CN103091275B - QI and blood exchange is blood oxygen saturation monitoring device based - Google Patents
QI and blood exchange is blood oxygen saturation monitoring device based Download PDFInfo
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- CN103091275B CN103091275B CN201110337596.0A CN201110337596A CN103091275B CN 103091275 B CN103091275 B CN 103091275B CN 201110337596 A CN201110337596 A CN 201110337596A CN 103091275 B CN103091275 B CN 103091275B
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Abstract
The present invention relates to a kind of QI and blood exchange blood oxygen saturation monitoring device based, including QI and blood inverting chamber and blood oxygen detection part；Described QI and blood inverting chamber is separated into three chambers by two pieces of ventilated membranes, respectively centrally located blood chamber enters and carries out QI and blood exchange in the blood in described blood chamber through two ventilated membranes with laying respectively at the nitrous ether (ethyl nitrite) gaseous mixture body cavity of described blood chamber both sides, oxygen chamber, the nitrous ether (ethyl nitrite) mixing gas in described nitrous ether (ethyl nitrite) gaseous mixture body cavity and the oxygen in described oxygen chamber respectively；Described blood oxygen detection part is photo-electric blood oxygen detection, for detecting the blood oxygen saturation of the blood after QI and blood exchanges.Adopt assembly of the invention, first pass through the oxygen content that ventilated membrane carries out QI and blood exchange and improves blood；And whether the blood after detecting exchange by blood oxygen detection part reaches sufficient oxygen content；Photo-electric blood oxygen detection is adopted also to have the feature that degree of accuracy is high, it is possible to increase blood oxygen detection accuracy.
Description
Technical field
The present invention relates to medical instruments field, more particularly, it relates to a kind of QI and blood exchange is blood oxygen saturation monitoring device based.
Background technology
Erythrocyte is (also referred to as blood red ball, English abbreviation RBC) deformability is to maintain one of principal element that microcirculation effectively irrigates, its quality not only affects the oxygen supply of organ, and destructiveness when can affect RBC by blood capillary, the quality of impact blood transfusion, and these changes of RBC are relevant with the disappearance of nitric oxide (NO).Nitrous ether (ethyl nitrite) gas is quantitatively supplemented in blood transfusion blood, nitrosothiols (RSNO) can be formed in blood, thus discharging NO, being possible not only to improve the quality of blood transfusion blood, but also the RSNO of formation and the NO of release can be made to play certain physiology's effect.
Nitrous ether (ethyl nitrite) is the congener of NO, the mainly fracture in the way of heterolytic fission of nitrous ether (ethyl nitrite) covalent bond, produces NO+, there is the biological activity of many similar NO, it is easy to produce RSNO with nucleophile (being mainly the polypeptide containing sulfydryl, protein in organism) by turning nitro effect.
Blood oxygen saturation (SPO2) referring to that in blood, HbO2 Oxyhemoglobin accounts for the percentage ratio of hemoglobin sum, hemoglobin includes becoming HbO2 Oxyhemoglobin (HbO after reproducibility hemoglobin (RHb) is combined with oxygen2).Blood oxygen saturation is one of vital sign index of human metabolism, also it is human respiratory and the important physiological parameter of blood circulation diseases diagnosis, the clinical manifestation of a lot of diseases all can cause the blood oxygen saturation in human body linked groups and organ to change, thus causing anoxia, even threat to life.So, improve the blood oxygen saturation of patient and blood oxygen saturation effectively monitored extremely important.
At present, market carries out QI and blood switch but without two kinds of gases of nitrous ether (ethyl nitrite), oxygen simultaneously.The method at present detection method of blood oxygen saturation mainly being had optical detection and Electrochemical Detection, sell there being complete equipment and instrument on the market, but these instrument and equipments are all directly act on tissue, inside of human body blood is carried out the detection of hurtless measure blood oxygen saturation, when inside of human body being carried out blood oxygen saturation detection, it is easy to be subject to the interference of individual's health, such as beating of pulse, its hetero-organization absorption etc. to light so that measure inaccurate.
Summary of the invention
The technical problem to be solved in the present invention is in that, for the drawbacks described above of prior art, it is provided that a kind of QI and blood exchange is blood oxygen saturation monitoring device based.
