CN103083741A - Gas and blood exchange blood oxygen saturation monitoring device - Google Patents
Gas and blood exchange blood oxygen saturation monitoring device Download PDFInfo
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- CN103083741A CN103083741A CN 201110341135 CN201110341135A CN103083741A CN 103083741 A CN103083741 A CN 103083741A CN 201110341135 CN201110341135 CN 201110341135 CN 201110341135 A CN201110341135 A CN 201110341135A CN 103083741 A CN103083741 A CN 103083741A
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Abstract
The invention relates to a gas and blood exchange blood oxygen saturation monitoring device which comprises a gas and blood exchange cavity and a blood oxygen detection assembly. The gas and blood exchange cavity is divided into three cavities by two gas permeable membranes, the three cavities include a blood cavity, an ethyl nitrite mixed gas cavity and an oxygen cavity, the blood cavity is positioned in the middle of the gas and blood exchange cavity, the ethyl nitrite mixed gas cavity and the oxygen cavity are respectively positioned on two sides of the blood cavity, and ethyl nitrite mixed gas in the ethyl nitrite mixed gas cavity and oxygen in the oxygen cavity are filled into blood in the blood cavity via the two gas permeable membranes, so that gas and blood exchange can be carried out; and the blood oxygen detection assembly detects the blood oxygen saturation of blood after the blood is subjected to gas and blood exchange. The gas and blood exchange blood oxygen saturation monitoring device has the advantages that ethyl nitrite gas and the oxygen can simultaneously permeate into the blood via the gas permeable membranes in advance, the oxygen content of the blood is improved after the blood is subjected to gas and blood exchange, the blood oxygen detection assembly detects whether the oxygen content of the blood is sufficient or not after the blood is subjected to gas and oxygen exchange, and accordingly the quality of the blood is guaranteed.
Description
Technical field
The present invention relates to medical instruments field, more particularly, relate to a kind of QI and blood exchange blood oxygen saturation monitoring device based.
Background technology
Erythrocyte (also claims blood red ball, the English RBC of abbreviation) deformability is one of principal element that keeps the effective perfusion of microcirculation, its quality not only affects the oxygen supply of organ, and can affect the destructiveness of RBC when the blood capillary, the quality of impact blood transfusion, and these variations of RBC are relevant with the disappearance of nitric oxide (NO).Quantitatively replenish nitrous ether (ethyl nitrite) gas in blood transfusion blood, can form nitrosothiols (RSNO) in blood, thereby discharge NO, not only can improve the quality of blood transfusion blood, but also can make the RSNO of formation and the certain physiology's effect of NO performance of release.
Nitrous ether (ethyl nitrite) is the congener of NO, and the nitrous ether (ethyl nitrite) covalent bond mainly with the fracture of the mode of heterolytic fission, produces NO
+, have the biological activity of many similar NO, be easy to produce RSNO with nucleophile (being mainly polypeptide, the protein that contains sulfydryl in organism) by turning the nitro effect.
Blood oxygen saturation (SPO
2) referring to that HbO2 Oxyhemoglobin in blood accounts for the percentage ratio of hemoglobin sum, hemoglobin becomes HbO2 Oxyhemoglobin (HbO after comprising reproducibility hemoglobin (RHb) and combination with oxygen
2).Blood oxygen saturation is one of metabolic vital sign index of human body, it is also the important physiological parameter of human respiratory and blood circulation diseases diagnosis, the clinical manifestation of a lot of diseases can cause that all the blood oxygen saturation in human body linked groups and organ changes, thereby cause anoxia, even threat to life.So, improve patient's blood oxygen saturation and effectively monitor extremely important to blood oxygen saturation.
At present, also do not have two kinds of gases of nitrous ether (ethyl nitrite), oxygen to carry out simultaneously the QI and blood switch on market.At present the detection method of blood oxygen saturation is mainly contained the method for optical detection and Electrochemical Detection, complete equipment and instrument sale is being arranged on the market, but these instrument and equipments are all to directly act on tissue, inside of human body blood is carried out the detection of noinvasive blood trouble oxygen saturation, when inside of human body being carried out the blood oxygen saturation detection, easily be subject to the interference of individual health, as beating of pulse, its hetero-organization is to Optical Absorption etc., make measure inaccurate.
Summary of the invention
The technical problem to be solved in the present invention is, for the defects of prior art, provides a kind of QI and blood exchange blood oxygen saturation monitoring device based.
