CN103091275A - Qi-blood exchange blood oxygen saturation monitoring device - Google Patents

Qi-blood exchange blood oxygen saturation monitoring device Download PDF

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Publication number
CN103091275A
CN103091275A CN2011103375960A CN201110337596A CN103091275A CN 103091275 A CN103091275 A CN 103091275A CN 2011103375960 A CN2011103375960 A CN 2011103375960A CN 201110337596 A CN201110337596 A CN 201110337596A CN 103091275 A CN103091275 A CN 103091275A
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blood
oxygen
exchange
chamber
ethyl nitrite
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CN2011103375960A
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CN103091275B (en
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刘若鹏
徐冠雄
王文剑
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JIANGSU SANHE BIOENGINEERING Co.,Ltd.
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Kuang Chi Institute of Advanced Technology
Kuang Chi Innovative Technology Ltd
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Abstract

The invention relates to a qi-blood exchange blood oxygen saturation monitoring device. The device comprises a qi-blood exchange chamber and a blood oxygen detection part; the qi-blood exchange chamber is divided into three cavities by two gas-permeable films, the three cavities comprise a blood cavity positioned in the middle and an ethyl nitrite mixed gas cavity and an oxygen cavity which are positioned at two sides of the blood cavity respectively, and an ethyl nitrite mixed gas in the ethyl nitrite mixed gas cavity and oxygen in the oxygen cavity respectively permeate the two gas-permeable films and enter blood in the blood cavity for qi-blood exchange; and the blood oxygen detection part is a photoelectric blood oxygen detector and is used for detecting the blood oxygen saturation of the blood after the qi-blood exchange. The qi-blood exchange is carried out by permeating the gas-permeable films through adopting the device in order to improve the oxygen content of the blood; whether the exchanged blood has a full oxygen content or not is detected through the blood oxygen detection part; and the adoption of the photoelectric blood oxygen detector enables the accuracy to be high and the blood oxygen detection accuracy to be improved.

