CN103096897A - 包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物 - Google Patents

包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物 Download PDF

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Publication number
CN103096897A
CN103096897A CN2011800395439A CN201180039543A CN103096897A CN 103096897 A CN103096897 A CN 103096897A CN 2011800395439 A CN2011800395439 A CN 2011800395439A CN 201180039543 A CN201180039543 A CN 201180039543A CN 103096897 A CN103096897 A CN 103096897A
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China
Prior art keywords
pharmaceutical composition
budesonide
composition according
pharmaceutically acceptable
tiotropium bromide
Prior art date
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Pending
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CN2011800395439A
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English (en)
Chinese (zh)
Inventor
G·马尔霍特拉
S·M·普兰德尔
A·卢拉
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Cipla Ltd
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Cipla Ltd
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Priority to CN201510665216.4A priority Critical patent/CN105412122A/zh
Priority to CN201910504867.3A priority patent/CN110237260A/zh
Publication of CN103096897A publication Critical patent/CN103096897A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2011800395439A 2010-07-16 2011-07-18 包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物 Pending CN103096897A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201510665216.4A CN105412122A (zh) 2010-07-16 2011-07-18 包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物
CN201910504867.3A CN110237260A (zh) 2010-07-16 2011-07-18 包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
IN2051MU2010 2010-07-16
IN2051/MUM/2010 2010-07-16
IN3156/MUM/2010 2010-11-18
IN3157/MUM/2010 2010-11-18
IN3156MU2010 2010-11-18
IN3157MU2010 2010-11-18
PCT/GB2011/001077 WO2012007729A2 (en) 2010-07-16 2011-07-18 Pharmaceutical compositions

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201510665216.4A Division CN105412122A (zh) 2010-07-16 2011-07-18 包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物
CN201910504867.3A Division CN110237260A (zh) 2010-07-16 2011-07-18 包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物

Publications (1)

Publication Number Publication Date
CN103096897A true CN103096897A (zh) 2013-05-08

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN201910504867.3A Pending CN110237260A (zh) 2010-07-16 2011-07-18 包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物
CN2011800395439A Pending CN103096897A (zh) 2010-07-16 2011-07-18 包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物
CN201510665216.4A Pending CN105412122A (zh) 2010-07-16 2011-07-18 包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物

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CN201910504867.3A Pending CN110237260A (zh) 2010-07-16 2011-07-18 包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物

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CN201510665216.4A Pending CN105412122A (zh) 2010-07-16 2011-07-18 包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物

Country Status (13)

Country Link
US (4) US20130274232A1 (enExample)
EP (2) EP2593108A2 (enExample)
JP (3) JP2013531056A (enExample)
KR (2) KR20140020815A (enExample)
CN (3) CN110237260A (enExample)
AU (1) AU2011278096B2 (enExample)
BR (1) BR112013001119A2 (enExample)
CA (1) CA2805700A1 (enExample)
MX (1) MX2013000642A (enExample)
NZ (1) NZ605920A (enExample)
RU (1) RU2568882C2 (enExample)
WO (1) WO2012007729A2 (enExample)
ZA (1) ZA201300718B (enExample)

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CN104606205A (zh) * 2015-01-13 2015-05-13 段希福 一种奥达特罗和布地奈德的药物组合物及其用途
CN104744271A (zh) * 2013-12-26 2015-07-01 成都伊诺达博医药科技有限公司 一种合成维兰特罗的新工艺
CN106466322A (zh) * 2016-08-25 2017-03-01 杭州百诚医药科技股份有限公司 一种以布地奈德和噻托溴铵为活性成分的复方制剂
CN106470700A (zh) * 2014-05-12 2017-03-01 梯瓦制药欧洲有限责任公司 用于治疗copd的噻托溴铵、福莫特罗和布地奈德的组合
CN108289843A (zh) * 2015-12-04 2018-07-17 墨西哥氟石股份公司 药物组合物
CN115811978A (zh) * 2020-06-23 2023-03-17 广州谷森制药有限公司 包含奥达特罗、噻托溴铵和布地奈德的药物组合物的制备

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CN110237260A (zh) 2010-07-16 2019-09-17 希普拉有限公司 包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物
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CN110051629A (zh) * 2019-05-17 2019-07-26 南京望知星医药科技有限公司 一种用于治疗呼吸疾病的雾化沙丁胺醇溶液及其制备方法
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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104744271A (zh) * 2013-12-26 2015-07-01 成都伊诺达博医药科技有限公司 一种合成维兰特罗的新工艺
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