CN103071550A - Multi-component liquid drop generation device based on different-incidence-angle micro-channels, and method thereof - Google Patents
Multi-component liquid drop generation device based on different-incidence-angle micro-channels, and method thereof Download PDFInfo
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- CN103071550A CN103071550A CN2012105489231A CN201210548923A CN103071550A CN 103071550 A CN103071550 A CN 103071550A CN 2012105489231 A CN2012105489231 A CN 2012105489231A CN 201210548923 A CN201210548923 A CN 201210548923A CN 103071550 A CN103071550 A CN 103071550A
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Abstract
The invention provides a multi-component liquid drop generation device based on different-incidence-angle micro-channels, and method thereof. The device comprises a primary channel, a secondary channel forming an acute angle with the primary channel, and a group of micro-channels used for adding other wrapping components; and a continuous phase solution flows through the primary channel, a dispersion phase solution flows through the secondary channel, and meets the continuous phase solution in the primary channel to form a large first liquid drop, and the other wrapping components flow into the primary channel through the micro-channels and forms a plurality of small second liquid drops in the first liquid drop. The method is characterized in that the continuous phase is let in through the primary channel, the dispersion phase is let in through the secondary channel after the continuous phase flows stably, the flow rates of the continuous phase and the dispersion phase are adjusted to guarantee the formation of the large first liquid drop, and a needed component solution is let in through the micro-channels after the size and the frequency of the first liquid drop are stable in order to guarantee the generation of the small second liquid drops in the first liquid drop. A multi-component liquid drop is generated through adopting the simple device in the invention.
Description
Technical field
The present invention relates to a kind of device that produces dual multicomponent drop, can be used for the application that co-culture of cells, capsule prepare the aspect.
Background technology
Process along with modern industrialization, little chemical industry also becomes one of new developing direction of Chemical Engineering subject, and also more and more receives people's concern as the generation technique of little drop of little chemical industry core technology, and it is at food, medical science, there is great using value the chemical industry aspect.The drop that can produce at present has two kinds of multiple drop and many components drops, and wherein, the purposes of multicomponent drop comprises: the production of cell cultivation, bio-pharmaceuticals, cosmetics.And present many components drop all is to generate by the bushing type micro-channel device, and this apparatus structure is complicated, cost is high, the control difficulty is large.
In theory, can realize that by the control to T-shaped microchannel incident angle the drop that varies in size prepares, based on this thought, we propose to produce dual many components drop with the microchannel of varied angle.Concretism is as follows: at first the microchannel with little incidence angle produces a large drop, and take this large drop as continuous phase, the microchannel with several different incidence angles produces droplet in large drop the inside again; In whole preparation process, can by control incidence angle and each phase flow rate, realize the accurate control of large drop and droplet volume and quantity.
Summary of the invention
Technical problem to be solved by this invention provides a kind of technology that produces dual multicomponent drop, and it can produce multi-component drop under controlled and the condition that is easy to realize.
A kind of generation device of multicomponent drop is characterized in that: comprise the main channel, with the acutangulate subchannel in main channel and the microchannel family that be used for to add other parcel compositions; Continuous phase solution flows through from the main channel, decentralized photo solution flows through and meets and form the first larger drop with the continuous phase solution in the trunk line from subchannel, other parcel compositions flow into the main channel in microchannel, form a plurality of the second less drops in the first drop.
As the preferred embodiments of the present invention, the width of described main channel is greater than inferior duct width, and inferior duct width is greater than the width of each microchannel.
As the preferred embodiments of the present invention, the width of described main channel is 1 ~ 2 times of time duct width.
As the preferred embodiments of the present invention, each microchannel in the family of described microchannel all becomes the obtuse angle setting with the main channel.
As the preferred embodiments of the present invention, the distance of described microchannel family and subchannel is within the liquid film coating scope of large drop.
A kind of method that produces the multicomponent drop, from the main channel, pass into continuous phase, after mobile the settling out of continuous phase, from inferior pipeline, pass into decentralized photo, regulate the flow of continuous phase and decentralized photo, guarantee to form the first larger drop, after the size and frequency stabilization of the first drop, from the microchannel, pass into the component solution that needs, guarantee in the first drop, to produce the second less drop.
