CN103041374A - Marine biological solution for treating onychomycosis and paronychia and preparation method thereof - Google Patents
Marine biological solution for treating onychomycosis and paronychia and preparation method thereof Download PDFInfo
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- CN103041374A CN103041374A CN2012105461664A CN201210546166A CN103041374A CN 103041374 A CN103041374 A CN 103041374A CN 2012105461664 A CN2012105461664 A CN 2012105461664A CN 201210546166 A CN201210546166 A CN 201210546166A CN 103041374 A CN103041374 A CN 103041374A
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Abstract
The invention discloses a marine biological solution for treating onychomycosis and paronychia and a preparation method thereof. The marine biological solution comprises the following components by weight percent: 1.5-2.5% of carboxymethyl chitosan, 3.0-4.0% of algal polysaccharide, 2.0-4.0% of mucopeptide-N-acetylmuramoylhydrolase, 6.0-9.0% of cecropin, 2.0-3.0% of glycerol, 1.0-4.0% of algae powder, and 73.5-84.5% of water. According to the invention, the marine biological solution for treating onychomycosis and paronychia is a non-toxic, colorless, odorless, non-irritant, non-corrosive and pollution-free green marine biological product, and has the advantages of convenience in use, high sterilization efficiency, wide bactericidal spectrum, high cure rate, short healing time and the like.
Description
It is 201110423461.6 that the present invention requires application number, and the applying date is 2011.12.16, and denomination of invention is the priority of the Chinese invention patent of " marine organisms plain degerming type tinea unguium alive, paronychia treatment liquid ".
Technical field
The present invention relates to tinea unguium, paronychia medicine, relate in particular to a kind of marine organisms tinea unguium, paronychia treatment liquid and preparation method thereof.
Background technology
Tinea unguium, paronychia are a kind of common foot afflictions, have the characteristics of healing time length, patient's sharp ache.
Tinea unguium also claims tinea unguium, is caused by fungal infection, and modal fungus has trichophyton, trichophyton gypseum, acrothesium floccosum etc.Other also can cause tinea unguium such as trichophyton, Trichophyton violaceum, trichophyton, trichophyton meginii and Trichophyton concentricunm and occur.Fingernail and toenail are the invasion and attack that very hard, intact deck can be resisted any microorganism fully.But as suffer from the tinea manuum or tinea pedis then more easily develops into tinea unguium (tinea unguium), fungus is at first invaded the skin around the first, then the growth by fingernail or toenail develops, and invades in the deck gradually, and further growth and breeding, until destroy whole deck.Therefore, this also is the key factor that often can cause the reason of tinea unguium.If fungus is invaded nail root section, affected the growth of first, will cause onychodysplasia or first deformity.In general this process is more slowly, and in the more situation tinea unguium (tinea unguium) be since finger (toe) first because of wound or the tinea unguium of often scratching and causing damaged postoperative infection fungus to cause.Tinea unguium (tinea unguium) has very strong infectiousness, and the short time be difficult for to cure, and treats untimelyly, can cause cross infection.
Paronychia is owing to infection of staphylococcus aureus causes, because toe (finger) the first direction of growth is incorrect, causes the other tissue inflammation of toe (finger) first, red and swollen, bitterly, the symptom such as suppurate.Inflammation is of long duration, and tissue produces granuloma, and toe (finger) first is sunk deeper and deeper, and is not easy spontaneous recovery.Paronychia is apt to occur in thumb, and pathogenic bacteria is invaded from wound, spreads along nail groove.Subcutaneous tissue hyperemia this moment, edema, leukocyte chemotaxis, then histiocyte degeneration, necrosis, the liquefaction of damage; Form semi-circular abscess.Pus also can spread to the subcutaneous of nail root section and offside nail groove from nail groove-side.The patient has violent pain, seriously also can cause fever.Paronychia is not treated and can be fully recovered voluntarily, and the time has been grown and will occur later suppurating.Not treating for a long time toenail can gross distortion, causes nail matrix to destroy, and last toenail is damaged, severe patient even cause not growing fingernail.If toenail is inflammation repeatedly, easily cause subungual abscess, serious might cause osteomyelitis.Some patients do not treat for a long time; cause the immunity at fingernail position to reduce the effect of the natural protective barrier lost fingernail; cause fungal infection disease tinea unguium (tinea unguium); tinea unguium is the very strong fungal disease of a kind of infectiousness; may cause tinea capitis as not treating, a series of disease such as the tinea manuum.Clinical antibiotic is often adopted in paronychial treatment, severe patient is taked to pull out Party A's formula and is treated, and the patient can be very painful during treatment.