The technical solution adopted for the present invention to solve the technical problems is: structure a kind of QI and blood exchange is blood oxygen saturation monitoring device based, including QI and blood inverting chamber and blood oxygen detection part；Described QI and blood inverting chamber is separated into three chambers by two pieces of ventilated membranes, respectively centrally located blood chamber enters and carries out QI and blood exchange in the blood in described blood chamber through two ventilated membranes with laying respectively at the nitrous ether (ethyl nitrite) gaseous mixture body cavity of described blood chamber both sides, oxygen chamber, the nitrous ether (ethyl nitrite) mixing gas in described nitrous ether (ethyl nitrite) gaseous mixture body cavity and the oxygen in described oxygen chamber respectively；Described blood oxygen detection part is photo-electric blood oxygen detection, for detecting the blood oxygen saturation of the blood after QI and blood exchanges.
In device of the present invention, described blood chamber is provided with blood entry port and blood outlet, described blood entry port connects promising described blood chamber by pipeline the blood bag of blood is provided, being provided with reference cell on the pipeline of described blood entry port, described blood oxygen detection part also detects in described reference cell not yet through the blood of QI and blood exchange.
In device of the present invention, described blood after QI and blood exchanges flows into human vein by flexible pipe, being provided with measuring cell on described flexible pipe, blood flows through described measuring cell, and described blood oxygen detection part detects the blood in described measuring cell after QI and blood exchanges.
In device of the present invention, described reference cell and measuring cell all adopt quartz colorimetric utensil.
In device of the present invention, described blood oxygen detection part includes LED HONGGUANG and infrared light generator, beam splitter, optical-electrical converter, signal amplification circuit and single-chip microcomputer.
In device of the present invention, described LED HONGGUANG and infrared light generator include two Light-Emitting Diodes, it is the light of 660nm and 940nm that wavelength occurs respectively, and the mixed light that the light of two kinds of wavelength is formed is divided into the identical light of two bundles in described beam splitter and injects respectively in described reference cell and measuring cell.
In device of the present invention, described optical-electrical converter converts the light that two bundles pass through described reference cell and measuring cell respectively to two signals of telecommunication, the said two signal of telecommunication is amplified and sends into process and analysis in described single-chip microcomputer, two groups of blood oxygen saturation data after exchanging with QI and blood before obtaining QI and blood exchange by described signal amplification circuit.
In device of the present invention, described nitrous ether (ethyl nitrite) gaseous mixture body cavity is provided with the first air inlet and the first gas outlet, described first air inlet is connected to high pressure nitrous ether (ethyl nitrite) mixing gas tank, between its with described first air inlet, is connected and is provided with valve and effusion meter by pipeline.
In device of the present invention, described oxygen chamber is provided with the second air inlet and the second gas outlet, and described second air inlet is connected to oxygen tank, is connected and is provided with valve and effusion meter between its with described second air inlet by pipeline.
In device of the present invention, the pipeline between described blood bag and blood entry port is provided with the valve controlling flow.
Implement assembly of the invention, have the advantages that the QI and blood exchange adopting the present invention is blood oxygen saturation monitoring device based, ventilated membrane can be passed through first blood is penetrated into nitrous ether (ethyl nitrite) G&O simultaneously, the oxygen content of blood is improved through QI and blood exchange, and whether the blood after detecting QI and blood exchange by blood oxygen detection part reaches sufficient oxygen content, if oxygen content is not, can increase or reduce the content of nitrous ether (ethyl nitrite) and oxygen by adjusting valve, so that it is guaranteed that the quality of blood, the blood use safety for patient provides safeguard；And adopt photo-electric blood oxygen detection, have degree of accuracy and highly sensitive, eliminate the external factor interference of human detection, simple and easy to do advantage.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the invention will be further described, in accompanying drawing:
The QI and blood that Fig. 1 is the preferred embodiment of the present invention exchanges blood oxygen saturation monitoring device based structural representation.
Detailed description of the invention
The present invention relates to a kind of QI and blood exchange blood oxygen saturation monitoring device based, mainly include QI and blood inverting chamber and blood oxygen detection part.
As it is shown in figure 1, be provided with two pieces of ventilated membranes in QI and blood inverting chamber, respectively the first ventilated membrane 82 and the second ventilated membrane 83.Cavity space is separated into three independent chambers by two pieces of ventilated membranes, respectively centrally located blood chamber 10 and be positioned at the nitrous ether (ethyl nitrite) gaseous mixture body cavity 20 of blood chamber 10 both sides, oxygen chamber 30.Nitrous ether (ethyl nitrite) gaseous mixture body cavity 20 is used to hold nitrous ether (ethyl nitrite) mixing gas, described nitrous ether (ethyl nitrite) mixing gas is to be made up of nitrogen and nitrous ether (ethyl nitrite) gas, wherein the volume by volume concentration of nitrous ether (ethyl nitrite) gas is between 70～100ppm, and concrete content adjusts according to practical situation；What be filled with in oxygen chamber 30 is oxygen.Two kinds of gases enter thus mixing with blood in blood chamber 10 respectively through the first ventilated membrane 82 and the second ventilated membrane 83, carry out QI and blood exchange.And blood cannot pass through ventilated membrane 82,83 and enter in nitrous ether (ethyl nitrite) gaseous mixture body cavity 20 and oxygen chamber 30.
