CN103083741B - QI and blood exchanges blood oxygen saturation monitoring device based - Google Patents
QI and blood exchanges blood oxygen saturation monitoring device based Download PDFInfo
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- CN103083741B CN103083741B CN201110341135.0A CN201110341135A CN103083741B CN 103083741 B CN103083741 B CN 103083741B CN 201110341135 A CN201110341135 A CN 201110341135A CN 103083741 B CN103083741 B CN 103083741B
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Abstract
The present invention relates to a kind of QI and blood exchanges blood oxygen saturation monitoring device based, comprises QI and blood inverting chamber and blood oxygen detection part; Described QI and blood inverting chamber is separated into three chambers by two pieces of ventilated membranes, be respectively the nitrous ether (ethyl nitrite) gaseous mixture body cavity, the oxygen chamber that are positioned at middle blood chamber and lay respectively at described blood chamber both sides, the nitrous ether (ethyl nitrite) mist in described nitrous ether (ethyl nitrite) gaseous mixture body cavity and the oxygen in described oxygen chamber enter in the blood in described blood chamber through two ventilated membranes respectively and carry out QI and blood exchange; Described blood oxygen detection part detects the blood oxygen saturation of the blood after QI and blood exchanges.QI and blood of the present invention is adopted to exchange blood oxygen saturation monitoring device based, first can infiltrate nitrous ether (ethyl nitrite) G&O to blood by ventilated membrane simultaneously, exchange through QI and blood and improve the oxygen content of blood, and whether reach sufficient oxygen content by the blood after blood oxygen detection part detects QI and blood exchange, thus guarantee the quality of blood.
Description
Technical field
The present invention relates to medical instruments field, more particularly, relate to a kind of QI and blood and exchange blood oxygen saturation monitoring device based.
Background technology
Erythrocyte (also claims blood red ball, English abbreviation RBC) deformability keeps one of microcirculation principal element of effectively pouring into, its quality not only affects the oxygen supply of organ, and RBC can be affected by destructiveness during blood capillary, the quality of impact blood transfusion, and these changes of RBC are relevant with the disappearance of nitric oxide (NO).Quantitatively nitrous ether (ethyl nitrite) gas is supplemented in blood transfusion blood, nitrosothiols (RSNO) can be formed in blood, thus release NO, not only can improve the quality of blood transfusion blood, but also the RSNO of formation and the NO of release can be made to play certain physiology's effect.
Nitrous ether (ethyl nitrite) is the congener of NO, and nitrous ether (ethyl nitrite) covalent bond, mainly with the fracture of the mode of heterolytic fission, produces NO
+, there is the biological activity of many similar NO, being easy to produce RSNO with nucleophile (polypeptide, protein mainly containing sulfydryl in organism) by turning nitro effect.
Blood oxygen saturation (SPO
2) referring to that in blood, HbO2 Oxyhemoglobin accounts for the percentage ratio of hemoglobin sum, hemoglobin becomes HbO2 Oxyhemoglobin (HbO after comprising reproducibility hemoglobin (RHb) and combination with oxygen
2).Blood oxygen saturation is one of vital sign index of human metabolism, also be the important physiological parameter of human respiratory and blood circulation diseases diagnosis, the clinical manifestation of a lot of disease all can cause the blood oxygen saturation in human body linked groups and organ to change, thus cause anoxia, even threat to life.So, improve the blood oxygen saturation of patient and effectively monitor extremely important to blood oxygen saturation.
At present, market does not also have two kinds of gases of nitrous ether (ethyl nitrite), oxygen to carry out QI and blood switch simultaneously.At present the detection method of blood oxygen saturation is mainly contained to the method for optical detection and Electrochemical Detection, sell there being complete equipment and instrument on the market, but these instrument and equipments are all directly act on tissue, inside of human body blood is carried out to the detection of hurtless measure blood oxygen saturation, when carrying out blood oxygen saturation to inside of human body and detecting, be easily subject to the interference of individual health, as beating of pulse, its hetero-organization, to the absorption etc. of light, makes measurement inaccurate.
Summary of the invention
The technical problem to be solved in the present invention is, for the above-mentioned defect of prior art, provides a kind of QI and blood to exchange blood oxygen saturation monitoring device based.