Summary of the invention
An object of the present invention is to provide a kind of have preferably marine organisms tinea unguium, the paronychia treatment liquid of bactericidal effect.
Another object of the present invention provides a kind of have the marine organisms tinea unguium of bactericidal effect preferably, the preparation method of paronychia treatment liquid.
Marine organisms tinea unguium of the present invention, paronychia are treated liquid, comprise each component of following percetage by weight:
Carboxymethyl chitosan 1.5 ~ 2.5%;
Sargassum polysaccharides 3.0 ~ 4.0%;
N-acetylmuramide lycanohydrlase 2.0 ~ 4.0%;
Cecropin 6.0 ~ 9.0%;
Glycerol 2.0 ~ 3.0%;
Sargassum powder 1.0 ~ 4.0%;
Water 73.5 ~ 84.5%.
The preparation method of marine organisms tinea unguium of the present invention, paronychia treatment liquid comprises the steps:
Step S10: add carboxymethyl chitosan, Sargassum polysaccharides and the N-acetylmuramide lycanohydrlase of proportional quantity in 35 ~ 42 ℃ the water, mix to get mixed liquor A;
Step S20: add the cecropin of proportional quantity in the mixed liquor A, mix to get mixed liquid B;
Step S30: add the Sargassum powder of proportional quantity in the mixed liquid B, mix to get mixed liquor C;
Step S40: in mixed liquor C, add the glycerol of proportional quantity, and mix to get described marine organisms tinea unguium, paronychia treatment liquid.
Marine organisms tinea unguium of the present invention, paronychia treatment liquid main points are to select suitable component for above pathogen antibacterial, adopt rational mixture to become a kind of pure marine organisms plain degerming type tinea unguium (tinea unguium) alive, paronychia treatment liquid.That marine organisms tinea unguium of the present invention, paronychia treatment liquid belongs to is nontoxic, colourless, tasteless, non-stimulated, without the free of contamination green marine organisms product of burn into, have the advantages such as easy to use, that germicidal efficiency is high, fungicidal spectrum is wide, cure rate is high, healing time is short.
The preparation method of marine organisms tinea unguium of the present invention, paronychia treatment liquid, because order by merging and the mixing condition of each material are comparatively reasonable, so that the marine organisms tinea unguium that makes by preparation method of the present invention, each component mix homogeneously of paronychia treatment liquid, good stability.
The specific embodiment
Embodiment 1
A kind of marine organisms tinea unguium, paronychia are treated liquid, comprise each component of following percetage by weight:
Carboxymethyl chitosan 1.5 ~ 2.5%;
Sargassum polysaccharides 3.0 ~ 4.0%;
N-acetylmuramide lycanohydrlase 2.0 ~ 4.0%;
Cecropin 6.0 ~ 9.0%;
Glycerol 2.0 ~ 3.0%;
Sargassum powder 1.0 ~ 4.0%;
Water 73.5 ~ 84.5%.
Marine organisms tinea unguium of the present invention, paronychia treatment liquid main points are to select suitable component for above pathogen antibacterial, adopt rational mixture to become a kind of pure marine organisms plain degerming type tinea unguium (tinea unguium) alive, paronychia treatment liquid.That marine organisms tinea unguium of the present invention, paronychia treatment liquid belongs to is nontoxic, colourless, tasteless, non-stimulated, without the free of contamination green marine organisms product of burn into, have the advantages such as easy to use, that germicidal efficiency is high, fungicidal spectrum is wide, cure rate is high, healing time is short, in addition also have, healing time is short, good stability, cost price are low, to skin zero damage, make the patient need not the advantage of operative treatment.
