CN103025927B - 精确地比对与配准用于dna测序的阵列的方法及系统 - Google Patents

精确地比对与配准用于dna测序的阵列的方法及系统 Download PDF

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CN103025927B
CN103025927B CN201180021839.8A CN201180021839A CN103025927B CN 103025927 B CN103025927 B CN 103025927B CN 201180021839 A CN201180021839 A CN 201180021839A CN 103025927 B CN103025927 B CN 103025927B
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CN103025927A (zh
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布赖恩·P·斯泰克
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Complete Genomics Inc
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Callida Genomics Inc
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    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/20—Image preprocessing
    • G06V10/24—Aligning, centring, orientation detection or correction of the image
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
    • G06T7/32—Determination of transform parameters for the alignment of images, i.e. image registration using correlation-based methods
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
    • G06T7/33—Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
    • G06T7/337—Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods involving reference images or patches
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/70—Determining position or orientation of objects or cameras
    • G06T7/73—Determining position or orientation of objects or cameras using feature-based methods
    • G06T7/74—Determining position or orientation of objects or cameras using feature-based methods involving reference images or patches
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/20—Image preprocessing
    • G06V10/32—Normalisation of the pattern dimensions
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30072—Microarray; Biochip, DNA array; Well plate
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V2201/00—Indexing scheme relating to image or video recognition or understanding
    • G06V2201/04—Recognition of patterns in DNA microarrays

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Multimedia (AREA)
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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Image Processing (AREA)
  • Image Analysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CN201180021839.8A 2010-04-30 2011-04-27 精确地比对与配准用于dna测序的阵列的方法及系统 Active CN103025927B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US33013010P 2010-04-30 2010-04-30
US61/330,130 2010-04-30
US13/092,618 US8774494B2 (en) 2010-04-30 2011-04-22 Method and system for accurate alignment and registration of array for DNA sequencing
US13/092,618 2011-04-22
PCT/US2011/034178 WO2011137183A1 (en) 2010-04-30 2011-04-27 Method and system for accurate alignment and registration of array for dna sequencing

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CN103025927B true CN103025927B (zh) 2015-12-16