The technical solution adopted for the present invention to solve the technical problems is: construct a kind of QI and blood and exchange blood oxygen saturation monitoring device based, comprise QI and blood inverting chamber and blood oxygen detection part; Described QI and blood inverting chamber is separated into three chambers by two pieces of ventilated membranes, be respectively the nitrous ether (ethyl nitrite) gaseous mixture body cavity, the oxygen chamber that are positioned at middle blood chamber and lay respectively at described blood chamber both sides, the nitrous ether (ethyl nitrite) mist in described nitrous ether (ethyl nitrite) gaseous mixture body cavity and the oxygen in described oxygen chamber enter in the blood in described blood chamber through two ventilated membranes respectively and carry out QI and blood exchange; Described blood oxygen detection part detects the blood oxygen saturation of the blood after QI and blood exchanges.
In device of the present invention, described blood oxygen detection part comprises oximetry sensor, receive the current signal of described oximetry sensor and be processed into data signal electrochemical workstation, receive described data signal and demonstrate the computer of blood oxygen saturation information.
In device of the present invention, described oximetry sensor is Clark oxygen electrode.
In device of the present invention, described blood after QI and blood exchanges flows into human vein by flexible pipe, and described flexible pipe is provided with detection cell, and blood flows through described detection cell, and described Clark oxygen electrode inserts in described detection cell and contacting blood.
In device of the present invention, described nitrous ether (ethyl nitrite) gaseous mixture body cavity is provided with the first air inlet and the first gas outlet, described first air inlet is connected with high pressure nitrous ether (ethyl nitrite) mixing gas tank, is connected by pipeline between its with described first air inlet and is provided with valve and effusion meter.
In device of the present invention, described oxygen chamber is provided with the second air inlet and the second gas outlet, and described second air inlet is connected with oxygen tank, is connected and is provided with valve and effusion meter between its with described second air inlet by pipeline.
In device of the present invention, described blood chamber is provided with blood entry port and blood outlet, and described blood entry port connects by pipeline the blood bag that promising described blood chamber provides blood, and described blood outlet accesses human vein by flexible pipe.
In device of the present invention, the pipeline between described blood bag and blood entry port is provided with the valve controlling flow.
Implement device of the present invention, there is following beneficial effect: adopt QI and blood of the present invention to exchange blood oxygen saturation monitoring device based, first can infiltrate nitrous ether (ethyl nitrite) G&O to blood by ventilated membrane simultaneously, exchange through QI and blood and improve the oxygen content of blood, and whether reach sufficient oxygen content by the blood after blood oxygen detection part detects QI and blood exchange, if oxygen content is inadequate, increase or reduce the content of nitrous ether (ethyl nitrite) and oxygen by adjustment valve, thus guarantee the quality of blood, for the blood use safety of patient improves guarantee.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the invention will be further described, in accompanying drawing:
Fig. 1 is that the QI and blood of the preferred embodiment of the present invention exchanges blood oxygen saturation monitoring device based structural representation.
Detailed description of the invention
The present invention relates to a kind of QI and blood exchanges blood oxygen saturation monitoring device based, mainly comprises QI and blood inverting chamber and blood oxygen detection part.
As shown in Figure 1, in QI and blood inverting chamber, be provided with two pieces of ventilated membranes, be respectively the first ventilated membrane 82 and the second ventilated membrane 83.Cavity space is separated into three independently chambers by two pieces of ventilated membranes, is respectively the nitrous ether (ethyl nitrite) gaseous mixture body cavity 20, the oxygen chamber 30 that are positioned at middle blood chamber 10 and are positioned at blood chamber 10 both sides.Nitrous ether (ethyl nitrite) gaseous mixture body cavity 20 is used to accommodation nitrous ether (ethyl nitrite) mist, described nitrous ether (ethyl nitrite) mist is made up of nitrogen and nitrous ether (ethyl nitrite) gas, wherein the volume by volume concentration of nitrous ether (ethyl nitrite) gas is between 70 ~ 100ppm, and concrete content adjusts according to practical situation; What be filled with in oxygen chamber 30 is oxygen.Two kinds of gas to enter in blood chamber 10 respectively by the first ventilated membrane 82 and the second ventilated membrane 83 thus mixes with blood, carries out QI and blood exchange.And blood cannot be entered in nitrous ether (ethyl nitrite) gaseous mixture body cavity 20 and oxygen chamber 30 by ventilated membrane 82,83.
Above-mentioned ventilated membrane be a kind of gas can by and thin film that liquid cannot pass through, in prior art, right and wrong are usually shown in known, and such as cell membrane is exactly a wherein class ventilated membrane.In the present invention, ventilated membrane selects TPE (thermoplastic elastomer (TPE), ThermoplasticElastomer), and thickness, preferably between 0.05 ~ 0.15mm, is 0.1mm in the present embodiment.
