CN103083690A

CN103083690A - Capsule for gastrointestinal color ultrasound contrast

Info

Publication number: CN103083690A
Application number: CN2013100595258A
Authority: CN
Inventors: 丁伟
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-02-25
Filing date: 2013-02-25
Publication date: 2013-05-08
Anticipated expiration: 2033-02-25
Also published as: CN103083690B

Abstract

The invention discloses a capsule for gastrointestinal color ultrasound contrast and belongs to the field of traditional Chinese medicines. The capsule provided by the invention comprises the following active components in parts by weight: 45-60 parts of Poria cocos, 40-55 parts of Bletilla, 35-50 parts of concha haliotidis, 30-48 parts of radix curcumae, 28-45 parts of Codonopsis pilosula, 25-40 parts of Mangnolia officinalis, 22-36 parts of talcum powder, 18-30 parts of oyster, 15-25 parts of immature bitter orange, 12-22 parts of Fritillaria thun-bergli, 8-18 parts of cuttlebone and 4-10 parts of cornu cervi degelatinatum. The capsule provided by the invention is novel in formula, excellently prepared, remarkable in strong echo spots and clear in display of gastrointestinal wall layers and meanwhile has the treatment effect on gastrointestinal diseases, and also has the functions of stopping blooding and omitting, inhibiting acid and detoxifies, slowing down adverse effect caused by color ultrasound contrast, and the resistance to drugs is reduce, so that the capsule is suitable for clinical application.

Description

A kind of capsule for the color gastrointestinal ultrasonic radiography

Affiliated technical field

The present invention relates to the field of Chinese medicines, relate in particular to a kind of capsule for the color gastrointestinal ultrasonic radiography.

Background technology

Clinically ultrasonic, color ultrasound has progressively substituted black-and-white B, bringing into play more and more important effect, it is to add color Doppler on the basis of black-and-white B, the blood flow signal that obtains through being superimposed upon in real time on two dimensional image after coloud coding, form the Color Doppler Ultrasonic picture, both had advantages of the two-dimensional ultrasound structural images, hemodynamic abundant information is provided again simultaneously.

No matter be that traditional B surpasses or color ultrasound, its operation principles has determined to need to use contrast agent in the perspective process, and its effect is to strengthen the ultrasonic backscattering degree, and image generates to provide clearly.Initial contrast agent is the microbubble of carbonated, oxygen or air, mostly adopts clinically the microbubble contrast agent of the materials such as albumin, liposome, polymer and the various surfactants parcel of degeneration at present.This class contrast agent mostly is greatly chemical reagent, and cost is higher, and only possesses the ultrasonic contrast function, can not have the treatment function in radiography concurrently.

Be positioned at the characteristic in gastro-intestinal digestion road based on gastrointestinal tract color ultrasound contrast agent, fully can be on the basis of contrast agent the additional treatment effect, also carried out fruitful scientific research in industry, such as the patent No. is that 87105799 contrast agent, the patent No. are 01128137.5 color ultrasound contrast agent, these patented technologies all adopt the Chinese crude drug preparation, when having better radiography effect, also can treat gastroenteropathy.But still there is slight bad reflection in these contrast agent, as the gastric acid strong reaction, pain and sense of discomfort are arranged, and especially are unsuitable for the gastrorrhagia patient and use.In addition, these contrast agent are also undesirable to the therapeutic effect of gastroenteropathy, and are very limited to the scope of application of disease.

Traditional Chinese medical theory is thought, that mostly gastroenteropathy is to be condensed into is long-pending, the qi depression to blood stasis in damp-heat accumulation due to Jiao, deficiency of spleen-QI, Deficiency and coldness of spleen and stomach causes, therefore when adopting Chinese prescription to treat, attack long-pending, eliminating damp-heat, the regulating the spleen and stomach of regulating the flow of vital energy, spleen invigorating QI invigorating, warming middle-JIAO with food stagnation removing and invigorate blood circulation as this, reach the purpose for the treatment of both the principal and secondary aspects of a disease.

Summary of the invention

The invention provides a kind of capsule for the color gastrointestinal ultrasonic radiography, strong echo luminous point is sufficient, and the radiography effect is remarkable, the therapeutic efficiency of have simultaneously eliminating damp-heat, the regulating the spleen and stomach of regulating the flow of vital energy, spleen invigorating QI invigorating, warming middle-JIAO being invigorated blood circulation.

