CN103083669A - 用于治疗炎性疾病和病症的方法 - Google Patents

用于治疗炎性疾病和病症的方法 Download PDF

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Publication number
CN103083669A
CN103083669A CN2012103111308A CN201210311130A CN103083669A CN 103083669 A CN103083669 A CN 103083669A CN 2012103111308 A CN2012103111308 A CN 2012103111308A CN 201210311130 A CN201210311130 A CN 201210311130A CN 103083669 A CN103083669 A CN 103083669A
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polypeptide
pkc
seq
inhibitor
disease
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Chinese (zh)
Inventor
利奥拉·布赖曼-维克斯曼
塔玛·滕宁鲍姆
尤瓦尔·萨吉夫
马里纳·加尔茨贝因
伊弗雷姆·布雷纳
摩西·本-哈莫
利亚特·哈默
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Healor Ltd
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Healor Ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4866—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11013—Protein kinase C (2.7.11.13)

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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CN2012103111308A 2010-01-11 2011-01-11 用于治疗炎性疾病和病症的方法 Pending CN103083669A (zh)

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US29379410P 2010-01-11 2010-01-11
US61/293,794 2010-01-11
US40550910P 2010-10-21 2010-10-21
US61/405,509 2010-10-21

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US (2) US8349793B2 (https=)
EP (3) EP2523677A2 (https=)
JP (2) JP2013516500A (https=)
CN (2) CN103083669A (https=)
AU (1) AU2011204425A1 (https=)
CA (2) CA2789972A1 (https=)
RU (2) RU2012133148A (https=)
WO (3) WO2011083481A2 (https=)

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AU2011327785A1 (en) * 2010-11-08 2013-03-07 Healor Ltd. Buffered ophthalmic compositions and methods of use thereof
WO2014041537A1 (en) * 2012-09-13 2014-03-20 Healor Ltd. Protein kinase c (pkc) alpha inhibitors for treatment and prevention of toxicities caused by radiation
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KR20170040132A (ko) 2014-06-02 2017-04-12 라보라토이레 프란카이즈 듀 프락티온네먼트 에트 데스 바이오테크놀로지스 Fc 단편의 제조
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