CA2788400A1 - Antibodies against cxcr4 - Google Patents
Antibodies against cxcr4 Download PDFInfo
- Publication number
- CA2788400A1 CA2788400A1 CA2788400A CA2788400A CA2788400A1 CA 2788400 A1 CA2788400 A1 CA 2788400A1 CA 2788400 A CA2788400 A CA 2788400A CA 2788400 A CA2788400 A CA 2788400A CA 2788400 A1 CA2788400 A1 CA 2788400A1
- Authority
- CA
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- Prior art keywords
- antibody
- sequence
- cxcr4
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30306010P | 2010-02-10 | 2010-02-10 | |
| GB1002238.2 | 2010-02-10 | ||
| US61/303,060 | 2010-02-10 | ||
| GBGB1002238.2A GB201002238D0 (en) | 2010-02-10 | 2010-02-10 | Antibodies |
| PCT/GB2011/000175 WO2011098762A2 (en) | 2010-02-10 | 2011-02-10 | Antibodies against cxcr4 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2788400A1 true CA2788400A1 (en) | 2011-08-18 |
Family
ID=42110504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2788400A Abandoned CA2788400A1 (en) | 2010-02-10 | 2011-02-10 | Antibodies against cxcr4 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8748107B2 (enExample) |
| EP (1) | EP2534177A2 (enExample) |
| JP (2) | JP6045914B2 (enExample) |
| KR (1) | KR20120130767A (enExample) |
| CN (1) | CN103003306B (enExample) |
| AU (1) | AU2011214179B2 (enExample) |
| BR (1) | BR112012020173A2 (enExample) |
| CA (1) | CA2788400A1 (enExample) |
| CO (1) | CO6630117A2 (enExample) |
| EA (1) | EA201290759A1 (enExample) |
| GB (1) | GB201002238D0 (enExample) |
| MX (1) | MX2012009144A (enExample) |
| NZ (1) | NZ601943A (enExample) |
| SG (1) | SG182795A1 (enExample) |
| WO (1) | WO2011098762A2 (enExample) |
| ZA (1) | ZA201206055B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| ES2758884T3 (es) | 2011-06-24 | 2020-05-06 | Stephen D Gillies | Proteínas de fusión de inmunoglobulina a través de cadena ligera y métodos de uso de ellas |
| JP6391574B2 (ja) * | 2012-08-31 | 2018-09-26 | アルゲン−エックス ビーブイビーエー | 種間標的内交差反応性を有する抗体分子を産生する方法 |
| EP3125919A4 (en) * | 2014-02-19 | 2018-01-03 | Microconstants China Inc. | Chemokine receptor antagonist and its combinational therapy |
| WO2016096640A2 (en) * | 2014-12-17 | 2016-06-23 | Cancer Research Technology Ltd | Anti-cxcl12 antibody molecules and their uses |
| KR102644875B1 (ko) | 2015-07-23 | 2024-03-06 | 베링거잉겔하임인터내쇼날유한회사 | Il-23a 및 b-세포 활성화 인자(baff)를 표적화하는 화합물 및 이의 용도 |
| EP3408378B1 (en) | 2016-01-25 | 2022-01-12 | NantCell, Inc. | Nk cells with altered cxcl12/cxcr4 signaling |
| EP3417653B1 (en) | 2016-02-15 | 2021-08-25 | Corning Optical Communications LLC | Methods for centralized channel selection across different cells in a radio access network |
| BR112018076260A2 (pt) | 2016-06-20 | 2019-03-26 | Kymab Limited | anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina |
| JP7447388B2 (ja) | 2018-07-13 | 2024-03-12 | ナンジン レジェンド バイオテック カンパニー，リミテッド | 感染性疾患の治療のための共受容体システム |
| WO2021142086A1 (en) | 2020-01-08 | 2021-07-15 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
| WO2022251575A1 (en) * | 2021-05-27 | 2022-12-01 | The United States Government As Represented By The Department Of Veterans Affairs | Human monoclonal antibodies specific to streptolysin o and methods of use |
| JPWO2024127456A1 (enExample) | 2022-12-12 | 2024-06-20 | ||
| CN117003876B (zh) * | 2023-08-31 | 2024-06-18 | 恺佧生物科技(上海)有限公司 | 一种Anti-CXCR4膜蛋白抗体及其制备方法和应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2437213A1 (fr) | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| WO1990010457A1 (en) | 1989-03-14 | 1990-09-20 | New York University | Method of treating hiv infections using immunotoxins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| CA2131528C (en) | 1992-03-05 | 2004-07-13 | Philip E. Thorpe | Methods and compositions for targeting the vasculature of solid tumors |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
| DE19801265C1 (de) | 1998-01-15 | 1999-08-12 | Deutsches Krebsforsch | Inhibierung von CD95-unabhängiger Apoptose bei AIDS |