Blood chamber 10 upper end is provided with blood entry port, and lower end is blood outlet.Blood entry port is connected with blood bag 1 by pipeline, is used for as blood chamber 10 provides blood.Pipeline is also provided with valve F1, is used for controlling the flow of blood.These blood may have the problems such as oxygen content is not enough, therefore need QI and blood to exchange and improve blood quality.Blood after QI and blood exchanges then flows out from blood outlet, and accessing in human vein by flexible pipe is patients with transfusion.
Nitrous ether (ethyl nitrite) gaseous mixture body cavity 20 is provided with the first air inlet and the first gas outlet, first air inlet is connected with high pressure nitrous ether (ethyl nitrite) mixing gas tank 2, be connected by pipeline between its with the first air inlet and be provided with valve F2 and effusion meter S1, effusion meter S1 is used for monitoring the flow of nitrous ether (ethyl nitrite) mist of release from high pressure gas holder 2, valve F2 is used for controlling its flow, and the flow that effusion meter S1 is shown is in suitable scope.
Equally, oxygen chamber 30 is provided with the second air inlet and the second gas outlet, the second air inlet is connected with oxygen tank 3, is connected and is provided with valve F3 and effusion meter S2 between its with described second air inlet by pipeline.Effusion meter S2 and valve F3 is used to independent control oxygen flow.
Adopt QI and blood inverting chamber of the present invention, by infiltrating nitrous ether (ethyl nitrite) G&O to blood simultaneously, oxygen content and other Hematologic Values of blood can be significantly improved.In order to guarantee the quality of blood further, the present invention is also provided with blood oxygen detection part, is used for detecting the blood oxygen saturation of blood after QI and blood exchanges.
As shown in Figure 1, the blood oxygen detection part of the present embodiment comprise oximetry sensor, receive the current signal of described oximetry sensor and be processed into data signal electrochemical workstation 6, receive described data signal and demonstrate the computer 7 of blood oxygen saturation information.
Oximetry sensor comprises a variety of, and according to known prior art, comprise finger cot type sensor probe, photoelectric sensor etc., oximetry sensor of the present invention is preferably Clark oxygen electrode 5.Different from common photoelectric sensor, Clark oxygen electrode 5 measures the Hb oxygen saturation in blood oxygen, and photoelectric sensor measures partial pressure of oxygen, and therefore the former measurement result is more accurate.
As shown in Figure 1, the blood outlet of blood chamber is connected with flexible pipe, flexible pipe is provided with detection cell 4, blood flows through described detection cell 4, Clark oxygen electrode 5 and inserts in described detection cell 4 and contacting blood.There is redox cycle reaction on Clark oxygen electrode 5 surface, cause the variable quantity of electric current and Hb oxygen saturation linear within the specific limits, can be used for the blood oxygen saturation of mensuration blood.Detect the current signal obtained through Clark oxygen electrode 5, receive post processing through electrochemical workstation 6 and become data signal, and export to computer 7 and process and demonstrate blood oxygen saturation information with certain form.
Certainly, blood oxygen detection part of the present invention is not limited in the above-mentioned parts based on Clark oxygen electrode 5, also any equipment, instrument and parts for measuring blood oxygen saturation of the prior art, such as art pO2 measuring instrument, real non-destructive hinder percutaneous oxygen pressure measuring instrument, photoelectric measuring instrument, pulse formula blood oxygen measuring device etc.
QI and blood of the present invention is adopted to exchange blood oxygen saturation monitoring device based, first can infiltrate nitrous ether (ethyl nitrite) G&O to blood by ventilated membrane simultaneously, exchange through QI and blood and improve the oxygen content of blood, and whether reach sufficient oxygen content by the blood after blood oxygen detection part detects QI and blood exchange, if oxygen content is inadequate, increase or reduce the content of nitrous ether (ethyl nitrite) and oxygen by adjustment valve, thus guarantee the quality of blood, for the blood use safety of patient improves guarantee.
By reference to the accompanying drawings embodiments of the invention are described above; but the present invention is not limited to above-mentioned detailed description of the invention; above-mentioned detailed description of the invention is only schematic; instead of it is restrictive; those of ordinary skill in the art is under enlightenment of the present invention; do not departing under the ambit that present inventive concept and claim protects, also can make a lot of form, these all belong within protection of the present invention.
Claims (7)
1. a QI and blood exchanges blood oxygen saturation monitoring device based, it is characterized in that, comprises QI and blood inverting chamber and blood oxygen detection part;
Described QI and blood inverting chamber is separated into three chambers by two pieces of ventilated membranes, be respectively the nitrous ether (ethyl nitrite) gaseous mixture body cavity, the oxygen chamber that are positioned at middle blood chamber and lay respectively at described blood chamber both sides, the nitrous ether (ethyl nitrite) mist in described nitrous ether (ethyl nitrite) gaseous mixture body cavity and the oxygen in described oxygen chamber enter in the blood in described blood chamber through two ventilated membranes respectively and carry out QI and blood exchange;
Described blood oxygen detection part detects the blood oxygen saturation of the blood after QI and blood exchanges, described blood oxygen detection part comprises oximetry sensor, receive the current signal of described oximetry sensor and be processed into data signal electrochemical workstation, receive described data signal and demonstrate the computer of blood oxygen saturation information.
2. device according to claim 1, is characterized in that, described oximetry sensor is Clark oxygen electrode.
3. device according to claim 2, it is characterized in that, described blood after QI and blood exchanges flows into human vein by flexible pipe, and described flexible pipe is provided with detection cell, blood flows through described detection cell, and described Clark oxygen electrode inserts in described detection cell and contacting blood.
4. device according to claim 1, it is characterized in that, described nitrous ether (ethyl nitrite) gaseous mixture body cavity is provided with the first air inlet and the first gas outlet, described first air inlet is connected with high pressure nitrous ether (ethyl nitrite) mixing gas tank, is connected by pipeline between its with described first air inlet and is provided with valve and effusion meter.
5. device according to claim 1, it is characterized in that, described oxygen chamber is provided with the second air inlet and the second gas outlet, and described second air inlet is connected with oxygen tank, is connected and is provided with valve and effusion meter between its with described second air inlet by pipeline.
6. device according to claim 1, it is characterized in that, described blood chamber is provided with blood entry port and blood outlet, and described blood entry port connects by pipeline the blood bag that promising described blood chamber provides blood, and described blood outlet accesses human vein by flexible pipe.
7. device according to claim 6, is characterized in that, the pipeline between described blood bag and blood entry port is provided with the valve controlling flow.
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| CN201110341135.0A CN103083741B (en) | 2011-11-02 | 2011-11-02 | QI and blood exchanges blood oxygen saturation monitoring device based |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110341135.0A CN103083741B (en) | 2011-11-02 | 2011-11-02 | QI and blood exchanges blood oxygen saturation monitoring device based |
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| CN103083741A CN103083741A (en) | 2013-05-08 |
| CN103083741B true CN103083741B (en) | 2016-03-09 |
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| CN103293125B (en) * | 2012-02-29 | 2016-12-14 | 深圳光启创新技术有限公司 | Detection device of ethyl nitrite gas-blood exchange rate |
| CN108205005A (en) * | 2018-01-03 | 2018-06-26 | 南通大学 | A kind of evaluating blood and its measuring method and measuring device of the total oxygen carrying content of substitute and oxygen saturation |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2730381Y (en) * | 2004-06-11 | 2005-10-05 | 朱永锋 | Oxygenation blood transfusion apparatus |
| GB2437254A (en) * | 2006-04-13 | 2007-10-24 | Haemair Ltd | Blood air mass exchange apparatus |
| CN201220008Y (en) * | 2007-12-10 | 2009-04-15 | 西安西京医疗用品有限公司 | Integral membrane oxygenator |
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2011
- 2011-11-02 CN CN201110341135.0A patent/CN103083741B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2730381Y (en) * | 2004-06-11 | 2005-10-05 | 朱永锋 | Oxygenation blood transfusion apparatus |
| GB2437254A (en) * | 2006-04-13 | 2007-10-24 | Haemair Ltd | Blood air mass exchange apparatus |
| CN201220008Y (en) * | 2007-12-10 | 2009-04-15 | 西安西京医疗用品有限公司 | Integral membrane oxygenator |
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Effective date of registration: 20201116 Address after: 226600 No. 16 Garden Avenue, Haian Industrial Park, Haian City, Nantong City, Jiangsu Province Patentee after: JIANGSU SANHE BIOENGINEERING Co.,Ltd. Address before: 518057, No. 9 software building, central high tech Zone, Nanshan District hi tech Zone, Guangdong, Shenzhen Patentee before: KUANG-CHI INSTITUTE OF ADVANCED TECHNOLOGY Patentee before: KUANG-CHI INNOVATIVE TECHNOLOGY Ltd. |