Preferably, in order to obtain better therapeutic effect, described marine organisms tinea unguium, paronychia treatment liquid is characterized in that, comprise each component of following percetage by weight:
Carboxymethyl chitosan 1.5%;
Sargassum polysaccharides 3.0%;
N-acetylmuramide lycanohydrlase 2.0%;
Cecropin 6.0 ~ 7.0%;
Glycerol 2.0 ~ 3.0%;
Sargassum powder 1.0 ~ 2.0%;
Water 81.5 ~ 84.5%.
Preferably, in order to obtain better therapeutic effect, described marine organisms tinea unguium, paronychia treatment liquid is characterized in that, comprise each component of following percetage by weight:
Carboxymethyl chitosan 2.0%;
Sargassum polysaccharides 3.5%;
N-acetylmuramide lycanohydrlase 2.0 ~ 4.0%;
Cecropin 7.0 ~ 8.0%;
Glycerol 2.0 ~ 3.0%;
Sargassum powder 2.5 ~ 3.0%;
Water 76.5 ~ 81%.
Preferably, in order to obtain better therapeutic effect, described marine organisms tinea unguium, paronychia treatment liquid is characterized in that, comprise each component of following percetage by weight:
Carboxymethyl chitosan 2.5%;
Sargassum polysaccharides 4.0%;
N-acetylmuramide lycanohydrlase 2.0 ~ 4.0%;
Cecropin 8.0 ~ 9.0%;
Glycerol 2.0 ~ 3.0%;
Sargassum powder 3.0 ~ 4.0%;
Water 73.5 ~ 78.5%.
Preferably, described Sargassum polysaccharides is one or more the mixture in fucoidin, red seaweed polysaccharide, chlorella polysaccharide and the blue algae polysaccharide.
Preferably, for each component that makes foreign biological tinea unguium, paronychia treatment liquid mix more even, described water is deionized water.
It is the cecropin described in the CN101104637B that described cecropin can adopt notification number, can certainly adopt other cecropin.
Embodiment 2
The present embodiment provides the preparation method of a kind of marine organisms tinea unguium for embodiment 1, paronychia treatment liquid, comprises the steps:
Step S10: add carboxymethyl chitosan, Sargassum polysaccharides and the N-acetylmuramide lycanohydrlase of proportional quantity in 30 ~ 42 ℃ the water, mix to get mixed liquor A;
Step S20: add the cecropin of proportional quantity in the mixed liquor A, mix to get mixed liquid B;
Step S30: add the Sargassum powder of proportional quantity in the mixed liquid B, mix to get mixed liquor C;
Step S40: in mixed liquor C, add the glycerol of proportional quantity, and mix to get described marine organisms tinea unguium, paronychia treatment liquid.
Preferably, for make each component can be quicker, mix more uniformly, among the described step S10, the temperature of water is 40 ℃.
Preferably, more even for what each component can be mixed, among the described step S10, the time that mixes is 20 ~ 30 minutes; Among the described step S20, the time of mixing is 8 ~ 12 minutes; Among the described step S30, the time of mixing is 8 ~ 12 minutes.
Preferably, after step S40, also comprise step S50: packing is but carried out in described marine organisms tinea unguium, paronychia treatment liquid cooling afterwards.
By the marine organisms tinea unguium of the present embodiment, the preparation method of paronychia treatment liquid, because order by merging and the mixing condition of each material are comparatively reasonable, so that the marine organisms tinea unguium that makes by preparation method of the present invention, each component mix homogeneously of paronychia treatment liquid, good stability.
Embodiment 3
The present embodiment provides a kind of marine organisms tinea unguium, paronychia treatment liquid, comprises each component of following percetage by weight:
Carboxymethyl chitosan 1.5%;
Fucoidin 3.0%;
N-acetylmuramide lycanohydrlase 2.0%;
Cecropin 6.0%;
Glycerol 2.0%;
Sargassum powder 1.0%;
Deionized water 84.5%.