| US6863887B1 (en) | 1998-03-30 | 2005-03-08 | Northwest Biotherapeutics, Inc. | Therapeutic and diagnostic applications based on the role of the CXCR-4 gene in tumorigenesis |
| US6610834B1 (en) | 1998-11-18 | 2003-08-26 | Peter I. Lobo | Human IgM antibodies to chemokine receptors |
| CN1308347C (zh) | 1999-04-28 | 2007-04-04 | 德克萨斯大学董事会 | 用于通过选择性抑制vegf来治疗癌症的组合物和方法 |
| US6703020B1 (en) | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| US7005503B2 (en) | 2002-02-08 | 2006-02-28 | Genetastix Corporation | Human monoclonal antibody against coreceptors for human immunodeficiency virus |
| AU2003209059A1 (en) | 2002-02-08 | 2003-09-02 | Genetastix Corporation | Human monoclonal antibodies against membrane proteins |
| DE10240064A1 (de) * | 2002-08-30 | 2004-03-11 | Universitätsklinikum Freiburg | CXCR4-Rezeptor-Antagonisten |
| US20050266009A1 (en) | 2003-06-30 | 2005-12-01 | Savient Pharmaceuticals, Inc. | Antibodies and uses thereof |
| WO2006124013A2 (en) * | 2004-04-30 | 2006-11-23 | Five Prime Therapeutics, Inc. | Novel stromal cell-derived factor-1 polypeptides, polynucleotides, modulators thereof, and method of use |
| EP1871807B1 (en) | 2005-02-18 | 2012-11-28 | Dana-Farber Cancer Institute, Inc. | Antibodies against cxcr4 and methods of use thereof |
| SG178712A1 (en) * | 2006-10-02 | 2012-03-29 | Medarex Inc | Human antibodies that bind cxcr4 and uses thereof |
| FR2915102B1 (fr) | 2007-04-23 | 2014-05-16 | Pf Medicament | Utilisation d'un anticorps anti-cxcr4 pour le traitement du cancer |
| MX2010012435A (es) | 2008-05-14 | 2011-05-03 | Lilly Co Eli | Anticuerpos anti-cxcr4. |
-
2010
- 2010-02-10 GB GBGB1002238.2A patent/GB201002238D0/en not_active Ceased
-
2011
- 2011-02-10 NZ NZ601943A patent/NZ601943A/en not_active IP Right Cessation
- 2011-02-10 KR KR1020127023204A patent/KR20120130767A/ko not_active Ceased
- 2011-02-10 WO PCT/GB2011/000175 patent/WO2011098762A2/en not_active Ceased
- 2011-02-10 EP EP11730035A patent/EP2534177A2/en not_active Withdrawn
- 2011-02-10 EA EA201290759A patent/EA201290759A1/ru unknown
- 2011-02-10 BR BR112012020173A patent/BR112012020173A2/pt not_active IP Right Cessation
- 2011-02-10 CA CA2788400A patent/CA2788400A1/en not_active Abandoned
- 2011-02-10 MX MX2012009144A patent/MX2012009144A/es not_active Application Discontinuation
- 2011-02-10 AU AU2011214179A patent/AU2011214179B2/en not_active Ceased
- 2011-02-10 JP JP2012552459A patent/JP6045914B2/ja not_active Expired - Fee Related
- 2011-02-10 SG SG2012056321A patent/SG182795A1/en unknown
- 2011-02-10 CN CN201180019263.1A patent/CN103003306B/zh not_active Expired - Fee Related
- 2011-02-10 US US13/024,698 patent/US8748107B2/en not_active Expired - Fee Related
-
2012
- 2012-08-13 ZA ZA2012/06055A patent/ZA201206055B/en unknown
- 2012-09-03 CO CO12150358A patent/CO6630117A2/es unknown
-
2014
- 2014-05-16 US US14/279,728 patent/US9353185B2/en not_active Expired - Fee Related
-
2016
- 2016-05-11 US US15/152,414 patent/US20160244527A1/en not_active Abandoned
- 2016-07-29 JP JP2016149925A patent/JP2017012179A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EA201290759A1 (ru) | 2013-03-29 |
| MX2012009144A (es) | 2012-10-01 |
| US20160244527A1 (en) | 2016-08-25 |
| WO2011098762A3 (en) | 2012-01-19 |
| SG182795A1 (en) | 2012-08-30 |
| ZA201206055B (en) | 2014-01-29 |
| US8748107B2 (en) | 2014-06-10 |
| JP2017012179A (ja) | 2017-01-19 |
| EP2534177A2 (en) | 2012-12-19 |
| GB201002238D0 (en) | 2010-03-31 |
| KR20120130767A (ko) | 2012-12-03 |
| US9353185B2 (en) | 2016-05-31 |
| WO2011098762A8 (en) | 2011-10-20 |
| US20110311449A1 (en) | 2011-12-22 |
| US20140369925A1 (en) | 2014-12-18 |
| JP2013519367A (ja) | 2013-05-30 |
| CN103003306A (zh) | 2013-03-27 |
| NZ601943A (en) | 2014-11-28 |
| WO2011098762A2 (en) | 2011-08-18 |
| BR112012020173A2 (pt) | 2019-09-24 |
| CO6630117A2 (es) | 2013-03-01 |
| AU2011214179B2 (en) | 2015-08-06 |
| AU2011214179A1 (en) | 2012-09-13 |
| CN103003306B (zh) | 2016-09-07 |
| JP6045914B2 (ja) | 2016-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20150903 |
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| FZDE | Dead |
Effective date: 20180212 |