CN103083423A - Traditional Chinese prescription for treating hyperglycemia and preparation method thereof - Google Patents
Traditional Chinese prescription for treating hyperglycemia and preparation method thereof Download PDFInfo
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- CN103083423A CN103083423A CN2013100290495A CN201310029049A CN103083423A CN 103083423 A CN103083423 A CN 103083423A CN 2013100290495 A CN2013100290495 A CN 2013100290495A CN 201310029049 A CN201310029049 A CN 201310029049A CN 103083423 A CN103083423 A CN 103083423A
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Abstract
The invention discloses a traditional Chinese prescription for treating hyperglycemia and a preparation method thereof. Calculated according to one-time oral dose of an adult who is 60kg in weight, the traditional Chinese prescription is prepared from the following crude drugs by weight: 10-20g of taibai bushy dasiphora leaf, 10-15g of glossy privet leaf, and 10-15g of persimmon leaf. Pharmacological tests show that the prescription has significant effect of reducing blood sugar, and is safe and innocuous.
Description
Technical field
The invention belongs to medical technical field, relate to a kind of Chinese medicinal formulae for the treatment of hyperglycemia and preparation method thereof.
Background technology
When during medically empty stomach (sugar-free and any sugary food intake in 8 hours), blood glucose is higher than normal range, (fasting glucose normal value 4.0-6.1mmol/L) is referred to as hyperglycemia, if two hours blood glucoses are higher than 7.8mmol/L after the meal, also can be called hyperglycemia.Diabetes are a kind of endocrinopathyes take carbohydrate metabolism disturbance as cardinal symptom, pathogenesis is hypoinsulinism or Insulin receptor INSR dysfunction in patient body, clinical manifestation is empty stomach or post-prandial glycemia rising, glycosuria and hyperlipemia, and its sickness rate just is being the trend that rises year by year.Although hyperglycemia is not a kind of disease, also not exclusively be equal to diabetes, but hyperglycemia and diabetes have inevitable internal relation, hyperglycemia easy induced Diabetic really clinically, and suffer from for a long time hyperglycemia and also may damage eyes, kidney, blood vessel, heart, nerve etc.
Still lack at present the specific drug for the treatment of diabetes.The drug main of western medical treatment diabetes will comprise orally-taken blood sugar reducing class medicine and insulin, and the orally-taken blood sugar reducing medicine comprises sulphanylureas, biguanides, meals glucose regulator etc.Although above these medicines have certain curative effect to the treatment of diabetes, but its effect is not clearly in clinical, and some medicine also has toxic and side effects to the patient, and side effect as the most serious in biguanides is to cause lactic acidosis, after occuring, mortality rate is 50%, unsuitable long-term taking.
On Chinese medicine, the category of diabetes ownership diabetes.Traditional Chinese medical science ancient books early has record to its cause of disease, diagnosis and treatment, and proposes many effective sides of quenching one's thirst, and still is applied to so far clinical.The characteristics such as Chinese medicinal formulae treatment diabetes are cheap due to it, draw materials conveniently, low toxic and side effects and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs than Western medicine, have irreplaceable superiority.
Mount Taibai, the Qinling Mountains, the mountain region is tall and big, and is with a varied topography, and weather conditions are richly endowed by nature, and this ground has bred and has enriched animal and plant resource, wherein is no lack of the specially good effect medicinal herbs, and saying of " Qin ground being without not busy grass " just arranged from ancient times, is one of treasure-house of China's resource medicine.This patent is theoretical according to the Chinese medicine dialectical relationship, in conjunction with the achievement in research of Chinese medical science in recent years, on the basis of excavation reagent combination among the people, tests by modern pharmacology, works out the blood sugar lowering prescription that the white Folium Potentillae Fruticosae of ether is monarch drug.This prescription is concocted the too white Folium Potentillae Fruticosae form and Fructus Ligustri Lucidi (Ligustrum lucidum) leaf and Fructus Kaki (Diospyros kaki) leaf by Rosaceae potentilla plants bush cinqefoil (Potentilla fruticosa) and is formed.By white mice pharmacology and toxicity test, result shows that this prescription has significant hypoglycemic activity, and its hypoglycemic activity is better than positive drug-metformin hydrochloride; And without any the secondary left and right of poison.
