CN103003306B - 抗体 - Google Patents
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- CN103003306B CN103003306B CN201180019263.1A CN201180019263A CN103003306B CN 103003306 B CN103003306 B CN 103003306B CN 201180019263 A CN201180019263 A CN 201180019263A CN 103003306 B CN103003306 B CN 103003306B
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
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- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30306010P | 2010-02-10 | 2010-02-10 | |
| GBGB1002238.2A GB201002238D0 (en) | 2010-02-10 | 2010-02-10 | Antibodies |
| US61/303060 | 2010-02-10 | ||
| GB1002238.2 | 2010-02-10 | ||
| PCT/GB2011/000175 WO2011098762A2 (en) | 2010-02-10 | 2011-02-10 | Antibodies against cxcr4 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103003306A CN103003306A (zh) | 2013-03-27 |
| CN103003306B true CN103003306B (zh) | 2016-09-07 |
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| CN201180019263.1A Expired - Fee Related CN103003306B (zh) | 2010-02-10 | 2011-02-10 | 抗体 |
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| JP (2) | JP6045914B2 (enExample) |
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| SG (1) | SG182795A1 (enExample) |
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| ZA (1) | ZA201206055B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| WO2012178137A1 (en) | 2011-06-24 | 2012-12-27 | Gillies Stephen D | Light chain immunoglobulin fusion proteins and methods of use thereof |
| IN2015DN00140A (enExample) * | 2012-08-31 | 2015-06-12 | Argen X Bv | |
| CN106794219A (zh) * | 2014-02-19 | 2017-05-31 | 北京迈康斯德医药技术有限公司 | 趋化因子受体拮抗体及其联合疗法 |
| CA2970857A1 (en) * | 2014-12-17 | 2016-06-23 | Cancer Research Technology Ltd | Anti-cxcl12 antibody molecules and their uses |
| PH12021552628A1 (en) | 2015-07-23 | 2022-06-27 | Boehringer Ingelheim Int | Compound targeting il-23a and b-cell activating factor (baff) and uses thereof |
| WO2017132202A1 (en) | 2016-01-25 | 2017-08-03 | Nant Holdings Ip, Llc | Nk cells with altered cxcl12/cxcr4 signaling |
| EP3417653B1 (en) | 2016-02-15 | 2021-08-25 | Corning Optical Communications LLC | Methods for centralized channel selection across different cells in a radio access network |
| NZ789594A (en) | 2016-06-20 | 2025-07-25 | Kymab Ltd | Anti-PD-L1 antibodies |
| KR20210031898A (ko) | 2018-07-13 | 2021-03-23 | 난징 레전드 바이오테크 씨오., 엘티디. | 전염병을 치료하기 위한 공동수용체 시스템 |
| JP2023509760A (ja) | 2020-01-08 | 2023-03-09 | シンシス セラピューティクス，インコーポレイテッド | Ａｌｋ５阻害剤複合体およびその使用 |
| EP4347643A4 (en) * | 2021-05-27 | 2025-09-17 | Us Gov Veterans Affairs | HUMAN MONOCLONAL ANTIBODIES SPECIFIC TO STREPTOLYSIN O AND METHODS OF USE |
| JPWO2024127456A1 (enExample) | 2022-12-12 | 2024-06-20 | ||
| CN117003876B (zh) * | 2023-08-31 | 2024-06-18 | 恺佧生物科技(上海)有限公司 | 一种Anti-CXCR4膜蛋白抗体及其制备方法和应用 |
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| FR2437213A1 (fr) | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| WO1990010457A1 (en) | 1989-03-14 | 1990-09-20 | New York University | Method of treating hiv infections using immunotoxins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5660827A (en) | 1992-03-05 | 1997-08-26 | Board Of Regents, The University Of Texas System | Antibodies that bind to endoglin |
| EP0627940B1 (en) | 1992-03-05 | 2003-05-07 | Board of Regents, The University of Texas System | Use of immunoconjugates for the diagnosis and/or therapy of vascularized tumors |
| DE19801265C1 (de) | 1998-01-15 | 1999-08-12 | Deutsches Krebsforsch | Inhibierung von CD95-unabhängiger Apoptose bei AIDS |
| US6863887B1 (en) | 1998-03-30 | 2005-03-08 | Northwest Biotherapeutics, Inc. | Therapeutic and diagnostic applications based on the role of the CXCR-4 gene in tumorigenesis |
| US6610834B1 (en) | 1998-11-18 | 2003-08-26 | Peter I. Lobo | Human IgM antibodies to chemokine receptors |
| AU763954B2 (en) | 1999-04-28 | 2003-08-07 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting VEGF |