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US (2) US8774494B2 (https=)
EP (2) EP2563953A4 (https=)
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SG (1) SG184963A1 (https=)
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Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2215209T3 (en) 2007-10-30 2018-09-03 Complete Genomics Inc DEVICE FOR HIGH-THROUGHPUT SEQUENCE OF NUCLEIC ACIDS
US8774494B2 (en) 2010-04-30 2014-07-08 Complete Genomics, Inc. Method and system for accurate alignment and registration of array for DNA sequencing
US9671344B2 (en) 2010-08-31 2017-06-06 Complete Genomics, Inc. High-density biochemical array chips with asynchronous tracks for alignment correction by moiré averaging
US9880089B2 (en) 2010-08-31 2018-01-30 Complete Genomics, Inc. High-density devices with synchronous tracks for quad-cell based alignment correction
JP2014523589A (ja) 2011-07-13 2014-09-11 ザ マルチプル ミエローマ リサーチ ファウンデーション， インコーポレイテッド データ収集及び配信のための方法
US9135497B2 (en) * 2012-01-27 2015-09-15 National Instruments Corporation Identifying randomly distributed microparticles in images to sequence a polynucleotide
US20130196880A1 (en) 2012-01-27 2013-08-01 Ventana Medical Systems, Inc. Patterned devices and methods for detecting analytes
CA2891939C (en) 2012-11-19 2020-10-27 Apton Biosystems, Inc. Digital analysis of molecular analytes using single molecule detection
US10829816B2 (en) 2012-11-19 2020-11-10 Apton Biosystems, Inc. Methods of analyte detection
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
US10088658B2 (en) * 2013-03-18 2018-10-02 General Electric Company Referencing in multi-acquisition slide imaging
WO2014153369A1 (en) * 2013-03-18 2014-09-25 Life Technologies Corporation Methods and systems for analyzing biological reaction systems
CA2921809A1 (en) 2013-08-22 2015-02-26 Apton Biosystems, Inc. Digital analysis of molecular analytes using electrical methods
US9519823B2 (en) * 2013-10-04 2016-12-13 The University Of Manchester Biomarker method
US9953417B2 (en) 2013-10-04 2018-04-24 The University Of Manchester Biomarker method
CN107735496B (zh) * 2014-12-26 2021-05-07 株式会社日立高新技术 核酸分析装置
JP2016174578A (ja) * 2015-03-20 2016-10-06 東ソー株式会社 微小粒子選別装置および前記装置を備えた微小粒子回収装置
US9330932B1 (en) * 2015-03-31 2016-05-03 Micron Technology, Inc. Methods of fabricating features associated with semiconductor substrates
JP2019505884A (ja) * 2015-12-10 2019-02-28 キアゲン ゲーエムベーハー デジタル画像内の少なくとも１つのオブジェクトの全体的明るさを判定するための方法
JP6672938B2 (ja) * 2016-03-25 2020-03-25 横浜ゴム株式会社 周波数選択板の設計方法および周波数選択板設計プログラム
US10467749B2 (en) * 2016-10-10 2019-11-05 Genemind Biosciences Company Limited Method and system for processing an image comprising spots in nucleic acid sequencing
DK3548652T3 (da) * 2016-12-01 2024-07-08 Nautilus Subsidiary Inc Fremgangsmåder til proteinanalyse