Summary of the invention
The object of the invention is to overcome the defective that above-mentioned technology exists, a kind of Chinese medicinal formulae for the treatment of hyperglycemia and preparation method thereof is provided.Pharmacological testing shows that this prescription has obvious effect of lowering blood sugar, and pharmacological testing shows this prescription safety non-toxic.
Its concrete technical scheme is:
A kind of Chinese medicinal formulae for the treatment of hyperglycemia can once take Rapid Dose Calculation orally according to the adult of body weight 60kg, and this prescription is made by the crude drug of following weight: too white Folium Potentillae Fruticosae 10-20g, Folium Ligustri Lucidi 10-15g, Folium Kaki 10-15g.
Further preferred, described prescription is made by the crude drug of following weight ratio: too white Folium Potentillae Fruticosae 10g, Folium Ligustri Lucidi 15g, Folium Kaki 10g.
A kind of preparation method for the treatment of the Chinese medicinal formulae of hyperglycemia comprises the following steps:
1) gather and concoct
Too white Folium Potentillae Fruticosae: be collected in alpine region, Mount Taibai, the Qinling Mountains, height above sea level 3000m between annual 5～June, adopts leaf, the bud or flower of Dasiphora fruticosa (L.) Rydb when putting when alabastrum, after rejecting impurity, blue or green, standby at 180～210 ℃ of lower parches or baking;
The Folium Ligustri Lucidi: in annual 4～5 collections, remove impurity, the 1～1.5min that completes in 80～100 ℃ of water drains after pulling out, then dries under 60～70 ℃, and is standby;
Folium Kaki: gather between annual 5～July, remove impurity, the 1min that completes in 70～80 ℃ of water drains after pulling out, then dries under 60 ℃, and is standby;
The stir-fry of above employing, the fixing method such as dry by the fire, boil, its objective is by high temperature destroy or the bright leaf of passivation in oxidase active, suppress the reaction of polyphenols generation enzymatic oxidation, also play sterilization simultaneously, remove assorted effect of distinguishing the flavor of.
2) preparation
Accurately take by weight ratio of the present invention the medical herbs that above three flavors cook, be placed in the decoction container, add the cold water soak 2h that is equivalent to 5～8 times of medical material amounts, boil 30～60min, filter; Again medicinal residues are added 3～5 times of water gagings and continue to decoct, boil 20～40min, filter.Merge fried liquid twice, but be concentrated into the concentration of prescription in water-bath; But its concentration range is the concentrated medicament of the former dose decocting and concentrating of every 100g 50～100ml, and the most applicable dose 35g that provides by this prescription so calculates, and can obtain the concentrated medicament of 17.5～35ml.The concentration of concentrated medicament can not coexist according to the dosage form of preparation and suitably adjusts in this concentration range.
3) prescription
The production of Chinese medicinal formulae of the present invention, can utilize general pharmaceutical technology (tcd) and equipment to make different dosage form: water decoction, pill, tablet and capsule etc., can satisfy different the need of patients.
Further preferably, step 2) planting described decoction container is crock, marmite, enamelled vessel.
Compared with prior art, beneficial effect of the present invention is:
Too white Folium Potentillae Fruticosae in prescription of the present invention, the Folium Ligustri Lucidi, Folium Kaki all contain more rich active ingredient of Chinese herbs such as flavone, polysaccharide, polyterpene, saponin, alkaloid etc., and the hypoglycemic activity of these active ingredient of Chinese herbs is confirmed by modern study.The too white Folium Potentillae Fruticosae of this prescription is the Ye Jihua of Rosaceae Potentilla bush cinqefoil, is one of most characteristic Chinese herbal medicine in Mount Taibai, takes on monarch drug in prescription.Pass on from one to another from Tang's Sun Simiao and begin with Dasiphora fruticosa (L.) Rydb leaf and tea flower, name day: too white Folium Potentillae Fruticosae.So far the custom of drinking this tea that also keeping among the people.Studies show that; Too white Folium Potentillae Fruticosae contains abundant flavone compound, and flavone component has and is remarkable hypoglycemic activity.Other two flavors Chinese herbal medicine also has certain function of blood sugar reduction as accessory drugs.Fructus Ligustri Lucidi element, oleanolic acid that the report Folium Ligustri Lucidis such as Peng Xiaoying extract all have good hypoglycemic activity.The researchs such as Hu Zhongze find that the Folium Kaki water extract also has stronger hypoglycemic activity.
