CN103055053A - Pill cleaning away heart-fire and preparation method thereof - Google Patents
Pill cleaning away heart-fire and preparation method thereof Download PDFInfo
- Publication number
- CN103055053A CN103055053A CN2012105593574A CN201210559357A CN103055053A CN 103055053 A CN103055053 A CN 103055053A CN 2012105593574 A CN2012105593574 A CN 2012105593574A CN 201210559357 A CN201210559357 A CN 201210559357A CN 103055053 A CN103055053 A CN 103055053A
- Authority
- CN
- China
- Prior art keywords
- fire
- heart
- away heart
- preparation
- crude drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to a pill cleaning away the heart-fire and a preparation method thereof. Composition ingredients of bulk pharmaceutical chemicals and parts of weight occupied of each ingredient are 5-20 of savia miltiorrhiza, 6-9 of magnoliopsida, 6-10 of medlar, 12-16 of raw hawthorn, 6-10 of gardenia jasminoides, 6-10 of cortex moutan, 8-12 of juncus effusus, 10-15 of ripe jujube kernel, 10-15 of lotus seed and 3-5 of liquorice.
Description
Technical field
The present invention relates to the ball and preparation method thereof that clears away heart-fire.
Background technology
Apoplexy myocardial infarction, exopathogenic factor heart arter disease (heart arter is atherosis, cardiovascular is narrow), heart coronary artery syndrome, severe palpitation, the cardiac conditions such as impatient all can cause insomnia.Though existing Bezoar Sedative Pills has certain calm sedative action, production cost is higher.
Summary of the invention
Goal of the invention of the present invention is to provide a kind of ball and preparation method thereof that clears away heart-fire, for the treatment impatient agitation, insomnia, obnubilation, lassitude, the appetite that are caused by cardiac conditions reduce gradually, body constitution is become thin and weakly have remarkable result, and production cost is lower.
Based on same inventive concept, the present invention has two independently technical schemes:
1, a kind of ball that clears away heart-fire is characterized in that: the shared parts by weight of the constituent of crude drug and each composition are: Radix Salviae Miltiorrhizae 15-20, Lignum Dalbergiae Odoriferae 6-9, Fructus Lycii 6-10, Fructus Crataegi 12-16, Fructus Gardeniae 6-10, Cortex Moutan 6-10, wick 8-12, ripe Semen Ziziphi Spinosae 10-15, lotus seed 10-15, Radix Glycyrrhizae 3-5.
Preferably, the shared parts by weight of each composition of crude drug are: Radix Salviae Miltiorrhizae 17, Lignum Dalbergiae Odoriferae 7, Fructus Lycii 8, Fructus Crataegi 14, Fructus Gardeniae 8, Cortex Moutan 8, wick 10, ripe Semen Ziziphi Spinosae 12, lotus seed 12, Radix Glycyrrhizae 4.
2, a kind of preparation method of the above-mentioned ball that clears away heart-fire is characterized in that: the raw materials of crude drug is ground into fine powder, and mix homogeneously and high temperature sterilize obtain crude drug; The aforementioned base materials medicine is mixed with into pill with refined honey.
Preferably, the raw materials of crude drug is ground into 300 order fine powders.
Preferably, high temperature sterilize adopts the high pressure steam sterilization method.
Preferably, refined honey is selected honey in the refining.
The beneficial effect that the present invention has:
Crude drug of the present invention comprises Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae, Fructus Lycii, Fructus Crataegi, Fructus Gardeniae, Cortex Moutan, wick, ripe Semen Ziziphi Spinosae, lotus seed, Radix Glycyrrhizae, compatibility is reasonable, and through repetition test, obtain best proportioning, to the apoplexy myocardial infarction, (heart arter is atherosis for exopathogenic factor heart arter disease, cardiovascular is narrow), the heart coronary artery syndrome, severe palpitation, impatiently wait the cardiac, comprise and wherein be with the cardiac skeleton patient, the impatient agitation that is caused by cardiac conditions, insomnia, obnubilation, lassitude, appetite reduces gradually, body constitution is become thin and weak symptom, have significant therapeutic effect, simultaneously the present invention ball that clears away heart-fire also has antiinflammatory, dampness removing, remove what, logical blood, the effect of the turbid descending.