WO2018170518A1 (en) 2017-03-17 2018-09-20 Apton Biosystems, Inc. Sequencing and high resolution imaging
EP3513280A4 (en) 2017-11-13 2020-07-22 The Multiple Myeloma Research Foundation, Inc. INTEGRATED, MOLECULAR, OMIC, IMMUNOTHERAPY, METABOLIC, EPIGENETIC AND CLINICAL DATABASE
JP7062926B2 (ja) * 2017-11-24 2022-05-09 凸版印刷株式会社 呈色反応検出システム、呈色反応検出方法及びプログラム
KR20250152680A (ko) 2017-12-29 2025-10-23 노틸러스 서브시디어리, 인크. 단백질 식별을 위한 디코딩 접근법
WO2019196019A1 (zh) * 2018-04-10 2019-10-17 深圳华大智造科技有限公司 荧光图像配准方法、基因测序仪及系统、存储介质
US11435283B2 (en) 2018-04-17 2022-09-06 Sharif University Of Technology Optically detecting mutations in a sequence of DNA
CN109035164B (zh) * 2018-07-13 2022-03-04 北京控制工程研究所 一种快速鲁棒图像杂光抑制的方法及系统
WO2020037570A1 (zh) * 2018-08-22 2020-02-27 深圳市真迈生物科技有限公司 图像配准方法、装置和计算机程序产品
KR102926915B1 (ko) 2018-09-19 2026-02-13 퍼시픽 바이오사이언스 오브 캘리포니아, 인크. 밀집 패킹된 분석물층 및 검출 방법
CN113227342A (zh) * 2019-01-09 2021-08-06 株式会社日立高新技术 核酸分析用基板、核酸分析用流动池以及图像分析方法
US11972583B2 (en) * 2019-01-31 2024-04-30 Bgi Shenzhen Fluorescence image registration method, gene sequencing instrument, and storage medium
EP4038546B1 (en) * 2019-10-01 2024-08-21 10X Genomics, Inc. Systems and methods for identifying morphological patterns in tissue samples
AU2020388047A1 (en) 2019-11-18 2022-06-23 10X Genomics, Inc. Systems and methods for tissue classification
EP4435718A3 (en) 2019-11-22 2024-12-18 10X Genomics, Inc. Systems and methods for spatial analysis of analytes using fiducial alignment
CN115428088A (zh) 2020-02-13 2022-12-02 10X基因组学有限公司 用于基因表达和dna染色质可及性的联合交互式可视化的系统和方法
CN111407222B (zh) * 2020-04-27 2024-11-29 重庆金山医疗技术研究院有限公司 一种电子内窥镜传像组件景深调试装置及调试方法
EP4053794A1 (en) * 2021-03-05 2022-09-07 Leica Microsystems CMS GmbH Multispectral microscope system and method for registering first and second images by means thereof
WO2022271689A1 (en) * 2021-06-25 2022-12-29 Illumina, Inc. Fiducials for use in registration of a patterned surface
EP4181077A1 (en) * 2021-11-11 2023-05-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method of evaluating at least one image of at least one micro-array
FR3133474B1 (fr) * 2022-03-11 2024-03-22 Aryballe Dispositif et procédé de caractérisation d’un alignement de caméra dans un capteur à puce photonique
EP4435717A1 (en) * 2023-03-24 2024-09-25 QIAGEN GmbH Method for providing an analysis of partition image data
CN119913026B (zh) * 2023-10-30 2025-12-02 迈克医疗电子有限公司 数字pcr仪及其通道微滴对齐方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6349144B1 (en) * 1998-02-07 2002-02-19 Biodiscovery, Inc. Automated DNA array segmentation and analysis
WO2009059022A1 (en) * 2007-10-30 2009-05-07 Complete Genomics, Inc. Apparatus for high throughput sequencing of nucleic acids
US20090250615A1 (en) * 2008-04-04 2009-10-08 Life Technologies Corporation Scanning system and method for imaging and sequencing

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US6610256B2 (en) 1989-04-05 2003-08-26 Wisconsin Alumni Research Foundation Image processing and analysis of individual nucleic acid molecules
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US6401267B1 (en) 1993-09-27 2002-06-11 Radoje Drmanac Methods and compositions for efficient nucleic acid sequencing
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
EP1033411B1 (en) 1996-06-04 2006-02-22 University of Utah Research Foundation Fluorescent donor-acceptor pair
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US6309824B1 (en) 1997-01-16 2001-10-30 Hyseq, Inc. Methods for analyzing a target nucleic acid using immobilized heterogeneous mixtures of oligonucleotide probes
US6432360B1 (en) 1997-10-10 2002-08-13 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
EP1114184A2 (en) 1998-09-15 2001-07-11 Yale University Molecular cloning using rolling circle amplification
WO2000040758A2 (en) 1999-01-06 2000-07-13 Hyseq Inc. Enhanced sequencing by hybridization using pools of probes
GB9901475D0 (en) 1999-01-22 1999-03-17 Pyrosequencing Ab A method of DNA sequencing
US20020150909A1 (en) * 1999-02-09 2002-10-17 Stuelpnagel John R. Automated information processing in randomly ordered arrays
US6272207B1 (en) 1999-02-18 2001-08-07 Creatv Microtech, Inc. Method and apparatus for obtaining high-resolution digital X-ray and gamma ray images
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
DE60030436T2 (de) 1999-05-20 2007-03-29 Illumina, Inc., San Diego Vorrichtung zur halterung und präsentation von mindestens einer mikrokugelmatrix zu lösungen und/oder zu optischen abbildungssystemen
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6754375B1 (en) 1999-07-16 2004-06-22 Packard Bioscience Company Method and system for interactively developing at least one grid pattern and computer-readable storage medium having a program for executing the method
WO2001023610A2 (en) 1999-09-29 2001-04-05 Solexa Ltd. Polynucleotide sequencing
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US6591196B1 (en) * 2000-06-06 2003-07-08 Agilent Technologies Inc. Method and system for extracting data from surface array deposited features
DE60124598T2 (de) * 2000-06-06 2007-09-06 Agilent Technologies, Inc., Palo Alto Verfahren und System zur Bestimmung der Orientierung eines Microarrays
KR20030028553A (ko) * 2000-07-21 2003-04-08 더 트러스티스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 이미지 모자이크 방법 및 장치
EP1573634A2 (en) * 2000-08-22 2005-09-14 Affymetrix, Inc. System method, and computer software product for controlling biological microarray scanner
US6873422B2 (en) * 2000-12-08 2005-03-29 Mitutoyo Corporation Systems and methods for high-accuracy displacement determination in a correlation based position transducer
US20020192650A1 (en) * 2001-05-30 2002-12-19 Amorese Douglas A. Composite arrays
US7157229B2 (en) * 2002-01-31 2007-01-02 Nimblegen Systems, Inc. Prepatterned substrate for optical synthesis of DNA probes
US6982793B1 (en) 2002-04-04 2006-01-03 Nanometrics Incorporated Method and apparatus for using an alignment target with designed in offset
US6980677B2 (en) * 2002-05-24 2005-12-27 Niles Scientific, Inc. Method, system, and computer code for finding spots defined in biological microarrays
US20050049797A1 (en) 2003-08-27 2005-03-03 Srinka Ghosh Method and system for displacement-vector-based detection of zone misalignment in microarray data
US7323681B1 (en) * 2003-09-11 2008-01-29 Applera Corporation Image enhancement by sub-pixel imaging
JP2007526772A (ja) 2004-02-27 2007-09-20 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ インサイチュー配列決定用ポロニー蛍光ビーズ
US7072500B2 (en) 2004-05-07 2006-07-04 Wisconsin Alumni Research Foundation Image locking system for DNA micro-array synthesis
US20060024711A1 (en) 2004-07-02 2006-02-02 Helicos Biosciences Corporation Methods for nucleic acid amplification and sequence determination
WO2006073504A2 (en) 2004-08-04 2006-07-13 President And Fellows Of Harvard College Wobble sequencing
US7283677B2 (en) * 2004-08-31 2007-10-16 Hewlett-Packard Development Company, L.P. Measuring sub-wavelength displacements
JP5331476B2 (ja) 2005-06-15 2013-10-30 カリダ・ジェノミックス・インコーポレイテッド 遺伝子解析および化学解析用の単分子アレイ
SG170028A1 (en) 2006-02-24 2011-04-29 Callida Genomics Inc High throughput genome sequencing on dna arrays
US20090075343A1 (en) * 2006-11-09 2009-03-19 Complete Genomics, Inc. Selection of dna adaptor orientation by nicking
ES2628973T3 (es) * 2007-05-31 2017-08-04 University Of Washington Mutagénesis inducible de genes diana
JP5835680B2 (ja) * 2007-11-05 2015-12-24 株式会社東芝 画像位置合わせ装置
WO2009073629A2 (en) 2007-11-29 2009-06-11 Complete Genomics, Inc. Efficient shotgun sequencing methods
WO2009097368A2 (en) * 2008-01-28 2009-08-06 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
EP2319014B1 (en) * 2008-07-15 2015-04-29 Institut Pasteur Korea Method and apparatus for imaging of features on a substrate
US8774494B2 (en) 2010-04-30 2014-07-08 Complete Genomics, Inc. Method and system for accurate alignment and registration of array for DNA sequencing
US9671344B2 (en) 2010-08-31 2017-06-06 Complete Genomics, Inc. High-density biochemical array chips with asynchronous tracks for alignment correction by moiré averaging
US9880089B2 (en) 2010-08-31 2018-01-30 Complete Genomics, Inc. High-density devices with synchronous tracks for quad-cell based alignment correction
US8175452B1 (en) 2010-10-26 2012-05-08 Complete Genomics, Inc. Method and system for imaging high density biochemical arrays with sub-pixel alignment

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6349144B1 (en) * 1998-02-07 2002-02-19 Biodiscovery, Inc. Automated DNA array segmentation and analysis
WO2009059022A1 (en) * 2007-10-30 2009-05-07 Complete Genomics, Inc. Apparatus for high throughput sequencing of nucleic acids
US20090250615A1 (en) * 2008-04-04 2009-10-08 Life Technologies Corporation Scanning system and method for imaging and sequencing

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WO2011137183A1 (en) 2011-11-03
JP6042859B2 (ja) 2016-12-14
EP2563953A1 (en) 2013-03-06
JP2013527848A (ja) 2013-07-04
JP5654668B2 (ja) 2015-01-14
EP3043319A1 (en) 2016-07-13
US9359641B2 (en) 2016-06-07
CN103025927A (zh) 2013-04-03
JP2015042185A (ja) 2015-03-05
US20110268347A1 (en) 2011-11-03
US20150080231A1 (en) 2015-03-19
US8774494B2 (en) 2014-07-08
SG184963A1 (en) 2012-11-29
EP2563953A4 (en) 2015-06-03

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