahedral smectite (Beaufour-lpsen (Tianjin) pharmaceutical Co. Ltd) to carry out conventional therapy, 1 bag of child every day below 1 years old, minute 3 clothes; 1～2 bag of 1～2 year old every day, minute 3 clothes; 2～3 bags of every days more than 2 years old, minute 3 clothes when taking are poured this product into that in half cup warm water (approximately 50 milliliters), mixing takes fast.During the treatment acute diarrhea, initial dose should double.
Treatment group adopts medicine of the present invention to treat, and twice on the one is oral, and each 1 bag, every bag of 50 mg.
Diagnostic criteria:
1. diagnosis basis:
(1) the stool character changes, and is loose stool, watery stool, Mucous Stool or bloody purulent stool.
(2) times of defecation increases than usual.
2. course of disease classification
(1) children with acute diarrheal disease, the course of disease is within 2 weeks.
(2) persistent diarrhea is sick, and the course of disease was at 2 thoughtful 2 months.
(3) chronic diarrheal disease, the course of disease is more than 2 months.
3. state of an illness classification
(1) light-duty, without dehydration, without poisoning symptom.
(2) medium-sized, mild to moderate dehydration or calomel poisoning symptom.
(3) heavy type, severe dehydration or obvious poisoning symptom (agitation, lethargy, drowsiness, pale complexion, Gao Re or body temperature does not rise, numeration of leukocyte obviously increases etc. are arranged.）
4. clinical classification
(1) infectivity, enteritis, dysentery, cholera.
(2) non-infectious, bait (Diet) diarrhoeal diseases, symptomatic diarrhea sick (except intestinal outer infect same cause of disease with diarrhoea), sick, other diarrhoeal diseasess of allergic diarrhea.
Curative effect determinate standard:
Clinical recovery: times of defecation, character and symptom, sign are recovered normally fully, and abnormal physical and chemical index recovers normal.
Produce effects: times of defecation obviously reduces (be reduced to treatment before 1/3 below), the character improvement, and symptom, sign and abnormal physical and chemical index obviously improve.
Effectively: times of defecation be reduced to before treatment below 1/2, character takes a turn for the better, symptom, sign and abnormal physical and chemical index make moderate progress.
Invalid: as not meet above standard person.
After two groups of case treatments, the curative effect comparative result sees Table 1.
Table 1
| Group | Number of cases | Clinical recovery n(%) | Produce effects n(%) | Effective n(%) | Invalid n(%) | Total effective rate n(%) |
| Matched group | 60 | 35（58.3） | 13（21.7） | 4（6.7） | 8（13.3） | 52（86.7） |
| Treatment group | 60 | 49（81.7） | 7（11.7） | 3（5.0） | 1（1.7） | 59（98.3） |
Clinical test results proves, drug effect of the present invention obviously is better than matched group, has no any untoward reaction.
The specific embodiment
Embodiment
Get Glucurolactone 400kg, tannalbin 2000kg, Compound Di Fen Nuo Zhi 20kg with the mentioned component mix homogeneously, makes 100-120 order ground powder, and after sterilizing, in the bag of packing into, sealing gets final product.
Claims (2)
1. compound medicine for the treatment of infantile diarrhea is that the crude drug by following parts by weight prepares:
Glucurolactone 50-400 tannalbin 300-2000
Compound Di Fen Nuo Zhi 2.5-20.
2. a kind of compound medicine for the treatment of infantile diarrhea according to claim 1, its preparation method is: with the mentioned component mix homogeneously, make 100-120 order ground powder, after sterilizing, in the bag of packing into, sealing gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100656232A CN103100079A (en) | 2013-03-01 | 2013-03-01 | Compound medicine for treating infantile diarrhea and preparation method of compound medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100656232A CN103100079A (en) | 2013-03-01 | 2013-03-01 | Compound medicine for treating infantile diarrhea and preparation method of compound medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103100079A true CN103100079A (en) | 2013-05-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2013100656232A Pending CN103100079A (en) | 2013-03-01 | 2013-03-01 | Compound medicine for treating infantile diarrhea and preparation method of compound medicine |
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| CN (1) | CN103100079A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104258370A (en) * | 2014-10-14 | 2015-01-07 | 北京国仁堂医药科技发展有限公司 | Drug composition of oral rehydration salt and preparation method of drug composition |
| CN107281110A (en) * | 2017-07-20 | 2017-10-24 | 山东福美乐动物药业有限公司 | A kind of tannalbin soluble powder and preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322527A (en) * | 2000-05-12 | 2001-11-21 | 林喜顺 | Dysentery treating medicine |
| CN1689639A (en) * | 2004-04-27 | 2005-11-02 | 合肥霄云科技有限公司 | Tannalbin rapid disintegration preparation and preparing method thereof |
| CN101548990A (en) * | 2009-04-21 | 2009-10-07 | 杨国强 | Powder pharmaceutical formulations for treating infantile diarrhea |
-
2013
- 2013-03-01 CN CN2013100656232A patent/CN103100079A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322527A (en) * | 2000-05-12 | 2001-11-21 | 林喜顺 | Dysentery treating medicine |
| CN1689639A (en) * | 2004-04-27 | 2005-11-02 | 合肥霄云科技有限公司 | Tannalbin rapid disintegration preparation and preparing method thereof |
| CN101548990A (en) * | 2009-04-21 | 2009-10-07 | 杨国强 | Powder pharmaceutical formulations for treating infantile diarrhea |
Non-Patent Citations (1)
| Title |
|---|
| 孙丽等: "浅谈慢性肠炎治疗与饮食", 《中华医学研究杂志》, vol. 8, no. 4, 31 December 2008 (2008-12-31) * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104258370A (en) * | 2014-10-14 | 2015-01-07 | 北京国仁堂医药科技发展有限公司 | Drug composition of oral rehydration salt and preparation method of drug composition |
| CN107281110A (en) * | 2017-07-20 | 2017-10-24 | 山东福美乐动物药业有限公司 | A kind of tannalbin soluble powder and preparation method |
| CN107281110B (en) * | 2017-07-20 | 2020-05-05 | 山东福美乐动物药业有限公司 | Tannic acid protein powder capable of being administrated by drinking water and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130515 |