The technical solution adopted for the present invention to solve the technical problems is: it is blood oxygen saturation monitoring device based to construct the exchange of a kind of QI and blood, comprises QI and blood inverting chamber and blood oxygen detection part; Described QI and blood inverting chamber is separated into three chambers by two ventilated membranes, be respectively the blood chamber in the middle of being positioned at and lay respectively at nitrous ether (ethyl nitrite) gaseous mixture body cavity, the oxygen chamber of described blood chamber both sides, the oxygen in the nitrous ether (ethyl nitrite) mist in described nitrous ether (ethyl nitrite) gaseous mixture body cavity and described oxygen chamber sees through two ventilated membranes respectively and enters and carry out the QI and blood exchange in blood in described blood chamber; Described blood oxygen detection part detects the blood oxygen saturation through the blood after the QI and blood exchange.
In device of the present invention, described blood oxygen detection part comprises oximetry sensor, receives the current signal of described oximetry sensor and is processed into electrochemical workstation, the described data signal of reception of data signal and demonstrate the computer of blood oxygen saturation information.
In device of the present invention, described oximetry sensor is the Clark oxygen electrode.
In device of the present invention, the blood after the exchange of described process QI and blood flows into human vein by flexible pipe, is provided with detection cell on described flexible pipe, and blood flow is through described detection cell, and described Clark oxygen electrode inserts in described detection cell and contacts with blood.
In device of the present invention, described nitrous ether (ethyl nitrite) gaseous mixture body cavity is provided with the first air inlet and the first gas outlet, be connected with high pressure nitrous ether (ethyl nitrite) mixing gas tank on described the first air inlet, its with described the first air inlet between be connected and be provided with valve and effusion meter by pipeline.
In device of the present invention, described oxygen chamber is provided with the second air inlet and the second gas outlet, is connected with oxygen tank on described the second air inlet, its with described the second air inlet between be connected and be provided with valve and effusion meter by pipeline.
In device of the present invention, described blood chamber is provided with blood entrance and blood outlet, connects by pipeline the blood bag that promising described blood chamber provides blood on described blood entrance, and described blood outlet accesses human vein by flexible pipe.
In device of the present invention, be provided with the valve of controlling flow on the pipeline between described blood bag and blood entrance.
Implement device of the present invention, has following beneficial effect: adopt QI and blood exchange of the present invention blood oxygen saturation monitoring device based, can first infiltrate simultaneously the nitrous ether (ethyl nitrite) G﹠O to blood by ventilated membrane, improve the oxygen content of blood through the QI and blood exchange, and whether the blood that detects after QI and blood exchanges by blood oxygen detection part reaches sufficient oxygen content, if oxygen content not can increase or reduce by adjusting valve the content of nitrous ether (ethyl nitrite) and oxygen, thereby guarantee the quality of blood, be patient's blood use safety raising guarantee.
Description of drawings
The invention will be further described below in conjunction with drawings and Examples, in accompanying drawing:
Fig. 1 is the blood oxygen saturation monitoring device based structural representation of QI and blood exchange of the preferred embodiment of the present invention.
The specific embodiment
The present invention relates to a kind of QI and blood exchange blood oxygen saturation monitoring device based, mainly comprise QI and blood inverting chamber and blood oxygen detection part.
As shown in Figure 1, be provided with two ventilated membranes in the QI and blood inverting chamber, be respectively the first ventilated membrane 82 and the second ventilated membrane 83.Two ventilated membranes are separated into three independently chambers with cavity space, are respectively the blood chamber 10 in the middle of being positioned at and are positioned at nitrous ether (ethyl nitrite) gaseous mixture body cavity 20, the oxygen chamber 30 of blood chamber 10 both sides.Nitrous ether (ethyl nitrite) gaseous mixture body cavity 20 is used for holding the nitrous ether (ethyl nitrite) mist, described nitrous ether (ethyl nitrite) mist is to be made of nitrogen and nitrous ether (ethyl nitrite) gas, wherein the volume by volume concentration of nitrous ether (ethyl nitrite) gas is between 70～100ppm, and concrete content is adjusted according to practical situation; What be filled with in oxygen chamber 30 is oxygen.Thereby two kinds of gases enter in blood chamber 10 by the first ventilated membrane 82 and the second ventilated membrane 83 respectively and mix with blood, carry out the QI and blood exchange.And blood can't enter in nitrous ether (ethyl nitrite) gaseous mixture body cavity 20 and oxygen chamber 30 by ventilated membrane 82,83.