For achieving the above object, technical scheme of the present invention is implemented as follows:

A kind of capsule for the color gastrointestinal ultrasonic radiography, raw material composition and the parts by weight of making described capsule effective ingredient are:

30～48 parts of 35～50 portions of Radix Curcumaes of 40～55 parts of Concha Haliotidis of 45～60 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Poria

18～30 parts of 22～36 portions of Concha Ostreaes of 25～40 parts of Pulvis Talci of 28～45 parts of Cortex Magnoliae Officinalis of Radix Codonopsis

4～10 parts of 8～18 parts of Cornu Cervi Degelatinatums of 12～22 portions of Endoconcha Sepiaes of 15～25 portions of Bulbus Fritillariae Uninbracteataes of Fructus Aurantii Immaturus.

Raw material composition and the parts by weight of making described capsule effective ingredient are:

35～45 parts of 38～46 portions of Radix Curcumaes of 42～52 parts of Concha Haliotidis of 48～58 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Poria

22～28 parts of 25～33 portions of Concha Ostreaes of 28～38 parts of Pulvis Talci of 32～42 parts of Cortex Magnoliae Officinalis of Radix Codonopsis

6～8 parts of 10～16 parts of Cornu Cervi Degelatinatums of 14～18 portions of Endoconcha Sepiaes of 18～22 portions of Bulbus Fritillariae Uninbracteataes of Fructus Aurantii Immaturus.

40 parts of 42 portions of Radix Curcumaes of 47 parts of Concha Haliotidis of 53 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Poria

25 parts of 29 portions of Concha Ostreaes of 33 parts of Pulvis Talci of 37 parts of Cortex Magnoliae Officinalis of Radix Codonopsis

7 parts of 13 parts of Cornu Cervi Degelatinatums of 16 portions of Endoconcha Sepiaes of 20 portions of Bulbus Fritillariae Uninbracteataes of Fructus Aurantii Immaturus.

A kind of preparation method of the capsule for the color gastrointestinal ultrasonic radiography comprises following processing step:

(1) Endoconcha Sepiae, Cornu Cervi Degelatinatum are ground into powder after pulverizing, crossed 120 order fine powders, standby.

(2) Cortex Magnoliae Officinalis is fried to being coke yellow with slow fire, grind into powder after taking-up cools, cross 120 order fine powders, standby.

(3) Radix Curcumae is stir-fried for several times with slow fire, after the sprinkling rice vinegar, fried dry is ground into powder, crosses 120 order fine powders, and is standby.

(4) Concha Haliotidis, Concha Ostreae, Bulbus Fritillariae Uninbracteatae are calcined to high heat grind into powder after crisp, cross 120 order fine powders, standby.

(5) Pseudobulbus Bletillae (Rhizoma Bletillae), Pulvis Talci, Fructus Aurantii Immaturus are put into container, add the water of four times of amounts, boil rear continuation and soak after 6～8 hours, get immersion; Add again the water of triplication in remaining medicinal residues, boil rear continuation and soak after 3～4 hours, get immersion; Merge twice gained immersion, heating evaporation, under the simmer down to room temperature environment, the thick paste of relative density 1.10～1.15, standby.

(6) Poria, Radix Codonopsis are put into container, add the Ji Me Lao Jiu of triplication, boil rear continuation and soak after 3～4 hours, get immersion; Add again the Ji Me Lao Jiu of doubling dose in remaining medicinal residues, boil rear continuation and soak after 2～3 hours, get immersion; Merge twice gained immersion, heating evaporation, under the simmer down to room temperature environment, the thick paste of relative density 1.15～1.20, standby.

(7) with the fine powder of step (1), step (2), step (3), step (4) gained, after the thick paste mixing and stirring that makes with step (5), step (6), quick-freezing is powder, is prepared as the capsule product with modern technologies technique.

The property of medicine of the present invention's Chinese medicine used is as follows:

Poria: sweet in the mouth; Light; Property is put down.Enter the heart; Spleen; Lung; Kidney channel.Eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.Cure mainly dysuria; The edema distension; The phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Let out wash with watercolours." not Lu " carries: " only quench one's thirst, like to sleep, large abdomen drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema is drenched knot.Open the breast internal organs, transfer visceral-qi, cut down the kidney heresy, long cloudy, physical strength profiting is during guarantor god keeps." the modern medicine study confirmation; Poria all has inhibitory action to staphylococcus aureus, escherichia coli, Bacillus proteus etc.; can kill the antibacterials such as leptospira; digestive system, blood system and central nervous system are had certain protective effect; pachyman content is very high in addition, but anti-tumor activity.