The preparation method of the marine organisms tinea unguium in the present embodiment, paronychia treatment liquid comprises the steps:
Step S301: add carboxymethyl chitosan, Sargassum polysaccharides and the N-acetylmuramide lycanohydrlase of proportional quantity in 35 ℃ the water, mix to get mixed liquor A;
Step S302: add the cecropin of proportional quantity in the mixed liquor A, mix 20 minutes mixed liquid B;
Step S303: add the Sargassum powder of proportional quantity in the mixed liquid B, mix 8 minutes mixed liquor C;
Step S304: add the glycerol of proportional quantity in the mixed liquor C, and mix 8 minutes described marine organisms tinea unguium, paronychia treatment liquid.
Empirical tests, the marine organisms tinea unguium of the present embodiment, paronychia treatment liquid can effectively be treated tinea unguium, paronychia.
Embodiment 4
The present embodiment provides a kind of marine organisms tinea unguium, paronychia treatment liquid, comprises each component of following percetage by weight:
Carboxymethyl chitosan 2.5%;
Fucoidin 4.0%;
N-acetylmuramide lycanohydrlase 4.0%;
Cecropin 9.0%;
Glycerol 3.0%;
Sargassum powder 4.0%;
Deionized water 73.5%.
The preparation method of the marine organisms tinea unguium in the present embodiment, paronychia treatment liquid comprises the steps:
Step S401: add carboxymethyl chitosan, Sargassum polysaccharides and the N-acetylmuramide lycanohydrlase of proportional quantity in 42 ℃ the water, mix to get mixed liquor A;
Step S402: add the cecropin of proportional quantity in the mixed liquor A, mix 30 minutes mixed liquid B;
Step S403: add the Sargassum powder of proportional quantity in the mixed liquid B, mix 12 minutes mixed liquor C;
Step S404: add the glycerol of proportional quantity in the mixed liquor C, and mix 12 minutes described marine organisms tinea unguium, paronychia treatment liquid.
Empirical tests, the marine organisms tinea unguium of the present embodiment, paronychia treatment liquid can effectively be treated tinea unguium, paronychia.
Embodiment 5
The present embodiment provides a kind of marine organisms tinea unguium, paronychia treatment liquid, comprises each component of following percetage by weight:
Carboxymethyl chitosan 1.5%;
Fucoidin 3.0%;
N-acetylmuramide lycanohydrlase 2.0%;
Cecropin 7.0%;
Glycerol 3.0%;
Sargassum powder 2.0%;
Deionized water 81.5%.
The preparation method of the marine organisms tinea unguium in the present embodiment, paronychia treatment liquid comprises the steps:
Step S501: add carboxymethyl chitosan, Sargassum polysaccharides and the N-acetylmuramide lycanohydrlase of proportional quantity in 42 ℃ the water, mix to get mixed liquor A;
Step S502: add the cecropin of proportional quantity in the mixed liquor A, mix 20 minutes mixed liquid B;
Step S503: add the Sargassum powder of proportional quantity in the mixed liquid B, mix 10 minutes mixed liquor C;
Step S504: add the glycerol of proportional quantity in the mixed liquor C, and mix 10 minutes described marine organisms tinea unguium, paronychia treatment liquid.
Empirical tests, the marine organisms tinea unguium of the present embodiment, paronychia treatment liquid can effectively be treated tinea unguium, paronychia.
Embodiment 6
The present embodiment provides a kind of marine organisms tinea unguium, paronychia treatment liquid, comprises each component of following percetage by weight:
Carboxymethyl chitosan 2.0%;
Fucoidin 3.5%;
N-acetylmuramide lycanohydrlase 3.0%;
Cecropin 8.0%;
Glycerol 3.0%;
Sargassum powder 2.5%;
Deionized water 78%.
