CN103028453A - 流体歧管 - Google Patents
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Abstract
本发明涉及流体歧管和一种流体管理盒系统,其包括第一和第二相对的压板,在所述压板之间具有压缩的第一和第二相对薄膜。形成于所述压板中的一个或两个上的一个或多个通槽与所述薄膜形成流路,流体可被引导通过所述流路。阀门和其他流动控制机构可被结合在内。
Description
技术领域
本专利申请涉及流体歧管,并且更具体地讲,涉及其中流体流路在一对薄膜之间形成的歧管及其相关方法。
背景技术
在生物医学处理和分析领域,流体通常经由需要与控制装置连接和接口的管子而在各个位置之间操纵和引导。这些流体系统包括一个或多个可移除的束管器(tubing harness)和处理机。束管器或管盒通常为一次性的,以便保证纯净度或无菌性。束管器由操作者装在可重复使用的处理机上,操作者必须将诸如泵和阀门的控制装置连接到束管器。根据束管器的复杂性,在束管器的使用中需要大量的培训、耗费大量的时间以及存在出错的可能性。在管段和部件之间存在有可能泄漏的多个连接处。此外,一次性束管器或管盒的材料和组装成本是显著的并会影响产品和程序的商业适用性。
已发明了许多有助于这种安装过程以节约时间和避免出错的系统,诸如定制管盒和不同类型的管夹。已经发明了歧管系统,其中管子功能被结合在形成于刚性构件中的通槽内。通常,歧管、管盒和管夹方法在基本的束管器之上增加了材料成本。另外,管盒和管夹提供了在制造时限定的单一流体构型。歧管提供了一定程度上增加的构型灵活性,但局限于结合在设计中的流路。
发明内容
根据本发明的流体管理盒系统包括第一压板和与第一压板相对的第二压板。呈彼此相对关系的第一薄膜和第二薄膜被压缩在第一压板和第二压板之间。一个或多个通槽形成于第一压板和第二压板的至少一者中,由此流体可在该一个或多个通槽处被引导通过形成于第一薄膜和第二薄膜之间的流路。
优选地,第一薄膜具有面向第二薄膜的向内面,第二薄膜具有面向第一薄膜的向内面,并且其中第一薄膜向内面和第二薄膜向内面为无菌的。优选地,它们是一次性和可替换的。还优选地,它们围绕其周边的范围密封以便形成袋子。
优选地,存在包括阀门元件的阀门,阀门元件可紧贴第一或第二薄膜之一移动进入通槽中。在本发明的一个方面,当阀门元件完全移动进入通槽中时,流路被阻塞。阀门元件能部分地移动进入通槽以便在不完全阻塞的情况下在流路中实现流动限制。
在本发明的一个方面,第一压板和第二压板中的至少一者包括区段的矩阵,这些区段可从朝向第一压板和第二压板中的另一者的伸长位置移动至远离第一压板和第二压板中的所述另一者的回缩位置,并且由处于其回缩位置的区段的排列形成通槽。
通过可移动进入通槽中的区段中的一个或多个能在通槽中形成流量控制阀。
在本发明的一个方面,在第一和第二压板的至少一者中形成有流体泵。例如,可采用沿着一个或多个通槽之一并具有止回阀的室,该止回阀形成进入室的入口并且被布置成允许流进入室内,而在室处具有布置用于向在室处的第一和第二薄膜之一施加压力的泵元件。压力驱使流出室,而止回阀则防止流回。优选地,在出口处提供另一个止回阀以防止回流从出口进入室中。作为另外一种选择,泵可包括容积式元件,其可沿着一个或多个通槽之一移动以实现蠕动泵送作用。
根据本发明的方法可用于管理流体流。该方法包括:将相对的第一和第二薄膜截留在相对的第一和第二压板之间;经由形成于第一和第二压板的至少一者内的通槽在第一和第二薄膜之间形成流体流路;以及使流体流过该流路。
优选地,第一和第二薄膜具有在流路处的表面并且所述表面在使流体流过流路的步骤之前是无菌的。
优选地,阻止流体流过流路的步骤包括使阀门元件紧贴第一和第二薄膜中的至少一者移动并进入通槽以阻碍流通过流路。阀门元件向通槽中的移动能完全阻塞流体通过流路或仅仅通过部分地阻塞流路而节流。
在本发明的一个方面,第一和第二压板的至少一者包括区段的矩阵,这些区段可从朝向第一压板和第二压板中的另一者的伸长位置移动至远离第一压板和第二压板中的所述另一者的回缩位置,并且由处于其回缩位置的区段的排列形成通槽。
可通过使区段沿通槽以波浪形接合而引起沿通槽的流动来实现沿通槽泵送流体。
