CN103083690B

CN103083690B - Capsule for gastrointestinal color ultrasound contrast

Info

Publication number: CN103083690B
Application number: CN201310059525.8A
Authority: CN
Inventors: 丁伟
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-02-25
Filing date: 2013-02-25
Publication date: 2014-09-03
Anticipated expiration: 2033-02-25
Also published as: CN103083690A

Abstract

The invention discloses a capsule for gastrointestinal color ultrasound contrast and belongs to the field of traditional Chinese medicines. The capsule provided by the invention comprises the following active components in parts by weight: 45-60 parts of Poria cocos, 40-55 parts of Bletilla, 35-50 parts of concha haliotidis, 30-48 parts of radix curcumae, 28-45 parts of Codonopsis pilosula, 25-40 parts of Mangnolia officinalis, 22-36 parts of talcum powder, 18-30 parts of oyster, 15-25 parts of immature bitter orange, 12-22 parts of Fritillaria thun-bergli, 8-18 parts of cuttlebone and 4-10 parts of cornu cervi degelatinatum. The capsule provided by the invention is novel in formula, excellently prepared, remarkable in strong echo spots and clear in display of gastrointestinal wall layers and meanwhile has the treatment effect on gastrointestinal diseases, and also has the functions of stopping blooding and omitting, inhibiting acid and detoxifies, slowing down adverse effect caused by color ultrasound contrast, and the resistance to drugs is reduce, so that the capsule is suitable for clinical application.

Description

A kind of capsule for color gastrointestinal ultrasonic radiography

Affiliated technical field

The present invention relates to the field of Chinese medicines, relate in particular to a kind of capsule for color gastrointestinal ultrasonic radiography.

Background technology

Clinically ultrasonic, color ultrasound has progressively substituted black-and-white B, bringing into play more and more important effect, it is to add color Doppler on the basis of black-and-white B, the blood flow signal obtaining is superimposed upon in real time on two dimensional image after coloud coding, form Color Doppler Ultrasonic picture, both there is two-dimensional ultrasound structural images, hemodynamic abundant information is provided again simultaneously.

No matter be that traditional B surpasses or color ultrasound, its operation principles has determined in perspective process, to need to use contrast agent, and its effect is to strengthen ultrasonic backscattering degree, to provide image clearly to generate.Initial contrast agent is the microbubble of carbonated, oxygen or air, mostly adopts clinically the microbubble contrast agent of the material parcels such as albumin, liposome, polymer and various surfactants of degeneration at present.This class contrast agent is mostly chemical reagent, and cost is higher, and only possesses ultrasonic contrast function, can not in radiography, have treatment function concurrently.

Based on gastrointestinal tract color ultrasound contrast agent, be positioned at the characteristic in gastro-intestinal digestion road, completely can be on the basis of contrast agent additional treatment effect, in industry, also carried out fruitful scientific research, such as the patent No. contrast agent that is 87105799, the color ultrasound contrast agent that the patent No. is 01128137.5, these patented technologies all adopt Chinese crude drug preparation, when thering is better radiography effect, also can treat gastroenteropathy.But still there is slight bad reflection in these contrast agent, as gastric acid strong reaction, there are pain and sense of discomfort, be especially unsuitable for gastrorrhagia patient and use.In addition, these contrast agent are also undesirable to the therapeutic effect of gastroenteropathy, very limited to the scope of application of disease.

Traditional Chinese medical theory is thought, that mostly gastroenteropathy is to be condensed into is long-pending, the qi depression to blood stasis in damp-heat accumulation due to Jiao, deficiency of spleen-QI, Deficiency and coldness of spleen and stomach causes, therefore when adopting Chinese prescription to treat, with food stagnation removing, attack long-pending, eliminating damp-heat, the regulating the spleen and stomach of regulating the flow of vital energy, spleen invigorating QI invigorating, warming middle-JIAO and invigorate blood circulation as this, reach the object for the treatment of both the principal and secondary aspects of a disease.

Summary of the invention

The invention provides a kind of capsule for color gastrointestinal ultrasonic radiography, strong echo luminous point is sufficient, and radiography effect is remarkable, the therapeutic efficiency of simultaneously have eliminating damp-heat, the regulating the spleen and stomach of regulating the flow of vital energy, spleen invigorating QI invigorating, warming middle-JIAO being invigorated blood circulation.