Radix Salviae Miltiorrhizae: reinforcing the heart, blood stasis removing blood tissue regeneration promoting blood, enter the heart and percardium, broken stagnated blood, tissue regeneration promoting blood; The sedate of reposing in addition, the promoting blood circulation effect again can blood.
Lignum Dalbergiae Odoriferae: a surname, Xin Wen, it is strange to ward off bad odor.The hemostasis analgesic therapy, detumescence and promoting granulation.
Fructus Crataegi: rush down, dispelling the stagnated QI helps digestion, resolving phlegm and dissipating blood stasis, the sweet tepor of sour in the mouth, and the spleen invigorating circulation of qi promoting, the mill that helps digestion is long-pending.The kind smelling of fish or mutton that goes is long-pending, this medicinal wild hill short, bristly hair or beard, and little Fructus Crataegi has the effect of the hernia of controlling cold removing.
Cortex Moutan: rush down latent heat, blood stasis removing.Arduous acid is cold, enters the heart, liver, kidney Threefold Canon, so rush down in the blood that latent heat can be invigorated blood circulation, removing heat from blood and tissue regeneration promoting blood, heat in blood is then withered, and cold is then given birth to.Removing mass blood, the long-pending stasis of blood do not go, then newly do not give birth to.Qualcomm meridian.Zhang Zhongjing training the mind will is reused Cortex Moutan, heart storing spirit, and kidney storing will, the essence of fire is refreshing, the essence of water is kidney.
Fructus Gardeniae: removing pathogen in the heart lung three warmers fire.Bitter cold, the light lung that resembles, red complexion enters the heart, and the heresy of removing pathogen in the heart lung makes it the descending fire of flexing by urinating, can diuresis.Three warmers are hot and suffocating, to separate cold limbs due to intense heat in the interior.Fainted two kinds, pained with flat.Zhong Jing controls dysphoria and insomnia and reuses Fructus Gardeniae.Zhang Zhongjing is controlled vexed insomnia and reused Fructus Gardeniae, controls blood and can not the single file list ends, and is also can not pure usefulness cold and cool.
Ripe Semen Ziziphi Spinosae: tonifying liver, gallbladder arresting sweating, mind calming is amusing.The sweet sour Wen Errun of Semen Ziziphi Spinosae fries rear sour Wen Erxiang and also can be amusing, help cloudy gas relieving restlessness to be quenched the thirst, and makes ataraxia.
Lotus seed: the solid intestinal of reinforcing the heart spleen kidney, arresting seminal emission, and Gan Ping is puckery, can hand over extreme misery and reaches agreement heart kidney.Quiet heart kidney, arresting seminal emission gas, thick the intestines and stomach is controlled spleen and is rushed down chronic dysentery.The nebulousurine nocturnal emission, all disorders of blood of woman's metrorrhagia and leukorrhagia get Fructus Lycii power and more win.
Wick: light, logical, diuretic clears away heart-fire.Heart-fire falls in sweet light being slightly cold, clearing away lung-heat, sharp small intestinal, ventilation hemostasis.Control the five types of stranguria edema, invasion by pathogenic cold incontinence of urine person do not take.
Fructus Lycii: nourishing the liver and kidney and moistening, sweet tepor, nourishing liver and kidney, spermatogenesis is supporing yang, tonify deficiency labor, battalion's relieving restlessness is supported in bone and muscle strengthening, goes wind to make eye bright, and sharp intestine and small intestine QI invigorating is quenched one's thirst.
Radix Glycyrrhizae: sweet in the mouth, give birth to spleen reinforcing, stomach invigorating and eliminating heart-fire.This medicine can rise and can fall, and has to mend to have to rush down, give birth to cloudy blood.Current twelve channels and collaterals is separated the poison of hundred medicines, all medicines of coordinating.