Above-mentioned ventilated membrane be a kind of gas can by and thin film that liquid can't pass through, in prior art, right and wrong are usually seen with known, for example cell membrane is exactly a class ventilated membrane wherein.In the present invention, ventilated membrane is selected TPE (thermoplastic elastomer (TPE), Thermoplastic Elastomer), and thickness between 0.05～0.15mm, is preferably 0.1mm in the present embodiment.
Nitrous ether (ethyl nitrite) gaseous mixture body cavity 20 is provided with the first air inlet and the first gas outlet, be connected with high pressure nitrous ether (ethyl nitrite) mixing gas tank 2 on the first air inlet, its with the first air inlet between be connected and be provided with valve F2 and effusion meter S1 by pipeline, effusion meter S1 is used for monitoring the flow of the nitrous ether (ethyl nitrite) mist that discharges from high pressure gas holder 2, valve F2 is used for controlling its flow, makes the flow of effusion meter S1 demonstration in suitable scope.
Equally, oxygen chamber 30 is provided with the second air inlet and the second gas outlet, is connected with oxygen tank 3 on the second air inlet, its with described the second air inlet between be connected and be provided with valve F3 and effusion meter S2 by pipeline.Effusion meter S2 and valve F3 are used for the independent oxygen flow of controlling.
Adopt QI and blood inverting chamber of the present invention, by simultaneously blood being infiltrated the nitrous ether (ethyl nitrite) G﹠O, can significantly improve oxygen content and other Hematologic Values of blood.In order further to guarantee the quality of blood, the present invention also is provided with blood oxygen detection part, is used for detecting the blood oxygen saturation through the blood after the QI and blood exchange.
As shown in Figure 1, the blood oxygen detection part of the present embodiment comprises oximetry sensor, receives the current signal of described oximetry sensor and is processed into electrochemical workstation 6, the described data signal of reception of data signal and demonstrate the computer 7 of blood oxygen saturation information.
Oximetry sensor comprises a variety of, according to known prior art, comprises finger cot type sensor probe, photoelectric sensor etc., and oximetry sensor of the present invention is preferably Clark oxygen electrode 5.Different from common photoelectric sensor, Clark oxygen electrode 5 is Hb oxygen saturations of measuring in blood oxygen, and photoelectric sensor is to measure partial pressure of oxygen, so the former measurement result is more accurate.
As shown in Figure 1, be connected with flexible pipe in the blood outlet of blood chamber, be provided with detection cell 4 on flexible pipe, blood flow is through described detection cell 4, and Clark oxygen electrode 5 inserts in described detection cell 4 and contacts with blood.In the 5 surface generation redox cycle reactions of Clark oxygen electrode, cause that the variable quantity of electric current and Hb oxygen saturation are linear within the specific limits, can be used for measuring the blood oxygen saturation of blood.Survey through Clark oxygen electrode 5 current signal that obtains, receive post processing through electrochemical workstation 6 and become data signal, and export to computer 7 and process and demonstrate blood oxygen saturation information with certain form.
Certainly, blood oxygen detection part of the present invention is not limited in above-mentioned parts based on Clark oxygen electrode 5, also any equipment, instrument and parts for measuring blood oxygen saturation of the prior art, hinder percutaneous oxygen such as art pO2 measuring instrument, real non-destructive and press measuring instrument, photoelectric measuring instrument, pulse formula blood oxygen measuring device etc.
Adopt QI and blood exchange of the present invention blood oxygen saturation monitoring device based, can first infiltrate simultaneously the nitrous ether (ethyl nitrite) G﹠O to blood by ventilated membrane, improve the oxygen content of blood through the QI and blood exchange, and whether the blood that detects after QI and blood exchanges by blood oxygen detection part reaches sufficient oxygen content, if oxygen content not can increase or reduce by adjusting valve the content of nitrous ether (ethyl nitrite) and oxygen, thereby guarantee the quality of blood, be patient's blood use safety raising guarantee.
The above is described embodiments of the invention by reference to the accompanying drawings; but the present invention is not limited to the above-mentioned specific embodiment; the above-mentioned specific embodiment is only schematic; rather than restrictive; those of ordinary skill in the art is under enlightenment of the present invention; not breaking away from the scope situation that aim of the present invention and claim protects, also can make a lot of forms, within these all belong to protection of the present invention.
Claims (8)
1. a QI and blood exchange is blood oxygen saturation monitoring device based, it is characterized in that, comprises QI and blood inverting chamber and blood oxygen detection part;
Described QI and blood inverting chamber is separated into three chambers by two ventilated membranes, be respectively the blood chamber in the middle of being positioned at and lay respectively at nitrous ether (ethyl nitrite) gaseous mixture body cavity, the oxygen chamber of described blood chamber both sides, the oxygen in the nitrous ether (ethyl nitrite) mist in described nitrous ether (ethyl nitrite) gaseous mixture body cavity and described oxygen chamber sees through two ventilated membranes respectively and enters and carry out the QI and blood exchange in blood in described blood chamber;
Described blood oxygen detection part detects the blood oxygen saturation through the blood after the QI and blood exchange.
2. device according to claim 1, it is characterized in that, described blood oxygen detection part comprises oximetry sensor, receives the current signal of described oximetry sensor and is processed into electrochemical workstation, the described data signal of reception of data signal and demonstrate the computer of blood oxygen saturation information.
3. device according to claim 2, is characterized in that, described oximetry sensor is the Clark oxygen electrode.
4. device according to claim 3, it is characterized in that, the blood after the exchange of described process QI and blood flows into human vein by flexible pipe, is provided with detection cell on described flexible pipe, blood flow is through described detection cell, and described Clark oxygen electrode inserts in described detection cell and contacts with blood.
5. device according to claim 1, it is characterized in that, described nitrous ether (ethyl nitrite) gaseous mixture body cavity is provided with the first air inlet and the first gas outlet, be connected with high pressure nitrous ether (ethyl nitrite) mixing gas tank on described the first air inlet, its with described the first air inlet between be connected and be provided with valve and effusion meter by pipeline.
6. device according to claim 1, it is characterized in that, described oxygen chamber is provided with the second air inlet and the second gas outlet, is connected with oxygen tank on described the second air inlet, its with described the second air inlet between be connected and be provided with valve and effusion meter by pipeline.
7. device according to claim 1, it is characterized in that, described blood chamber is provided with blood entrance and blood outlet, connects by pipeline the blood bag that promising described blood chamber provides blood on described blood entrance, and described blood outlet accesses human vein by flexible pipe.
8. device according to claim 7, is characterized in that, is provided with the valve of controlling flow on the pipeline between described blood bag and blood entrance.
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| CN201110341135.0A CN103083741B (en) | 2011-11-02 | 2011-11-02 | QI and blood exchanges blood oxygen saturation monitoring device based |
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| CN201110341135.0A CN103083741B (en) | 2011-11-02 | 2011-11-02 | QI and blood exchanges blood oxygen saturation monitoring device based |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103293125A (en) * | 2012-02-29 | 2013-09-11 | 深圳光启创新技术有限公司 | Detecting device for gas-blood exchange rate of ethyl nitrite |
| CN108205005A (en) * | 2018-01-03 | 2018-06-26 | 南通大学 | A kind of evaluating blood and its measuring method and measuring device of the total oxygen carrying content of substitute and oxygen saturation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2730381Y (en) * | 2004-06-11 | 2005-10-05 | 朱永锋 | Oxygenation blood transfusion apparatus |
| GB2437254B (en) * | 2006-04-13 | 2010-11-17 | Haemair Ltd | Blood/air mass exchange apparatus |
| CN201220008Y (en) * | 2007-12-10 | 2009-04-15 | 西安西京医疗用品有限公司 | Integral membrane oxygenator |
-
2011
- 2011-11-02 CN CN201110341135.0A patent/CN103083741B/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103293125A (en) * | 2012-02-29 | 2013-09-11 | 深圳光启创新技术有限公司 | Detecting device for gas-blood exchange rate of ethyl nitrite |
| CN108205005A (en) * | 2018-01-03 | 2018-06-26 | 南通大学 | A kind of evaluating blood and its measuring method and measuring device of the total oxygen carrying content of substitute and oxygen saturation |
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| CN103083741B (en) | 2016-03-09 |
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Effective date of registration: 20201116 Address after: 226600 No. 16 Garden Avenue, Haian Industrial Park, Haian City, Nantong City, Jiangsu Province Patentee after: JIANGSU SANHE BIOENGINEERING Co.,Ltd. Address before: 518057, No. 9 software building, central high tech Zone, Nanshan District hi tech Zone, Guangdong, Shenzhen Patentee before: KUANG-CHI INSTITUTE OF ADVANCED TECHNOLOGY Patentee before: KUANG-CHI INNOVATIVE TECHNOLOGY Ltd. |
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