For achieving the above object, technical scheme of the present invention is implemented as follows:

For a capsule for color gastrointestinal ultrasonic radiography, raw material composition and the parts by weight of making described capsule effective ingredient are:

30～48 parts of 35～50 portions of Radix Curcumaes of 40～55 parts of Concha Haliotidis of 45～60 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Poria

18～30 parts of 22～36 portions of Concha Ostreaes of 25～40 parts of Pulvis Talci of 28～45 parts of Cortex Magnoliae Officinalis of Radix Codonopsis

4～10 parts of 8～18 parts of Cornu Cervi Degelatinatums of 12～22 portions of Endoconcha Sepiaes of 15～25 portions of Bulbus Fritillariae Uninbracteataes of Fructus Aurantii Immaturus.

Raw material composition and the parts by weight of making described capsule effective ingredient are:

35～45 parts of 38～46 portions of Radix Curcumaes of 42～52 parts of Concha Haliotidis of 48～58 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Poria

22～28 parts of 25～33 portions of Concha Ostreaes of 28～38 parts of Pulvis Talci of 32～42 parts of Cortex Magnoliae Officinalis of Radix Codonopsis

6～8 parts of 10～16 parts of Cornu Cervi Degelatinatums of 14～18 portions of Endoconcha Sepiaes of 18～22 portions of Bulbus Fritillariae Uninbracteataes of Fructus Aurantii Immaturus.

40 parts of 42 portions of Radix Curcumaes of 47 parts of Concha Haliotidis of 53 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Poria

25 parts of 29 portions of Concha Ostreaes of 33 parts of Pulvis Talci of 37 parts of Cortex Magnoliae Officinalis of Radix Codonopsis

7 parts of 13 parts of Cornu Cervi Degelatinatums of 16 portions of Endoconcha Sepiaes of 20 portions of Bulbus Fritillariae Uninbracteataes of Fructus Aurantii Immaturus.

A preparation method for the capsule of color gastrointestinal ultrasonic radiography, comprises following processing step:

(1) Endoconcha Sepiae, Cornu Cervi Degelatinatum are ground into powder after pulverizing, crossed 120 order fine powders, standby.

(2) Cortex Magnoliae Officinalis is fried to being coke yellow with slow fire, after taking-up cools, grind into powder, cross 120 order fine powders, standby.

(3) Radix Curcumae is stir-fried for several times with slow fire, after sprinkling rice vinegar, fried dry is ground into powder, crosses 120 order fine powders, standby.

(4) Concha Haliotidis, Concha Ostreae, Bulbus Fritillariae Uninbracteatae are calcined to high heat after crisp and grind into powder, cross 120 order fine powders, standby.

(5) Pseudobulbus Bletillae (Rhizoma Bletillae), Pulvis Talci, Fructus Aurantii Immaturus are put into container, add the water of four times of amounts, boil rear continuation and soak after 6～8 hours, get immersion; In remaining medicinal residues, add again the water of triplication, boil rear continuation and soak after 3～4 hours, get immersion; Merge twice gained immersion, heating evaporation, under simmer down to room temperature environment, the thick paste of relative density 1.10～1.15, standby.

(6) Poria, Radix Codonopsis are put into container, add the Ji Me Lao Jiu of triplication, boil rear continuation and soak after 3～4 hours, get immersion; In remaining medicinal residues, add again the Ji Me Lao Jiu of doubling dose, boil rear continuation and soak after 2～3 hours, get immersion; Merge twice gained immersion, heating evaporation, under simmer down to room temperature environment, the thick paste of relative density 1.15～1.20, standby.

(7), by the fine powder of step (1), step (2), step (3), step (4) gained, after the thick paste mixing and stirring making with step (5), step (6), quick-freezing is powder, with modern technologies technique, is prepared as capsule product.

The property of medicine of the present invention's Chinese medicine used is as follows:

Poria: sweet in the mouth; Light; Property is put down.Enter the heart; Spleen; Lung; Kidney channel.Eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.Cure mainly dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Let out wash with watercolours.< < does not record > > and carries: " only quench one's thirst, like to sleep, large abdomen, drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema is drenched knot.Open breast internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, physical strength profiting, during guarantor god keeps." modern medicine study confirmation; Poria all has inhibitory action to staphylococcus aureus, escherichia coli, Bacillus proteus etc.; can kill the antibacterials such as leptospira; digestive system, blood system and central nervous system are had to certain protective effect; pachyman content is very high in addition, can anti-tumor activity.