Above-mentioned ventilated membrane be a kind of gas can by and thin film that liquid cannot pass through, in prior art, right and wrong are usually shown in known, for instance cell membrane is exactly one type ventilated membrane.In the present invention, ventilated membrane selects TPE (thermoplastic elastomer (TPE), ThermoplasticElastomer), and thickness, preferably between 0.05～0.15mm, is 0.1mm in the present embodiment.
Blood chamber 10 upper end is provided with blood entry port, and lower end is blood outlet.Blood entry port is connected to blood bag 1 by pipeline, is used for providing blood for blood chamber 10.Pipeline is additionally provided with valve F1, is used for controlling the flow of blood.Blood in blood bag 1 may by problems such as oxygen content are not enough, it is therefore desirable to QI and blood exchange improves blood quality.Blood after QI and blood exchanges then flows out from blood outlet, and being accessed in human vein by flexible pipe is patients with transfusion.
Being provided with reference cell 61 on the pipeline being connected between blood entry port with blood bag 1, blood flows through from reference cell 61, and the material that reference cell 61 selects transmittance high is made, preferred quartz colorimetric utensil in the present invention.Blood outlet flows into human vein by flexible pipe, and described flexible pipe is provided with measuring cell 62, and blood flows through measuring cell 62, and measuring cell 62 also to select the material that transmittance is high to make, and selects quartz colorimetric utensil in the present embodiment equally.Reference cell 61 and measuring cell 62 are arranged to facilitate blood oxygen detection part detection blood oxygen saturation, and the two can be arranged in a container and make one, become a detection cell 6.
Nitrous ether (ethyl nitrite) gaseous mixture body cavity 20 is provided with the first air inlet and the first gas outlet, first air inlet is connected to high pressure nitrous ether (ethyl nitrite) mixing gas tank 2, it is connected and is provided with valve F2 and effusion meter S1 between its with the first air inlet by pipeline, effusion meter S1 is used for monitoring the flow of the nitrous ether (ethyl nitrite) mixing gas of release from high pressure gas holder 2, valve F2 is used for controlling its flow, makes the effusion meter S1 flow shown in suitable scope.
Equally, oxygen chamber 30 is provided with the second air inlet and the second gas outlet, and the second air inlet is connected to oxygen tank 3, is connected and is provided with valve F3 and effusion meter S2 between its with described second air inlet by pipeline.Effusion meter S2 and valve F3 is used to independent control oxygen flow.
Adopt the QI and blood inverting chamber of the present invention, by blood being penetrated into nitrous ether (ethyl nitrite) G&O simultaneously, it is possible to significantly improve oxygen content and other Hematologic Values of blood.In order to further ensure that the quality of blood, the present invention is additionally provided with blood oxygen detection part, is used for detecting the blood oxygen saturation of the blood after QI and blood exchanges.
The blood oxygen detection part of the present invention is photo-electric blood oxygen detection, for detecting the blood oxygen saturation of the blood after QI and blood exchanges.In the preferred embodiment of the present invention, blood oxygen detection part includes LED HONGGUANG and infrared light generator 4, beam splitter 5, optical-electrical converter 7, signal amplification circuit 8 and single-chip microcomputer 9.
As shown in Figure 1, LED HONGGUANG and infrared light generator 4 include two Light-Emitting Diodes, it is the light of 660nm and 940nm that wavelength occurs respectively, the mixing of the light of just both wavelength that generator sends, mixed light is divided into the light that two bundles are identical in beam splitter, and two-beam is injected in reference cell 61 and measuring cell 62 respectively.
Two-beam be each passed through non-QI and blood exchange blood and QI and blood exchange after blood, formed two bundle transmission light.This two bundles transmission light converts two signals of telecommunication to through optical-electrical converter 7 respectively, is amplified by the said two signal of telecommunication by signal amplification circuit 8 and sends into and processes in described single-chip microcomputer 9 and analyze, before obtaining QI and blood exchange and QI and blood exchange after two groups of blood oxygen saturation data.
