CN103055138A - 一种治疗缺血性肝炎的中药 - Google Patents
一种治疗缺血性肝炎的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗缺血性肝炎的中药，由以下重量配比的药材制备而成：党参12份、黄芪10份、山药14份、金樱子12份、百合10份、天门冬10份、玉竹14份、金腰8份、当归12份、肉苁蓉6份、锁阳6份、何首乌12份、白芍14份、百合12份、穿心莲10份、番红花8份、地龙6份、吴茱萸6份。临床实验证明，本发明能够安全有效治疗缺血性肝炎。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗缺血性肝炎的中药。
背景技术
缺血性肝炎系指可逆性严重低血压和低氧血症导致肝小叶中央坏死，常由充血性心力衰竭、休克、肝外伤及心脏手术后，致心源性或低血容量性休克，特别是与休克后肝脏再灌注性损伤有关。临床表现类似急性肝炎，丙氨酸氨基转移酶(ALT)及乳酸脱氢酶(LDH)持续显著性升高，但无肝炎病毒感染及肝毒性药到病除物的证据。
对于缺血性肝炎目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
党参【来源】中药党参为桔梗科多年生草本植物【功能主治】具有补中益气，健脾益肺之功效。增强免疫力、扩张血管、降压、改善微循环、增强造血功能等作用
黄芪【来源】为豆科植物蒙古黄芪或膜荚黄芪的根。除去须根及根头，晒干，切片，生用或蜜炙用。【功能主治】有增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。
山药【来源】多年生草本植物，茎蔓生，常带紫色，块根圆柱形，叶子对生，卵形或椭圆形，花乳白色，雌雄异株。块根含淀粉和蛋白质。【功能主治】补脾养胃，生津益肺，补肾涩精。用于脾虚食少，久泻不止，肺虚喘咳，肾虚遗精，带下，尿频，虚热消渴。
金樱子【来源】常绿蔓性灌木，无毛根皮提制栲胶；果实入药。【功能主治】止咳平喘，抗痉挛，有利尿、补肾作用；抗菌消炎，降血脂。叶有解毒消肿作用；根药用，能活血散瘀、拔毒收敛、祛风驱湿。
百合【来源】百合科百合属多年生草本球根植物，其花、鳞状茎均可入药，是一种药食兼用的花卉。【功能主治】性微寒平，具有清火、润肺、安神的功效。
天门冬【来源】百合科植物。又名天冬。性寒，味甘，微苦。具有养阴清热，润肺滋肾的功效。【功能主治】用于治阴虚发热、咳嗽吐血、肺痈、咽喉肿痛、消渴、便秘等病症。
玉竹【来源】为百合科多年生草本植物。根茎横走，肉质黄白色，密生多数须根。晒干，或蒸透后，揉至半透明，晒干，切厚片或段用。【功能主治】滋阴润肺；养胃生津。燥咳；劳嗽；热病阴液耗伤之咽干口渴；内热消渴；阴虚外感；头昏眩晕；筋脉挛痛。
金腰【来源】虎耳草科金腰Chrysosplenium grayanum Maxim.，以全草入药。【功能主治】排脓解毒。外用治黑头疔疮。
当归【来源】学名：Angelica sinensis，多年生草本植物，茎带紫色。各地均有栽培。根可入药，是最常用的中药之一。【功能主治】抗缺氧、调节机体免疫功能、抗癌、护肤美容、补血活血、抑菌、抗动脉硬化
肉苁蓉【来源】一种寄生在沙漠树木梭梭、红柳根部的寄生植物，【功能主治】补肾阳、益精血，能抑制“阳虚”症状的出现，防止体重减轻。可有效地预防、治疗男子肾虚阳痿、遗精早泄及女子月经不调、闭经不孕等疾病。
锁阳【来源】又名不老药，多年生肉质寄生草本。地下茎粗短，具有多数瘤突吸收根，野生于沙漠戈壁，生长之处不积雪、地不冻。【功能主治】有补肾润肠、治阳痿，尿血等功效。。
何首乌【来源】为蓼科多年生缠绕藤本植物。根细长，末端成肥大的块根，外表红褐色至暗褐色。植物的块根、藤茎及叶均可供药用。【功能主治】解毒、润肠通便、消痈；补益精血、乌须发、强筋骨、补肝肾。促进造血功能，增强免疫功能。
白芍【来源】为双子叶植物药毛茛科植物芍药(栽培种)的根。已栽植3～4年的芍药根，除去根茎及须根，洗净，刮去粗皮，入沸水中略煮，使芍根发软，捞出晒干。【功能主治】养血柔肝，缓中止痛，敛阴收汗。治胸腹胁肋疼痛，泻痢腹痛，自汗盗汗，阴虚发热，月经不调，崩漏，带下。
百合【来源】百合科百合属多年生草本球根植物，其花、鳞状茎均可入药，是一种药食兼用的花卉。【功能主治】性微寒平，具有清火、润肺、安神的功效。
穿心莲【来源】：爵床科植物穿心莲(圆锥须药草)Andrographis paniculata(Burm.f.)Nees的干燥地上部分。秋初茎叶茂盛时采割，晒干。【功能主治】清热解毒，凉血，消肿，燥湿。主治：感冒发热，咽喉肿痛，口舌生疮，顿咳劳嗽，泄泻痢疾，热淋涩痛，痈肿疮疡，毒蛇咬伤。
番红花【来源】又称藏红花、西红花，是一种鸢尾科番红花属的多年生花卉，也是一种常见的香料。具有强大的生理活性。【功能主治】有镇静、祛痰、解痉作用，用于胃病、调经、麻疹、发热、黄胆、肝脾肿大等的治疗。
地龙【来源】环节动物门钜蚓科动物参环毛蚓【功能主治】性寒，味咸。清热定惊，通络、平喘，利尿；用于高热神昏惊痫抽搐，关节麻痹，肢体麻木，半身不遂，肺热喘咳，尿少水肿，高血压症。
吴茱萸【来源】为芸香科植物吴茱萸Evodia rutaecarpa的近成熟果实。【功能主治】其性热味苦寒，有散热止痛、降逆止呕之功，用于治疗肝胃虚寒、阴浊上逆所致的头痛或胃脘疼痛等症。
发明内容
本发明旨在提供一种治疗缺血性肝炎的中药，通过选择合适的药材及其配比，达到安全有效治愈缺血性肝炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗缺血性肝炎的中药，其特征在于，由以下重量配比的药材制备而成：党参12份、黄芪10份、山药14份、金樱子12份、百合10份、天门冬10份、玉竹14份、金腰8份、当归12份、肉苁蓉6份、锁阳6份、何首乌12份、白芍14份、百合12份、穿心莲10份、番红花8份、地龙6份、吴茱萸6份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2009年11月-2011年9月间共收集85例缺血性肝炎的门诊患者，年龄12-52岁，病程0.5-7年。随机分为：治疗组60例，空白组25例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程30天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程30天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1两组疗效比较
可见，本发明制得的药物能够安全有效治缺血性肝炎。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：党参12克、黄芪10克、山药14克、金樱子12克、百合10克、天门冬10克、玉竹14克、金腰8克、当归12克、肉苁蓉6克、锁阳6克、何首乌12克、白芍14克、百合12克、穿心莲10克、番红花8克、地龙6克、吴茱萸6克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗缺血性肝炎。口服，每日分早晚两次服用。
具体实施例2
称取：党参12克、黄芪10克、山药14克、金樱子12克、百合10克、天门冬10克、玉竹14克、金腰8克、当归12克、肉苁蓉6克、锁阳6克、何首乌12克、白芍14克、百合12克、穿心莲10克、番红花8克、地龙6克、吴茱萸6克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗缺血性肝炎。口服，每日分早晚两次服用。
具体实施例3
称取：党参12克、黄芪10克、山药14克、金樱子12克、百合10克、天门冬10克、玉竹14克、金腰8克、当归12克、肉苁蓉6克、锁阳6克、何首乌12克、白芍14克、百合12克、穿心莲10克、番红花8克、地龙6克、吴茱萸6克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗缺血性肝炎。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗缺血性肝炎的中药，其特征在于，由以下重量配比的药材制备而成：党参12份、黄芪10份、山药14份、金樱子12份、百合10份、天门冬10份、玉竹14份、金腰8份、当归12份、肉苁蓉6份、锁阳6份、何首乌12份、白芍14份、百合12份、穿心莲10份、番红花8份、地龙6份、吴茱萸6份。
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1113779A (zh) * | 1994-06-17 | 1995-12-27 | 殷广全 | 抗乙肝制剂 |
| CN101455354A (zh) * | 2007-12-14 | 2009-06-17 | 中国科学院微生物研究所 | 天然菌草保肝解酒剂 |
| CN101810816A (zh) * | 2010-05-25 | 2010-08-25 | 泰一和浦（北京）中医药研究院有限公司 | 一种治疗带下的中药组合物及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1113779A (zh) * | 1994-06-17 | 1995-12-27 | 殷广全 | 抗乙肝制剂 |
| CN101455354A (zh) * | 2007-12-14 | 2009-06-17 | 中国科学院微生物研究所 | 天然菌草保肝解酒剂 |
| CN101810816A (zh) * | 2010-05-25 | 2010-08-25 | 泰一和浦（北京）中医药研究院有限公司 | 一种治疗带下的中药组合物及其制备方法 |
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