The belt supporting frame patient mainly is that foreign body enters heart, the rear cardiovascular of support implantation has led to but the yin and yang 2 Qi deficiency and excess is uncomfortable, one loses it puts down, support has retardance to blood vessel, saying on the traditional Chinese medical science stagnates then gives birth to the stasis of blood, then cardiovascular is obstructed to give birth to the stasis of blood, Here it is belt supporting frame patient why behind the heart implant frame after a period of time, do again the reason of cardiac stent operation.The mind is upset in the hot and suffocating interior life of meeting behind the foreign body implantation heart, and refreshing uneasiness has just caused insomnia.Hot and suffocating interior life, heat in blood are attacked in heart network, and the mind is fidgety and impatient.Pathogenic heat pent-up, liver and gall QI rising in reverse order, heresy are taken advantage of in the heart, and god does not keep, and heresy is taken advantage of in stomach and the appetite minimizing, and it is weak to become thin.The pulse condition diagnosis: pulse condition is counted accurately, stringy and rapid pulse.
The heart is the monarch, and main gods " interior warp. the secret allusion quotation of Ling Shu Miraculous Pivot or Divine Axis " cloud, heart person monarch, here gods go out." Ling Shu Miraculous Pivot or Divine Axis evil visitor a piece of writing " said, heart storing spirit, the big master of the heart person vital organs of the human body, spirit give up also.Zhang Zhongjing is said, and the internal organs bones of the body collectively only is the clever wisdom of life, there's no one who doesn't or isn't by it, here goes out so say gods.More than the explanation heart is the commander of health, all over the body big master.The motion of the mind of human body and extremity bones of the body collectively and the vital organs of the human body are all taken orders from the heart, if the heart is sound, and the main bright then lower peace of meaning.Gods are sensible, conscious, hale and hearty, human body is then healthy.If heart monarch is unstrong, the main not clear then twelve interior organs danger of meaning.Can make Airway obstruction, shape is large wound, and human body is disease.Foreign body enters heart, and there have resistance just to have to be stagnant, and the then living stasis of blood that stagnates being arranged, and has the stasis of blood then to give birth to heat, and heart master blood, blood is warm then, and heat in blood is yang imbalance then, and one loses it puts down, and the mind is upset in hot and suffocating interior life, and refreshing uneasiness is then had a sleepless night.Heat in blood is attacked in heart network, and then the mind is irritated.Zhang Zhongjing is said: pathogenic heat pent-up, bend the god without institute, and liver and gall QI rising in reverse order, heresy are taken advantage of in the heart, and god does not keep, and heresy is taken advantage of in stomach.So appetite reduces, it is weak to become thin.
Enter the true card of foreign body in heart, real person uses Fructus Crataegi when rushing down.Foreign body retardance bad odor is then given birth to the stasis of blood, when eliminating blood stasis to promote regeneration of blood a surname Tongxinluo, with Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae.Have the stasis of blood then to give birth to heat, heart master blood is used Cortex Moutan when the blood stasis dispelling removing heat from blood.The mind is then upset in hot and suffocating interior life, causes insomnia, uses ripe Semen Ziziphi Spinosae.The pathogenic heat network of making a psychological attack, pathogenic heat pent-up is the impairment of mentality then, kidney storing will, resolving depression reduces phlegm and internal heat, and the quiet monarch fire of coition heart kidney is the heresy of fire mutually, usefulness Fructus Gardeniae, lotus seed.The liver and gall QI rising in reverse order falls in resolving depression, and heart heresy is gone the mind peace, and stomach is evil is amusing except the invigorating the liver and kidney mind calming, uses Fructus Lycii, wick, ripe Semen Ziziphi Spinosae.Current twelve channels and collaterals is separated the poison of hundred medicines, and all medicines of coordinating are used Radix Glycyrrhizae.
Further specify beneficial effect of the present invention in conjunction with clinical experiment.