Description

The qi and blood exchange is blood oxygen saturation monitoring device based
Technical field
The present invention relates to medical instruments field, more particularly, relate to a kind of qi and blood exchange blood oxygen saturation monitoring device based.
Background technology
Red blood cell (also claims blood red ball, the English RBC of abbreviation) deformability is one of principal element that keeps the effective perfusion of microcirculation, its quality not only affects the oxygen supply of organ, and can affect the destructiveness of RBC when the capillary, the quality of impact blood transfusion, and these variations of RBC are relevant with the disappearance of nitrogen monoxide (NO).Quantitatively replenish nitrous ether (ethyl nitrite) gas in blood transfusion blood, can form nitrosothiols (RSNO) in blood, thereby discharge NO, not only can improve the quality of blood transfusion blood, but also can make the RSNO of formation and the certain physiology effect of NO performance of release.
Nitrous ether (ethyl nitrite) is the congener of NO, and the nitrous ether (ethyl nitrite) covalent bond mainly with the fracture of the mode of heterolytic fission, produces NO +, have the biologically active of many similar NO, be easy to produce RSNO with nucleophile (being mainly polypeptide, the protein that contains sulfydryl in biosome) by turning the nitro effect.
Blood oxygen saturation (SPO 2) referring to that oxyhemoglobin in blood accounts for the number percent of haemoglobin sum, haemoglobin becomes oxyhemoglobin (HbO after comprising reductibility haemoglobin (RHb) and combination with oxygen 2).Blood oxygen saturation is one of metabolic vital sign index of human body, it is also the important physiological parameter of human respiratory and circulation system disease diagnosis, the clinical manifestation of a lot of diseases can cause that all the blood oxygen saturation in human body linked groups and organ changes, thereby cause anoxic, even threat to life.So, improve patient's blood oxygen saturation and effectively monitor extremely important to blood oxygen saturation.
At present, also do not have two kinds of gases of nitrous ether (ethyl nitrite), oxygen to carry out simultaneously the qi and blood switch on market.At present the detection method of blood oxygen saturation is mainly contained the method for optical detection and Electrochemical Detection, complete equipment and instrument sale is being arranged on the market, but these instrument and equipments are all to directly act on tissue, inside of human body blood is carried out detection without the wound blood oxygen saturation, when inside of human body being carried out the blood oxygen saturation detection, easily be subject to the interference of individual health, as beating of pulse, its hetero-organization is to Optical Absorption etc., make measure inaccurate.
Summary of the invention
The technical problem to be solved in the present invention is, for the defects of prior art, provides a kind of qi and blood exchange blood oxygen saturation monitoring device based.
The technical solution adopted for the present invention to solve the technical problems is: it is blood oxygen saturation monitoring device based to construct the exchange of a kind of qi and blood, comprises qi and blood inverting chamber and blood oxygen detection part; Described qi and blood inverting chamber is separated into three chambers by two ventilated membranes, be respectively the blood chamber in the middle of being positioned at and lay respectively at nitrous ether (ethyl nitrite) combination gas body cavity, the oxygen chamber of described blood chamber both sides, the oxygen in the nitrous ether (ethyl nitrite) mixed gas in described nitrous ether (ethyl nitrite) combination gas body cavity and described oxygen chamber sees through two ventilated membranes respectively and enters and carry out the qi and blood exchange in blood in described blood chamber; Described blood oxygen detection part is photo-electric blood oxygen detection, for detection of the blood oxygen saturation through the blood after the qi and blood exchange.
In device of the present invention, described blood chamber is provided with blood entrance and blood outlet, connect by pipeline the blood bag that promising described blood chamber provides blood on described blood entrance, be provided with reference cell on the pipeline of described blood entrance, described blood oxygen detection part also detects the blood that not yet exchanges through qi and blood in described reference cell.
In device of the present invention, blood after the exchange of described process qi and blood flows into human vein by flexible pipe, be provided with measuring cell on described flexible pipe, blood flow is through described measuring cell, and described blood oxygen detection part detects in described measuring cell through the blood after the qi and blood exchange.
In device of the present invention, described reference cell and measuring cell all adopt quartz colorimetric utensil.
In device of the present invention, described blood oxygen detection part comprises LED ruddiness and infrared light generator, optical splitter, photoelectric commutator, signal amplification circuit and single-chip microcomputer.
In device of the present invention, described LED ruddiness and infrared light generator comprise two light emitting diodes, the light that wavelength is 660nm and 940nm occurs respectively, and the formed mixed light of the light of two kinds of wavelength is divided into the identical light of two bundles and injects respectively in described reference cell and measuring cell in described optical splitter.
In device of the present invention, described photoelectric commutator converts the light that two bundles see through respectively described reference cell and measuring cell to two electric signal, described signal amplification circuit amplifies described two electric signal and sends into and process in described single-chip microcomputer and analyze, and obtains two groups of blood oxygen saturation data after qi and blood exchanges front and qi and blood exchange.
In device of the present invention, described nitrous ether (ethyl nitrite) combination gas body cavity is provided with the first air intake opening and the first gas outlet, be connected with high pressure nitrous ether (ethyl nitrite) mixing gas tank on described the first air intake opening, its with described the first air intake opening between be connected and be provided with valve and flowmeter by pipeline.
In device of the present invention, described oxygen chamber is provided with the second air intake opening and the second gas outlet, is connected with oxygen tank on described the second air intake opening, its with described the second air intake opening between be connected and be provided with valve and flowmeter by pipeline.
In device of the present invention, be provided with the valve of controlling flow on the pipeline between described blood bag and blood entrance.
Implement device of the present invention, has following beneficial effect: adopt qi and blood exchange of the present invention blood oxygen saturation monitoring device based, can first infiltrate simultaneously the nitrous ether (ethyl nitrite) G﹠O to blood by ventilated membrane, improve the oxygen level of blood through the qi and blood exchange, and whether the blood that detects after qi and blood exchanges by blood oxygen detection part reaches sufficient oxygen level, if oxygen level not can increase or reduce by adjusting valve the content of nitrous ether (ethyl nitrite) and oxygen, thereby guarantee the quality of blood, for patient's blood use safety provides safeguard; And adopt photo-electric blood oxygen detection, have advantages of degree of accuracy and highly sensitive, as to have eliminated human detection external factor disturb, simple and easy to do.
Description of drawings
The invention will be further described below in conjunction with drawings and Examples, in accompanying drawing:
Fig. 1 is the blood oxygen saturation monitoring device based structural representation of qi and blood exchange of the preferred embodiment of the present invention.
Embodiment
The present invention relates to a kind of qi and blood exchange blood oxygen saturation monitoring device based, mainly comprise qi and blood inverting chamber and blood oxygen detection part.
As shown in Figure 1, be provided with two ventilated membranes in the qi and blood inverting chamber, be respectively the first ventilated membrane 82 and the second ventilated membrane 83.Two ventilated membranes are separated into three independently chambers with cavity space, are respectively the blood chamber 10 in the middle of being positioned at and are positioned at nitrous ether (ethyl nitrite) combination gas body cavity 20, the oxygen chamber 30 of blood chamber 10 both sides.Nitrous ether (ethyl nitrite) combination gas body cavity 20 is used for holding the nitrous ether (ethyl nitrite) mixed gas, described nitrous ether (ethyl nitrite) mixed gas is to be made of nitrogen and nitrous ether (ethyl nitrite) gas, wherein the volume by volume concentration of nitrous ether (ethyl nitrite) gas is between 70~100ppm, and concrete content is adjusted according to actual conditions; What be filled with in oxygen chamber 30 is oxygen.Thereby two kinds of gases enter in blood chamber 10 by the first ventilated membrane 82 and the second ventilated membrane 83 respectively and mix with blood, carry out the qi and blood exchange.And blood can't enter in nitrous ether (ethyl nitrite) combination gas body cavity 20 and oxygen chamber 30 by ventilated membrane 82,83.
Above-mentioned ventilated membrane be a kind of gas can by and film that liquid can't pass through, in prior art, right and wrong are usually seen with known, for example cell membrane is exactly a class ventilated membrane wherein.In the present invention, ventilated membrane is selected TPE (thermoplastic elastomer, Thermoplastic Elastomer), and thickness between 0.05~0.15mm, is preferably 0.1mm in the present embodiment.
Blood chamber 10 upper ends are provided with the blood entrance, and the lower end is the blood outlet.Be connected with blood bag 1 by pipeline on the blood entrance, be used for providing blood for blood chamber 10.Also be provided with valve F1 on pipeline, be used for controlling the flow of blood.Blood in blood bag 1 may by problems such as oxygen level deficiencies, therefore need qi and blood to exchange to improve blood quality.Flow out from the blood outlet through the blood after the qi and blood exchange, accessing in human vein by flexible pipe is patients with transfusion.
Be provided with reference cell 61 on the pipeline that is connected between blood entrance and blood bag 1, blood flows through from reference cell 61, and reference cell 61 selects the high material of penetrability to make, preferred quartz colorimetric utensil in the present invention.The blood outlet flows into human vein by flexible pipe, is provided with measuring cell 62 on described flexible pipe, and blood flow is through measuring cell 62, and measuring cell 62 also will select the high material of penetrability to make, the same quartz colorimetric utensil of selecting in the present embodiment.Reference cell 61 and measuring cell 62 arrange in order to facilitate blood oxygen detection part to detect blood oxygen saturation, both can be arranged on and make one in a container, become a detection cell 6.
Nitrous ether (ethyl nitrite) combination gas body cavity 20 is provided with the first air intake opening and the first gas outlet, be connected with high pressure nitrous ether (ethyl nitrite) mixing gas tank 2 on the first air intake opening, its with the first air intake opening between be connected and be provided with valve F2 and flowmeter S1 by pipeline, flowmeter S1 is used for monitoring the flow of the nitrous ether (ethyl nitrite) mixed gas that discharges from high pressure gas holder 2, valve F2 is used for controlling its flow, makes the flow of flowmeter S1 demonstration in suitable scope.
Equally, oxygen chamber 30 is provided with the second air intake opening and the second gas outlet, is connected with oxygen tank 3 on the second air intake opening, its with described the second air intake opening between be connected and be provided with valve F3 and flowmeter S2 by pipeline.Flowmeter S2 and valve F3 are used for the independent oxygen flow of controlling.
Adopt qi and blood inverting chamber of the present invention, by simultaneously blood being infiltrated the nitrous ether (ethyl nitrite) G﹠O, can significantly improve oxygen level and other Hematologic Values of blood.In order further to guarantee the quality of blood, the present invention also is provided with blood oxygen detection part, is used for detecting the blood oxygen saturation through the blood after the qi and blood exchange.
Blood oxygen detection part of the present invention is photo-electric blood oxygen detection, for detection of the blood oxygen saturation through the blood after the qi and blood exchange.In the preferred embodiment of the present invention, blood oxygen detection part comprises LED ruddiness and infrared light generator 4, optical splitter 5, photoelectric commutator 7, signal amplification circuit 8 and single-chip microcomputer 9.
As shown in Figure 1, LED ruddiness and infrared light generator 4 comprise two light emitting diodes, the light that wavelength is 660nm and 940nm occurs respectively, the only mixing of the light of these two kinds of wavelength that generator sends, mixed light is divided into the two identical light of bundle in optical splitter, two-beam is injected respectively in reference cell 61 and measuring cell 62.
Two-beam passes respectively the blood of not qi and blood exchange and the blood after the qi and blood exchange, forms two bundle transmitted lights.This two bundles transmitted light converts two electric signal to through photoelectric commutator 7 respectively, by signal amplification circuit 8, described two electric signal amplified and send into and process in described single-chip microcomputer 9 and analyze, obtaining two groups of blood oxygen saturation data after qi and blood exchanges front and qi and blood exchange.
Certainly, blood oxygen detection part of the present invention is not limited in above-mentioned photo-electric blood oxygen detection, any known photo-electric blood oxygen detection of the prior art also, perhaps it must not comprise optical splitter and adopt two identical LED ruddiness and infrared light generator to incide respectively reference cell and measuring cell, perhaps must not have single-chip microcomputer but directly be linked into and carry out the data processing in computing machine, etc.
Adopt qi and blood exchange of the present invention blood oxygen saturation monitoring device based, can first infiltrate simultaneously the nitrous ether (ethyl nitrite) G﹠O to blood by ventilated membrane, improve the oxygen level of blood through the qi and blood exchange, and whether the blood that detects after qi and blood exchanges by blood oxygen detection part reaches sufficient oxygen level, if oxygen level not can increase or reduce by adjusting valve the content of nitrous ether (ethyl nitrite) and oxygen, thereby guarantee the quality of blood, be patient's blood use safety raising guarantee.And photo-electric blood oxygen detection of the present invention adopts quartz colorimetric utensil, and degree of accuracy is high, and is highly sensitive, and whole detection part is simple in structure, and is simple, but has good generalization.
The above is described embodiments of the invention by reference to the accompanying drawings; but the present invention is not limited to above-mentioned embodiment; above-mentioned embodiment is only schematic; rather than restrictive; those of ordinary skill in the art is under enlightenment of the present invention; not breaking away from the scope situation that aim of the present invention and claim protect, also can make a lot of forms, within these all belong to protection of the present invention.