The traditional Chinese medical science thinks that diabetes is YIN fluid deficiency to the category of diabetes ownership diabetes, scorching inclined to one side Sheng, and take the deficiency of YIN as this, scorching is mark, both reciprocal causations.Treatment is with clearing away heat-fire, and clearing stomach lung moistening, promoting the production of body fluid to quench thirst are principle.Folium Potentillae Fruticosae function in this prescription cures mainly heat clearing away and quenches one's thirst, the stomach invigorating removing dampness; The Folium Ligustri Lucidi has clearing away heat to improve acuity of vision, removes the effect of the loose blood of wind; Folium Kaki energy heat-clearing and toxic substances removing, the lung moistening of quenching the thirst.The present invention meets the Chinese medical discrimination theory on Chinese crude drug selection and compatibility, and compound method is simple.Animal pharmacology and toxicity test result show, make water decoction after three flavor medicine compatibilities, and be remarkable to zoic model with hyperglycemia and diabetes patient's therapeutic effect, and have no side effect, and reached complementary purpose in drug matching.
The specific embodiment
Below in conjunction with specific embodiment, technical scheme of the present invention is described in more detail zoopery
Pharmacodynamics test and acute toxinology experiment to the water decoction that makes.
Pharmacodynamics test
1 material
1.1 animal
240 of Kunming kind white mice, the SPF level, body weight (20 ± 2) g, male and female half and half are provided by Xi'an Jiaotong University Medical College's Experimental Animal Center.The animal quality certification number: SCXK (Shan) 2007-001.
1.2 medicine and reagent
Prescription is comprised of Folium Potentillae Fruticosae, the Folium Ligustri Lucidi, Folium Kaki, all picks up from Mount Taibai, the Qinling Mountains." herbal pharmacology experimental methodology " with reference to the Li Yikui chief editor, people's pharmaceutical quantities is converted into mice dosage, prepares water decoction, high pressure steam sterilization (110 ℃, 15min), 4 ℃ of preservations, standby are the medicinal liquid of 1.52g/ml with distilled water diluting to concentration before use; Metformin hydrochloride tablet MetforminHydrochloride (Beijing Sihuan Pharmaceutical Co., Ltd, batch number: 20110131), porphyrize is made into 0.5% suspension before use; ACCU-CHEK Integra Germany's integrated blood glucose meter of Luo Shi and supporting blood sugar test paper (Luo Shi diagnostic products (Shanghai) Co., Ltd.); Alloxan Alloxan (U.S. Sigma company product).
1.3 instrument
TGL-19 table-type high-speed refrigerated centrifuge (ShangHai City centrifugal Machine Institute product); Electric heating constant-temperature water-bath tank (Shanghai Fang Rui
Instrument plant's product); MP2000D electronic balance (Shanghai Hengping Science Instrument Co., Ltd.'s product.
2 methods
2.1 the foundation of animal model
Alloxan is made into 200mgkg with normal saline
-1Dosage, get 100 healthy Kunming white mice (50 of ♂, 50 of ♀) next day, the lumbar injection alloxan is 2 times, water 12h is can't help in mice fasting in the 5th day, blood is got in docking, survey its fasting glucose concentration with the Luo Shi blood glucose meter, reach 11.1mmolL-1 and above person for successful hyperglycemia model mice with blood sugar concentration, be used for the blood sugar lowering therapeutic test.
2.2 the impact on normal mouse blood sugar
Before test, 36 Kunming white mice are surveyed its fasting blood sugar with the Luo Shi blood glucose meter, be divided at random afterwards the blank group, positive drug-metformin hydrochloride group (0.10gkg
-1) and prescription group (1.52gkg
-1).Administration group administration every day 1 time, blank group gives the equal-volume distilled water, continuously 28d.After the last administration, water 12h is can't help in the mice fasting, and tail vein blood is surveyed its fasting blood sugar with the Luo Shi blood glucose meter.
2.3 alloxan is caused the impact of hyperglycemia model mouse blood sugar
Select successfully 36 of hyperglycemia model mices, be divided at random model group, metformin hydrochloride group, prescription group, 12/every group, male and female sub-cage rearing, regularly perfusion of every morning 9:00; Separately getting 12 mices is the blank group, gavages the equal-volume distilled water every day.Respectively at surveying its fasting blood sugar after perfusion in 7 days, 14 days, 21 days, 28 days.