Choose 30 routine cardiacs, have all that the impatient agitation, insomnia, obnubilation, lassitude, the appetite that are caused by cardiac conditions reduce gradually, body constitution is become thin and the symptom such as weak, take the present invention's ball that clears away heart-fire to the patient, one twice-daily, one ball (8 gram/ball), take 15 days courses for the treatment of, impatient agitation, insomnia, obnubilation, lassitude, the appetite that patient's cardiac conditions causes reduces gradually, body constitution is become thin and the symptom such as weak all is significantly improved, takes above symptom elimination after six courses for the treatment of.
Choose band cardiac skeleton patient 30 examples, the impatient agitation that is caused by cardiac conditions is all arranged, insomnia, obnubilation, lassitude, appetite reduces gradually, body constitution is become thin and the symptom such as weak, take the present invention's ball that clears away heart-fire to the patient, one twice-daily, one ball (8 gram/ball), take 15 days courses for the treatment of, the impatient agitation that patient's cardiac conditions causes, insomnia, obnubilation, lassitude, appetite reduces gradually, body constitution is become thin and the symptom such as weak all is significantly improved, take above symptom elimination after 12 courses for the treatment of, but because foreign body in heart is implanted, disease easily repeatedly after the drug withdrawal, after the suggestion physical recovery health, adhere to per month taking this ball that clears away heart-fire, quantity is cut down according to the circumstance and is got final product to taking per month a course for the treatment of.
The specific embodiment
1. raw materials medicine medicated powder.
In the present embodiment, the shared parts by weight of the constituent of crude drug and each composition are: Radix Salviae Miltiorrhizae 17, Lignum Dalbergiae Odoriferae 7, Fructus Lycii 8, Fructus Crataegi 14, Fructus Gardeniae 8, Cortex Moutan 8, wick 10, ripe Semen Ziziphi Spinosae 12, lotus seed 12, Radix Glycyrrhizae 4.
The raw materials of above-mentioned raw materials medicine is cleaned, remove the impurity of the inside;
Moisture content is removed in the raw materials oven dry, for pulverizing is prepared;
Raw materials will be pulverized with Chinese medicine grinder, and the medicated powder after the pulverizing reaches 300 orders, and with the medicated powder mix homogeneously;
With the medicated powder high temperature sterilize, in the present embodiment, select sterilization by saturated steam under pressure.With the high temperature sterilization that adds high pressure, not only can kill deathly antibacterial, bacterial spore is also had killing effect, be the most reliable, use the most general physical sterilization method.The points for attention of autoclaving: 1. parcel should excessive, tension, generally should be less than 30cm * 30cm * 50cm; 2. the parcel in the pressure cooker is not arranged De Taimi, penetrates with the obstruction free steam, affects sterilization effect; 3. generally heat and got final product in 20 minutes; 4. will carry out next process the same day after the sterilization.
2. refined honey.The purpose of refined honey is to remove impurity, destroys ferment, kill microorganisms, and transpiring moisture strengthens viscosity.Its method is: the straight fire heating of limited production available copper pot or pot, slow fire refining; A large amount of used vapour jacketed pans of producing, the reduction vaporization concentration pan is refined, and filters out impurities at last.The degree of refined honey is divided into three kinds of tender honey, middle honey, old honey.In the present embodiment, select honey in the refining, middle honey is applicable to the moderate medicine pill of viscosity.Middle honey means that Mel is heated to 116～118 ℃, occurs the evenly goods of faint yellow thin bubble in the panful.The refined honey water content is about 10～13%, toughness more than twisting with the fingers with finger, but two fingers occur without long white silk separately the time.
3. close medicine.The refined honey of having refined is mixed in proportion with medicated powder (ratio of medicated powder and refined honey is roughly 1: 1, and summer is less slightly with honey amount, and winter is slightly many with the honey amount.Imaging surface group sample ball piece (mechanical mixture or manually mixing in other container in blender) is done in equably kneading.When closing medicine, Mel generally adds while hot, and is abundant and even, makes it inside and outside all moist, and color and luster is consistent, and is neither too hard, nor too soft, and arbitrarily kneading model gets final product.