The Pseudobulbus Bletillae (Rhizoma Bletillae): bitter in the mouth; Sweet; Puckery; Cold nature.Enter lung; Liver; The stomach warp.Eliminating phlegm and stopping cough; Promoting blood circulation and hemostasis.Cure mainly cough with copious phlegm; Hemoptysis." Japan hanako materia medica " carries: " spasmolytic is evil, blood is evil, dysentery, and acute conjunctivitis, crux, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, the hemorrhoid wart, cutter arrow skin ulcer is flutterred damage, warm malaria, dysentery, sore due to scald and burn, granulation promoting pain relieving, migratory arthralgia." the modern medicine study confirmation, the Pseudobulbus Bletillae (Rhizoma Bletillae) is rich in colloid, starch, volatilization wet goods, effectively resists bacillus, suppresses the activity of plasmin, is widely used in all kinds of traumatic hemorrhage.

Concha Haliotidis: salty in the mouth; Cold in nature.Return Liver Channel.Calming liver and clearing heat; Removing nebula makes eye bright.Cure mainly headache dizzy; The conjunctival congestion cataracta; Blurring of vision; The optic atrohic blindness nyctalopia." Records of Tradition Chinese and Western Medicine in Combination " carries: " Concha Haliotidis is the key medicine of cool liver town liver, main liver-wind heat, the hectic fever due to YIN-deficiency labor utmost point." the modern medicine study confirmation, Concha Haliotidis has heat clearing away, calmness, blood pressure lowering, sympatheticomimetic effect, and staphylococcus aureus, escherichia coli, bacillus pyocyaneus are had significant inhibition effect, expands tracheobronchial smooth muscle, extends clotting time.

Radix Curcumae: acrid in the mouth; Bitter; Cold in nature.Enter the heart; Liver; Gallbladder meridian.The relieving convulsion of invigorating blood circulation; Promoting QI circulation for relieving depression; Removing heat from blood clears away heart-fire; Depressed liver-energy dispersing and function of gallbladder promoting.Cure mainly all pains of breast abdomen side of body rib; The WEIJIA caking; The calentura coma; Demented; Infantile convulsion; Spit blood; Epistaxis; Jaundice.Essentials of Matea Medica carries: " circulation of qi promoting, resolving depression; Let out blood, removing blood stasis with potent drugs.Cool heat in the heart, loose stagnation of liver-QI can be opened the strongly fragrant of lung gold." the modern medicine study confirmation, Radix Curcumae is rich in the Radix Curcumae polysaccharide, has the reticuloendothelial system of enhancing activity, and ethanol extract can reduce T-CHOL and content of triglyceride in aorta to the original obvious impact of fibrin.

Radix Codonopsis: sweet in the mouth; Property is put down.Return spleen; Lung meridian.Strengthening the spleen and tonifying the lung; Supplementing QI for promoting the production of body fluid.Cure mainly weakness of the spleen and stomach; Anorexia and loose stool; Limbs fatigue; The deficiency of the lung is breathed with cough; The spontaneous perspiration of breathing hard; The all cards of deficiency of both QI and blood." moral is joined book on Chinese herbal medicine " carries: " the lung heat clearing gold, invigorating primordial QI is opened sound, helps biceps." the modern medicine study confirmation; Radix Codonopsis energy Gastrointestinal motility adjustment, antiulcer, enhancing immunologic function; to excited all influential with two kinds of nervous process of inhibition, can raise erythrocyte, hemoglobin, reticulocyte, the effect of slow down aging and antioxidation, radioprotective, blood pressure lowering in addition.

Cortex Magnoliae Officinalis: bitter in the mouth; Hot; Warm in nature.Enter spleen; Stomach; Large intestine channel.The circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.Cure mainly stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO; The gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant is stopped up QI rising in reverse order; The fullness in the chest cough with asthma." not Lu " carries: " warming middle-JIAO QI invigorating, the expectorant therapeutic method to keep the adverse QI flowing downwards.Treat cholera and the distension of suffering from abdominal pain, cold in the stomach is vomitted incessantly in the heart against reaching, and lets out dysentery and drenches dew, removes and shies, the earnest stuffy sensation with restlessness of going or staying, thick the intestines and stomach." the modern medicine study confirmation, it is movable, antibiotic that Cortex Magnoliae Officinalis has the gastrointestinal of impact, antiviral, and antiallergic action, loose muscle suppresses nervus centralis, antiallergic and the effect of keeping the adjusting oral cavity bacterium.