The Pseudobulbus Bletillae (Rhizoma Bletillae): bitter in the mouth; Sweet; Puckery; Cold nature.Enter lung; Liver; Stomach warp.Eliminating phlegm and stopping cough; Promoting blood circulation and hemostasis.Cure mainly cough with copious phlegm; Hemoptysis.< < Japan hanako materia medica > > carries: " spasmolytic is evil, blood is evil, dysentery, acute conjunctivitis, crux, carbuncle on the back; scrofula, and hemorrhoidal hamorrhage, hemorrhoid wart, cutter arrow skin ulcer is flutterred damage, warm malaria; dysentery, sore due to scald and burn, granulation promoting pain relieving, migratory arthralgia." modern medicine study confirmation, the Pseudobulbus Bletillae (Rhizoma Bletillae) is rich in colloid, starch, volatilization wet goods, effectively resists bacillus, suppresses the activity of plasmin, is widely used in all kinds of traumatic hemorrhage.

Concha Haliotidis: salty in the mouth; Cold in nature.Return Liver Channel.Calming liver and clearing heat; Improving eyesight removing nebula.Cure mainly headache dizzy; Conjunctival congestion cataracta; Blurring of vision; Optic atrohic blindness nyctalopia.< < Records of Tradition Chinese and Western Medicine in Combination > > carries: " Concha Haliotidis, the key medicine of Wei Lianggan town liver, main liver-wind heat, the hectic fever due to YIN-deficiency labor utmost point." modern medicine study confirmation, Concha Haliotidis has heat clearing away, calmness, blood pressure lowering, sympatheticomimetic effect, and staphylococcus aureus, escherichia coli, bacillus pyocyaneus are had to significant inhibition effect, expands tracheobronchial smooth muscle, extends clotting time.

Radix Curcumae: acrid in the mouth; Bitter; Cold in nature.Enter the heart; Liver; Gallbladder meridian.The relieving convulsion of invigorating blood circulation; Promoting QI circulation for relieving depression; Removing heat from blood clears away heart-fire; Depressed liver-energy dispersing and function of gallbladder promoting.Cure mainly all pains of breast abdomen side of body rib; WEIJIA caking; Calentura coma; Demented; Infantile convulsion; Spit blood; Epistaxis; Jaundice.< < Bencao Beiyao > > carries: " circulation of qi promoting, resolving depression; Let out blood, removing blood stasis with potent drugs.Cool heat in the heart, loose stagnation of liver-QI, can open the strongly fragrant of lung gold." modern medicine study confirmation, Radix Curcumae is rich in Radix Curcumae polysaccharide, has the reticuloendothelial system of enhancing active, and ethanol extract, on the original obvious impact of fibrin, can reduce T-CHOL and content of triglyceride in aorta.

Radix Codonopsis: sweet in the mouth; Property is put down.Return spleen; Lung meridian.Strengthening the spleen and tonifying the lung; Supplementing QI for promoting the production of body fluid.Cure mainly weakness of the spleen and stomach; Anorexia and loose stool; Limbs fatigue; The deficiency of the lung is breathed with cough; The spontaneous perspiration of breathing hard; The all cards of deficiency of both QI and blood.< < moral is joined herbal > > and is carried: " lung heat clearing gold, invigorating primordial QI, opens sound, helps biceps." modern medicine study confirmation; Radix Codonopsis energy Gastrointestinal motility adjustment, antiulcer, enhancing immunologic function; excited and two kinds of nervous process of inhibition are had to impact, and can raise erythrocyte, hemoglobin, reticulocyte, also have the effect of slow down aging and antioxidation, radioprotective, blood pressure lowering.

Cortex Magnoliae Officinalis: bitter in the mouth; Pungent; Warm in nature.Enter spleen; Stomach; Large intestine channel.Circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.Cure mainly stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO; Gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant is stopped up QI rising in reverse order; Fullness in the chest cough with asthma.< < does not record > > and carries: " warming middle-JIAO QI invigorating, the expectorant therapeutic method to keep the adverse QI flowing downwards.Treat cholera and stomachache distension, cold in the stomach is contrary and vomit in the heart incessantly, and let out dysentery and drench and reveal, except frightened, the earnest stuffy sensation with restlessness of going or staying, thick the intestines and stomach." modern medicine study confirmation, it is movable that Cortex Magnoliae Officinalis has the gastrointestinal of impact, antibacterial, antiviral, and antiallergic action, loose muscle, suppresses nervus centralis, antiallergic and the effect that maintains adjusting oral cavity bacterium.