As the preferred embodiments of the present invention, the size of described the second drop is controlled by the flow of regulating the microchannel.
As the preferred embodiments of the present invention, the big or small stable criterion of described the first drop is: the first drop of formation has comprised the zone of all microchannel families.
Compared with prior art, the present invention has the following advantages at least: the present invention at first produces first a larger drop by the flow velocity of regulating continuous phase and decentralized photo, then at the second less drop of the inner generation of the first drop,
Description of drawings
Fig. 1 is the structural representation of apparatus of the present invention.
The specific embodiment
The generation device of many components drop of the present invention comprises: the main channel 1 of circulation continuous phase liquid, the subchannel 2 of circulation decentralized photo liquid, the microchannel family 3 of circulation component solution, wherein main channel and subchannel are acute angle, each microchannel in main channel and the microchannel family angled (within 90 ~ 180 °) also has within the liquid film scope of the first larger drop that the distance of microchannel family and subchannel should form in the main channel.
Should look different continuous phase as for the acute angle described in the invention and the size at obtuse angle, decentralized photo and component solution and decide make it can produce desirable many components drop and get final product under suitable flow.
The main channel should be greater than subchannel (main channel be 1 ~ 2 times of subchannel) in theory as for the size of three passages in the invention, and subchannel should be greater than the microchannel, and concrete size is situation and deciding.
Working control: at first from the main channel, pass into continuous phase, treat that the mobile of continuous phase settled out, pass into decentralized photo from subchannel, the flow of regulating the two makes the droplet size of generation suitable, and the standard of judgement is the zone that the size of drop just can comprise all microchannels.When the size of drop to be generated and frequency are more stable, pass into component solution from the microchannel, regulate the flow of each microchannel in needed ratio, make it to satisfy proportion requirement and can produce sizeable drop, just can produce on request from the main channel corresponding many components drop afterwards.
The above only is one embodiment of the present invention, it or not whole or unique embodiment, the conversion of any equivalence that those of ordinary skills take technical solution of the present invention by reading specification of the present invention is claim of the present invention and contains.
Claims (8)
1. generation device based on the multicomponent drop of different incidence angles microchannel is characterized in that: comprise main channel (1), with the acutangulate subchannel in main channel (2) and the microchannel family (3) that is used for adding other parcel compositions; Continuous phase solution from the main channel (1) flow through, decentralized photo solution flows through and meets and form the first larger drop with the continuous phase solution in the trunk line from subchannel (2), other parcel compositions flow into the main channel in microchannel, form a plurality of the second less drops in the first drop.
2. device as claimed in claim 1, it is characterized in that: the width of described main channel is greater than inferior duct width, and inferior duct width is greater than the width of each microchannel.
3. device as claimed in claim 1 or 2 is characterized in that: the width of described main channel is 1 ~ 2 times of time duct width.
4. device as claimed in claim 1, it is characterized in that: each microchannel in the family of microchannel all becomes the obtuse angle setting with the main channel.
5. device as claimed in claim 1 is characterized in that: the distance of described microchannel family and subchannel is within the liquid film coating scope of large drop.
6. method that is produced the multicomponent drop by device claimed in claim 1, it is characterized in that: from the main channel, pass into continuous phase, after mobile the settling out of continuous phase, from inferior pipeline, pass into decentralized photo, regulate the flow of continuous phase and decentralized photo, guarantee to form the first larger drop, after the size and frequency stabilization of the first drop, from the microchannel, pass into the component solution that needs, guarantee in the first drop, to produce the second less drop.
7. method as claimed in claim 6 is characterized in that: the size of described the second drop is controlled by the flow of regulating the microchannel.
8. method as claimed in claim 6, it is characterized in that: the big or small stable criterion of described the first drop is: the first drop of formation has comprised the zone of all microchannel families.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012105489231A CN103071550A (en) | 2012-12-17 | 2012-12-17 | Multi-component liquid drop generation device based on different-incidence-angle micro-channels, and method thereof |
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| CN2012105489231A CN103071550A (en) | 2012-12-17 | 2012-12-17 | Multi-component liquid drop generation device based on different-incidence-angle micro-channels, and method thereof |
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| CN103071550A true CN103071550A (en) | 2013-05-01 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106573242A (en) * | 2014-08-06 | 2017-04-19 | J·舒福莱企业公司 | Method for fusing or contacting reagent droplets and reagent droplets in a microfluidics device or a microfluidics device |
| TWI638653B (en) | 2017-11-22 | 2018-10-21 | 財團法人金屬工業研究發展中心 | Apparatus for producing microparticles |
| CN114602564A (en) * | 2022-03-04 | 2022-06-10 | 广东省科学院生物与医学工程研究所 | Droplet microfluidic system and control method |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040068019A1 (en) * | 2001-02-23 | 2004-04-08 | Toshiro Higuchi | Process for producing emulsion and microcapsules and apparatus therefor |
| US20050103690A1 (en) * | 2003-11-19 | 2005-05-19 | Aisin Seiki Kabushiki Kaisha | Micro liquid control system |
| WO2006098700A1 (en) * | 2005-03-18 | 2006-09-21 | Nanyang Technological University | Microfluidic sensor for interfacial tension measurement and method for measuring interfacial tension |
| CN101110278A (en) * | 2007-08-10 | 2008-01-23 | 东南大学 | Method for preparing fusion pallet based on micro-fluid |
| CN101474541A (en) * | 2008-12-16 | 2009-07-08 | 深圳先进技术研究院 | Integrated chip and device thereof, and method for preparing micrometre level dispersoid |
| CN102008983A (en) * | 2010-11-01 | 2011-04-13 | 武汉大学 | Microfluidic chip suitable for producing microcapsules |
| WO2012162296A2 (en) * | 2011-05-23 | 2012-11-29 | President And Fellows Of Harvard College | Control of emulsions, including multiple emulsions |
-
2012
- 2012-12-17 CN CN2012105489231A patent/CN103071550A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040068019A1 (en) * | 2001-02-23 | 2004-04-08 | Toshiro Higuchi | Process for producing emulsion and microcapsules and apparatus therefor |
| US20050103690A1 (en) * | 2003-11-19 | 2005-05-19 | Aisin Seiki Kabushiki Kaisha | Micro liquid control system |
| WO2006098700A1 (en) * | 2005-03-18 | 2006-09-21 | Nanyang Technological University | Microfluidic sensor for interfacial tension measurement and method for measuring interfacial tension |
| CN101110278A (en) * | 2007-08-10 | 2008-01-23 | 东南大学 | Method for preparing fusion pallet based on micro-fluid |
| CN101474541A (en) * | 2008-12-16 | 2009-07-08 | 深圳先进技术研究院 | Integrated chip and device thereof, and method for preparing micrometre level dispersoid |
| CN102008983A (en) * | 2010-11-01 | 2011-04-13 | 武汉大学 | Microfluidic chip suitable for producing microcapsules |
| WO2012162296A2 (en) * | 2011-05-23 | 2012-11-29 | President And Fellows Of Harvard College | Control of emulsions, including multiple emulsions |
Non-Patent Citations (3)
| Title |
|---|
| ANSGAR HUEBNER ETAL.: "Microdroplets: A sea of applications", 《LAB ON A CHIP》 * |
| HELEN SONG ETAL.: "Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of Reagents", 《JACS》 * |
| 龚莹莹: "液滴微流控芯片用于酶活力的测定和细胞包裹", 《中国优秀博硕士学位论文全文数据库（硕士）基础科学辑》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106573242A (en) * | 2014-08-06 | 2017-04-19 | J·舒福莱企业公司 | Method for fusing or contacting reagent droplets and reagent droplets in a microfluidics device or a microfluidics device |
| CN106573242B (en) * | 2014-08-06 | 2019-01-08 | J·舒福莱企业公司 | Method for fusing or contacting reagent droplets and reagent droplets in a microfluidics device or a microfluidics device |
| TWI638653B (en) | 2017-11-22 | 2018-10-21 | 財團法人金屬工業研究發展中心 | Apparatus for producing microparticles |
| CN114602564A (en) * | 2022-03-04 | 2022-06-10 | 广东省科学院生物与医学工程研究所 | Droplet microfluidic system and control method |
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Application publication date: 20130501 |