附图说明
图1是根据本发明的流体歧管的分解透视图;
图2是图1的流体歧管的透视图;
图3是沿图1的线3--3的剖视图,其压板显示为中间具有袋的间隔构型;
图4是如图3中那样的剖视图,但压板被压在一起并且流体流路正在输送流体;
图5是示出泵送室的沿图1的线5--5的剖视图;
图6是示出止回阀的沿图1的线6--6截取的剖视图;
图7是根据本发明的可供选择流体歧管的底块的透视图,其具有可重构的流体通槽;以及
图8A至8D是图7的歧管的流路按时间顺序的侧正视图,示出了蠕动泵送作用。
具体实施方式
图1和2示出了根据本发明的流体歧管系统10,其大体上包括成型底块12、柔顺流体袋14和未成型顶块16。袋14为包含流体或气体的室,其优选地通过折叠或密封生物相容性材料的薄膜并安装一个或多个入口连接18和一个或多个出口连接20而形成,这些生物相容性材料诸如但不限于PVC、聚氨酯、聚乙烯、硅树脂和聚丙烯。其他布置方式也是可能的;例如,可提供流体输送管(图1和2中未示出),其已经连接到袋14并承载它们自己的连接器以用于连接到流体源或分配设备。连接器和管子中的一者或两者可与袋14一体地形成。顶块16具有平坦的下表面22,其接触形成袋14的上薄膜24。底块12具有上表面26,其具有形成于其上的通槽28并接触形成袋14的下薄膜30。顶块下表面22也可具有配合通槽(未示出),而不是平坦的,这些配合通槽与底块12的通槽28对准或相对于这些通槽28独立地定位。
现在进一步回到图3至6,在袋14、顶块16和底块12以及通槽28之间的相互作用形成通过袋14的流体流路32。袋被截留在充当压板的块12和16之间,压板在某些区域压缩袋而在存在通槽28的位置则不压缩。袋是柔性的,以充当密封流路32的衬垫。优选地,袋14本身的材料具有一定回弹性以增强其在作为衬垫密封时的作用。虽然块12和16优选地为刚性的以便耐用,但其中一者或两者可由弹性材料形成或附接有弹性材料以有助于密封。该材料可方便地施加到平坦表面22并在磨损时或需要不同的弹性特性时可替换。
通槽28的布置方式(在图1和2中最清楚地示出)决定流体流路32。图示流体歧管系统10具有入口34,并且通槽28从入口引导至止回阀36。通槽28从止回阀引导至可变流量阀3 8,然后引导至泵送室40。两个通槽28从泵送室40引导至第一出口阀42和出口44,以及引导至第二出口阀46和第二出口48。入口34与袋入口连接1 8以及出口44和48与袋出口连接20优选地以适当的布置相对应,使得袋14仅在一个取向上装配以防止其放置不当。
出口阀42和46为简单的柱塞50,其阻塞流路32以防止流从中流过。可变流量阀38也包括柱塞,该柱塞可被调节以部分地阻塞流路32。止回阀36包括阀体41,阀体41具有弯曲的入口表面43和平坦的出口表面45并且被弹簧47偏置封闭。逆着入口表面43的流提供了压力以克服弹簧47的偏置并将阀体41移动至打开以允许流动。逆着出口表面45的流不会产生足以克服偏置的压力。
通过经空气管线52交替地向泵送室40施加抽吸和压力,可实现泵送效应,并且止回阀36将促使流朝向出口44和48。在泵送室40的出口上可能需要附加的止回阀(未示出)以防止回流到泵送室中并提高泵送效率。也可采用诸如活塞(未示出)的机械解决方案,该活塞在泵送室40处抵靠薄膜30移动。作为另外一种选择,可将辊(未示出)或其他容积式驱动器应用到流路32的区段以实现蠕动泵送作用。
通过将诸如应变仪的测力传感器在流路32处放入块12或16之一中可构成压力传感器(未示出)。由流路32内的流体施加到其上的力可经过校准以指示压力。利用多个压力传感器,并计算通过传感器之间具有已知尺寸的一段流路32的压降可确定流量,这可能要在以计量方式限制流路32的情况下辅助进行。流量测量值也可用外部流量计校准。
在替换块12的块54(参见图7)的第二实施例中可实现流体管理的灵活性。块54包括区段56的矩阵,区段56中的每一个能够优选地可变地独立致动,使得可通过收缩某些区段56形成通槽58,并可通过在通槽58内延伸区段56而形成阀门57。阀门57可通过仅部分地延伸区段56而成为流量控制阀。为说明原理仅示出简化形式,其中通槽58由收缩的区段56形成并且从入口51延伸并分支到两个出口53和55,出口55被阀门57阻塞,阀门57包括伸入通槽58的区段56中的一个。块54的整个操作部分可包括区段56或者可具有永久性地形成于其中的某些通槽和结构,其中块54的仅某些部分由区段56构成。区段56可用来实现阀门和泵以及其他流量控制部件。
例如,通过以如图8A至8D中示出的波浪形致动通槽58内的区段56可实现蠕动泵送作用,其中区段56中的每一个编有用于图示的字母,并且它们在第一刚性表面60和由各个区段56形成的第二表面62之间操作(为清楚起见省略了袋14,但其将被定位在表面60和62之间)。在时间T1(图8A)处,编有“a”的区段56被完全致动,编有“b”的区段在上升的途中。在稍晚的时间T2(图8B)处,编有“a”的区段56在其下降的途中,“b”被完全致动,而“c”则在其上升的途中。到时间T3(图8C)时,“a”被完全收回,“b”在下降途中,“c”被完全致动,而“d”则在上升途中。到时间T4(图8D)时,“a”和“c”被完全收回,等等。以这种方式,形成通过通槽58的波浪形流。
优选地,每个区段经由控制系统和单独的线性致动器或螺线管60而独立地控制和致动。设想了用于独立地控制区段56的移动的其他合适的机构,诸如气压或液压缸、机械杠杆致动器、电动马达等。在一些应用中,所需区段可能小于成本合理的致动器,在这种情况下,致动器60可被布置成矩阵62(图7仅示出这样的矩阵的一小部分),优选地与区段56的矩阵相匹配,并且诸如鲍登线的一系列移动致动线64可将致动器的移动传递到各个区段56。因此,致动器将不需要微型化以满足区段56的尺寸要求。
以上参照一些优选实施例对本发明作了描述。显然,他人一旦阅读并获知了以上对本发明的具体说明,他们就会想到对本发明的一些修改和变更。本发明被认定应理解为包括所有这种修改和变更,只要它们在所附权利要求书及其等同物的范围内。
Claims (19)
1.一种流体管理盒系统,包括:
第一压板和与所述第一压板相对的第二压板;
第一薄膜和第二薄膜,所述第一薄膜和第二薄膜呈彼此相对关系并且被压缩在所述第一压板和所述第二压板之间;以及
一个或多个形成于所述第一压板和第二压板的至少一者中的通槽,由此流体可在所述一个或多个通槽处被引导通过形成于所述第一薄膜和第二薄膜之间的流路。
2.根据权利要求1所述的流体管理盒系统,其中所述第一薄膜具有面向所述第二薄膜的向内面,所述第二薄膜具有面向所述第一薄膜的向内面,并且其中所述第一薄膜向内面和所述第二薄膜向内面为无菌的。
3.根据权利要求1所述的流体管理盒系统,还包括具有阀门元件的阀门,所述阀门元件可紧贴所述第一或第二薄膜之一移动进入所述通槽中。
4.根据权利要求3所述的流体管理盒系统,其中所述流路在所述阀门元件完全移动进入所述通槽中时被阻塞。
5.根据权利要求3所述的流体管理盒系统,其中所述阀门元件可部分地移动进入所述通槽以实现所述流路中的流量限制。
6.根据权利要求1所述的流体管理盒系统,其中所述第一薄膜和第二薄膜为一次性和可替换的。
7.根据权利要求1所述的流体管理盒系统,其中所述第一薄膜和第二薄膜围绕其周边的范围密封以便形成袋。
8.根据权利要求1所述的流体管理盒系统,其中所述第一压板和第二压板的至少一者包括区段的矩阵,所述区段可从朝向所述第一压板和第二压板中的另一者的伸长位置移动至远离所述第一压板和第二压板中的所述另一者的回缩位置,并且由处于其回缩位置的所述区段的排列形成所述通槽。
9.根据权利要求8所述的流体管理盒系统,其中所述通槽中的流量控制阀包括可移动进入所述通槽中的所述区段中的一个或多个。
10.根据权利要求1所述的流体管理盒系统,还包括形成于所述第一和第二压板的至少一者中的流体泵。
11.根据权利要求10所述的流体管理盒系统,其中所述泵包括:室,所述室沿着所述一个或多个通槽之一;止回阀,所述止回阀形成从所述一个或多个通槽进入所述室的入口并被布置成允许流进入所述室;泵元件,所述泵元件在所述室处被布置成在所述室处抵靠所述第一和第二薄膜之一施加压力,由此所述压力驱使流离开所述室。
12.根据权利要求10所述的流体管理盒系统,其中所述泵包括可沿所述一个或多个通槽移动以实现蠕动泵送作用的容积式元件。
13.一种管理流体流的方法,包括:
将相对的第一和第二薄膜截留在相对的第一和第二压板之间;
经由形成于所述第一和第二压板的至少一者内的通槽在所述第一和第二薄膜之间形成流体流路;以及
使流体流过所述流路。
14.根据权利要求1 3所述的方法,其中所述第一和第二薄膜具有在所述流路处的表面并且所述表面在使流体流过所述流路的步骤之前是无菌的。
15.根据权利要求1 3所述的方法,还包括通过使阀门元件紧贴所述第一和第二薄膜中的至少一者移动并进入所述通槽以阻碍流体通过所述流路而阻止流体通过所述流路流动的步骤。
16.根据权利要求15所述的方法,其中所述阀门元件进入所述通槽的所述移动完全阻塞流体通过所述流路。
17.根据权利要求15所述的方法,其中所述阀门元件进入所述通槽的所述移动部分地阻塞流体通过所述流路。
18.根据权利要求13所述的方法,其中所述第一和第二压板中的至少一者包括区段的矩阵,所述区段可从朝向所述第一压板和第二压板中的另一者的伸长位置移动至远离所述第一压板和第二压板中的所述另一者的回缩位置,并且包括由处于其回缩位置的所述区段的排列形成所述通槽的步骤。
19.根据权利要求18所述的方法,还包括通过使区段沿所述通槽以波浪形接合而引起沿所述通槽的流动来沿所述通槽泵送流体。
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US13/249,470 US20130081697A1 (en) | 2011-09-30 | 2011-09-30 | Fluidic manifold |
US13/249,470 | 2011-09-30 |
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US (1) | US20130081697A1 (zh) |
EP (1) | EP2574789A3 (zh) |
JP (1) | JP6316535B2 (zh) |
CN (1) | CN103028453A (zh) |
AU (3) | AU2012227342A1 (zh) |
BR (1) | BR102012024787A2 (zh) |
CA (1) | CA2790471A1 (zh) |
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CN112747182A (zh) * | 2019-10-29 | 2021-05-04 | 兴中环保科技股份有限公司 | 方形回转接头 |
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DE102018107679A1 (de) | 2018-03-29 | 2019-10-02 | Sartorius Stedim Biotech Gmbh | Konfigurierbare Vorrichtung zur flexiblen Bereitstellung von Verbindungen und/oder Funktionen in einem biopharmazeutischen Prozess |
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AU2017208193A1 (en) | 2017-08-10 |
JP6316535B2 (ja) | 2018-04-25 |
EP2574789A2 (en) | 2013-04-03 |
AU2012227342A1 (en) | 2013-04-18 |
US20130081697A1 (en) | 2013-04-04 |
EP2574789A3 (en) | 2013-08-28 |
CA2790471A1 (en) | 2013-03-30 |
JP2013079956A (ja) | 2013-05-02 |
BR102012024787A2 (pt) | 2015-01-06 |
AU2016200017A1 (en) | 2016-01-28 |
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