CN103007002B - 一种治疗高脂血症的中药降脂汤 - Google Patents
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Abstract
本发明公开了一种治疗高脂血症的中药降脂汤，该降脂汤是针对高脂血症形成的病因是以肝脾不调为本，以湿盛痰瘀脂浊为标，选择具有补益肝肾、活血化瘀、化痰降浊、清热利湿的中草药韭菜籽、柴胡、山药、栀子、连翘、茯苓、丹参、赤芍、乳香、桂枝、杏仁制成汤剂。经临床试验证明，总有效率为96.0％，明显高于对照组，值得临床推广应用。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗高脂血症的中药降脂汤。
背景技术
高脂血症是人体脂质代谢失常，血浆内脂质浓度超过正常范围的病症。因脂质多与血浆中蛋白结合，故又称高脂蛋白血症。根据病因可分为原发性和继发性两类。原发性系由于脂质和脂蛋白代谢先天性缺陷引起，继发性者主要继发于某种疾病，如糖尿病、肝脏疾病、肾脏疾病、甲状腺疾病等，以及饮酒、肥胖、饮食与生活方式等环境因素的影响。主要危害是导致动脉粥样硬化，进而导致众多的相关疾病，其中最常见的一种致命性疾病就是冠心病。
目前，对高脂血症的药物治疗，一般采用西药和中药，西药治疗常用的降脂药有他汀类药物，贝特类药物，胆酸螯合剂，烟酸和其他降脂药物；长期服用，副作用较大。中药治疗虽有一些方剂，但均存在治疗效不理想的问题。
发明内容
本发明的目的是提供一种治疗高脂血症的中药降脂汤，该降脂汤是祖传秘方，多年来，为周围百姓治愈了较多的高脂血症。针对高脂血症形成的病因是以肝脾不调为本，以湿盛痰瘀脂浊为标，选择具有补益肝肾、活血化瘀、化痰降浊、清热利湿的中草药制成汤剂。
本发明的目的是通过以下技术方案实现的，该治疗高脂血症的中药降脂汤由以下重量份的中药制成：韭菜籽9-15份、柴胡7-13份、山药7-13份、栀子9-12份、连翘7-12份、茯苓9-12份、丹参7-9份、赤芍7-10份、乳香7-9份、桂枝9-12份、杏仁6-9份。
优选的，该治疗高脂血症的中药降脂汤由以下重量份的中药制成：韭菜籽12份、柴胡10份、山药10份、栀子11份、连翘9份、茯苓10份、丹参8份、赤芍9份、乳香8份、桂枝10份、杏仁7份。
将上药按常规煎制方法制成降脂汤。
方中：以韭菜籽温补肝肾、壮阳固精，柴胡疏散退热、升阳舒肝；山药健脾益胃、滋肾益精共为君药；栀子清热利湿，连翘清热解毒、消肿散结，茯苓补脾利湿为臣药；丹参活血调经、祛瘀止痛，赤芍清热凉血、散瘀止痛，乳香调气活血共为佐药；桂枝散寒解表、温通经脉、通阳化气，杏仁消痰润肺、逐痹散结为使药。诸药合用，既能补益肝肾、活血化瘀，又善清热利湿、化痰降浊。
临床资料
1、一般资料 所选100例病例均为2005年4月到2007年6月来我院就诊的病例，并附合以下入选标准。将其随机分为治疗组和对照组，每组各50例。治疗组50例中男29例，女21例；年龄41～75岁，平均54.5岁；病程1个月～10年；合并冠心病者10例，高血压者9例，脂肪肝者8例，脑动脉硬化者13例。对照组50例中男28例，女22例；年龄40～76岁，平均53.6岁；病程1个月～10.5年；冠心病者9例，高血压病者8例，脂肪肝者9例，脑动脉硬化者12例。两组一般资料比较差异无统计学意义(P＞0.05)。
2、入选标准 参照《中药新药治疗高血脂症的临床研究指导原则》1997年全国血脂异常防治对策研究组编写的《血脂异常防治建议》拟定。患者在卫生宣教4周后，且正常饮食情况下，2周内(新患者)如2次测血脂符合以下情况之一者，即可确诊：①胆固醇(TC)≥5.7mmol/L；②三酰甘油(TG)≥1.7mmol/L；低密度脂蛋白(LDL-C)≥3.6mmol/L；高密度脂蛋(HDL-C)≤1.0mmol/L。
3、治疗方法 治疗组服用本发明降脂汤，1剂/d，水煎，分2次服；对照组口服北大维信的血脂康胶囊，0.6g/次，2次/d。两组均以30d为1个疗程，治疗前1周和服药期间均停用其他降血脂药物。胆固醇、三酰甘油、低密度脂蛋白、高密度脂蛋白、肝功能、肾功能、心电图等均于治疗前后各检测1次。
4、疗效标准 参照《中药新药治疗高血脂症的临术研究指导原则》拟定。治疗后血脂检测恢复正常为临床控制；治疗后血脂检测达到以下任何1项者，即TC下降≥20％，或TG下降≥40％，或HDL-C上升≥0.26mmol/L，或HDL-C/LDL-C≥20％为显效；治疗后血脂检测达到以下任何一项者，即TC下降＜20％，或TG下降≥20％＜40％，HDL-C上升≥0.104mmol/L＜0.26mmol/L，或HDL-C/LDL-C≥10％＜20％为有效；治疗后血脂检测无明显改善或改善达不到有效标准者为无效。
5、治疗结果 治疗组50例，临床控制23例，显效18例，有效7例，无效2例，总有效率96.0％；对照组50例，临床控制14例，显效15例，有效12例，无效9例，总有效率82.0％。两组比较差异有统计学意义。
具体实施方式
实施例一：取韭菜籽12g、柴胡10g、山药10g、栀子11g、连翘9g、茯苓10g、丹参8g、赤芍9g、乳香8g、桂枝10g、杏仁7g。将上药按常规煎制方法制成降脂汤。
实施例二：取韭菜籽15g、柴胡13g、山药7g、栀子9g、连翘12g、茯苓9g、丹参7g、赤芍10g、乳香9g、桂枝9g、杏仁6g。将上药按常规煎制方法制成降脂汤。
实施例三：取韭菜籽9g、柴胡7g、山药13g、栀子12g、连翘7g、茯苓12g、丹参9g、赤芍7g、乳香7g、桂枝12g、杏仁9g。将上药按常规煎制方法制成降脂汤。
Claims (1)
1.一种治疗高脂血症的中药降脂汤，其特征在于该中药降脂汤由以下重量的中药制成：韭菜籽12g、柴胡10g、山药10g、栀子11g、连翘9g、茯苓10g、丹参8g、赤芍9g、乳香8g、桂枝10g、杏仁7g。
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