2.4 date processing
All data all with
Expression, group difference use the SPSS20.0 statistical software to carry out one factor analysis of variance.
3 results
3.1 the impact on normal mouse blood sugar value
Experimental result shows, normal mouse continues medication after 28d, and positive drug-metformin hydrochloride can significantly reduce the blood glucose value (P＜0.05) of mice, affects without significance and this prescription aligns normal mouse blood sugar value.Concrete outcome sees Table 1.
The impact of table 1 on normal mouse blood sugar value
N=12)
Annotate: before and after medication, self compares: A represents P＞0.05, and B represents P＜0.05.
3.2 the impact on hyperglycemia mould mouse blood sugar value
Before administration, except the blank group, each blood glucose value of organizing between mice does not all have significant difference (P＞0.05), and the blood glucose value of respectively organizing mice all the utmost point be significantly higher than blank group (P＜0.01), illustrate that zoic model with hyperglycemia is successfully established.Continued medication 28 days, and surveyed its fasting blood sugar every 7 days, the results are shown in Table 2.
As known from Table 2, administration is after 7 days, and the blood glucose of prescription group mice is significantly lower than blood glucose value before administration (P＜0.05); After administration 14 days, the blood glucose value of positive drug-metformin hydrochloride group mice is significantly lower than blood glucose value before administration (P＜0.05), and the blood glucose value of prescription group mice illustrates that extremely significantly lower than the blood glucose value before administration (P＜0.01) this prescription is rapid-action in treatment mice hyperglycemia process.
Through the treatment of 28 days, the blood glucose value of metformin hydrochloride group and prescription group mice was all extremely significantly lower than the blood glucose value before administration (P＜0.01); Compare with model group, the inequality heteropole is (P＜0.01) significantly.Compare with the blank group, only have the blood glucose value of this prescription group mice there is no significant difference (P＞0.05).
The impact of table 2 on hyperglycemia mould mouse blood sugar value
N=12)
Annotate: 1) before and after medication, self compares: * represents P＜0.05, and * * represents P＜0.01; 2) after medication, test group and model group compare: △ represents P＜0.01; 3) after medication, test group and blank group compare: # represents P＞0.05.
Conclusion
This prescription causes the hyperglycemia model mice to alloxan extremely significant hypoglycemic activity (P＜0.01), and normal mouse blood sugar value is affected without significance.Result of study points out this prescription to have preferably hypoglycemic activity and without obvious toxic-side effects.
Acute toxinology experiment
The maximum dosage-feeding experiment has only been done in this experiment.Can fill with concentration (3g/ml) with the maximum that can make, maximum gavage capacity (0.4ml/20g) gavages this prescription twice altogether through stomach, and wherein the gavage volume reduces by half for the second time.After gavage, mice outward appearance, behavioral activity, breathing, secretions, Excreta no abnormality seen, do not have dead mouse.Record maximum tolerated dose 〉=90g/kg, this dosage is more than 529 times of clinical adult (calculating with 60kg) oral dose 0.17g/kg every day.According to acute toxicity grading criteria, think this tested material to animal subject without acute toxicity.
Clinical effectiveness
Because the present invention not yet obtains country about the relevant official written reply of new Chinese medicine clinical research, can not enter clinical research, therefore only carry out clinical trial with it 3 routine volunteers, clinical test results all is cited as " produce effects ".Wherein 1 example is as follows.
* *, man, 51 years old, height 171cm, body weight 53kg, Xianyang, Shanxi province people from city.
Readme: thirsty polydipsia, polyuria, weak, become thin.Treating 3 times, fasting blood sugar is that 8.54 ± 1.21,3 postprandial plasma glucose levels are 13.89 ± 1.67.Tcm diagnosis is diabetes, and Western medicine diagnose is type ii diabetes.Take the water decoction that the present invention makes, every day 2 times.After medication 11 days, the polyuria transference cure, fasting blood sugar is reduced to 7.4mmol/L, and postprandial plasma glucose level is reduced to 8.5moml/L.After one month, " more than three " symptom disappears substantially, and fasting blood sugar is down to 6.3moml/L, and postprandial plasma glucose level is down to 7.5moml/L.Clinical therapeutic efficacy is cited as " produce effects ".