4. pill.The dough sample soft material that gets togather is placed certain hour, spice is mixed with honey component moisten, and get final product rubbing after producing certain viscosity, rubbing wants thickness consistent, smooth in appearance.Can be by hand or the pill plate make a certain amount of, smooth, the spherical pill in garden, produce in a large number available mechanical pill.
During pill, first the medicine agglomerate is weighed, so that minute accurate measurement, namely requiredly make the number of pill and the total amount of every ball is calculated by each, take by weighing again rubbing of agglomerate by amount of calculation, make the pill of desired number, the metering that every ball adds behind the honey is 8 grams, be divided into segment after the ball bar is rubbed with the hands, the round globulate gets final product again again.
For avoiding the sticking hands of medicine group and sticking utensil, can be with an amount of lubricant during operation.Lubricant can be with glycerol or Oleum Sesami (Oleum Arachidis hypogaeae semen), Cera Flava by a certain percentage, heat fused forms.Summer, Cera Flava can suitably be added a bit.
Pack after this product technique is finished and preserve: the honeyed pill of making, can adopt paraffin paper, cellophane, plastic bag, wax shell to wrap and be stored in shady and cool dry place.
Claims (6)
1. ball that clears away heart-fire, it is characterized in that: the shared parts by weight of the constituent of crude drug and each composition are:
Radix Salviae Miltiorrhizae 15-20, Lignum Dalbergiae Odoriferae 6-9, Fructus Lycii 6-10, Fructus Crataegi 12-16, Fructus Gardeniae 6-10, Cortex Moutan 6-10, wick 8-12, ripe Semen Ziziphi Spinosae 10-15, lotus seed 10-15, Radix Glycyrrhizae 3-5.
2. the ball that clears away heart-fire according to claim 1, it is characterized in that: the shared parts by weight of each composition of crude drug are:
Radix Salviae Miltiorrhizae 17, Lignum Dalbergiae Odoriferae 7, Fructus Lycii 8, Fructus Crataegi 14, Fructus Gardeniae 8, Cortex Moutan 8, wick 10, ripe Semen Ziziphi Spinosae 12, lotus seed 12, Radix Glycyrrhizae 4.
3. the preparation method of the described ball that clears away heart-fire of claim 1 is characterized in that: the raw materials of crude drug is ground into fine powder, mix homogeneously and high temperature sterilize, acquisition crude drug; The aforementioned base materials medicine is mixed with into pill with refined honey.
4. the preparation method of the described ball that clears away heart-fire according to claim 3, it is characterized in that: the raw materials of crude drug is ground into 300 order fine powders.
5. the preparation method of the described ball that clears away heart-fire according to claim 4, it is characterized in that: high temperature sterilize adopts the high pressure steam sterilization method.