| US6703020B1 (en) | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| US7005503B2 (en) | 2002-02-08 | 2006-02-28 | Genetastix Corporation | Human monoclonal antibody against coreceptors for human immunodeficiency virus |
| AU2003209059A1 (en) | 2002-02-08 | 2003-09-02 | Genetastix Corporation | Human monoclonal antibodies against membrane proteins |
| DE10240064A1 (de) | 2002-08-30 | 2004-03-11 | Universitätsklinikum Freiburg | CXCR4-Rezeptor-Antagonisten |
| US20050266009A1 (en) | 2003-06-30 | 2005-12-01 | Savient Pharmaceuticals, Inc. | Antibodies and uses thereof |
| WO2006124013A2 (en) * | 2004-04-30 | 2006-11-23 | Five Prime Therapeutics, Inc. | Novel stromal cell-derived factor-1 polypeptides, polynucleotides, modulators thereof, and method of use |
| EP1871807B1 (en) | 2005-02-18 | 2012-11-28 | Dana-Farber Cancer Institute, Inc. | Antibodies against cxcr4 and methods of use thereof |
| EA018836B1 (ru) * | 2006-10-02 | 2013-11-29 | Медарекс, Л.Л.К. | Человеческие антитела, которые связываются с cxcr4, и их применение |
| FR2915102B1 (fr) | 2007-04-23 | 2014-05-16 | Pf Medicament | Utilisation d'un anticorps anti-cxcr4 pour le traitement du cancer |
| MX2010012435A (es) | 2008-05-14 | 2011-05-03 | Lilly Co Eli | Anticuerpos anti-cxcr4. |
-
2010
- 2010-02-10 GB GBGB1002238.2A patent/GB201002238D0/en not_active Ceased
-
2011
- 2011-02-10 WO PCT/GB2011/000175 patent/WO2011098762A2/en not_active Ceased
- 2011-02-10 US US13/024,698 patent/US8748107B2/en not_active Expired - Fee Related
- 2011-02-10 NZ NZ601943A patent/NZ601943A/en not_active IP Right Cessation
- 2011-02-10 SG SG2012056321A patent/SG182795A1/en unknown
- 2011-02-10 JP JP2012552459A patent/JP6045914B2/ja not_active Expired - Fee Related
- 2011-02-10 KR KR1020127023204A patent/KR20120130767A/ko not_active Ceased
- 2011-02-10 MX MX2012009144A patent/MX2012009144A/es not_active Application Discontinuation
- 2011-02-10 EA EA201290759A patent/EA201290759A1/ru unknown
- 2011-02-10 EP EP11730035A patent/EP2534177A2/en not_active Withdrawn
- 2011-02-10 CN CN201180019263.1A patent/CN103003306B/zh not_active Expired - Fee Related
- 2011-02-10 CA CA2788400A patent/CA2788400A1/en not_active Abandoned
- 2011-02-10 AU AU2011214179A patent/AU2011214179B2/en not_active Ceased
- 2011-02-10 BR BR112012020173A patent/BR112012020173A2/pt not_active IP Right Cessation
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2012
- 2012-08-13 ZA ZA2012/06055A patent/ZA201206055B/en unknown
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2014
- 2014-05-16 US US14/279,728 patent/US9353185B2/en not_active Expired - Fee Related
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2016
- 2016-05-11 US US15/152,414 patent/US20160244527A1/en not_active Abandoned
- 2016-07-29 JP JP2016149925A patent/JP2017012179A/ja not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| （Characterization of Nef-CXCR4 Interactions Important for Apoptosis Induction;Ming-Bo Huang;《JOURNAL OF VIROLOGY》;20041031;第78卷(第2期);11084–11096 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2534177A2 (en) | 2012-12-19 |
| CN103003306A (zh) | 2013-03-27 |
| AU2011214179A1 (en) | 2012-09-13 |
| KR20120130767A (ko) | 2012-12-03 |
| WO2011098762A3 (en) | 2012-01-19 |
| EA201290759A1 (ru) | 2013-03-29 |
| NZ601943A (en) | 2014-11-28 |
| SG182795A1 (en) | 2012-08-30 |
| ZA201206055B (en) | 2014-01-29 |
| BR112012020173A2 (pt) | 2019-09-24 |
| WO2011098762A8 (en) | 2011-10-20 |
| MX2012009144A (es) | 2012-10-01 |
| US9353185B2 (en) | 2016-05-31 |
| US20160244527A1 (en) | 2016-08-25 |
| JP2013519367A (ja) | 2013-05-30 |
| JP2017012179A (ja) | 2017-01-19 |
| US20110311449A1 (en) | 2011-12-22 |
| US8748107B2 (en) | 2014-06-10 |
| CO6630117A2 (es) | 2013-03-01 |
| WO2011098762A2 (en) | 2011-08-18 |
| GB201002238D0 (en) | 2010-03-31 |
| AU2011214179B2 (en) | 2015-08-06 |
| JP6045914B2 (ja) | 2016-12-14 |
| CA2788400A1 (en) | 2011-08-18 |
| US20140369925A1 (en) | 2014-12-18 |
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