The above; only be the better specific embodiment of the present invention; protection scope of the present invention is not limited to this; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses, the simple change of the technical scheme that can obtain apparently or equivalence are replaced and are all fallen within the scope of protection of the present invention.
Claims (5)
1. a Chinese medicinal formulae for the treatment of hyperglycemia, is characterized in that, can once take Rapid Dose Calculation orally according to the adult of body weight 60kg, and this prescription is made by the crude drug of following weight: too white Folium Potentillae Fruticosae 10-20g, Folium Ligustri Lucidi 10-15g, Folium Kaki 10-15g.
2. the Chinese medicinal formulae for the treatment of hyperglycemia according to claim 1, is characterized in that, described prescription is made by the crude drug of following weight ratio: too white Folium Potentillae Fruticosae 10g, Folium Ligustri Lucidi 15g, Folium Kaki 10g.
3. the preparation method of the Chinese medicinal formulae of the described treatment hyperglycemia of claim 1, is characterized in that, comprises the following steps:
1) gather and concoct
Too white Folium Potentillae Fruticosae: be collected in alpine region, Mount Taibai, the Qinling Mountains, height above sea level 3000m between annual 5～June, adopts leaf, the bud or flower of Dasiphora fruticosa (L.) Rydb when putting when alabastrum, after rejecting impurity, blue or green, standby at 180～210 ℃ of lower parches or baking;
The Folium Ligustri Lucidi: in annual 4～5 collections, remove impurity, the 1～1.5min that completes in 80～100 ℃ of water drains after pulling out, then dries under 60～70 ℃, and is standby;
Folium Kaki: gather between annual 5～July, remove impurity, the 1min that completes in 70～80 ℃ of water drains after pulling out, then dries under 60 ℃, and is standby;
2) preparation
Accurately take by weight ratio claimed in claim 1 the medical herbs that above three flavors cook, be placed in the decoction container, add the cold water soak 2h that is equivalent to 5～8 times of medical material amounts, boil 30-60min, filter; Again medicinal residues are added 3-5 times of water gaging and continue to decoct, boil 20～40min, filter, merge fried liquid twice, but be concentrated into the concentration of prescription in water-bath; But its concentration range is the concentrated medicament of the former dose decocting and concentrating of every 100g 50～100ml;
3) prescription
Make different dosage form: water decoction, pill, tablet and capsule.
4. the preparation method of the Chinese medicinal formulae for the treatment of hyperglycemia according to claim 3, is characterized in that step 2) described concentrated medicament 7.5～35ml.
5. the preparation method of the Chinese medicinal formulae for the treatment of hyperglycemia according to claim 3, is characterized in that step 2) to plant described decoction container be crock, marmite, enamelled vessel.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103891835A (en) * | 2014-03-12 | 2014-07-02 | 安徽金鹰农业科技有限公司 | Cookie made of canna edulis ker and bananas and making method thereof |
| CN104782835A (en) * | 2015-04-08 | 2015-07-22 | 魏冰星 | Compound health keeping medicinal tea applicable to sub-healthy groups |
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| CN101172131A (en) * | 2006-11-01 | 2008-05-07 | 中国医药研究开发中心有限公司 | Method for preparing potentilla plants total-triterpene extract |
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| USPP12258P2 (en) * | 2000-04-07 | 2001-12-04 | University Of Manitoba | Potentilla fruticosa plant named ‘UMan’ |
| CN101172131A (en) * | 2006-11-01 | 2008-05-07 | 中国医药研究开发中心有限公司 | Method for preparing potentilla plants total-triterpene extract |
| CN101172109A (en) * | 2006-11-01 | 2008-05-07 | 中国医药研究开发中心有限公司 | Medicine use of potentilla plants total-triterpene extract |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103891835A (en) * | 2014-03-12 | 2014-07-02 | 安徽金鹰农业科技有限公司 | Cookie made of canna edulis ker and bananas and making method thereof |
| CN103891835B (en) * | 2014-03-12 | 2015-04-29 | 安徽金鹰农业科技有限公司 | Cookie made of canna edulis ker and bananas and making method thereof |
| CN104782835A (en) * | 2015-04-08 | 2015-07-22 | 魏冰星 | Compound health keeping medicinal tea applicable to sub-healthy groups |
| CN104782835B (en) * | 2015-04-08 | 2017-11-17 | 魏冰星 | Compound health care medicinal tea suitable for sub-health population |
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Application publication date: 20130508 |