Claims (10)

1. a qi and blood exchange is blood oxygen saturation monitoring device based, it is characterized in that, comprises qi and blood inverting chamber and blood oxygen detection part;
Described qi and blood inverting chamber is separated into three chambers by two ventilated membranes, be respectively the blood chamber in the middle of being positioned at and lay respectively at nitrous ether (ethyl nitrite) combination gas body cavity, the oxygen chamber of described blood chamber both sides, the oxygen in the nitrous ether (ethyl nitrite) mixed gas in described nitrous ether (ethyl nitrite) combination gas body cavity and described oxygen chamber sees through two ventilated membranes respectively and enters and carry out the qi and blood exchange in blood in described blood chamber;
Described blood oxygen detection part is photo-electric blood oxygen detection, for detection of the blood oxygen saturation through the blood after the qi and blood exchange.
2. device according to claim 1, it is characterized in that, described blood chamber is provided with blood entrance and blood outlet, connect by pipeline the blood bag that promising described blood chamber provides blood on described blood entrance, be provided with reference cell on the pipeline of described blood entrance, described blood oxygen detection part also detects the blood that not yet exchanges through qi and blood in described reference cell.
3. device according to claim 2, it is characterized in that, the blood after the exchange of described process qi and blood flows into human vein by flexible pipe, is provided with measuring cell on described flexible pipe, blood flow is through described measuring cell, and described blood oxygen detection part detects in described measuring cell through the blood after the qi and blood exchange.
4. device according to claim 3, is characterized in that, described reference cell and measuring cell all adopt quartz colorimetric utensil.
5. device according to claim 4, is characterized in that, described blood oxygen detection part comprises LED ruddiness and infrared light generator, optical splitter, photoelectric commutator, signal amplification circuit and single-chip microcomputer.
6. device according to claim 5, it is characterized in that, described LED ruddiness and infrared light generator comprise two light emitting diodes, the light that wavelength is 660nm and 940nm occurs respectively, and the formed mixed light of the light of two kinds of wavelength is divided into the identical light of two bundles and injects respectively in described reference cell and measuring cell in described optical splitter.
7. device according to claim 6, it is characterized in that, described photoelectric commutator converts the light that two bundles see through respectively described reference cell and measuring cell to two electric signal, described signal amplification circuit amplifies described two electric signal and sends into and process in described single-chip microcomputer and analyze, and obtains two groups of blood oxygen saturation data after qi and blood exchanges front and qi and blood exchange.
8. device according to claim 7, it is characterized in that, described nitrous ether (ethyl nitrite) combination gas body cavity is provided with the first air intake opening and the first gas outlet, be connected with high pressure nitrous ether (ethyl nitrite) mixing gas tank on described the first air intake opening, its with described the first air intake opening between be connected and be provided with valve and flowmeter by pipeline.
9. device according to claim 1, it is characterized in that, described oxygen chamber is provided with the second air intake opening and the second gas outlet, is connected with oxygen tank on described the second air intake opening, its with described the second air intake opening between be connected and be provided with valve and flowmeter by pipeline.
10. device according to claim 2, is characterized in that, is provided with the valve of controlling flow on the pipeline between described blood bag and blood entrance.
CN201110337596.0A 2011-10-31 2011-10-31 QI and blood exchange is blood oxygen saturation monitoring device based Active CN103091275B (en)

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