The preparation method of the marine organisms tinea unguium in the present embodiment, paronychia treatment liquid comprises the steps:
Step S601: add carboxymethyl chitosan, Sargassum polysaccharides and the N-acetylmuramide lycanohydrlase of proportional quantity in 40 ℃ the water, mix to get mixed liquor A;
Step S602: add the cecropin of proportional quantity in the mixed liquor A, mix 20 minutes mixed liquid B;
Step S603: add the Sargassum powder of proportional quantity in the mixed liquid B, mix 10 minutes mixed liquor C;
Step S604: add the glycerol of proportional quantity in the mixed liquor C, and mix 10 minutes described marine organisms tinea unguium, paronychia treatment liquid.
S605: packing is but carried out in described marine organisms tinea unguium, paronychia treatment liquid cooling afterwards.
Empirical tests, the marine organisms tinea unguium of the present embodiment, paronychia treatment liquid can effectively be treated tinea unguium, paronychia.
Embodiment 7
The present embodiment provides a kind of marine organisms tinea unguium, paronychia treatment liquid, comprises each component of following percetage by weight:
Carboxymethyl chitosan 2.0%;
Red seaweed polysaccharide 3.5%;
N-acetylmuramide lycanohydrlase 4.0%;
Cecropin 8.0%;
Glycerol 3.0%;
Sargassum powder 3.0%;
Deionized water 76.5%.
The preparation method of the marine organisms tinea unguium in the present embodiment, paronychia treatment liquid comprises the steps:
Step S701: add carboxymethyl chitosan, Sargassum polysaccharides and the N-acetylmuramide lycanohydrlase of proportional quantity in 40 ℃ the water, mix to get mixed liquor A;
Step S702: add the cecropin of proportional quantity in the mixed liquor A, mix 20 minutes mixed liquid B;
Step S703: add the Sargassum powder of proportional quantity in the mixed liquid B, mix 10 minutes mixed liquor C;
Step S704: add the glycerol of proportional quantity in the mixed liquor C, and mix 10 minutes described marine organisms tinea unguium, paronychia treatment liquid.
S705: packing is but carried out in described marine organisms tinea unguium, paronychia treatment liquid cooling afterwards.
Empirical tests, the marine organisms tinea unguium of the present embodiment, paronychia treatment liquid can effectively be treated tinea unguium, paronychia.
Embodiment 8
The present embodiment provides a kind of marine organisms tinea unguium, paronychia treatment liquid, comprises each component of following percetage by weight:
Carboxymethyl chitosan 2.0%;
Chlorella polysaccharide 3.5%;
N-acetylmuramide lycanohydrlase 2.0%;
Cecropin 7.0%;
Glycerol 2.0%;
Sargassum powder 2.5%;
Deionized water 81%.
The preparation method of the marine organisms tinea unguium in the present embodiment, paronychia treatment liquid comprises the steps:
Step S801: add carboxymethyl chitosan, Sargassum polysaccharides and the N-acetylmuramide lycanohydrlase of proportional quantity in 40 ℃ the water, mix to get mixed liquor A;
Step S802: add the cecropin of proportional quantity in the mixed liquor A, mix 20 minutes mixed liquid B;
Step S803: add the Sargassum powder of proportional quantity in the mixed liquid B, mix 10 minutes mixed liquor C;
Step S804: add the glycerol of proportional quantity in the mixed liquor C, and mix 10 minutes described marine organisms tinea unguium, paronychia treatment liquid.
S805: packing is but carried out in described marine organisms tinea unguium, paronychia treatment liquid cooling afterwards.
Empirical tests, the marine organisms tinea unguium of the present embodiment, paronychia treatment liquid can effectively be treated tinea unguium, paronychia.
Embodiment 9
The present embodiment provides a kind of marine organisms tinea unguium, paronychia treatment liquid, comprises each component of following percetage by weight:
Carboxymethyl chitosan 2.5%;
Blue algae polysaccharide 4.0%;
N-acetylmuramide lycanohydrlase 2.0%;
Cecropin 8.0%;
Glycerol 2.0%;
Sargassum powder 3.0%;
Deionized water 78.5%.