6. according to claim 3 to the preparation method of 5 any one described ball that clear away heart-fire, it is characterized in that: refined honey is selected honey in the refining.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210559357.4A CN103055053B (en) | 2012-12-21 | 2012-12-21 | Pill cleaning away heart-fire and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210559357.4A CN103055053B (en) | 2012-12-21 | 2012-12-21 | Pill cleaning away heart-fire and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103055053A true CN103055053A (en) | 2013-04-24 |
| CN103055053B CN103055053B (en) | 2014-07-16 |
Family
ID=48098148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210559357.4A Active CN103055053B (en) | 2012-12-21 | 2012-12-21 | Pill cleaning away heart-fire and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103055053B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362911A (en) * | 2015-12-11 | 2016-03-02 | 赵爱良 | Miscarriage preventing pill and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1073205A (en) * | 1991-12-14 | 1993-06-16 | 张洪林 | The prescription of compound red-rooted salvia wine and production method |
| CN1742902A (en) * | 2004-09-03 | 2006-03-08 | 韩战友 | Chinese medicinal pills for treating coronary heart disease |
| CN102370757A (en) * | 2010-08-20 | 2012-03-14 | 高英豪 | Traditional Chinese medicine composition for treating coronary heart disease |
-
2012
- 2012-12-21 CN CN201210559357.4A patent/CN103055053B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1073205A (en) * | 1991-12-14 | 1993-06-16 | 张洪林 | The prescription of compound red-rooted salvia wine and production method |
| CN1742902A (en) * | 2004-09-03 | 2006-03-08 | 韩战友 | Chinese medicinal pills for treating coronary heart disease |
| CN102370757A (en) * | 2010-08-20 | 2012-03-14 | 高英豪 | Traditional Chinese medicine composition for treating coronary heart disease |
Non-Patent Citations (2)
| Title |
|---|
| 杨志宏；等: "清心宁神汤治疗失眠症62例", 《北京中医药大学学报(中医临床版)》, vol. 16, no. 4, 31 December 2009 (2009-12-31), pages 27 - 28 * |
| 韩丽萍: "宣郁清心汤治疗郁病62例疗效观察", 《山西中医学院学报》, vol. 5, no. 3, 31 December 2004 (2004-12-31), pages 38 - 39 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362911A (en) * | 2015-12-11 | 2016-03-02 | 赵爱良 | Miscarriage preventing pill and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103055053B (en) | 2014-07-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101461879B (en) | Plaster for treating neck, spine, protrusion of lumbar vertebral disc, hyperosteogeny, arthralgia and myalgia | |
| CN103637205A (en) | Formula of rhizoma acori graminei brain tonifying and strengthening soup base and production method | |
| CN101507776B (en) | Traditional Chinese medicine preparation for treating kidney deficiency, waist and knees soreness and preparation method thereof | |
| CN107349360A (en) | For nursing one's health empty Chinese medicine composition of energy and blood of human body two and preparation method thereof | |
| CN102366541A (en) | Traditional Chinese medicine composition for treatment of diabetes | |
| CN101912551B (en) | Miscarriage-prevention Chinese medicinal composition | |
| CN103381258A (en) | Depression-dispelling nerve-soothing granules and preparation method for oral solution of same | |
| CN104338050A (en) | Health care product capable of improving sleep quality | |
| CN101884779A (en) | Siberian solomonseal rhizome composition for intervening sub-health state and preparation method thereof | |
| CN107320555A (en) | A kind of pharmaceutical composition with antifatigue effect and its production and use | |
| CN103055053B (en) | Pill cleaning away heart-fire and preparation method thereof | |
| CN103211919A (en) | Leonurus paste and preparation method thereof | |
| CN103212037B (en) | Traditional Chinese medicine for treating female endocrine disorder and preparation method of traditional Chinese medicine | |
| CN102949598B (en) | Pill for alleviating diabetic symptoms and preparation method thereof | |
| CN103599239A (en) | Traditional Chinese medicine ointment for treating osteoporosis | |
| CN103989968B (en) | A kind of oral medication stenosis Chinese medicine composition | |
| CN102908396A (en) | Chinese medicinal composition for promoting sleeping and preparation method thereof | |
| CN110339334A (en) | A kind of warm palace oral solution and its preparation process of warding off the cold | |
| CN101862009B (en) | Health beverage for eliminating hiccup, chest and back pain and intestinal and abdominal spasm and preparation method thereof | |
| CN104815275A (en) | Oral medicine for treating pregnancy reaction and preparation method thereof | |
| CN103223107A (en) | Traditional Chinese medicine used for adjusting blood fat and blood pressure, and preparation technology thereof | |
| CN104687137A (en) | Formula and production method of pilose antler brain-strengthening nerves-calming soup material | |
| CN102670898A (en) | Honeyed pills for treating deficiency constipation | |
| CN105596770A (en) | Externally-used ointment for promoting bone fracture healing and preparation method thereof | |
| CN102669354A (en) | Chinese machine tea bag for treating myopia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |