CN211385061U - Micro-fluidic re-emulsification system - Google Patents
Micro-fluidic re-emulsification system Download PDFInfo
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- CN211385061U CN211385061U CN201922227632.2U CN201922227632U CN211385061U CN 211385061 U CN211385061 U CN 211385061U CN 201922227632 U CN201922227632 U CN 201922227632U CN 211385061 U CN211385061 U CN 211385061U
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Abstract
The utility model relates to a micro-fluidic re-emulsification system, the base plate has seted up A in proper order on the horizontal direction and has compatibly accomodate the groove, B is compatibly accomodate the groove, C is compatibly accomodate the groove and is mixed compatibly and accomodate the groove, A is compatibly accomodate the groove and is mixed compatibly and accomodate the first miniflow channel groove intercommunication through having at least two reposition of redundant personnel grooves between the groove, first miniflow channel groove and A are compatibly accomodate and are equipped with first confluence, first miniflow channel groove and mixed compatibly are accomodate and are equipped with the second confluence between the groove, B is compatibly accomodate and are communicated through the second miniflow channel groove that has at least two reposition of redundant personnel grooves between groove, second miniflow channel groove and B are compatibly accomodate and are equipped with the third confluence, be equipped with the fourth confluence between second miniflow channel groove and the second confluence, C is compatibly accomodate groove and fourth confluence; the utility model provides a make heterogeneous torrent, laminar flow and the atomizing state of reaching in the microchannel, realized the micro-fluidic multiple emulsion system that the multiple emulsion of sample required.
Description
Technical Field
The utility model relates to a pharmacy field especially relates to a micro-fluidic multiple emulsion system.
Background
Double emulsion, which is a multi-layer emulsion formed by dispersing an emulsion in another continuous phase, generally has two types of O/W/O and W/O/W. The double emulsion has a unique 'two-membrane three-phase' multi-compartment structure, can dissolve substances with different properties in different phases respectively, has multiple functional effects of protection, isolation, controlled release, targeted release and the like, and is applied to the fields of pharmacy, food, cosmetics, chemical industry and the like. However, since the double emulsion is a thermodynamically unstable system, the preparation method of the process may limit its application in various fields.
The micro-fluidic re-emulsification system is connected with the micro-fluidic chip through the preparation pump and the high-pressure delivery pump, and the phase A, the phase B and the phase C can be slowly and mildly delivered into the chip at a constant speed according to a certain proportion for mixing and emulsification. Different flow channel structures are designed in the micro-fluidic chip, different speeds are controlled, so that the sample can reach a turbulent flow state, a laminar flow state or an atomization state in the micro-fluidic chip, and the requirement of the re-emulsification of the sample can be met. The prepared sample is conveyed into a high-pressure microfluidic chip through a high-pressure pump, and the particle size is controlled through impact force and shearing force to enable the particle size to reach the required range. The particle size can be within 100nm at the minimum, and the PDI is less than 0.1.
The micro-fluidic re-emulsification system in the prior art has the problems that the pressure is too low, effective process preparation and particle size processing cannot be carried out on a sample, sample residue and the like exist, and the temperature of the sample cannot be controlled. For expensive samples, this is too costly and time consuming to handle.
In view of the above-mentioned drawbacks, the present designer has made active research and innovation to create a microfluidic re-emulsification system that can meet the requirements of laboratory sample preparation and processing, so that the system has industrial utility value.
SUMMERY OF THE UTILITY MODEL
In order to solve the technical problem, the utility model aims at providing a micro-fluidic multiple emulsification system that can carry out effectual technology preparation and particle size processing to the sample.
The utility model discloses a micro-fluidic system of reemulsification, including apron and base plate, its characterized in that: the base plate is sequentially provided with an A compatible containing groove, a B compatible containing groove, a C compatible containing groove and a mixed compatible containing groove in the horizontal direction, the A compatible containing groove and the mixed compatible containing groove are communicated through a first micro-channel groove with at least two shunt channel grooves, a first confluence point is arranged between the first micro-channel groove and the A compatible containing groove, a second confluence point is arranged between the first micro-channel groove and the mixed compatible containing groove, the B compatible containing groove and the second confluence point are communicated through a second micro-channel groove with at least two shunt channel grooves, a third confluence point is arranged between the second micro-channel groove and the B compatible containing groove, a fourth confluence point is arranged between the second micro-channel groove and the second confluence point, the C compatible containing groove and the fourth confluence point are communicated, and a cover plate positioned above the base plate is respectively provided with the A compatible containing groove, the B compatible containing groove, the C compatible containing groove, the mixed compatible containing groove, the first micro-channel groove and the second micro-channel groove, The phase A liquid inlet hole, the phase B liquid inlet hole, the phase C liquid inlet hole and the mixed phase liquid outlet hole are communicated with the phase C holding tank and the mixed holding tank.
Furthermore, the two branch channel grooves are arranged in parallel.
Furthermore, the distance between the A phase containing groove, the B phase containing groove and the C phase containing groove is consistent.
Further, the slot line length between the hybrid compatible nano-slot and the second bus point is greater than the slot line length between the A-compatible nano-slot and the first bus point.
Furthermore, the cover plate and the base plate are fixedly connected through a plurality of matched threaded holes and screws.
Furthermore, an annular sealing groove is further formed in the substrate.
Further, the A compatible nano-groove, the B compatible nano-groove, the C compatible nano-groove and the mixed compatible nano-groove are distributed on the same horizontal line.
The above description is only an overview of the technical solution of the present invention, and in order to make the technical means of the present invention clearer and can be implemented according to the content of the description, the following detailed description is made with reference to the preferred embodiments of the present invention and accompanying drawings.
Drawings
Fig. 1 is a top view of a microfluidic reemulsification system of the present invention;
fig. 2 is a top view of the substrate of fig. 1.
1 base plate 2 cover plate
3A-phase accommodating groove and 4B-phase accommodating groove
5C compatible nano-groove 6 mixed compatible nano-groove
7 first microchannel 8 first confluence point
9 second confluence point 10 second microchannel
11 third bus point 12 fourth bus point
13A phase liquid inlet hole and 14B phase liquid inlet hole
15C phase liquid inlet hole and 16 mixed phase liquid outlet hole
17 threaded hole 18 ring seal groove
Detailed Description
The following detailed description of the embodiments of the present invention is provided with reference to the accompanying drawings and examples. The following examples are intended to illustrate the invention, but are not intended to limit the scope of the invention.
A microfluidic double emulsification system as shown in fig. 1 and 2, comprising a cover plate 2 and a base plate 1, wherein: the substrate 1 is sequentially provided with an A compatible containing groove 3, a B compatible containing groove 4, a C compatible containing groove 5 and a mixed compatible containing groove 6 in the horizontal direction, the A compatible containing groove 3 and the mixed compatible containing groove 6 are communicated through a first micro-runner groove 7 with at least two shunt channel grooves, a first confluence point 8 is arranged between the first micro-runner groove 7 and the A compatible containing groove 3, a second confluence point 9 is arranged between the first micro-runner groove 7 and the mixed compatible containing groove 6, the B compatible containing groove 4 and the second confluence point 9 are communicated through a second micro-runner groove 10 with at least two shunt channel grooves, a third confluence point 11 is arranged between the second micro-runner groove 10 and the B compatible containing groove 4, a fourth confluence point 12 is arranged between the second micro-runner groove 10 and the second confluence point 9, the C compatible containing groove 5 and the fourth confluence point 12 are communicated, a cover plate 2 positioned above the substrate 1 is respectively provided with the A compatible containing groove 3, the B compatible containing groove 4, the C compatible containing groove 4, the first micro-runner groove and the second confluence point 9, Phase A liquid inlet hole 13, phase B liquid inlet hole 14, phase C liquid inlet hole 15 and mixed phase liquid outlet hole which are communicated with phase B holding tank 4, phase C holding tank 5 and mixed phase holding tank 6.
The utility model provides a micro-fluidic reemulsification system's principle as follows:
the preparation pump and the high-pressure delivery pump are connected with the micro-fluidic re-emulsification system, wherein, the phase A, the phase B and the phase C can be respectively delivered to the phase A containing groove 3, the phase B containing groove 4 and the phase C containing groove 5 on the substrate 1 through the phase A liquid inlet hole 13, the phase B liquid inlet hole 14 and the phase C liquid inlet hole 15 which are arranged on the cover plate 2 at a constant speed according to a certain proportion, wherein the phase C in the phase C holding tank 5 reaches the fourth confluence point 12 through a tank line, meanwhile, the phase B in the phase B holding tank 4 slowly and mildly reaches the fourth confluence point 12 through the second microchannel groove 10, the phase B and the phase C are mixed and emulsified and then reach the second confluence point 9, meanwhile, the phase A in the phase A holding tank slowly and mildly passes through the first micro-runner tank 7 to reach the second confluence point 9 to realize the mixed emulsification of the phase A, the phase B and the phase C, and then the phase A, the phase B and the phase C reach the mixed holding tank 6 and then flow out through the mixed phase liquid outlet hole 16 to finish the re-emulsification.
In this embodiment, in order to realize confluence, diversion and confluence in sequence, two runner channels are arranged in parallel with each other.
In this embodiment, in order to control the mixing and emulsification among the phases a, B and C, the spaces between the phase a holding grooves 3, the phase B holding grooves 4 and the phase C holding grooves 5 are uniform.
In the present embodiment, in order to achieve the optimum re-emulsification effect by the buffer-stable fusion of the mixed phases, the slot line length between the mixed-phase accommodating groove and the second bus point 9 is larger than the slot line length between the a-phase accommodating groove 3 and the first bus point 8.
In the embodiment, in order to realize the close adhesion between the cover plate 2 and the base plate 1, the cover plate 2 and the base plate 1 are fixedly connected through a plurality of matched threaded holes 17 and screws.
In this embodiment, in order to prevent overflow, an annular sealing groove 18 is further disposed on the substrate 1, and the annular sealing groove 18 surrounds the whole re-emulsification system, so that the re-emulsification can be smoothly completed by matching with the preparation pump and the high-pressure delivery pump.
In the present embodiment, in order to accurately calculate the time required for the mutual communication distances in the a-, B-, C-and mixed- phase accommodating chambers 3, 4, 5 and 6, the a-, B-, C-and mixed- phase accommodating chambers 3, 4, 5 and 6 are arranged on the same horizontal line.
Borrow by above-mentioned scheme, the utility model discloses at least, have following advantage:
1. controlling the particle size: the pressure of the laboratory is more than 20Mpar, and the highest pressure can reach 25 Mpa;
2. sample range: the sample can be continuously and stably output 0.1-200 ml per minute, and can be completely removed, and no residue is caused in the channel;
3. temperature control: the temperature can be regulated and controlled within 0-100 ℃;
4. micro flow channel size: the micro-channel has the size of 20 um-1 mm, and is suitable for different sample preparation and processing requirements;
5. the microfluidic emulsification system can realize the sample preparation and processing technology in a pipeline, can realize continuous operation, and has good process reproduction and amplification advantages.
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, it should be noted that, for those skilled in the art, a plurality of modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.
Claims (7)
1. A micro-fluidic multiple emulsion system, includes apron and base plate, its characterized in that: the base plate is sequentially provided with an A compatible containing groove, a B compatible containing groove, a C compatible containing groove and a mixed compatible containing groove in the horizontal direction, the A compatible containing groove and the mixed compatible containing groove are communicated through a first micro-channel groove with at least two shunt channel grooves, a first confluence point is arranged between the first micro-channel groove and the A compatible containing groove, a second confluence point is arranged between the first micro-channel groove and the mixed compatible containing groove, the B compatible containing groove and the second confluence point are communicated through a second micro-channel groove with at least two shunt channel grooves, a third confluence point is arranged between the second micro-channel groove and the B compatible containing groove, a fourth confluence point is arranged between the second micro-channel groove and the second confluence point, the C compatible containing groove and the fourth confluence point are communicated, and a cover plate positioned above the base plate is respectively provided with the A compatible containing groove, the B compatible containing groove, the C compatible containing groove, the mixed compatible containing groove, the first micro-channel groove and the second micro-channel groove, The phase A liquid inlet hole, the phase B liquid inlet hole, the phase C liquid inlet hole and the mixed phase liquid outlet hole are communicated with the phase C holding tank and the mixed holding tank.
2. The microfluidic demulsification system of claim 1, wherein: the two branch channel grooves are arranged in parallel.
3. The microfluidic demulsification system of claim 1, wherein: the distance between the A phase containing groove, the B phase containing groove and the C phase containing groove is consistent.
4. The microfluidic demulsification system of claim 1, wherein: the length of the slot line between the mixed phase accommodating groove and the second confluence point is larger than that between the A phase accommodating groove and the first confluence point.
5. The microfluidic demulsification system of claim 1, wherein: the cover plate and the base plate are fixedly connected through a plurality of matched threaded holes and screws.
6. The microfluidic demulsification system of claim 1, wherein: an annular sealing groove is further formed in the substrate.
7. The microfluidic demulsification system of claim 1, wherein: the A compatible nano groove, the B compatible nano groove, the C compatible nano groove and the mixed compatible nano groove are distributed on the same horizontal line.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922227632.2U CN211385061U (en) | 2019-12-12 | 2019-12-12 | Micro-fluidic re-emulsification system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922227632.2U CN211385061U (en) | 2019-12-12 | 2019-12-12 | Micro-fluidic re-emulsification system |
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| CN211385061U true CN211385061U (en) | 2020-09-01 |
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| CN201922227632.2U Active CN211385061U (en) | 2019-12-12 | 2019-12-12 | Micro-fluidic re-emulsification system |
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