The preparation method of the marine organisms tinea unguium in the present embodiment, paronychia treatment liquid comprises the steps:
Step S801: add carboxymethyl chitosan, Sargassum polysaccharides and the N-acetylmuramide lycanohydrlase of proportional quantity in 40 ℃ the water, mix to get mixed liquor A;
Step S802: add the cecropin of proportional quantity in the mixed liquor A, mix 20 minutes mixed liquid B;
Step S803: add the Sargassum powder of proportional quantity in the mixed liquid B, mix 10 minutes mixed liquor C;
Step S804: add the glycerol of proportional quantity in the mixed liquor C, and mix 10 minutes described marine organisms tinea unguium, paronychia treatment liquid.
S805: packing is but carried out in described marine organisms tinea unguium, paronychia treatment liquid cooling afterwards.
Empirical tests, the marine organisms tinea unguium of the present embodiment, paronychia treatment liquid can effectively be treated tinea unguium, paronychia.
The below provides the marine organisms tinea unguium among the embodiment 6, zoopery and the clinical experiment situation of paronychia treatment liquid.
Pharmacodynamics research of the present invention:
One, verify antipruritic and antibacterial action of the present invention from the zoopery aspect:
1 material
1.1 animal
Mice, regular grade, male and female half and half, body weight 18-22g, rat, male, body weight 180-220g.
1.2 medicine and reagent
Modeling reagent: depilatory cream: carrageenin:; Histamine phosphate; Dimethylbenzene.
Use marine organisms tinea unguium, paronychia treatment liquid among medicine: the embodiment 6.
Key instrument
Electronic balance, electric-heated thermostatic water bath, sufficient sole of the foot capacity measurer
2 methods and result
2.1 itching-relieving action:
Get 20 of mices and be divided at random two groups, 10 every group, male and female half and half are respectively matched group, test group.24h before the experiment shaves hair to each right back instep of group Cavia porcellus, smears 1 time each 5 seconds with cotton swab.Test the same day, abrade right back foot with coarse sandpaper and shave hair place, area 1c ㎡.Smear 1 time with cotton swab the part, and each 5 seconds 1 time, beginning is only dripped 0.01% 0.05ml/ of histamine phosphate behind the 10min at the wound surface place, after this every 3min 0.02%, 0.03% ... progressive concentration only is 0.05ml/ at every turn.Until later licking the right back histamine phosphate's total amount (μ g) that gives when sufficient, Cavia porcellus is itch-threshold.Record and itch-threshold of relatively respectively organizing.The result shows: dehumidifying itching-relieving gels group itch-threshold (321 ± 350.8) μ g, compare P＜0.01 with matrix group (55 ± 47.2) μ g.As seen product of the present invention has the effect of pruritus due to the obvious antagonism histamine phosphate.
2.2 bacteriostasis
Carry out external susceptibility MIC test:
Test strain: Escherichia coli, bacillus pyocyaneus, staphylococcus aureus, yeast, Candida albicans, aspergillus niger, fungus.
Method: each test strain is made bacteria suspension with normal saline, and to be diluted to turbidity be the above bacteria suspension of 2.0McF, use again 100 times of normal saline dilutions, 10 times of RPMII640 dilutions, test group (the marine organisms tinea unguium among the embodiment 6, paronychia treatment liquid) and matched group (" bright first " tinea unguium treatment liquid that the happy safe Pharmaceutical in Harbin is produced) doubling dilution, cultivate 72-96h in 96 well culture plates, slight concussion, the 490nm place carries out photoelectric colorimetry.
Table 1
2.3 conclusion
Referring to table 1, the mice ear test due to the xylol of the present invention, the rat toes swelling test due to the fresh albumen, the test of the guinea pig skin pruritus due to the histamine phosphate all have the inhibitory action (P＜0.05 or P＜0.01) of highly significant; Have a look at out through external susceptibility MIC test: the present invention all has stronger antibacterial action to Escherichia coli, bacillus pyocyaneus, staphylococcus aureus, yeast, Candida albicans, aspergillus niger.
Above test shows: marine organisms tinea unguium of the present invention, paronychia treatment liquid have the effect of antipruritic antibacterial.