Pulvis Talci: sweet in the mouth; Light; Cold in nature; Nontoxic.Enter stomach; Urinary bladder channel.Relieving stranguria by diuresis; Clearing away summer-heat; Removing dampness sore; Cure mainly damp-heat in the urinary bladder; Summer-heat excessive thirst; Dysuria; Have loose bowels; Urine drenches puckery pain; Edema; Epistaxis.< < Amplification on Materia Medica addendum > > carries: " dampness, diversion channel, real large intestine, relieving dyspepsia poison, row is stagnant, by blood coagulation, separates dry yearningly, and the key medicine of heart-fire, falls in tonifying the spleen and stomach." modern medicine study shows; Talcum has inhibitory action to Bacillus typhi, paratyphoid fever bacillus, meningococcus; external can be adsorbed a large amount of chemical irritants or poisonous substance; can protect the surface of inflammation or damaged tissue; the gastrointestinal mucosa except protection inflammation for oral administration and bring into play that town is told, anti-diarrhea effect, can also stop the absorption of poisonous substance in gastrointestinal tract.

Concha Ostreae: salty in the mouth; Cold nature.Enter liver; Kidney channel.Suppressing the hyperactive liver and subsiding YANG; Tranquillization with heavy prescription; Hard masses softening and resolving; Restrain astringent or styptic treatment for spontaneous sweating.Cure mainly vertigo and tinnitus; Palpitation with fear insomnia; Scrofula goiter; WEIJIA mass in the abdomen; Spontaneous sweating.< < Compendium of Materia Medica > > carries: " resolving phlegm and softening hard masses, removing damp-heat stop heart temper pain, under dysentery, and reddish and whitish turbid urine, the hernia that disappears abdominal mass is amassed piece, wart disease tuberculosis." modern medicine study confirmation, Concha Ostreae has convergence, calmness, removing toxic substances, analgesic effect, and acidic extraction thing has inhibitory action to poliovirus.

Fructus Aurantii Immaturus: bitter in the mouth; Pungent; Cold in nature.Enter spleen; Stomach; Liver; Heart channel.Dispelling the stagnated QI removing food stagnancy; Reduce phlegm except painful abdominal mass.Cure mainly in stagnant and stop; Feeling of fullness distending pain; Constipation; Heavy after dysentery; Blocked-up chest; Gastroptosis.< < medicineization justice > > carries: " Fructus Aurantii Immaturus is specially let out excess of the stomach; convince hard knot by patient analysis; the main middle part of gastric cavity is to control blood system; treat the interventral reality of umbilicus full, expectorant addiction, dispels and cut off the water; by dyspepsia; broken blocked-up chest, and relieving constipation is closed, and gets power that its pungent loose hardship rushes down also." Fructus Aurantii Immaturus can alleviate little enterospasm, increases gastrointestinal and shrinks the rhythm and pace of moving things, impels gallbladder contraction, increases Oddi's sphincter tension force, suppresses thrombosis, particularly has antiulcer effect.

Bulbus Fritillariae Uninbracteatae: salty in the mouth; Cold in nature.Return liver; Heart channel.Suppressing the hyperactive liver and subsiding YANG; The arresting convulsion of calming the nerves; Liver heat removing and eyesight improving.Cure mainly dizziness; Tinnitus; Cardiopalmus; Insomnia; Demented; Infantile convulsion; Spit blood; Epistaxis.< < Chinese medicine voluminous dictionary > > carries: " liver nourishing is cloudy, and clearing away liver-fire, controls demented infantile convulsion, doublely enters the heart, liver two warps, relates to mind patient, this." modern medicine study confirmation, Bulbus Fritillariae Uninbracteatae has obvious antitussive and phlegm-dispelling functions, and pepsin is had to significant inhibitory action, obviously suppresses stress ulcer and central nervous system, also has in addition loose intestinal tube and spasmolytic effect.

Endoconcha Sepiae: salty in the mouth; Puckery; Warm in nature.Enter liver; Kidney channel.Astringing to arrest bleeding; Treating spontaneous emission and leukorrhagia; Relieving gastric hyperacidity to alleviate stomachache; Removing dampness sore.Cure mainly haematemesis; Hematemesis; Have blood in stool; Epistaxis; Wound hemorrhage; Emission due to deficiency of the kidney spermatorrhea; Leucorrhea with red and white discharge; Have a stomachache noisy; Yuan gas pantothenic acid; Eczema ulcer.< < Bencao Jingshu > > carries: " salty temperature enters Liver and kidney, promoting blood circulation and dispelling cold and dampness enters liver and gall, and Shu Yingqi, temperature and dampness, the many pus of main skin ulcer are also again." modern medicine study confirmation, sepiellae seu sepiae decocting liquid has significant radiation resistance, can obviously promote bone defect repair.