Pulvis Talci: sweet in the mouth; Light; Cold in nature; Nontoxic.Enter stomach; Urinary bladder channel.Relieving stranguria by diuresis; Clearing away summer-heat; The removing dampness sore; Cure mainly damp-heat in the urinary bladder; The summer-heat excessive thirst; Dysuria; Have loose bowels; Urine drenches puckery pain; Edema; Epistaxis." Amplification on Materia Medica addendum " carries: " dampness, diversion channel, real large intestine, the relieving dyspepsia poison, row is stagnant, by blood coagulation, separates dry yearningly, the key medicine of heart-fire falls in tonifying the spleen and stomach." modern medicine study shows; Talcum has inhibitory action to Bacillus typhi, paratyphoid fever bacillus, meningococcus; external can be adsorbed a large amount of chemical irritants or poisonous substance; can protect the surface of inflammation or damaged tissue; for oral administration except the protection inflammation gastrointestinal mucosa and bring into play that the town tells, anti-diarrhea effect, can also stop the absorption of poisonous substance in gastrointestinal tract.

Concha Ostreae: salty in the mouth; Cold nature.Enter liver; Kidney channel.Suppressing the hyperactive liver and subsiding YANG; Tranquillization with heavy prescription; Hard masses softening and resolving; Restrain astringent or styptic treatment for spontaneous sweating.Cure mainly vertigo and tinnitus; The palpitation with fear insomnia; The scrofula goiter; The WEIJIA mass in the abdomen; Spontaneous sweating.Compendium of Material Medica is carried: " resolving phlegm and softening hard masses, removing damp-heat stop heart temper pain, under dysentery, and reddish and whitish turbid urine, the hernia that disappears abdominal mass is amassed piece, wart disease tuberculosis." the modern medicine study confirmation, Concha Ostreae has convergence, calmness, detoxifcation, analgesic effect, and the acidic extraction thing has inhibitory action to poliovirus.

Fructus Aurantii Immaturus: bitter in the mouth; Hot; Cold in nature.Enter spleen; Stomach; Liver; Heart channel.The dispelling the stagnated QI removing food stagnancy; Reduce phlegm except painful abdominal mass.Cure mainly and stop in stagnant; The feeling of fullness distending pain; Constipation; Heavy after dysentery; Blocked-up chest; Gastroptosis." medicineization justice " carries: " Fructus Aurantii Immaturus is specially let out excess of the stomach, convinces hard knot by patient analysis, and the main middle part of gastric cavity is treated the interventral reality of umbilicus full to control blood system, and the expectorant addiction is dispelled and cut off the water, by dyspepsia, and broken blocked-up chest, relieving constipation is closed, and gets power that its hot loose hardship rushes down also." Fructus Aurantii Immaturus can alleviate little enterospasm, increases gastrointestinal and shrinks the rhythm and pace of moving things, impels gallbladder contraction, increases Oddi's sphincter tension force, suppresses thrombosis, particularly has the antiulcer effect.

Bulbus Fritillariae Uninbracteatae: salty in the mouth; Cold in nature.Return liver; Heart channel.Suppressing the hyperactive liver and subsiding YANG; The arresting convulsion of calming the nerves; Liver heat removing and eyesight improving.Cure mainly dizziness; Tinnitus; Cardiopalmus; Insomnia; Demented; Infantile convulsion; Spit blood; Epistaxis." Chinese medicine voluminous dictionary " carries: " liver nourishing is cloudy, and clearing away liver-fire is controlled demented infantile convulsion, doublely enters the heart, liver two warps, relates to the mind patient, this." the modern medicine study confirmation, Bulbus Fritillariae Uninbracteatae has obvious antitussive and phlegm-dispelling functions, and pepsin is had significant inhibitory action, obviously suppresses stress ulcer and central nervous system, also has in addition loose intestinal tube and spasmolytic effect.

Endoconcha Sepiae: salty in the mouth; Puckery; Warm in nature.Enter liver; Kidney channel.Astringing to arrest bleeding; Treating spontaneous emission and leukorrhagia; Relieving gastric hyperacidity to alleviate stomachache; The removing dampness sore.Cure mainly haematemesis; Hematemesis; Have blood in stool; Epistaxis; Wound hemorrhage; The emission due to deficiency of the kidney spermatorrhea; Leucorrhea with red and white discharge; Have a stomachache noisy; Yuan gas pantothenic acid; Eczema ulcer." Bencao Jingshu " carries: " salty temperature enters Liver and kidney, promoting blood circulation and dispelling cold and dampness enters liver and gall, and Shu Yingqi, temperature and dampness, the many pus of main skin ulcer are also again." the modern medicine study confirmation, sepiellae seu sepiae decocting liquid has significant radiation resistance, can obviously promote the bone defect repair.