Foreign biological tinea unguium in the embodiment of the invention 6, paronychia are treated liquid to tinea unguium 30 examples, paronychia 30 examples, and paronychia type tinea unguium 15 examples have been done clinical trial:
Treat tinea unguium (tinea unguium): after repairing thin sick first with blade, dip stock solution of the present invention to sick first cold compress with absorbent cotton, every day 2 times, 1 month course for the treatment of, followed up a case by regular visits to after the healing 2 months.
Treatment paronychia: dip stock solution of the present invention to sick first cold compress with absorbent cotton, every day 3 times, 10 days courses for the treatment of, followed up a case by regular visits to after the healing 3 months.
Treatment tinea unguium: after stock solution was diluted 20-40 times, warm water's foot bath 30 minutes, 10 days courses for the treatment of, was followed up a case by regular visits to 1 month at every day 1 time.
Table 2
Referring to table 2, above test shows, the present invention treats tinea unguium, paronychial therapeutic effect is remarkable, short treating period, and efficient is high, and relapse rate is low.
It should be noted that at last: above embodiment only in order to technical scheme of the present invention to be described, is not intended to limit; Although with reference to previous embodiment the present invention is had been described in detail, those of ordinary skill in the art is to be understood that: it still can be made amendment to the technical scheme that aforementioned each embodiment puts down in writing, and perhaps part technical characterictic wherein is equal to replacement; And these modifications or replacement do not make the essence of appropriate technical solution break away from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (10)
1. a marine organisms tinea unguium, paronychia are treated liquid, it is characterized in that, comprise each component of following percetage by weight:
Carboxymethyl chitosan 1.5 ~ 2.5%;
Sargassum polysaccharides 3.0 ~ 4.0%;
N-acetylmuramide lycanohydrlase 2.0 ~ 4.0%;
Cecropin 6.0 ~ 9.0%;
Glycerol 2.0 ~ 3.0%;
Sargassum powder 1.0 ~ 4.0%;
Water 73.5 ~ 84.5%.
2. marine organisms tinea unguium according to claim 1, paronychia treatment liquid is characterized in that, comprise each component of following percetage by weight:
Carboxymethyl chitosan 1.5%;
Sargassum polysaccharides 3.0%;
N-acetylmuramide lycanohydrlase 2.0%;
Cecropin 6.0 ~ 7.0%;
Glycerol 2.0 ~ 3.0%;
Sargassum powder 1.0 ~ 2.0%;
Water 81.5 ~ 84.5%.
3. marine organisms tinea unguium according to claim 1, paronychia treatment liquid is characterized in that, comprise each component of following percetage by weight:
Carboxymethyl chitosan 2.0%;
Sargassum polysaccharides 3.5%;
N-acetylmuramide lycanohydrlase 2.0 ~ 4.0%;
Cecropin 7.0 ~ 8.0%;
Glycerol 2.0 ~ 3.0%;
Sargassum powder 2.5 ~ 3.0%;
Water 76.5 ~ 81%.
4. marine organisms tinea unguium according to claim 1, paronychia treatment liquid is characterized in that, comprise each component of following percetage by weight:
Carboxymethyl chitosan 2.5%;
Sargassum polysaccharides 4.0%;
N-acetylmuramide lycanohydrlase 2.0 ~ 4.0%;
Cecropin 8.0 ~ 9.0%;
Glycerol 2.0 ~ 3.0%;
Sargassum powder 3.0 ~ 4.0%;
Water 73.5 ~ 78.5%.
5. each described marine organisms tinea unguium, paronychia treatment liquid is characterized in that according to claim 1-4, and described Sargassum polysaccharides is one or more the mixture in fucoidin, red seaweed polysaccharide, chlorella polysaccharide and the blue algae polysaccharide.
6. each described marine organisms tinea unguium, paronychia treatment liquid is characterized in that according to claim 1-4, and described water is deionized water.