Certainly, the blood oxygen detection part of the present invention is not limited in above-mentioned photo-electric blood oxygen detection, can also be any known photo-electric blood oxygen detection of the prior art, or it not necessarily includes beam splitter and adopts two identical LED HONGGUANG and infrared light generator to incide reference cell and measuring cell respectively, or not necessarily there is single-chip microcomputer but be directly connected in computer and carry out data process, etc..
The QI and blood exchange adopting the present invention is blood oxygen saturation monitoring device based, ventilated membrane can be passed through first blood is penetrated into nitrous ether (ethyl nitrite) G&O simultaneously, the oxygen content of blood is improved through QI and blood exchange, and whether the blood after detecting QI and blood exchange by blood oxygen detection part reaches sufficient oxygen content, if oxygen content is not, can increase or reduce the content of nitrous ether (ethyl nitrite) and oxygen by adjusting valve, so that it is guaranteed that the quality of blood, the blood use safety for patient improves guarantee.And the photo-electric blood oxygen detection of the present invention, adopting quartz colorimetric utensil, degree of accuracy is high, highly sensitive, whole detection part simple in construction, simple, has good replicability.
Above in conjunction with accompanying drawing, embodiments of the invention are described; but the invention is not limited in above-mentioned detailed description of the invention; above-mentioned detailed description of the invention is merely schematic; rather than it is restrictive; those of ordinary skill in the art is under the enlightenment of the present invention; without departing under present inventive concept and scope of the claimed protection situation, it may also be made that a lot of form, these belong within the protection of the present invention.
Claims (7)
1. a QI and blood exchange is blood oxygen saturation monitoring device based, it is characterised in that include QI and blood inverting chamber and blood oxygen detection part；
Described QI and blood inverting chamber is separated into three chambers by two pieces of ventilated membranes, respectively centrally located blood chamber enters and carries out QI and blood exchange in the blood in described blood chamber through two ventilated membranes with laying respectively at the nitrous ether (ethyl nitrite) gaseous mixture body cavity of described blood chamber both sides, oxygen chamber, the nitrous ether (ethyl nitrite) mixing gas in described nitrous ether (ethyl nitrite) gaseous mixture body cavity and the oxygen in described oxygen chamber respectively；
Described blood oxygen detection part is photo-electric blood oxygen detection, for detecting the blood oxygen saturation of the blood after QI and blood exchanges, wherein, described blood oxygen detection part includes LED HONGGUANG and infrared light generator, beam splitter, optical-electrical converter, signal amplification circuit and single-chip microcomputer, described LED HONGGUANG and infrared light generator send the mixed light that wavelength is different respectively, described mixed light is divided into the light that two bundles are identical by described beam splitter, and be each passed through non-QI and blood exchange blood and QI and blood exchange after blood with is formed two restraint transmission light, restraint transmission light by described two and convert two signals of telecommunication to through described optical-electrical converter respectively, by described signal amplification circuit the said two signal of telecommunication amplified and send into described single-chip microcomputer and carry out processing and analyzing, obtain two groups of blood oxygen saturation data before QI and blood exchange and after QI and blood exchange.
2. device according to claim 1, it is characterized in that, described blood chamber is provided with blood entry port and blood outlet, described blood entry port connects promising described blood chamber by pipeline the blood bag of blood is provided, being provided with reference cell on the pipeline of described blood entry port, described blood oxygen detection part also detects in described reference cell not yet through the blood of QI and blood exchange.
3. device according to claim 2, it is characterized in that, described blood after QI and blood exchanges flows into human vein by flexible pipe, and described flexible pipe is provided with measuring cell, blood flows through described measuring cell, and described blood oxygen detection part detects the blood in described measuring cell after QI and blood exchanges.
4. device according to claim 3, it is characterised in that described reference cell and measuring cell all adopt quartz colorimetric utensil.
5. device according to claim 1, it is characterized in that, described nitrous ether (ethyl nitrite) gaseous mixture body cavity is provided with the first air inlet and the first gas outlet, described first air inlet is connected to high pressure nitrous ether (ethyl nitrite) mixing gas tank, between its with described first air inlet, is connected and is provided with valve and effusion meter by pipeline.
6. device according to claim 1, it is characterised in that described oxygen chamber is provided with the second air inlet and the second gas outlet, and described second air inlet is connected to oxygen tank, is connected by pipeline and is provided with valve and effusion meter between its with described second air inlet.
7. device according to claim 2, it is characterised in that be provided with the valve controlling flow on the pipeline between described blood bag and blood entry port.
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| CN201110337596.0A CN103091275B (en) | 2011-10-31 | 2011-10-31 | QI and blood exchange is blood oxygen saturation monitoring device based |
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