Cornu Cervi Degelatinatum: salty in the mouth; Puckery; Warm in nature.Enter kidney; Liver Channel.Reinforcing the kidney and supporting YANG; Astringing to arrest bleeding.Cure mainly insufficiency of kidney-YANG; Deficiency and coldness of spleen and stomach; Anorexia and loose stool; Impotence and seminal emission; Frequent urination and enuresis; Wound hemorrhage; Skin infection disunion of a specified duration." Shengji Zonglu " carries: " control the renal cold weakness and emaciation, give birth to yang-energy, mend marrow, control weakness, thin and weak unbearably person." the modern medicine study discovery, the Cornu Cervi Degelatinatum main component is calcium phosphate, calcium carbonate, nitride and colloid, also contains in addition several amino acids, and the effect that promotes vasoconstriction, improves the body immune system function is arranged.

The present invention compared with prior art has following beneficial effect:

Prescription of the present invention is novel, concocts superiorly, and strong echo luminous point is remarkable, and gastrointestinal wall level clear display has the treatment function of gastroenteropathy simultaneously concurrently, the hemostasis emesis, presses down the acidolysis poison, the untoward reaction of the color ultrasound of releiving radiography, and the reduction Drug resistance is suitable for clinical application.

The specific embodiment

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material of capsule effective ingredient of the present invention forms and weight is:

Poria 58g Pseudobulbus Bletillae (Rhizoma Bletillae) 50g Concha Haliotidis 46g Radix Curcumae 42g

Radix Codonopsis 39g Cortex Magnoliae Officinalis 36g Pulvis Talci 32g Concha Ostreae 28g

Fructus Aurantii Immaturus 24g Bulbus Fritillariae Uninbracteatae 20g Endoconcha Sepiae 16g Cornu Cervi Degelatinatum 9g.

The processing step of capsule preparation method thereof of the present invention is:

Usage and dosage: front oral 0.8g/ time of radiography

Embodiment 2

Poria 53g Pseudobulbus Bletillae (Rhizoma Bletillae) 47g Concha Haliotidis 42g Radix Curcumae 40g

Radix Codonopsis 37g Cortex Magnoliae Officinalis 33 Pulvis Talci 29g Concha Ostreae 25g

Fructus Aurantii Immaturus 20g Bulbus Fritillariae Uninbracteatae 16g Endoconcha Sepiae 13g Cornu Cervi Degelatinatum 7g.

Capsule preparation method thereof processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

Embodiment 3

Poria 50g Pseudobulbus Bletillae (Rhizoma Bletillae) 45g Concha Haliotidis 40g Radix Curcumae 36g

Radix Codonopsis 33g Cortex Magnoliae Officinalis 30g Pulvis Talci 26g Concha Ostreae 22g

Fructus Aurantii Immaturus 18g Bulbus Fritillariae Uninbracteatae 15g Endoconcha Sepiae 11g Cornu Cervi Degelatinatum 5g.

Clinical data:

Through Clinical Laboratory, contrast gels wafer of the present invention can clarify a diagnosis human body gastritis, gastric ulcer, gastric cancer, gastroptosis, prolapse of gastric mucosa, duodenal bulbar inflammation, duodenal bulbar ulcer, phase morning, noon and afternoon gastrointestinal tumor, gastrointestinal tract calculus, esophagus road, up and down and cardia place cancerous protuberance, radiography is clear, press down sour effect remarkable, have no adverse reaction, and above-mentioned each disease is had obvious therapeutic effect.

Claims

1. capsule that is used for the color gastrointestinal ultrasonic radiography is characterized in that: the raw material of making described capsule effective ingredient forms and parts by weight are:

2. a kind of capsule for the color gastrointestinal ultrasonic radiography according to claim 1 is characterized in that: the raw material of making described capsule effective ingredient forms and parts by weight are:

3. a kind of capsule for the color gastrointestinal ultrasonic radiography according to claim 1 is characterized in that: the raw material of making described capsule effective ingredient forms and parts by weight are:

4. preparation method that is used for the capsule of color gastrointestinal ultrasonic radiography is characterized in that: comprise following processing step:

(6) Poria, Radix Codonopsis are put into container, add the Ji Me Lao Jiu of triplication, boil rear continuation and soak

After 3～4 hours, get immersion; Add again the Ji Me Lao Jiu of doubling dose in remaining medicinal residues, boil rear continuation and soak after 2～3 hours, get immersion; Merge twice gained immersion, heating evaporation, under the simmer down to room temperature environment, the thick paste of relative density 1.15～1.20, standby.