7. the preparation method such as each described marine organisms tinea unguium of claim 1-6, paronychia treatment liquid is characterized in that, comprises the steps:
Step S10: add carboxymethyl chitosan, Sargassum polysaccharides and the N-acetylmuramide lycanohydrlase of proportional quantity in 35 ~ 42 ℃ the water, mix to get mixed liquor A;
Step S20: add the cecropin of proportional quantity in the mixed liquor A, mix to get mixed liquid B;
Step S30: add the Sargassum powder of proportional quantity in the mixed liquid B, mix to get mixed liquor C;
Step S40: in mixed liquor C, add the glycerol of proportional quantity, and mix to get described marine organisms tinea unguium, paronychia treatment liquid.
8. the preparation method of marine organisms tinea unguium according to claim 7, paronychia treatment liquid is characterized in that, among the described step S10, the temperature of water is 40 ℃.
9. the preparation method of marine organisms tinea unguium according to claim 7, paronychia treatment liquid is characterized in that, among the described step S10, the time that mixes is 20 ~ 30 minutes; Among the described step S20, the time of mixing is 8 ~ 12 minutes; Among the described step S30, the time of mixing is 8 ~ 12 minutes.
10. the preparation method of marine organisms tinea unguium according to claim 7, paronychia treatment liquid is characterized in that, also comprises step S50 after step S40: packing is but carried out in described marine organisms tinea unguium, paronychia treatment liquid cooling afterwards.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012105461664A CN103041374A (en) | 2011-12-16 | 2012-12-14 | Marine biological solution for treating onychomycosis and paronychia and preparation method thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110423461.6 | 2011-12-16 | ||
| CN2011104234616A CN102552872A (en) | 2011-12-16 | 2011-12-16 | Marine biotin degerming liquid for treating onychomycosis and paronychia |
| CN2012105461664A CN103041374A (en) | 2011-12-16 | 2012-12-14 | Marine biological solution for treating onychomycosis and paronychia and preparation method thereof |
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| CN2012105461664A Pending CN103041374A (en) | 2011-12-16 | 2012-12-14 | Marine biological solution for treating onychomycosis and paronychia and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690416A (en) * | 2013-12-05 | 2014-04-02 | 青岛海芬海洋生物科技有限公司 | Foot mask containing marine bioactive substances and preparation method thereof |
| CN103705410A (en) * | 2013-12-05 | 2014-04-09 | 青岛海芬海洋生物科技有限公司 | Hand skin care film containing marine organism components and preparation method therefor |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102552872A (en) * | 2011-12-16 | 2012-07-11 | 青岛海芬海洋生物科技有限公司 | Marine biotin degerming liquid for treating onychomycosis and paronychia |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102511507A (en) * | 2011-12-16 | 2012-06-27 | 青岛海芬海洋生物科技有限公司 | Marine bios sterilization solution |
| CN102552872A (en) * | 2011-12-16 | 2012-07-11 | 青岛海芬海洋生物科技有限公司 | Marine biotin degerming liquid for treating onychomycosis and paronychia |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102511507A (en) * | 2011-12-16 | 2012-06-27 | 青岛海芬海洋生物科技有限公司 | Marine bios sterilization solution |
| CN102552872A (en) * | 2011-12-16 | 2012-07-11 | 青岛海芬海洋生物科技有限公司 | Marine biotin degerming liquid for treating onychomycosis and paronychia |
Non-Patent Citations (2)
| Title |
|---|
| 《中国医药指南》 20110731 刘淑鑫等 "溶菌酶医学应用研究概况" 第9卷, 第21期 * |
| 刘淑鑫等: ""溶菌酶医学应用研究概况"", 《中国医药指南》, vol. 9, no. 21, 31 July 2011 (2011-07-31) * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690416A (en) * | 2013-12-05 | 2014-04-02 | 青岛海芬海洋生物科技有限公司 | Foot mask containing marine bioactive substances and preparation method thereof |
| CN103705410A (en) * | 2013-12-05 | 2014-04-09 | 青岛海芬海洋生物科技有限公司 | Hand skin care film containing marine organism components and preparation method therefor |
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| CN102552872A (en) | 2012-07-11 |
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