Cornu Cervi Degelatinatum: salty in the mouth; Puckery; Warm in nature.Enter kidney; Liver Channel.Reinforcing the kidney and supporting YANG; Astringing to arrest bleeding.Cure mainly insufficiency of kidney-YANG; Deficiency and coldness of spleen and stomach; Anorexia and loose stool; Impotence and seminal emission; Frequent urination and enuresis; Wound hemorrhage; Skin infection disunion of a specified duration.< < Shengji Zonglu > > carries: " control renal cold weakness and emaciation, raw yang-energy, mends marrow, controls weakness, thin and weak unbearably person." modern medicine study discovery, Cornu Cervi Degelatinatum main component is calcium phosphate, calcium carbonate, nitride and colloid, also contains in addition several amino acids, has the effect that promotes vasoconstriction, improves body immune system function.

The present invention compared with prior art, has following beneficial effect:

Prescription of the present invention is novel, concocts superiorly, and strong echo luminous point is remarkable, and gastrointestinal wall level clear display has the treatment function of gastroenteropathy concurrently simultaneously, hemostasis emesis, presses down acidolysis poison, and the untoward reaction of the color ultrasound of releiving radiography, reduces Drug resistance, is suitable for clinical application.

The specific embodiment

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material of capsule effective ingredient of the present invention forms and weight is:

Poria 58g Pseudobulbus Bletillae (Rhizoma Bletillae) 50g Concha Haliotidis 46g Radix Curcumae 42g

Radix Codonopsis 39g Cortex Magnoliae Officinalis 36g Pulvis Talci 32g Concha Ostreae 28g

Fructus Aurantii Immaturus 24g Bulbus Fritillariae Uninbracteatae 20g Endoconcha Sepiae 16g Cornu Cervi Degelatinatum 9g.

The processing step of capsule preparation method thereof of the present invention is:

Usage and dosage: first oral 0.8g/ time of radiography

Embodiment 2

Poria 53g Pseudobulbus Bletillae (Rhizoma Bletillae) 47g Concha Haliotidis 42g Radix Curcumae 40g

Radix Codonopsis 37g Cortex Magnoliae Officinalis 33 Pulvis Talci 29g Concha Ostreae 25g

Fructus Aurantii Immaturus 20g Bulbus Fritillariae Uninbracteatae 16g Endoconcha Sepiae 13g Cornu Cervi Degelatinatum 7g.

Capsule preparation method thereof processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

Embodiment 3

Poria 50g Pseudobulbus Bletillae (Rhizoma Bletillae) 45g Concha Haliotidis 40g Radix Curcumae 36g

Radix Codonopsis 33g Cortex Magnoliae Officinalis 30g Pulvis Talci 26g Concha Ostreae 22g

Fructus Aurantii Immaturus 18g Bulbus Fritillariae Uninbracteatae 15g Endoconcha Sepiae 11g Cornu Cervi Degelatinatum 5g.

Clinical data:

Through Clinical Laboratory, contrast gels wafer of the present invention can clarify a diagnosis human body gastritis, gastric ulcer, gastric cancer, gastroptosis, prolapse of gastric mucosa, duodenal bulbar inflammation, duodenal bulbar ulcer, phase morning, noon and afternoon gastrointestinal tumor, gastrointestinal tract calculus, the upper and lower road of esophagus and cardia place cancerous protuberance, radiography is clear, press down sour effect remarkable, have no adverse reaction, and above-mentioned each disease is had to obvious therapeutic effect.

Claims

1. for a capsule for color gastrointestinal ultrasonic radiography, it is characterized in that: raw material composition and the parts by weight of making described capsule effective ingredient are:

2. a kind of capsule for color gastrointestinal ultrasonic radiography according to claim 1, is characterized in that: the raw material of making described capsule effective ingredient forms and parts by weight are:

3. a kind of capsule for color gastrointestinal ultrasonic radiography according to claim 1, is characterized in that: the raw material of making described capsule effective ingredient forms and parts by weight are:

4. for a preparation method for the capsule of color gastrointestinal ultrasonic radiography, it is characterized in that: comprise following processing step:

(6) Poria, Radix Codonopsis are put into container, add the Ji Me Lao Jiu of triplication, boil rear continuation and soak

After 3～4 hours, get immersion; In remaining medicinal residues, add again the Ji Me Lao Jiu of doubling dose, boil rear continuation and soak after 2～3 hours, get immersion; Merge twice gained immersion, heating evaporation, under simmer down to room temperature environment, the thick paste of relative density 1.15～1.20, standby.